KR20040073039A - The method for manufacturing of feed - Google Patents
The method for manufacturing of feed Download PDFInfo
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- KR20040073039A KR20040073039A KR1020030008964A KR20030008964A KR20040073039A KR 20040073039 A KR20040073039 A KR 20040073039A KR 1020030008964 A KR1020030008964 A KR 1020030008964A KR 20030008964 A KR20030008964 A KR 20030008964A KR 20040073039 A KR20040073039 A KR 20040073039A
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- feed additive
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K30/00—Processes specially adapted for preservation of materials in order to produce animal feeding-stuffs
- A23K30/20—Dehydration
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
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Abstract
Description
본 발명은 애완용 동물의 자양강장 기능성 영양제로 천연재료와 한방재료를 혼합 처방함으로서 지속적인 면역력 강화는 물론, 활동성을 증가시켜주는 사료첨가제가 함유된 사료 및 그의 제조방법에 관한 것이다.The present invention relates to a feed containing a feed additive for increasing the activity as well as continuous strengthening immunity by prescribing a mixture of natural and herbal ingredients as a nutritive tonic functional nutrient for pets, and a method for producing the same.
현대사회에서는 핵가족화 되면서 애완용 동물이 가족의 일원처럼 여겨지며 그만큼 관심이 커지고 애완용 동물의 식생활은 물론 평균수명까지도 우려하는 애완 인구가 증가하고 있다. 그러나 애완동물의 식생활이 고급화되고, 가정에서 키우는 만큼 운동부족으로 인하여 모든 장기의 기능이 저하되고, 질병에 대한 면역력이 약화되고 있다. 물론 애완동물 병원에서 화학약재에 의한 예방 또는 치료는 가능하지만, 지속적으로 영향을 줄 수 있는 보약, 즉 건강보조식품 형태의 영양제가 필요로 하다고 할 수 있다. 따라서 본 발명자는 상기와 같은 각종 질환에 유효한 애완용 자양강장식품대용으로 사용하는 사료첨가제가 함유된 사료 및 그의 제조방법을 개발하게 되었다.In modern society, pet families are considered to be part of the family as nuclear families become more and more and more pet populations are concerned about the pet's diet and the average life span. However, the diet of pets is upscale, and as a result of lack of exercise as a family raises the function of all organs are lowered, and the immune system to disease is weakened. Of course, pets can be prevented or treated with chemicals in the hospital, but it can be said that the need for supplements that can be continuously affected, that is, nutritional supplements in the form of dietary supplements. Therefore, the present inventors have developed a feed containing a feed additive used as a substitute for nourishing tonic foods effective for various diseases as described above and a method of manufacturing the same.
애완동물들은 초기면역체계가 잡혀지기 전 생후 1개월 내에 치사율이 너무높기 때문에 자생력을 강화시켜 건강하게 자랄 수 있는 토대를 만들어주는 것이 매우 중요하다.Pets have a high mortality rate within one month of birth before the initial immune system is established, so it is important to strengthen their viability and lay the foundation for healthy growth.
어린 애완동물에게 가장 많이 발병하는 장염(파보바이러스 감염)을 치료하는 약품 등이 시판되고 있으나, 이는 언제까지나 화학 약재로 이루어진 양약으로서 짧은 기간동안의 면역력을 높여줄 뿐 장시간동안 건강을 유지하기 힘들다. 또한, 애완동물을 키우는 주인들의 바쁜 사회생활들로 인하여 운동부족에 의한 활동성이 떨어진다. 활동성이 떨어짐으로서 체중이 증가하고, 이러한 비만으로부터 생겨나는 소화계, 내분비계 등에 장에 문제가 생기고, 근육경직 등이 일어남으로서 평균수명이 낮아지는 경향이 있다.Drugs for treating enteritis (parvovirus infection), which are most common in young pets, are on the market, but these drugs are forever made of chemicals, which increase immunity for a short period of time and are difficult to maintain health for a long time. In addition, due to the busy social life of pet owners are less active due to lack of exercise. As the activity decreases, the weight increases, the digestive system, the endocrine system, and the like caused by the obesity cause intestinal problems, and muscle stiffness, etc., tends to decrease the average lifespan.
종래 기술에는 축산용에 많이 사용되는 주사제가 있으나 (예 : 바이엘 동물약품) 천연재료와 한방재료를 이용하여 처방한 복합적인 자양강장 기능성 영양제로서의 사료첨가제로 사용하는 예는 없는 실정이다.In the prior art, there are many injections that are widely used for animal husbandry (eg Bayer animal drugs), but there are no examples of using them as feed additives as a complex nutritional nutritional supplement prescribed using natural and herbal ingredients.
대한민국특허공보 등록번호 특1993-1451호에는 한약재를 원료로 하여 약용이나 보신용을 위해 물 또는 용매 추출한 한약재 부산물에 쥐눈이 콩 또는 감초가루, 소화제, 제올라이트와 탄산칼슘의 혼합물과 식용폐유를 혼합 건조시킨 한약부산물을 이용한 돼지사료의 제조방법이 기재되어 있고,Korean Patent Publication No. 1993-1451 discloses a herb obtained by mixing dried herbal oil with soybean or licorice powder, digestive agent, zeolite and calcium carbonate, and edible waste oil. It describes a method of producing pig feed using by-products,
동 공보 등록번호 특1996-0012396호에는 소맥피, 밀겨, 깻묵, 사카로마이세스속??, 칸디다소균주, 토룰롭시스속균주로 구성된 사료첨가제가 기술되어 있으며,Korean Patent Publication No. 1996-0012396 discloses a feed additive consisting of bovine bark, wheat bran, rice cake, genus Saccharomyces, Candida microbial strain, and tolulopsis microbial strain.
대한민국공개특허공보 공개번호 제1996-0016742호에는 선별된 한약재를 지올라이느, 인삼박, 유지박, 감초박이 가축사료에 첨가된 한방생약추출박을 이용한 사료첨가제의 제조방법이 기술되어 있고,Korean Laid-Open Patent Publication No. 1996-0016742 discloses a method for preparing a feed additive using a herbal extract extracted with ziolaine, ginseng, oil and licorice, which are selected as herbal medicines in animal feed.
동 공보 공개번호 특2001-0011937호에는 산조인, 석창포가 일반사료에 혼합된 생약제를 이용한 가축의 성장촉진용 사료가 기재되어 있으며,Publication No. 2001-0011937 discloses feed for promoting the growth of livestock using a herbal medicine mixed with Sanjoin and Seokchangpo in general feed.
동 공보 공개번호 제2002-0025433호에는 인삼,황금,백출,복령,황기,산약, 택사, 감초 계지, 당귀, 산수유, 숙지황, 목단피등 적어도 둘이상의 조합이나 이들의 선택적 조합 이외에 대추, 산사자, 사인, 진피, 후박, 음양곽, 천궁, 작약, 산약, 녹각등의 하나 또는 둘 이상의 추가적 조합에 의해 이뤄지고, 여기에 펙틴, 당분, 탄수화물, 안식향산, 판토텐산칼슘, 염산글루타민산, 메치오닌, 염산리신, L-로이신, L-페닐알라닌, L-트레오닌, L-발린 아미노산, 비타민 A,B,C,E, 등에서 선택된 하나 또는 둘이상의 기능성 물질을 소량 포함하는 것을 특징으로 하는 동물 기능강화조성물이 기재되어 있으나,Publication No. 2002-0025433 discloses jujube, hawthorn, sign, and other combinations of ginseng, golden, baekchul, bokyeong, huanggi, mountain medicine, taxa, licorice cinnamon, donkey, cornus, sujijihwang, and bark skin. By one or more additional combinations, such as dermis, groin, yin and yang, zirconia, peony, medicinal herb, green tea, etc. , L-phenylalanine, L-threonine, L- valine amino acids, vitamins A, B, C, E, etc., characterized in that the animal functional composition comprising a small amount of one or more functional substances selected,
상기와 같은 종래의 기술들은 일반적으로 사용하는 범용의 한약재이며 또 이는 시럽 형태로 동물들이 복용하는데 있어서 거부가 생길 수 있고, 추출, 농축 등에 복잡한 제조방법에 따른 고가의 제품이라는 것이 문제점으로 남아 있다.The conventional techniques as described above are general purpose herbal medicines that are generally used, and this may cause rejection of the animals in the form of syrup, and remains a problem that they are expensive products according to complex manufacturing methods such as extraction and concentration.
상기와 같은 문제점을 해결하기 위하여 본 발명은 사람에게만 적용되어 왔던 한방약재들과 천연재료들의 추출 또는 원재료들을 적절히 배합한 첨가제로 조성된 사료를 애완동물에게 먹임으로서 지속적으로 건강을 유지할 수 있는 사료첨가제가 함유된 사료 및 그의 제조방법을 제공하는 것이 본 발명이 이루고자 하는 기술적과제인 것이다.In order to solve the above problems, the present invention is a feed additive that can maintain a healthy health by feeding the pet to the pet food consisting of the herbal medicines and natural ingredients that have been applied only to humans, or additives properly blended raw materials It is a technical problem to be achieved by the present invention to provide a feed containing and a method for producing the same.
상기와 같은 목적을 달성하기 위하여 본 발명은 알리신 4~5중량부, 구연산 2중량부, 차전자 2중량부, 산약 7~8중량부, 유산균 3중량부, 연교 4중량부, 금은화 4~5중량부, 황연 1.3중량부, 향부자 2.5중량부, 알긴 8~12.2중량부와 통상의 애완용동물용 사료 50~55중량부로 조성되어 있음을 특징으로 하는 사료첨가제가 함유된 사료 및 그의 제조방법에 관한 것이다.In order to achieve the above object, the present invention is 4 to 5 parts by weight of allicin, 2 parts by weight of citric acid, 2 parts by weight of tea tea, 7 to 8 parts by weight of acid, 3 parts by weight of lactic acid bacteria, 4 parts by weight of duct bridge, 4 to 5 gold coins Feed additive containing a feed additive comprising a weight part, 1.3 parts by weight of sulfur, 2.5 parts by weight of flavor rich, 8-12.2 parts by weight of algin and 50-55 parts by weight of a conventional pet food, and a method for producing the same will be.
본 발명을 좀더 구체적으로 설명하면, 각종질환의 예방과 치료에 유효한 천연 유기 및 고분자 추출물(천연재료)과 특수한 한방재료의 적절한 배합에 따른 부작용 최소화 및 자양강장 효과를 높일 수 있는 조성물로서 이하 목적을 달성하기 위한 조성물은 다음과 같다.The present invention will be described in more detail as a composition that can minimize side effects and increase the nourishing tonic effect according to the appropriate combination of natural organic and macromolecular extracts (natural materials) and special herbal ingredients effective for the prevention and treatment of various diseases. The composition to achieve is as follows.
- 조성물 -Composition
기본재료 : 탄수화물, 지방, 단백질, 비타민등으로 로 이루어진 애완용 사료Base material: pet food consisting of carbohydrate, fat, protein, vitamin
천연재료 : 구연산, 알긴, 마늘 (알리신, 스코르디닌, 캡사이신), 유산균 3종(락토바실루스속, 스트렙토코쿠스속, 페디오코쿠스속), 탄닌, 프로폴리스Natural Ingredients: Citric Acid, Algin, Garlic (Allicin, Scordinin, Capsaicin), 3 kinds of Lactic Acid Bacteria (Lactobacillus, Streptococcus, Pediococcus), Tannin, Propolis
한방재료 : 차전자피, 산약, 연교, 금은화, 황련, 향부자, 어성초, 결명자, 유카, 백작약, 정향, 치커리Herbal Ingredients: Cha-e-Pi, San-Cheung, Yeon-Gyo, Geum-Gin-Hwa, Hwang-Ryun, Hyangbu-ja, Eoseongcho, Catch-up, Yucca, Earl of Peony, Clove, Chicory
상기 약재들에 포함되어 있는 성분과 영향Ingredients and Influences in the Herbs
구연산 : ( 영향 : 항균, 신진대사 촉진, 약알칼리성 혈액화, 유산억제, 면역력증진, 혈액순환강화, 간기능 강화 )Citric Acid: (Effect: Antibacterial, Metabolism Promoting, Alkalescent Hematization, Lactic Inhibition, Immune Strength, Blood Circulation, Liver Function)
유산균 : ( 영향 : 장내 유해균 억제, 면역증강, 감염 억제, 항암작용, 노화억제, 비타민 생성, 피부미용효과 )Lactobacillus: (Effect: Intestinal harmful bacteria suppression, immunity enhancement, infection inhibition, anticancer activity, anti-aging, vitamin production, skin beauty effect)
알 긴 : ( 영향 : 체내지방흡수, 중금속 제거, 숙변제거 )Al-Long: (Impact: Body fat absorption, heavy metal removal, stool removal)
스코르디닌 :( 영향 : 강장 및 근육증강효과 )Sordinin :( effect: tonic and muscle strengthening effect)
캡사이신 : ( 영향 : 활성산소 생성 차단 및 노화억제기능 )Capsaicin: (Effect: Blocking free radical production and anti-aging)
알리신 : ( 영향 : 살균, 항혈전효과, 노화방지, 신진 대사효과 )Allicin: (Effect: bactericidal, antithrombotic, anti-aging, metabolic effect)
탄 닌 : 갈릭산(gallic acid), 폴리페놀(polyphenol) (영향: 항균효과, 살균효과, 지혈작용 및 모세혈관을 강화작용 )Tannins: gallic acid, polyphenols (effects: antibacterial, bactericidal, hemostatic and capillary)
프로폴리스 : 플라보노이드(flavonoid), 안식향산 (benzoic acid), 에스크레틴(escuretin), 스코포레틴(scopoletin) (영향 : 면역기능강화, 항암효과, 경합조직 강화 )Propolis: flavonoids, benzoic acid, escuretin, scopoletin (impact: immune function enhancement, anticancer effect, competitive tissue strengthening)
- 차전자피 : 플란타산(plantansan), 아우쿠빈(Aucubin) ( 영향: 장기능강화, 거담 )-Cha blood: plantansan, aucubin (effect: intestinal function, expectoration)
- 산약 : 베타타신(batatasin), 아밀라제(amylase), 디오스신(dioscin), 뮤친(mucine) ( 영향 : 비장 보신, 자양강장, 기관지 보호)-Pesticides: betasin, amylase, dioscin, mucine (effects: spleen bowel, nourishment tonic, bronchial protection)
- 연교 : 아크티제닌 (arctigenin), 아크틴(arctiin), 베튜리닉산(betulinicacid), 우솔릭 산(ursolic acid) (영향 : 협심증, 심근경색 예방, 해열해독, 비타민B1 흡수강화)Fate: Arctigenin, arctiin, arctuinic acid, betulinic acid, ursolic acid (effects: angina pectoris, prevention of myocardial infarction, antipyretic detoxification, vitamin B1 absorption)
- 금은화 : 루테올린(luteolin), 클로로제닉산 (chlorogenic acid) (영향 : 이뇨, 해독, 소염, 지혈)Gold and silver coins: luteolin, chlorogenic acid (impacts: diuresis, detoxification, anti-inflammatory, hemostasis)
- 황련 : 버버린 (berberine), 팔마틴 (palmatine), 자테오진 (jateorhzine)-Husband: berberine, palmatine, jateorhzine
(영향 : 건위·진정·소염·항군)(Impact: healthy stomach, soothing, anti-inflammatory, anti-gun)
- 향부자 : 정유, α-싸이페론 (α-cyperone), 싸이페로툰돈 (cyperotundone), 싸리페롤 (cyperol) (영향 : 경폐통경, 진경약으로 월경불순, 한산복통, 유방창통, 간욱기체, 신경통, 소화불량 )-Hyangbuja: essential oils, α-cyperone, α-cyperone, cyperotundone, cyperol (cyperol) Indigestion )
- 어성초 : 정유, 데타노일 아세트 알데히드, 쿠에르치트린 (Quercitrin), 쿠에르체틴(Quercetin) (영향 : 해독 작용, 피부질환, 간장질환 )-Echoseong: essential oil, detanoyl acetaldehyde, quercitrin, quercetin (effect: detoxification, skin disease, liver disease)
- 결명차 : 에모딘 (emodine), 피션 (physcion), 알로에-에모딘(aloe-emodine) (영향 : 콜레스테롤 저하, 간장기능저하, 간기능강화)-Name difference: emodine, physcion, aloe-emodine (impact: lowered cholesterol, reduced liver function, enhanced liver function)
- 유카 : 사포닌 ( saponin) (영향 : 배설물 냄새제거, 장기능강화)-Yucca: Saponin (Effect: Deodorization, Enhancement of Bowel Function)
- 백작약 : 페오니플로린( Paeoniflorin ), 옥시페오니플로린 (Oxypaeoniflorin) 타닌(Tannin) (영향 : 부인병, 복통, 해열, 지혈)Earl: Paeoniflorin, Oxypaeoniflorin, Tannin (effects: women's diseases, abdominal pain, fever, hemostasis)
- 정향 : 정유, 에우게놀(Eugenol) (영향 : 소화촉진, 진통, 항염, 구충작용 )-Clove: essential oil, Eugenol (impact: promote digestion, analgesic, anti-inflammatory, antiparasitic)
- 치커리 : 이눌린(inulin) (영향 : 장기능강화, 구충작용, 당뇨예방)-Chicory: Inulin (Effect: Intestinal Function Enhancement, Insect Repellent, Diabetes Prevention)
상기 천연물질과 한방약재들의 적절한 혼합 처방은 건강유지는 물론 면역력을 증가할 수 있지만, 한 성분 단독 또는 과량을 복용할 경우 부작용이 올 수 있다. 따라서 물질안전보건자료(MSDS) 및 반수치사약량[LD50(rat이용)]값을 이용하여 한의학적으로 적절한 조성비를 이루어져야 한다.Proper mixing of the natural substances and herbal medicines can increase immunity as well as maintaining health, but may take side effects when taken alone or in large amounts. Therefore, the appropriate composition ratio should be achieved by using MSDS and the half-dose [LD50 (rat)] value.
추출은 추출이 필요한 일정 성분의 건조중량에 대하여 탄소수 1-3개의 무수 또는 함수 고급 알코올, 에테르를 1~15배 부피량으로 가하여 냉각콘덴서가 장치되어 유효성분이 증발되는 것을 방지한 상태에서 50~100℃로 3~12시간 가열하여 추출한다. 또한 무수 또는 함수 에탄올 또는 메탄올 추출물에 적당한 양의 물을 가한 뒤, 여기에 에틸아세테이트를 가하여 잘 섞은 다음 방치하여 층을 분리시킨 뒤, 상층을 분리하여 사용할 수도 있다. 이렇게 추출한 천연식물 및 한약재추출물을 냉각콘덴서가 달린 증류장치를 이용하여 증발되어 나오는 용매를 회수하면서 완전히 감압 농축하여 농축액 또는 건조 파우더를 얻었다.Extraction is carried out by adding 1 to 15 times by volume of anhydrous or hydrous higher alcohols and ethers of 1 to 15 carbon atoms to the dry weight of certain components that need to be extracted. Extract by heating to 3 ~ 12 hours. In addition, an appropriate amount of water may be added to anhydrous or hydrous ethanol or methanol extract, ethyl acetate may be added thereto, mixed well, left to separate layers, and the upper layer may be separated. Thus extracted natural plants and herbal extracts were concentrated under reduced pressure completely while recovering the solvent evaporated using a distillation apparatus equipped with a cooling capacitor to obtain a concentrate or dry powder.
시료예 1~17을 각각 100g씩을 추출병에 따로 넣고 95~99% 고급 에탄올을 1~15배의 부피량을 넣고 냉각콘덴서가 부착된 추출기에서 70~80℃로 12시간 가열하여 추출한다. 추출액을 와트만(Waterman) 종이 여과지로 감압 여과한 후, 건더기를 제거하고 나머지 추출액을 냉각콘덴서가 달린 증류장치에서 감압 농축하여 동결 건조시켜 건조분말을 얻는다.100g each of Sample Examples 1-17 were put into an extraction bottle separately, and a volume of 95-99% higher ethanol was added 1-15 times and extracted by heating at 70-80 ° C for 12 hours in an extractor equipped with a cooling capacitor. The extract was filtered under reduced pressure with a Waterman paper filter paper, and then, the dried extract was concentrated under reduced pressure in a distillation apparatus equipped with a cooling capacitor to freeze-dried to obtain a dry powder.
단, 상기 물질들은 실시 예에 한정되지 않고, 기타 공지의 화합물들을 포함할 경우 발명의 효과를 볼 수 있다.However, the above materials are not limited to the examples, and when the other known compounds are included, the effect of the invention can be seen.
이하 본 발명을 실시예를 통하여 상세히 설명하기로 한다.Hereinafter, the present invention will be described in detail through examples.
실시예1Example 1
차전자 2g, 산약8g, 연교 4g, 금은화 5g, 황연 1.3g, 향부자 2.5g를 95~99% 에탄올 1~15배의 부피량에 넣고 냉각 콘데서가 부착된 추출기에서 70~80℃로 12시간 가열하여 추출한 다음, 추출액을 와트만(Waterman) 종이 여과지로 감압 여과한 후, 건더기를 제거하고 나머지 추출액을 냉각콘덴서가 달린 증류장치에서 감압 농축하여 통상의 동결건조기에서 동결건조시켜 건조분말을 얻은 후에, 알리신 5g, 구연산 2g, 유산균 3g, 알긴 12.2g 및 애완용동물용 사료 55g에 첨가하여, 통상의 분쇄기로 100매시 정도의 크기로 분쇄하여 분말화 한 다음, 밀폐 포장하여 사료를 제조하였다.2g of charcoal, 8g of acid, 4g of duct, 5g of gold and silver, 1.3g of sulfur, and 2.5g of Hyangbuja in a volume of 1 ~ 15 times of 95 ~ 99% ethanol and heated at 70 ~ 80 ℃ for 12 hours in an extractor equipped with a cooling condenser. After extraction by extraction, the extract was filtered under reduced pressure with a Waterman paper filter paper, and then the residue was removed, and the remaining extract was concentrated under reduced pressure in a distillation apparatus equipped with a cooling condenser, lyophilized in a conventional freeze dryer to obtain a dry powder. It was added to 5g of allicin, 2g of citric acid, 3g of lactic acid bacteria, 12.2g of algin and 55g of pet food.
실시예2Example 2
차전자 2g, 산약8g, 연교 4g, 금은화 5g, 황연 1.3g, 향부자 2.5g를 95~99% 에탄올 1~15배의 부피량에 넣고 냉각 콘데서가 부착된 추출기에서 70~80℃로 12시간 가열하여 추출한 다음, 추출액을 와트만(Waterman) 종이 여과지로 감압 여과한 후, 건더기를 제거하고 나머지 추출액을 냉각콘덴서가 달린 증류장치에서 감압 농축하여 통상의 동결건조기에서 동결건조시켜 건조분말을 얻은 후에, 알리신 5g, 구연산 2g, 유산균 3g, 알긴 12.2g 및 애완용동물용 사료 55g에 첨가하여, 통상의 분쇄기로 100매시 정도의 크기로 분쇄하여 분말화 한 다음, 함유된 물을 넣어 통상의 타형기로 일정크기 직경 약 0.5~1Cm의 크기로 타형하여 성형한 후에, 수분을 제거하기 위해서 통상의 건조기에서 105℃ 정도에서 건조시켜 밀폐 포장하여 사료를제조하였다.2g of charcoal, 8g of acid, 4g of duct, 5g of gold and silver, 1.3g of sulfur, and 2.5g of Hyangbuja in a volume of 1 ~ 15 times of 95 ~ 99% ethanol and heated at 70 ~ 80 ℃ for 12 hours in an extractor equipped with a cooling condenser. After extraction by extraction, the extract was filtered under reduced pressure with a Waterman paper filter paper, and then the residue was removed, and the remaining extract was concentrated under reduced pressure in a distillation apparatus equipped with a cooling condenser, lyophilized in a conventional freeze dryer to obtain a dry powder. It is added to 5g of allicin, 2g of citric acid, 3g of lactic acid bacteria, 12.2g of algin and 55g of pet food, and pulverized to a size of about 100 mash with a conventional grinder, and then powdered with water, After molding by molding to a size of about 0.5 ~ 1Cm diameter, dried to about 105 ℃ in a conventional dryer in order to remove the moisture to prepare a feed.
실시예3Example 3
상기 실시예1에서 제조한 사료첨가제가 함유된 사료를 대상동물에 대하여 단계별로 복용시키는데 있어서, 애완동물의 체중이 1Kg 이하일 경우에는 체중대비 0.003~0.1 중량%를, 1~5Kg 일때는 체중대비 0.003~0.05중량%를, 5Kg 이상일 경우에는 체중대비 0.003~0.5중량%를 1일 2~3회 복용시켰다.In taking the feed containing the feed additive prepared in Example 1 step by step for the target animal, when the weight of the pet is less than 1Kg 0.003 ~ 0.1% by weight compared to the weight, 0.003 to the weight when 1 ~ 5Kg ~ 0.05% by weight, if more than 5Kg 0.003 ~ 0.5% by weight of the weight was taken 2-3 times a day.
상기 발명된 물질의 효능을 확인하기 위하여 상기 방법으로 제조된 복합 물질들을 이용하여 간단한 임상실험을 수행하였다. 아래 실험예를 통하여 살펴보면,In order to confirm the efficacy of the invented material, a simple clinical experiment was performed using the composite materials prepared by the above method. Looking at the experiment below,
실험예1Experimental Example 1
상기 복합 보조식품을 육견 농장에서 태어난(약 15∼45일) 같은 종(육견) 강아지 40마리 중 20마리에게 30일 복용시킨 후 복용하지 않은 20마리의 강아지와 비교하였다. 비교는 아래 결과와 같이 일반적으로 애견들의 건강상태를 확인할 수 있는 것으로 확인하였다.The combination supplement was compared to 20 dogs that were not taken after 20 days of 20 of 40 dogs of the same species (dogs) born on a dog farm (about 15-45 days). The comparison confirmed that the health status of the dogs was generally confirmed as follows.
단, 위 실험 결과는 15마리 이상을 평균적으로 관찰한 결과임.However, the above test results are the average observation of more than 15 animals.
실험예2Experimental Example 2
상기 복합 보조식품들의 면역력 강화를 확인하기 위하여 랫드(흰쥐, 백서)를 이용하여 실험동물에 대한 혈핵학적 임상실험을 실시하였다. 결과는 아래와 같이 혈액학적 검사와 백혈구 감별검사로 판단할 수 있었다.In order to confirm the immunity strengthening of the complex supplements, rats (white rats, white paper) were used to conduct hematological clinical trials on experimental animals. The results were judged by hematologic test and leukocyte differential test as follows.
실험 동물은 (주)대한 실험 동물 센터에서 4주령된 제중 100∼150g의 특정병원체제 부재 (Specific Pathogen Free SPF) 숫컷 SD(Sprague-Dawley)계 랫드를 분양 받아서 23±3℃, 습도 50±5%, 환기 10∼15회/1일, 12시간 주기 명암 교대 및 조도 150∼300Lux의 환경 조건에서 일주일간 적응 순화시킨 5주령의 건강한 동물을 선택하여 폴리카보네트 사육 상자(케이지, 280W×400L×1700H, mm)당 평균 체중에 대한차이를 최소화하여 3마리씩 넣어 군분리를 시행하여 실험하였으며, 사용한 깔짚은 펼프 재질을 사용하였다. 동물 사료와 음용수 섭취는 배합 사료 (삼양유지사료 Co., 탄수화물 65.6%, 지방 3.5% 이상, 단백질 22.1%, 인 0.4% 이상, 칼슘 0.6% 이상, 회분 8.0%이하, 섬유5.0% 이하 함유)와 상기 실시예3과 같이 제조된 사료를 복용시켰고, 음용수로는 일반 수도수로 실험 동물인 랫드에 공급하였다.Experimental animals were pre-packed at 23 ± 3 ° C and humidity 50 ± 5 with 100-150 g of specific pathogen free SPF male SD (Sprague-Dawley) rats at 4 weeks of age at Daehan Experimental Animal Center. %, Ventilation 10-15 cycles / day, 12-hour cycle of contrast and light intensity of 150-300Lux. 1700H, mm) to minimize the difference in the average body weight was carried out by performing a group separation of three dogs were used, and the used litter was used the spread material. Animal feed and drinking water intakes are included in the blended feed (Samyang Fat Feed Co., Carbohydrate 65.6%, Fat 3.5%, Protein 22.1%, Phosphorus 0.4%, Calcium 0.6%, Ash 8.0%, Fiber 5.0%) The feed prepared as in Example 3 was taken, and drinking water was supplied to rats, which are experimental animals, in general drinking water.
랫드에 대한 경구투여시 혈액학적 성분 효과Effect of Hematological Components on Oral Administration in Rats
백혈구는(WBC) 6.60∼12.6×103/μL를 정상범위로 보면, 실험 20일 후에 투여군의 경우 백혈구 수치가 대조군에 비해 정상적인 백혈구 수치를 나타냄으로서 면역력이 유지 또는 증가되고 있으나, 대조군의 경우에는 일부에서 정상범위보다 면역력 감소에 의해 감소하거나 감염에 의한 증가를 나타내었다.Leukocytes (WBC) 6.60 ~ 12.6 × 10 3 / μL in the normal range, after 20 days of the experimental group in the white blood cells in the administration group showed normal white blood cell levels compared to the control group, immunity is maintained or increased, but in the control group In some cases it was reduced by decreased immunity or increased by infection than the normal range.
적혈구(RBC)는 정상범위가 6.76∼9.75×106/μL[135∼136]임을 감안하면, 각투여군의 범위는 정상범위 내에 있는 것으로 판단되었고, 대조군도 정상범위를 확인 할 수 있었다.Considering that the red blood cell (RBC) ranged from 6.76 to 9.75 × 10 6 / μL [135 to 136], the range of each administration group was determined to be within the normal range, and the control group was able to confirm the normal range.
헤모글로빈(HGB)은 정상범위를 13.4∼15.8g/dL[135∼136]로 보면, 투여군에서 역시 정상범위내에 있음을 확인하였다.When hemoglobin (HGB) is in the normal range of 13.4-15.8 g / dL [135-136], it was confirmed that hemoglobin (HGB) was also in the normal range.
혈구용적(HCT), 평균적혈구 용적(MCV), 평균적혈구혈색소량(MCH), 평균적혈구 혈색소농도(MCHC), 혈소판수(PLT), 등에서는 과다 출혈이 발생하지 않았으므로 대체적으로 정상범위내에 있음을 확인하였다.Hematocrit (HCT), mean erythrocyte volume (MCV), mean erythrocyte hemoglobin (MCH), mean erythrocyte hemoglobin (MCHC), platelet count (PLT), etc., were generally within the normal range It was confirmed.
대체적으로 본 발명에서 상기물질을 투여한 경우에는 백혈구 수치와 헤모글로빈의 혈액학적 결과로 볼 때 면역력과, 원활한 혈액순환이 대조군에 비해서 우수함을 확인하였다.In general, in the present invention, when the above-mentioned substance was administered, it was confirmed that immunity and smooth blood circulation were superior to the control group in view of the hematologic results of hematoglobin and hemoglobin.
백혈구 감별 검사(differential counts)에서는 백혈구 중 무과립 백혈구인 단핵구(monocyte)와 림프구(lymphocyte)는 이물 처리와 면역기능을 하며 과립 백혈구인 호산구(eosiniphil), 호중구(neutrophil) 및 호염기구(basophil)는 식균, 혈액응고, 면역 기능 및 살균 작용을 하는 것으로 알려져 있으며 특히 호산구는 피부, 소화기 및 기도 등의 내벽에 위치하여 외부로부터 들어오는 독성 물질을 해독 하는데 중요 역할을 하며 피부 아레르기(allergy) 질환 등이 있으면 상당히 증가한다.In the differential counts, granulocytes (monocytes and lymphocytes), which are non-granular leukocytes, perform foreign body treatment and immune function, while granulocytes, eosiniphil, neutrophil and basophil, It is known to have phagocytosis, coagulation, immune function, and bactericidal effect. Especially, eosinophils are located on the inner wall of skin, digestive organs and airways, and play an important role in detoxifying toxic substances from the outside. If it increases significantly.
아래에 결과를 나타내었다. (일반적인 내용이라서)The results are shown below. (General)
랫드에 대한 경구투여시 백혈구 감별검사Differentiation of White Blood Cells in Oral Administration in Rats
백혈구 감별검사에서는 투여군과 대조군이 정상범위안에 거의 들어 있으나, 일부 대조군에서 감염 또는 면역력 약화에 의하여 정상범위를 벗어나 있다는 것을 확인하였다.In the leukocyte differential test, the administration group and the control group were almost in the normal range, but some of the control group were found to be out of the normal range due to infection or weakened immunity.
본 발명의 복합물질은 애완동물에 대한 관심이 높아지는 지금, 식생활에 따라 단순 서양식(비타민, 미네랄)의 영양 처방제와는 차별화 되는 천연 생약추출 성분 및 한방재료의 조합에 따른 시너지 효과를 창출할 수 있다.The composite material of the present invention can create a synergistic effect of the combination of natural herbal extract ingredients and herbal ingredients that are differentiated from simple Western diets (vitamins, minerals) nutritional prescription according to the diet now, the interest in pets is increased have.
본 발명품인 저가의 보조식품을 자견, 병약견, 노쇠견 및 성견 등 모든 애완동물에게 복용하게 함으로서 모체로부터 면역력을 부여받을 수 있으며 생후 초기 치사율을 줄일 수 있고, 초기에 장염예방 및 성장발육에도 큰 영향을 줄 수 있다. 고가의 애견의 경우 30 ~ 40%되는 치사율을 낮출 수 있고, 성장기의 건강, 노쇠기의 노화 억제 및 번식률 또한 높일 수 있어서, 애완동물을 사랑하는 사람들에게 큰 각광을 받을 수 있을 것으로 예상된다.By taking the low-cost supplements of the present invention to all pets such as dogs, sick dogs, old dogs and adult dogs, immunity from the mother can be given, and early mortality can be reduced after birth. May affect In the case of expensive dogs, it is possible to lower the mortality rate of 30 to 40%, increase the health of the growing season, suppress the aging of the aging period, and also increase the breeding rate.
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Cited By (4)
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CN103549137A (en) * | 2013-11-13 | 2014-02-05 | 易祥 | Antiviral livestock and poultry health care feed additive |
KR20160061494A (en) * | 2014-11-21 | 2016-06-01 | (주) 에이티바이오 | Feed for improving immunity and manufacturing method for the feed |
KR20180101772A (en) * | 2017-03-06 | 2018-09-14 | 상하이 지슈아이 바이오 테크놀로지 컴퍼니 리미티드 | Cat feed containing nano microcrystalline cellulose |
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KR100884086B1 (en) | 2007-04-26 | 2009-02-18 | 대한민국 | Extracting method of feed additives using a coptic rhizome and forsythia fruit extract |
KR100880915B1 (en) | 2007-11-16 | 2009-02-04 | 대한민국(관리부서:농촌진흥청) | A method of producing a functional composition and a feed additive comprising it |
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KR101442711B1 (en) * | 2013-03-18 | 2014-09-23 | 김수봉 | Vacuum freeze drying method and drying feed manufacturing method for companion animal manufactured by the method |
KR101716739B1 (en) | 2016-04-01 | 2017-03-15 | (주)비타바이오 | Composition comprising extract of Plantaginis Semen having activity of immune enhancement or for treating or preventing virus disease |
KR20160113563A (en) | 2016-09-20 | 2016-09-30 | (주)비타바이오 | Composition comprising extract of Plantaginis Semen having activity of immune enhancement or for treating or preventing virus disease |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103549137A (en) * | 2013-11-13 | 2014-02-05 | 易祥 | Antiviral livestock and poultry health care feed additive |
KR20160061494A (en) * | 2014-11-21 | 2016-06-01 | (주) 에이티바이오 | Feed for improving immunity and manufacturing method for the feed |
KR20180101772A (en) * | 2017-03-06 | 2018-09-14 | 상하이 지슈아이 바이오 테크놀로지 컴퍼니 리미티드 | Cat feed containing nano microcrystalline cellulose |
KR20220065448A (en) * | 2020-11-13 | 2022-05-20 | 서성원 | Feed composition for companion animals comprising micropterus salmoides and manufacturing method of feed using the same |
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