KR20040036272A - A composition for promoting growth or secretion of growth hormone comprising an extract of artemisia capillaris thunberg. and functional cereals coated by same - Google Patents

Abstract

PURPOSE: A composition containing an Artemisia capillaris thunb. extract as an effective ingredient is provided. It shows excellent effects of promoting growth and growth hormone secretion and can be used a health supplementary food for promoting growth when coated to cereals. CONSTITUTION: A composition for promoting growth and growth hormone secretion comprises 10 to 100% by weight of an Artemisia capillaris thunb. extract, 0 to 90% by weight of herbal plants and 5 to 50% by weight of a starch solution. The herbal plants are one or more components selected from Acanthopanacis Cortex, Acanthopanax Senticosus(Rupr. et Maxim.) Harms, Phlomis umbrosa Turez. Lycii Cortex Radicis, Carthami Flos, Eucommiae Cortex, Poria cocos, Cuscutae Semen, Ginseng Radix, Cervi cornu and calcium. The composition is coated to cereals selected from white rice, unpolished rice, barley, foxtail millet, sorghum or glutinous rice.

Description

A composition containing phosphorus mugwort having an effect of promoting growth or secretion of growth hormone and functional coated grains coated using the same, and the functional coated grains coated with the same. AND FUNCTIONAL CEREALS COATED BY SAME}

The present invention relates to a composition containing phosphorus mugwort having an effect of promoting growth or secretion of growth hormone, and a functional coated grains coated using the same, a method of preparing the coated grains, and a processed cereals manufactured using the coated grains.

In recent years, the development of children and adolescents has been greatly improved due to changes in eating habits and nutritional status due to economic growth. In addition, a social atmosphere that favors large height has been formed, and interest in promoting height growth is increasing in normal children as well as patients with growth disorders. Growth promotion methods for this purpose include the administration of growth hormone or thyroid hormone, vitamin D, insulin positive factors, etc. (Klaus G et al., Pediatr. Nephrol .. 14 : 612-615 (2000) ), Ilizanov surgery and functional foods are mainly used. However, these methods currently used have various problems. For example, side effects from growth hormone administration include pruritus, redness, pain, fat atrophy and hypertension, glucose intolerance, pancreatitis, systemic allergic reactions, growth hormone antibody positive, cancer development, and feminization in men. Back symptoms appear. Ilizanov surgery is commonly used for asymmetric bilateral lower limb lengths.If it is applied to a shorter person and is forced to stretch both legs, the patient's pain or social cost may be lost due to unexpected side effects. Failure to walk normally can also occur.

Traditionally, Chinese medicine classifies the causes of pediatric growth disorders into congenital and acquired factors, and Shin is known as the "born natural book" in the form of Jangjeong, Jugol, and bottled water. It is the basis of the 生, and the cerebrospinal fluid sea, and the rain is called the "fucheonjibon", which means the main meat, the injection paper, and the main blood metabolism. It is said to be a support (主 氣血 化生 之 原). In addition, the growth of the body is good when the nourishment is good and the dryness is dry. However, the lack of congenital and post-acquired dysfunction causes the growth to be impaired. , Kidney, tooth development, movement, intelligence, etc. have been reported (Hong Won-sik, Emperor's Endooral Rumors, Seoul, Institute of Oriental Medicine, pp11, 24, 34, 39, 69, 166, 333 (1985)). There are two types of growth disorders, 'Oji' and 'Ohyeon'. The Oji is the location of children, their habits, and their feet. , Development, delayed development of the larvae and eoji, and impaired behavior, language, and tooth growth. Oh Yeon (軟) refers to yeonyeon (항), hangyeon (수), Hakyeonyeon (手脚) 성장), yukyeonyeon (肌肉 軟), cough (口 軟) usually refers to growth disorders, such as cerebral dysfunction due to congenital weakness, premature birth or acquired malnutrition. Herbal treatments for growth disorders include Boik ((), Blood (Blood), Boyang (보 陽), Boeum (補陰), Live Blood Chemistry (Activ 血 化 온 法), Warm There are past Korean laws, and the double reward law is known to be the most important.

On the basis of the traditional Chinese medicine theory, the dietary supplements on the market are mainly composed of prickly pear, ogapi, safflower seed, tofu, baekbokyeong, earth and sand, bokbunja, and green tea. In the case of psorigalpi, the main components are known as eleutherosides A to E. In addition, chlorogenic acid, β-sitosterol, friedelin, and betulinic acid , Amigdalin, iosfraxidin and the like. Psoriasis has been studied for its bone-growth-promoting effect (Park Sun-young and five others, Korean Society for Pharmacy Symposium , 2002), and health promotion for growth including safflower seed, tofu, baekbokyeong, bokbunja, earthenware and greenery and calcium Supplements (Korean Patent No. 0278206) are already commercially available.

On the other hand, growth hormones reorganize organs according to aging progress, increase protein synthesis and inhibit degradation, break down fat to treat obesity, improve immune function and energy efficiency, improve kidney function, bone growth, increase bone density, decrease blood pressure, cardiac function It is administered for the purpose of reducing cholesterol, improving LDL and improving memory, improving sexual function, improving wound healing, improving skin condition and removing wrinkles by lowering LDL and raising HDL.

Therefore, the inventors of the present invention while researching to develop a drug that can promote growth or secretion of growth hormone, Artemisia capillaris Thunberg, which has a safe, nontoxic, and various pharmacological action, promotes growth or secretes growth hormone. The present invention has been completed by discovering that it can be promoted.

Injin mugwort has the effect of lowering heat and eliminating moistness, and is known to be effective in treating the symptoms of moist jaundice and poor urine, and its pharmacological action is to inhibit liver damage (Ichiho et al., Two livestock foods). Society's 22nd Fall Conference Abstract Collection, 1998), Anticancer Effect (3 persons including Jung-Gwon Chung, Hakkuk Food Science Association Spring Conference Abstract Collection , 1998), antioxidant activity, blood lipid reduction and liver function improvement effect (Han Eun-kyung and 4 others, Hakkuk) Food Science and nutrition Conference, 1997), anti-mutation effect (five other choedongseong, Korea Society for Biotechnology and Bioengineering paper, 2000), and antibacterial effects (jangmaehui and essential components and antibacterial effects of wormwood joyeonhui, injinssuk, sacheolssuk, sajabal), etc. are known have.

However, there has been no report on the effect of growth or secretion of growth hormone of Injin mugwort.

Accordingly, it is an object of the present invention to provide a composition that promotes growth or secretion of growth hormone.

Another object of the present invention is to provide a functional coated grains coated with the composition, a method of manufacturing the same, and a functional cereal processed product using the same.

In order to achieve the above object, the present invention provides a composition for promoting growth or secretion of growth hormone comprising the extract of jinjinjin as an active ingredient.

In order to achieve the above another object, the present invention provides a functional coated cereals and functional cereals manufactured using the same, which are effective in promoting growth or secretion of growth hormone coated with the composition.

In addition, the present invention provides a method for producing a functional coated grains, characterized in that the grain coating composition is added to the grains, mixed and dried.

The composition of the present invention comprises the extract of Injin mugwort as an active ingredient for promoting growth or secretion of growth hormone secretion. Phosphorus mugwort extract is extracted with an ultrasonic grinder for 48 to 72 hours or refluxed for 4 to 7 hours in water or an organic solvent of 3 to 6 times the weight ratio of pulverized mugwort pulverized to 30-50 mesh, and then 0.1 to 10 as necessary After filtration with a 탆 filter it can be obtained by concentrating under reduced pressure 5 to 10 times at 60 to 80 ℃ temperature for 24 to 60 hours to cool to 30 ℃ or less. The quality of the extracts that can be used is 20 to 50 brix. In this case, as the organic solvent, lower alcohols such as ethanol, methanol, isopropyl alcohol, 50% or more of aqueous solution thereof, or alcohol, etc. may be used, and alcohol or 70% ethanol is particularly preferable.

The composition of the present invention by promoting the growth hormone secretion, regrowth of organs according to the aging progress, protein synthesis and inhibition of degradation, fat degradation to treat obesity, immune function and energy efficiency, kidney function, bone growth, bone density increase Lowering blood pressure, improving heart function, lowering LDL and increasing HDL are effective in reducing cholesterol, enhancing vision and memory, improving sexual function, improving wound healing, improving skin condition and removing wrinkles.

The composition of the present invention may further include other pharmaceutically acceptable herbal medicines or extracts thereof to enhance the pharmacological effect. In this case, an extract of the herbal medicine may be prepared according to the extraction method and then added to the pharmaceutical composition, or the extract obtained by extracting by the above method after mixing Injin mugwort and the herbal medicine may be included in the composition.

The herbal medicine that may be added to the composition of the present invention may be any pharmaceutically acceptable herbal medicine, for example, Ogapi, prickly gallop, sokdan, wolfberry, safflower seed, tofu, baekbokyeong, bokbunja, tosa and ginseng, respectively Or can be used in combination. In addition, the composition of the present invention may further comprise a rust or calcium to enhance the pharmacological effect.

Phosphorus mugwort extract may be included in an amount of 10 to 100% by weight, preferably 20 to 50% by weight, based on the total weight of the composition, 0 to 90% by weight of the herbal extract, or greenery or calcium, preferably Preferably in an amount of 50 to 80% by weight.

In order to promote the secretion of growth or growth hormone, the extract of the ginseng worm is administered to the mammal in the form of a composition comprising the composition, which may be a pharmaceutical composition or a composition for grain coating for the production of functional coating grains.

The pharmaceutical compositions of the present invention can be used to prepare pharmaceutical formulations according to conventional methods. In the preparation of the formulation, it is preferable to mix or dilute the active ingredient, Phosphorus mugwort extract with the carrier, or to enclose it in a carrier in the form of a container. When the carrier is used as a diluent, it may be a solid, semisolid or liquid substance which acts as a vehicle, excipient or medium for the active ingredient. Thus, the formulations may be in the form of tablets, pills, powders, assays, elixirs, suspensions, emulsions, solutions, syrups, aerosols, soft or hard gelatin capsules, sterile injectables, sterile powders and the like. Examples of suitable carriers, excipients and diluents include lactose, dextrose, sucrose, sorbitol, mannitol, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, Propylhydroxybenzoate, talc, magnesium stearate and mineral oil. The formulation may further comprise fillers, anti-coagulants, lubricants, wetting agents, fragrances, emulsifiers, preservatives and the like. Pharmaceutical compositions according to the invention can be formulated using methods well known in the art to provide rapid, sustained or delayed release of the active ingredient after administration to a mammal.

The pharmaceutical compositions according to the invention can be administered via several routes including oral, transdermal, subcutaneous, intravenous or intramuscular. For humans, typical daily dosages can range from 0.1 to 100 mg / kg body weight and can be administered once or in divided doses. However, the actual dosage should be determined in light of several relevant factors such as the route of administration, the age, sex and weight of the patient, the state of health and the severity of the disease.

In addition, in the composition for grain coating of the present invention, a starch solution having a concentration of 10 to 50% is additionally added to the composition in order to prevent diffusion of the coating solution, which does not expand when the white rice is expanded as it is expanded while cooking. It is possible to prevent the diffusion of the coating liquid by allowing the coating liquid to expand together with the expansion of the grains.

The starch solution may be added to the composition for grain coating of the present invention in an amount of 5 to 50% by weight, preferably 5 to 15% by weight based on the total weight of the composition.

Grains that may be used in the present invention include white rice, brown rice, barley, crude, sorghum, glutinous rice and the like.

In addition, in the present invention, the grain coating composition is added to the grains in an amount of 10 to 250 g, preferably 20 to 200 g, per 1 kg of cereal grains, mixed and then dried at 30 to 60 ° C. for 30 minutes to 2 hours. Functional coated grains having a growth or growth hormone secretion promoting effect can be prepared. In addition, it can be used to produce a variety of cereal products, such as porridge, rice, rice cakes and instant rice.

The functional coated grains of the present invention not only exhibit excellent growth or growth hormone secretion promoting effect but also do not cause diffusion of the coating solution during cooking, and have excellent sensory evaluation results when compared to general rice, and thus can be widely used as functional supplements.

Hereinafter, the present invention will be described in more detail with reference to the following examples. only. The following examples are only for illustrating the present invention, but the scope of the present invention is not limited thereto.

Examples 1 to 5: Preparation of a composition comprising a ginko wormwood extract

Dried phosphorus mugwort, staphylococcus, fast, and wolfberry were ground to 30-50 mesh. 5 ml 70% ethanol was added to 1 g of each component having the composition shown in Table 1 below and extracted using an ultrasonic grinder at 30 ° C. for 48 hours, and then all the liquid components were evaporated. 5 ml of 50% ethanol was added to the remaining solid components and mixed for 10 minutes using a vortexer, which was then used as an extract. In the concentrate of Example 1, 5 ml, 1.7 ml, 1 ml, and 0.5 ml of 50% ethanol was added to the solid component remaining after evaporation, and the concentrates were used to make 1-fold, 3-fold, 5-fold, and 10-fold concentrates, respectively.

Example 1 Mugwort Extract Example 2 Injin mugwort + organ extract (mixture ratio of 1: 1) Example 3 Injin mugwort + fast extract (mixture ratio of 1: 1) Example 4 Injin mugwort + agapi + fast extract (mixing ratio of 1: 1: 1) Example 5 Injin mugwort + Ogapi + Sokpo + Wolfberry extract (mixture ratio of 1: 0.5 :: 0.5: 1)

Test Example 1 cell proliferation test-growth hormone secretion promoting efficacy test

In vitro growth hormone secretion promoting effect was measured by the following method. In other words, 50 μl of each extract obtained in Examples 1 to 5 was added to 2 × 10 ⁶ cells of the GH4C1 (ATCC CCL-82.2) cell line cell lined for passage of pituitary gland cells, and in Ham's F12 medium. The growth hormone was secreted by incubating for 1 hour at 37 ℃. After incubating the culture medium containing growth hormone with chondrocytes of rabbits directly isolated from rabbits for 4 hours at 37 ° C, MTT assay (Kaiyoun Cai al., Biomaterials , 23 : 1153-1160 (2002)) was performed. By measuring the proliferation of the cells using the growth hormone secretion was observed. The proliferation of the cells was determined by extracting insoluble purple formazan formed from dehydrogenase in the mitochondria of the cells with isopropanol from the water-soluble tetrazolium salt and measuring the absorbance (OD) on a 570 nm spectrophotometer. .

Therefore, the higher the absorbance (O.D.) value can be seen that the more proliferation of cells, which can be seen as a greater growth hormone secretion. As a negative control group, 50% of 70% ethanol was added and cultured in the same cell line, and the positive control group was used in an amount of 50 μl of GHRF (Grow46 hormone, sigma), which promotes growth hormone secretion. Incubated with,

Test group O.D. Control 0.25 Positive control group 1.5 Example 1 (Injin mugwort 1-fold concentrate) 1.52 Example 1 (Injin mugwort 3 times concentrate) 1.75 Example 1 (Injin mugwort 5 times concentrate) 1.78 Example 1 (Injin mugwort 10-fold concentrate) 1.81 Example 2 1.75 Example 3 1.76 Example 4 1.83 Example 5 1.98

As shown in Table 2, the growth hormone secretion in the group containing the extract of the present invention showed a tendency to be promoted, the growth hormone secretion was also promoted by the mixing of phosphorus and other components. However, the concentration of phosphorus mugwort and growth hormone secretion were not proportional.

Test Example 2: Growth Acceleration Test-Rat Test

Five-week-old SPF Sprague Dauley rats (Sampaco BioKorea) were purified for 7 days, and normal and healthy rats were assigned to each of five females and males.

After freeze-drying the 1-fold concentrate of Injin mugwort prepared in Example 1, the rats of the test group were added to 6 ml of water to be 50 mg / kg, 100 mg / kg, 300 mg / kg and 500 mg / kg, respectively, and 240 ml of water. Mix in the daily free negative numbers. As the control group, only water was used, and the positive control group was subcutaneously administered once every two weeks based on the clinical application dose of 1.2 mg / kg / 14 days of bovine somatotropin (source: LG Chem). The test was performed for 8 weeks, body weights were measured every two weeks to determine the extent of growth promotion, and concentrations of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) were measured monthly. Significance between the control group and each dose group was compared by ANOVA and Dunnett-t test (Kaiyoun Cai al., Biomaterials , 23 : 1153-1160 (2002)). The concentration of GH was analyzed using the rat growth hormone RIA kit (Linco Res., Cat. # RGH 45-HK), and the measurement of IGF-1 was measured by immunoadiometric assay (IRMA) method (Conti, E., et al, J). Am. Coll. Cardiol. , 38, 26-32).

Tables 3 and 4 show male and female weight gains, Tables 5 and 6 show GH concentrations, and Tables 7 and 8 show IGF-1 concentrations.

weight Control Positive control group 50mg / kg group 100mg / kg group 300 mg / kg dose group 500 mg / kg dose group Start date (g) 190 ± 5.2 189 ± 6.8 190 ± 3.8 191 ± 6.7 190 ± 6.1 193 ± 2.1 2 weeks (g) 275 ± 4.5 281 ± 5.6 262 ± 2.7 279 ± 4.2 272 ± 4.8 273 ± 4.2 4 g (g) 332 ± 2.3 351 ± 5.4 332 ± 5.1 352 ± 1.9 356 ± 3.7 357 ± 1.8 6 g (g) 348 ± 1.9 375 ± 7.8 358 ± 2.4 365 ± 2.7 376 ± 2.8 375 ± 3.7 8 g (g) 353 ± 5.9 381 ± 1.9 375 ± 1.1 385 ± 3.4 386 ± 3.5 384 ± 6.4 % Increase 46.2 50.4 49.3 50.4 50.8 49.7

weight Control Positive control group 50mg / kg group 100mg / kg group 300 mg / kg dose group 500 mg / kg dose group Start date (g) 161 ± 1.5 159 ± 2.5 162 ± 7.5 158 ± 3.5 164 ± 2.1 158 ± 6.1 2 weeks (g) 209 ± 2.4 224 ± 3.4 219 ± 6.1 221 ± 3.4 225 ± 4.7 220 ± 2.7 4 g (g) 228 ± 3.2 241 ± 3.5 238 ± 5.2 245 ± 3.5 250 ± 5.1 246 ± 5.1 6 g (g) 235 ± 2.4 257 ± 6.4 254 ± 5.0 260 ± 4.2 271 ± 6.0 268 ± 3.4 8 g (g) 252 ± 1.5 268 ± 5.1 264 ± 4.2 271 ± 6.5 279 ± 4.8 275 ± 2.9 % Increase 36 40.7 38.6 41.7 41.2 42.5

As shown in Tables 3 and 4, the male and female weight gains of the control group were 46.2% and 36%, respectively, and the positive control group administered with the ileal hormone increased 50.4% and 40.7%, respectively, compared to the increase rate of the control group. ~ 5% higher growth rate. In addition, when the administration of the extract of Injin mugwort of the present invention shows a 3 to 6% higher increase rate compared to the increase rate of the control group can be seen that the same effect as the existing growth hormone.

GH Control Positive control group 50mg / kg group 100mg / kg group 300 mg / kg dose group 500 mg / kg dose group Start date (ng / mL) 1.05 0.90 0.95 0.98 0.99 1.01 1 month (ng / mL) 1.26 1.31 1.27 1.32 1.35 1.31 2 months (ng / mL) 1.21 1.35 1.31 1.36 1.42 1.36 % Increase 13.2 33.3 27.5 27.9 30.3 25.7

GH Control Positive control group 50mg / kg group 100mg / kg group 300 mg / kg dose group 500 mg / kg dose group Start date (ng / mL) 1.07 1.02 1.04 1.05 1.01 1.08 1 month (ng / mL) 1.32 1.39 1.35 1.36 1.37 1.34 2 months (ng / mL) 1.28 1.41 1.36 1.41 1.47 1.43 % Increase 16.4 27.7 23.5 25.5 31.3 24.5

As shown in Tables 5 and 6, the growth rate of the growth hormone amount in the positive control group was 11 ~ 20% higher than the growth rate of the growth hormone amount in the control group. In addition, the administration of the extract of the present invention of the mugwort extract 7-17% higher than the increase rate of the growth hormone amount of the control group, which can be seen that the better results than the positive control group. In addition, the growth hormone and the amount of the extract does not have a proportional relationship, but both males and females can be seen that the best results at the concentration of 300 mg / kg of the extract.

IGF-1 Control Positive control group 50mg / kg group 100mg / kg group 300 mg / kg dose group 500 mg / kg dose group Start date (ng / mL) 234 246 238 242 244 245 1 month (ng / mL) 252 259 249 253 257 251 2 months (ng / mL) 248 267 259 264 269 264 % Increase 5.6 7.9 8.1 8.3 9.3 7.2

IGF-1 Control Positive control group 50mg / kg group 100mg / kg group 300 mg / kg dose group 500 mg / kg dose group Start date (ng / mL) 251 249 253 256 255 254 1 month (ng / mL) 263 265 260 268 271 267 2 months (ng / mL) 269 280 275 284 292 287 % Increase 6.7 11.1 8 9.9 12.7 11.5

As shown in Tables 7 and 8, IGF-1 also showed the best effect in the 300 mg / kg jinsugui extract administration group, like growth hormone.

Test Example 3: Carp Growth Promotion Test

After adapting for about two weeks using 60 carp as a co-seeker, divided into six groups and free diet for two weeks, the body length and weight increase rate were measured, and the results are shown in Table 9 below. That is, 2 to 3% of the general diet (control) of the total body weight; 2 to 3% of normal weight in fish and 50 mg of mixed feed for fish growth promoters (Biomate, RNL Life Sciences); Feeds (experimental group) coated with 2 ~ 3% of the normal feed of fish body with 10 mg / kg, 30 mg / kg, 50 mg / kg, and 100 mg / kg of the 1-fold concentrate of Injin mugwort extract (Example 1) Administered.

Control Positive control group 10mg / kg dose group 30mg / kg group 50mg / kg group 100mg / kg group Growth rate (%) 0.55 3.53 2.23 3.12 3.58 3.61 % Weight gain 3.84 5.74 1.57 2.41 4.79 5.02

As shown in Table 9, 50 mg / kg or more of the Injin mugwort extract administration group showed similar results as the positive control. It can be seen that the extract of Injin mugwort of the present invention is effective in increasing body weight as well as body weight.

Formulation Example : Preparation of Functional Coated Grains

Formulation Examples 1 to 4

As shown in Table 10 below, the white rice was coated in an amount of 200 g per 1 kg of white rice using the coating composition prepared by mixing the ginsujin mugwort extract and the starch solution obtained in Example 1 in a weight ratio of 5: 1. The coating is used a mixer (obtained by: RNL Life Sciences Co., Ltd.) or a coating machine (obtained by Changi Eng), and when the mixer is used, it is dried at 50-55 ° C. for 2 hours after immersion mixing. In the case of using a coating machine, the coating composition was sprayed and dried while the coating was dried.

Formulation Example 1 Injin mugwort extract 6-fold concentrate (60 brix) + 10% starch solution Formulation Example 2 Injin mugwort extract 5 times concentrated solution (55 brix) + 25% starch solution Formulation Example 3 Injin mugwort extract 2x concentrate (45 brix) + 2% starch solution Formulation Example 4 Injin mugwort extract 4 times concentrated solution (52 brix) + 5% starch solution

Formulation Examples 5 to 7

To prepare a coating in the same manner as in Preparation Example 1 with the composition shown in Table 11.

Formulation Example 5 White Rice 97 wt% + Injin mugwort, Goji berry, Sokdan, Ogapi (1: 1: 1: 1 mix ratio) 5 times concentrate (55 brix) 2% wt + starch 1 wt% Formulation Example 6 White Rice 93 wt% + Injin mugwort, wolfberry, Sokdan, Ogapi (mixing ratio of 1.5: 1: 1: 1) 7 times concentrate (65 brix) 5 wt% + starch 2 wt% Formulation Example 7 White rice 96 wt% + Injin mugwort, wolfberry, sourdough, organo (mixture ratio of 1.5: 1: 1.5: 1) 6 times concentrate (60 brix) 3 wt% + starch 1 wt%

Test Example 4: Sensory Evaluation

Sensory evaluation of the general beauty and the coating beauty were performed on 10 teenage adolescent females and 10 males, and the results are shown in Table 12 below. With 5 points for general beauty, the top 10 points were superior to the general beauty, and the lowest 0 points were worse than the general beauty.

south female age Exterior incense flavor Organization Symbol age Exterior incense flavor Organization Symbol 13 7 8 9 8 8 13 6 7 6 7 7 14 8 8 9 8 9 11 7 6 7 6 7 12 8 7 8 7 8 12 7 6 6 7 6 11 8 8 8 9 7 12 8 6 7 6 6 11 7 8 9 8 8 13 7 7 6 6 7 12 7 9 8 7 8 14 6 6 7 7 6 14 8 8 7 8 8 15 5 6 7 6 6 16 7 8 8 7 8 16 6 6 6 6 7 15 9 8 8 8 8 13 7 7 6 7 7 15 9 9 7 9 7 13 7 6 6 7 6

As shown in Table 12, the coated rice of the present invention showed better sensory evaluation results than ordinary rice.

Test Example 5 Diffusion Prevention Test

The coated rice prepared in Formulation Examples 5 to 7 was put into a rice cooker, a hole having a diameter of 10 cm and a height of about 4 cm was placed in the center, and the coated rice was cooked to observe whether the coating liquid spreaded. Since the coating liquid is somewhat black, it is possible to distinguish diffusion and non-diffusion by color bleeding.

Formulation Formulation Example 5 Formulation Example 6 Formulation Example 7 Diffusion Non-proliferation Non-proliferation Non-proliferation

As shown in Table 13, it can be seen that the coating is coated using a coating composition comprising a starch prepared according to the present invention is prevented diffusion of the coating solution during cooking.

As such, the composition of the present invention containing the extract of jinjinjin exhibits growth promoting or growth hormone secretion promoting effect, excellent growth by using it as a pharmaceutical composition or as a composition for grain coating for coating on cereals used as a stock The functional coating grains prepared according to the present invention can not only promote growth, but also do not cause diffusion of the coating liquid during cooking, and have excellent sensory evaluation results compared to general beauty products as functional supplements for growth promotion. It can be widely used.

Claims (8)

A composition for promoting growth or secretion of growth hormone comprising an extract of Artemisia capillaris Thunberg. As an active ingredient. The method of claim 1, Composition comprising the 10 to 100% by weight of the extract of the jinsengui relative to the weight of the total composition. The method of claim 1, Ogapi, psorigogalpi, Sokdan, Gugija, safflower seed, tofu, baekbokyeong, bokbunja, earth and sand, ginseng, green and calcium containing one or more components from 0 (excess) to 90% by weight of the total composition further comprises Composition. The method according to any one of claims 1 to 3, A composition comprising the starch solution of 10 to 50% concentration of 5 to 50% by weight based on the total weight of the composition. Functional coated grains, which have a growth or secretion effect on growth hormone secretion, coated with the composition of any one of claims 1 to 4. The method of claim 5, wherein Functional cereals, characterized in that the grains are white rice, brown rice, barley, crude, sorghum or glutinous rice. A method for producing a functional coated grain, characterized in that the composition of any one of claims 1 to 4 added to the grain at a ratio of 10 to 250 g per 1 kg of cereal grains, mixed and dried. A functional grain processed product made using the coated grain of claim 5.