KR101252630B1 - Useful composition for growth and development of children and youths - Google Patents

Abstract

PURPOSE: A composition is provided to contribute to growth by activating skeletal growth and metabolism of children and teenagers in a balanced way by using a natural product. CONSTITUTION: A composition for promoting growth and development of children and teenagers comprises 5 to 20 wt% of a marsh snail powder, 5 to 20 wt% of sea tangle extract, 20 to 30 wt% of Injin wormwood extract, 20 to 30 wt% of chlorella, and 20 to 30 wt% of seaweed calcium based on 100 wt% of a total weight of the composition. The composition for promoting growth and development of children and teenagers further comprises at least one component selected from Dioscorea rhizoma extract, extract of acanthopanax, malt extract, Aurantii nobilis Pericarpium extract, radish seed extract, ponciri fructus extract, extract of schisandra chinensis, wild field berry extract, longan extract, extract of Angelica gigas Nakai, extract of cortex eucommiae, chinese quince extract, Phlomidis Radix choo choo excrescence, Bombycis Corpus extract, extract of puerariae radix, balloon-flower extract, Jujube extract, Glycyrrhiza extract, peppermint extract, and dried deer extract. The composition is a health promoting food in the form of a powder, a granule, a tablet, a capsule, or a beverage.

Description

Compositions that help children and adolescents grow and grow {USEFUL COMPOSITION FOR GROWTH AND DEVELOPMENT OF CHILDREN AND YOUTHS}

The present invention relates to a composition that aids in the growth development of children and adolescents.

In modern society, the increase in food production, economic growth, and changes in eating habits caused by multiculturalism are not only the primary functions of foods to solve the previous hunger, but also more delicious foods, long-lasting foods, and easy-to-eat foods. Interested in the research, as a result of the development of food additives, the development of instant foods, processed foods.

These various processed foods meet the visual and taste palatability, and the shelf life is improved, but various side effects appear. In other words, traces of nutrients are lost during the manufacturing process of processed foods, resulting in nutritional imbalances, and distorting the homeostasis of the body by overuse of chemical seasonings, colorants, and preservatives, thereby inhibiting the growth of infants and young children. In addition, side effects have been shown to reduce immunity and promote the early development of adult diseases.

Medically defined growth is a change in size that accompanies maturity. In particular, growth in children is a concept that encompasses not only an increase in height but also an increase in the size and function of each organ in the body, It is used only for the increase in height. This increase is achieved through skeletal metabolism, which includes the synthesis of cartilage, skeletal length growth, and extensive growth of skeletal tissue, which is a sensitive indicator of the health, nutrition, hormones, and genetic background of children. It is utilized as.

In general, when looking at human growth, genetic influences are generally considered to have the greatest impact, but in practice, genetic influence is only about 23%, and the remaining 77% is determined by acquired effects. For example, 31% of nutrition, 20% of exercise, 16% of environment, and 10% of other studies were reported. Therefore, in order to promote growth, it is required to reduce the intake of instant foods, to balance nutrition, to exercise appropriately, to improve the pollution environment, etc. Among these, the balance of influence is pointed out as the most important factor.

In order to achieve this balance of influence and ultimately promote growth, it is generally necessary to change dietary behavior entirely, but since this is not practically possible, alternatives to eating health supplements to promote growth As a result, various health supplements are being developed that can support the nutritional balance and promote growth.

For example, Korean Patent Registration No. 0715653 discloses health supplements including seaweed calcium, plant extracts, chlorella extracts, malt extracts and colostrum powder, and Korean Patent Registration No. 0601265 discloses Injin mugwort. Patent registration No. 278206 discloses health supplements including safflower seed, tofu, baekbokyeong, bokbunja, earth and sand, and green tea and calcium.

However, such conventional dietary supplements or growth promoting drugs are so important that only the growth of the skeleton is too important, and may temporarily activate abnormally the metabolism of the user's body, which is not practically utilized much. to be.

Therefore, an object of the present invention is to develop a composition that is useful for the development by balanced activation of skeletal growth and metabolism in children and adolescents using natural products.

The present invention, in order to solve the above problems, sage powder, kelp extract, jinjin wormwood extract, chlorella, seaweed calcium as an active ingredient, 1 to 20% by weight of the scotch powder with respect to the total weight of the extract 100% by weight, Helping children and adolescents grow, characterized in that it contains 1 to 20% by weight of kelp extract, 10 to 30% by weight of phosphorus mugwort extract, 10 to 30% by weight of chlorella, and 10 to 30% by weight of seaweed calcium. To provide a composition.

According to another embodiment of the present invention, mountain extract, ogapi extract, malt extract, dermis extract, nabokja extract, tanza extract, Schisandra extract, bokbunja extract, longan extract, Angelica extract, tofu extract, Chinese quince extract, soybean extract, It provides a composition for helping children and adolescents growth development, characterized in that it further comprises one or more components selected from Baeksijam extract, root extract, Gilge extract, jujube extract, licorice extract, peppermint extract, dried extract.

In the above, the composition provides a composition for helping children and adolescent growth development, characterized in that the health functional food in the form of powder, granules, tablets, capsules or beverages.

According to the present invention, the composition prepared using the powder of sesame seed, kelp extract, jinjin mugwort extract, chlorella, and seaweed calcium helps to promote the growth of children and adolescents by balancing the metabolic and body metabolism of children and adolescents.

The composition according to the present invention is prepared using sesame seed, kelp, jinjin worm, chlorella, seaweed calcium.

The active ingredient of the present invention, the plural group is rich in protein, iron and carbohydrates, while the total lipid is low. In particular, proteins are known to be composed of 16 kinds of amino acids, including arginine and lysine. Among them, arginine acid accounts for 7.74% of total amino acids, which is known to be richer in arginine acid than other fish and shellfish.

The arginine acid is one of the 20 amino acids constituting the protein in the body

It is a non-essential amino acid that contains NH ⁺ groups and is a non-essential amino acid that is synthesized in the body in adults, but it is recognized as an essential amino acid due to insufficient synthesis in the body in children who release growth hormone, and plays an important role in the immune response. Functions include promoting growth hormone, progenitors of nitric oxide (NO), which are vasodilators, and helping to maintain immune cells.

On the other hand, Injin mugwort as an active ingredient of the present invention is effective in lowering heat and eliminating moistness, and is known to be effective in treating symptoms of moist jaundice and urine, but its pharmacological action inhibits liver damage ( Lee Chi-ho and two others, Korean Society of Food Science and Nutrition, 22nd Autumn Conference, 1998), anticancer effect (3 others including Jung-Gwon Jung, Korean Society of Food Science and Technology Spring Conference, 1998), antioxidant activity, blood lipid reduction and liver function improvement Effects (Han Eun-kyung and 4 others, Korean Society of Food and Nutrition, Spring Conference, 1997), antimutagenic effects (Cho, Dong-Sung et al., Korean Journal of Biotechnology and Bioengineering, 2000) Ingredients and antibacterial effects), growth promoting or growth hormone secretion promoting effect (Korean Patent 0601265) and the like are known.

Phosphorus mugwort extract is extracted by using an ultrasonic grinder for 48 to 72 hours or refluxed for 4 to 7 hours in water or an organic solvent of 3 to 6 times the weight ratio of pulverized mugwort pulverized to 30-50 mesh, and then 0.1 to The extract obtained by filtration with a 10 μm filter and concentrated under reduced pressure 5 to 10 times at 60 to 80 ° C. for 24 to 60 hours and cooled to 30 ° C. or less may be obtained by freeze drying.

Laminaria japonica is a perennial large brown algae belonging to the Laminariales of the Laminariales, Phaeophyceae, Phaepphyta. Appearance is divided into lobe, stem, and root, the lobe is long in the shape of a band, the central part of the lobe part forms a thick middle part, and both sides of the middle part are vertically grooved. Stems are usually columnar, upright, and the roots are dendritic, branching from the bottom of the stem to the tea phase. It is a marine algae distributed along the coast of Korea and the suburbs. It grows in the north coast of the east coast, north of Wonsan and north of Hamgyong, and grows in the south of the east coast and Wando on the south coast.

Chlorella is a single-celled plant that grows through photosynthesis, with 50-60% protein and 15-20% carbohydrates, as well as nutrients such as chlorophyll, vitamins, minerals and dietary fiber. Chlorella extract is composed of polysaccharides and nucleic acid-related substances, and it is possible to efficiently consume protein by simply ingesting 2g of chlorella per day. Nucleic acid contained in the protein of chlorella has a growth promoting effect. In addition, about 30% of the lipids are linoleic acid, 15% is palmitic acid, and carbohydrates also contain a lot of hemicellulose.

In particular, Chlorella growth factor (CGH), known as chlorella-specific ingredient, is a substance that promotes the growth of animals or microorganisms and contains overwhelmingly large amounts of protein (57.3%) and is a major organelle that plays a pivotal role in protein synthesis in cells. It is known as a component that regenerates cells by maintaining and restoring the structure of mitochondria, which are organelles (Ribosom) and energy (ATP).

Calcium is the most abundant mineral in the human body, accounting for 1 ~ 2% of body weight, of which 99% mainly forms teeth and skeleton, and the remaining 1% is present in the blood, intracellular, and external fluids. It is in charge of function. Its main functions include muscle contraction, neurostimulatory transmission, blood vessel contraction and relaxation, promote blood coagulation, and regulate intracellular metabolic processes through the activation of enzymes.

Seaweed calcium is a natural calcium with 30% or more calcium content. It is tasteless, odorless, honeycomb porous structure with excellent oil and water absorption ability. It has excellent digestion absorption rate and excellent buffering ability, which neutralizes lactic acid in the mouth to prevent tooth decay. . In addition, it has no foreign matter, and has a very low heavy metal content and high mineral content, and is also attracting attention as an alternative raw material for calcium.

The composition of the present invention contains the ginsujin mugwort extract, marshmallow powder, kelp extract, chlorella, seaweed calcium as an active ingredient, 10-30% by weight of the ginsujin mugwort extract, 1-20% by weight Powder, 1 to 20% by weight of kelp extract, 10 to 30% by weight of chlorella, characterized in that it comprises 10 to 30% by weight of seaweed calcium.

The extract may be in any form, such as liquid, solid or powder, and is not particularly limited. Extracts prepared in solid or powder form may be formulated in a suitable solvent to form a liquid composition.

In addition, the composition of the present invention, if necessary, acid extract, Ogapi extract, malt extract, dermis extract, nabokja extract, tanza extract, Schisandra extract, bokbunja extract, longan extract, Angelica extract, sesame extract, Chinese quince extract, Sokcho extract, white squirt It may further include one or more components selected from extracts, root extracts, gildo extracts, jujube extracts, licorice extracts, peppermint extracts, dried extract.

The composition of the present invention may be provided in the form of a health functional food in the form of powder, granules, tablets, capsules or beverages, but is not limited thereto and may be any form that can be taken.

Hereinafter will be described in more detail by the embodiment of the present invention. However, the present invention is not limited by the following examples.

< Manufacturing example  1> Preparation of Swallowtail Powder

After collecting the mulberry, leave it at room temperature to discharge the impurities, and soak in salt water for a certain time to remove the secondary, then wash with clean water, leave a predetermined time, and then remove the lid of boiling water from boiling water After heating for 5 to 10 minutes in a state of washing with clean water, dried in a drier, cooled to room temperature and pulverized to obtain a fine powder.

< Manufacturing example  2> Inosugi  Preparation of Extract Powder

Phosphorus mugwort pulverized into 40 mesh was extracted using an ultrasonic grinder for 48 hours in a 5 times weight ratio of water or refluxed for 4 hours, and then filtered through a 0.1 to 10 μm filter if necessary, followed by 48 at a temperature of 60 to 80 ° C. Concentrated under reduced pressure for 5 times and then cooled to 30 ℃ or less extracts were freeze-dried to obtain the powder of the extract.

< Manufacturing example  3> Preparation of Kelp Extract

The dried kelp was sprayed once, dried in a hot air dryer (50 ° C.), and then heat-treated at 121 ° C. for 30 minutes. Thereafter, the resultant was dried in a hot air dryer (50 ° C.), pulverized to 80 mech, and used as an extraction sample while being kept frozen at −23 ° C.

<Examples 1 to 3>

The sage powder, phosphorus mugwort extract powder, kelp extract, and seaweed calcium powder (National Food, New Zealand) and chlorella extract powder (National Food, New Zealand) obtained by the same method as Preparation Examples 1 to 3, respectively, are shown in Table 1 below. The composition was prepared by mixing.

Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Mugwort Extract
Powder content (%) 30 20 30 40 40 Flake powder
content(%) 10 20 5 0 0 Kelp Extract
content(%) 20 20 5 10 0 Chlorella
content(%) 20 20 30 20 25 Seaweed calcium
content(%) 20 20 30 30 35 system(%) 100 100 100 100 100

< Experimental Example  1> Growth promoting effect of the composition administration

Five-week-old SPF Sprague-Dawley rets were purified after 7 days of normal development, and healthy rats were assigned to 5 males and 5 males in each group.

The compositions prepared in Example 2, Comparative Example 1 and Comparative Example 2 were added to 6 ml of water to be 50 mg / kg, 100 mg / kg, 300 mg / kg and 500 mg / kg, respectively, in the rats of the test group, mixed in 24 ml of water, and daily negative water. Freedom to feed. As a control group, only water was used, and growth hormone (somatotropin) was subcutaneously administered once every two weeks based on the clinical application dose of 1.2 mg / kg / 14 days. The test was performed for 8 weeks, body weights were measured every two weeks to determine the extent of growth promotion, and concentrations of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) were measured monthly. Significance between the control group and each dose group was compared by ANOVA and Dunnett-t assay (Kaiyoun Cai al., Biomaterials, 23: 1153-1160 (2002)). The concentration of GH was analyzed using the rat growth hormone RIA kit (Linco Res., Cat. # RGH 45-HK), and the measurement of IGF-1 was measured by immunoadiometric assay (IRMA) method (Conti, E., et al, J). Am. Coll. Cardiol., 38, 26-32).

Tables 2 and 3 below show male and female weight gains, Tables 4 and 5 show GH concentrations, and Tables 6 and 7 show IGF-1 concentrations.

weight Control group positivity
Control group Example 2
50 mg / kg
Administered group Example 2
100mg / kg
Administered group Example 2
300 mg / kg
Administered group Example 2
500mg / kg
Administered group Comparative Example 1
100mg / kg
Administered group Comparative Example 2
100mg / kg
Administered group Start date (g) 190 ± 5.1 189 ± 6.8 190 ± 3.8 191 ± 6.7 190 ± 6.7 193 ± 2.12 191 ± 1.2 190 ± 1.1 2 weeks (g) 275 ± 4.6 281 ± 5.6 262 ± 2.7 279 ± 4.2 272 ± 4.8 273 ± 4.2 274 ± 4.8 275 ± 5.1 4 g (g) 332 ± 2.4 351 ± 5.4 332 ± 5.1 352 ± 1.9 356 ± 3.7 357 ± 1.8 310 ± 2.2 305 ± 2.1 6 g (g) 348 ± 1.8 375 ± 7.8 358 ± 2.4 365 ± 2.7 376 ± 2.8 375 ± 3.7 350 ± 2.1 349 ± 3.2 8 g (g) 353 ± 5.9 381 ± 1.9 375 ± 1.1 385 ± 3.4 386 ± 3.5 384 ± 6.4 361 ± 1.2 356 ± 1.2 % Increase 46.2 50.4 49.3 50.4 50.8 49.7 47.1 46.6

weight Control group positivity
Control group Example 2
50 mg / kg
Administered group Example 2
100mg / kg
Administered group Example 2
300 mg / kg
Administered group Example 2
500mg / kg
Administered group Comparative Example 1
100mg / kg
Administered group Comparative Example 2
100mg / kg
Administered group Start date (g) 161 ± 1.5 159 ± 2.5 162 ± 7.5 158 ± 3.5 164 ± 2.1 158 ± 6.1 160 ± 1.2 159 ± 3.1 2 weeks (g) 209 ± 2.4 224 ± 3.4 219 ± 6.1 221 ± 4.7 225 ± 4.7 220 ± 2.7 210 ± 3.1 211 ± 2.6 4 g (g) 228 ± 3.2 241 ± 3.5 238 ± 5.2 245 ± 3.5 250 ± 5.1 246 ± 5.1 225 ± 3.4 219 ± 2.1 6 g (g) 235 ± 2.4 257 ± 6.4 254 ± 5.0 260 ± 4.2 271 ± 6.0 268 ± 3.4 235 ± 1.3 234 ± 5.1 8 g (g) 252 ± 1.5 268 ± 5.1 264 ± 4.2 271 ± 6.5 279 ± 4.8 275 ± 2.9 251 ± 2.2 250 ± 1.7 % Increase 36 40.7 38.6 41.7 41.2 42.5 36.3 36.4

As shown in Tables 2 and 3, the weight gain rates of males and females of the control group were 46.2% and 36%, respectively. In the positive control group to which growth hormone was administered, 50.4% and 40.7% of the control group increased 4 to 5 compared to the control group. % Increased rate. In addition, it can be seen that the administration of the composition of the present invention shows an increase rate of 3 to 6% compared to the increase rate of the control group shows an effect equivalent to the existing growth hormone.

GH Control group Positive control group 50 mg / kg
Administered group 100mg / kg
Administered group 300 mg / kg
Administered group 500mg / kg
Administered group Start date (ng / mL) 1.05 0.90 0.95 0.98 0.99 1.01 1 month (ng / mL) 1.25 1.31 1.27 1.32 1.35 1.31 2 months (ng / mL) 1.21 1.35 1.31 1.36 1.42 1.36 % Increase 13.2 33.3 27.5 27.9 30.3 25.7

GH Control group Positive control group 50 mg / kg
Administered group 100mg / kg
Administered group 300 mg / kg
Administered group 500mg / kg
Administered group Start date (ng / mL) 1.07 1.02 1.04 1.05 1.01 1.08 1 month (ng / mL) 1.32 1.39 1.35 1.36 1.37 1.34 2 months (ng / mL) 1.28 1.41 1.36 1.41 1.47 1.43 % Increase 16.4 27.7 23.5 25.5 31.3 24.5

As shown in Tables 4 and 5, the growth rate of the growth hormone amount in the positive control group was 11 ~ 20% higher than the growth rate of the growth hormone amount in the control group. In addition, when the composition of the present invention was administered, 7 ~ 17% higher than the increase rate of the growth hormone amount of the control group, which can be seen that the better results than the positive control group. In addition, the growth hormone and the amount of the composition does not have a proportional relationship, but both males and females can be seen that the best results at a composition concentration of 300 mg / kg.

IGF-1 Control group Positive control group 50 mg / kg
Administered group 100mg / kg
Administered group 300 mg / kg
Administered group 500mg / kg
Administered group Start date (ng / mL) 234 246 238 242 244 245 1 month (ng / mL) 252 259 249 253 257 254 2 months (ng / mL) 248 267 259 264 269 264 % Increase 5.6 7.9 8.1 8.8 9.8 7.2

IGF-1 Control group Positive control group 50 mg / kg
Administered group 100mg / kg
Administered group 300 mg / kg
Administered group 500mg / kg
Administered group Start date (ng / mL) 251 249 253 256 255 254 1 month (ng / mL) 263 265 260 268 271 267 2 months (ng / mL) 269 280 275 284 292 287 % Increase 6.7 11.1 8 9.9 12.7 11.5

As shown in Tables 6 and 7, IGF-1 also showed the best effect in the composition-administered group of 300 mg / kg as well as growth hormone.

Claims (3)

It contains 5 times 20% by weight of kelp extract, 5-20% by weight of kelp extract, 20-30% by weight of 100% by weight of the total weight of the composition. Composition for promoting growth and development of children and adolescents, characterized in that it comprises 20% 30% by weight of the extract, 20-30% by weight of chlorella, 20-30% by weight of seaweed calcium.
The extract according to claim 1, the extract of the mountain extract, Ogapi extract, malt extract, dermis extract, nabokja extract, tanza extract, Schisandra chinensis extract, Bokbunja extract, longan extract, Angelica extract, sesame extract, Chinese quince extract, soy extract , Gilgei extract, jujube extract, licorice extract, peppermint extract, a composition for promoting growth and growth of children and adolescents, characterized in that it further comprises one or more components selected from dried extract.
The composition for promoting growth and growth of children and adolescents according to claim 1, wherein the composition is a health functional food in the form of powder, granule, tablet, capsule or beverage.