KR20040029375A - 개, 고양이 및 말에서 결함있는 행태를 변화시키기 위한nk-1 수용체 길항제의 용도 - Google Patents
개, 고양이 및 말에서 결함있는 행태를 변화시키기 위한nk-1 수용체 길항제의 용도 Download PDFInfo
- Publication number
- KR20040029375A KR20040029375A KR10-2004-7000901A KR20047000901A KR20040029375A KR 20040029375 A KR20040029375 A KR 20040029375A KR 20047000901 A KR20047000901 A KR 20047000901A KR 20040029375 A KR20040029375 A KR 20040029375A
- Authority
- KR
- South Korea
- Prior art keywords
- methoxybenzylamino
- azabicyclo
- diphenylmethyl
- amino
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 title claims abstract description 48
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 title claims abstract description 48
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- 150000001875 compounds Chemical class 0.000 claims description 40
- 238000012360 testing method Methods 0.000 claims description 28
- -1 2-methoxybenzylamino Chemical group 0.000 claims description 20
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- 238000000926 separation method Methods 0.000 claims description 9
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 8
- 230000006378 damage Effects 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 7
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- ZXKQLZMZYWXUJC-CDZUIXILSA-N (2s,3s)-2-benzhydryl-n-(5-tert-butyl-2-methoxyphenyl)-2-methyl-1-azabicyclo[2.2.2]octan-3-amine Chemical compound COC1=CC=C(C(C)(C)C)C=C1N[C@@H]1[C@@](C(C=2C=CC=CC=2)C=2C=CC=CC=2)(C)N2CCC1CC2 ZXKQLZMZYWXUJC-CDZUIXILSA-N 0.000 claims description 3
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- LXDZLOATCVUXHT-PGRDOPGGSA-N (2s,3s)-3-[(5-tert-butyl-2-methoxyphenyl)methyl]-2-phenylpiperidin-1-amine Chemical compound COC1=CC=C(C(C)(C)C)C=C1C[C@H]1[C@@H](C=2C=CC=CC=2)N(N)CCC1 LXDZLOATCVUXHT-PGRDOPGGSA-N 0.000 claims description 3
- NNNAFENHFFKFSL-KBXCAEBGSA-N (2s,3s)-3-[[2-(difluoromethoxy)-5-(trifluoromethoxy)phenyl]methyl]-2-phenylpiperidin-1-amine Chemical compound C([C@@H]1CCCN([C@@H]1C=1C=CC=CC=1)N)C1=CC(OC(F)(F)F)=CC=C1OC(F)F NNNAFENHFFKFSL-KBXCAEBGSA-N 0.000 claims description 3
- RVXVTPXAIUDORO-OXJNMPFZSA-N (2s,3s)-3-[[2-ethoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenylpiperidin-1-amine Chemical compound CCOC1=CC=C(OC(F)(F)F)C=C1C[C@H]1[C@@H](C=2C=CC=CC=2)N(N)CCC1 RVXVTPXAIUDORO-OXJNMPFZSA-N 0.000 claims description 3
- UGIPKCIBIXXIEF-HNAYVOBHSA-N (2s,3s)-3-[[2-methoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenylpiperidin-1-amine Chemical compound COC1=CC=C(OC(F)(F)F)C=C1C[C@H]1[C@@H](C=2C=CC=CC=2)N(N)CCC1 UGIPKCIBIXXIEF-HNAYVOBHSA-N 0.000 claims description 3
- BTXTTXHHCNFOGR-HNAYVOBHSA-N (2s,3s)-3-[[5-chloro-2-(2,2,2-trifluoroethoxy)phenyl]methyl]-2-phenylpiperidin-1-amine Chemical compound C([C@@H]1CCCN([C@@H]1C=1C=CC=CC=1)N)C1=CC(Cl)=CC=C1OCC(F)(F)F BTXTTXHHCNFOGR-HNAYVOBHSA-N 0.000 claims description 3
- JWFRVJYQGQVKBH-ICSRJNTNSA-N (2s,3s)-n-[(2,5-dimethoxyphenyl)methyl]-2-phenylpiperidin-3-amine Chemical compound COC1=CC=C(OC)C(CN[C@@H]2[C@@H](NCCC2)C=2C=CC=CC=2)=C1 JWFRVJYQGQVKBH-ICSRJNTNSA-N 0.000 claims description 3
- HVWRVAHBKREIOR-HKUYNNGSSA-N (2s,3s)-n-[(5-chloro-2-methoxyphenyl)methyl]-2-phenylpiperidin-3-amine Chemical compound COC1=CC=C(Cl)C=C1CN[C@@H]1[C@H](C=2C=CC=CC=2)NCCC1 HVWRVAHBKREIOR-HKUYNNGSSA-N 0.000 claims description 3
- GKJVNRHHOMPGSG-NSIYGSDQSA-N (2s,3s,4s,5r)-2-benzhydryl-3-[(2-methoxy-5-methylphenyl)methylamino]-1-azabicyclo[2.2.2]octane-5-carboxylic acid Chemical compound C=1C=CC=CC=1C([C@@H]1N2CC[C@@]([C@H](C2)C(O)=O)([C@@H]1NCC=1C(=CC=C(C)C=1)OC)[H])C1=CC=CC=C1 GKJVNRHHOMPGSG-NSIYGSDQSA-N 0.000 claims description 3
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- PQKIWYJYAKTGNP-QGWOSTIUSA-N 1-(4-fluorophenyl)-4-[(2s,3s)-3-[(2-methoxyphenyl)methylamino]-2-phenylpiperidin-1-yl]butan-1-ol Chemical compound COC1=CC=CC=C1CN[C@@H]1[C@H](C=2C=CC=CC=2)N(CCCC(O)C=2C=CC(F)=CC=2)CCC1 PQKIWYJYAKTGNP-QGWOSTIUSA-N 0.000 claims description 3
- NPKIOBYABGRQLF-YTMVLYRLSA-N 2,4-dimethyl-n-(2-methylpropyl)-n-[3-[[[(2s,3s)-2-phenylpiperidin-3-yl]amino]methyl]-4-propan-2-yloxyphenyl]-1,3-thiazole-5-sulfonamide Chemical compound C1([C@@H]2NCCC[C@@H]2NCC=2C(OC(C)C)=CC=C(C=2)N(CC(C)C)S(=O)(=O)C2=C(N=C(C)S2)C)=CC=CC=C1 NPKIOBYABGRQLF-YTMVLYRLSA-N 0.000 claims description 3
- DKWJWICVVLNEFV-UHFFFAOYSA-N 2-benzhydryl-n-[2-methoxy-5-(trifluoromethoxy)phenyl]-2-methyl-1-azabicyclo[2.2.2]octan-3-amine Chemical compound COC1=CC=C(OC(F)(F)F)C=C1NC1C(C(C=2C=CC=CC=2)C=2C=CC=CC=2)(C)N2CCC1CC2 DKWJWICVVLNEFV-UHFFFAOYSA-N 0.000 claims description 3
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- 125000006499 2-trifluoromethoxy benzyl group Chemical group [H]C1=C([H])C(OC(F)(F)F)=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
- 125000000972 4,5-dimethylthiazol-2-yl group Chemical group [H]C([H])([H])C1=C(N=C(*)S1)C([H])([H])[H] 0.000 claims description 3
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- 150000001412 amines Chemical class 0.000 claims description 3
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 3
- JGCMPBRNZDBPGS-IGKIAQTJSA-N ethyl 6-[(2s,3s)-3-[(2-methoxyphenyl)methylamino]-2-phenylpiperidin-1-yl]hexanoate Chemical compound N([C@H]1CCCN([C@H]1C=1C=CC=CC=1)CCCCCC(=O)OCC)CC1=CC=CC=C1OC JGCMPBRNZDBPGS-IGKIAQTJSA-N 0.000 claims description 3
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/49—Cinchonan derivatives, e.g. quinine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30669201P | 2001-07-20 | 2001-07-20 | |
| US60/306,692 | 2001-07-20 | ||
| PCT/IB2002/002847 WO2003009848A1 (en) | 2001-07-20 | 2002-07-15 | Use of nk-1 receptor antagonists to modify unwanted behavior in dogs, cats and horses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20040029375A true KR20040029375A (ko) | 2004-04-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| KR10-2004-7000901A Ceased KR20040029375A (ko) | 2001-07-20 | 2002-07-15 | 개, 고양이 및 말에서 결함있는 행태를 변화시키기 위한nk-1 수용체 길항제의 용도 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20030139443A1 (enExample) |
| EP (1) | EP1411946A1 (enExample) |
| JP (1) | JP2005504029A (enExample) |
| KR (1) | KR20040029375A (enExample) |
| CN (1) | CN1529600A (enExample) |
| CA (1) | CA2448722A1 (enExample) |
| CZ (1) | CZ200434A3 (enExample) |
| HU (1) | HUP0401154A2 (enExample) |
| IL (1) | IL158990A0 (enExample) |
| PL (1) | PL367944A1 (enExample) |
| SK (1) | SK252004A3 (enExample) |
| WO (1) | WO2003009848A1 (enExample) |
| ZA (1) | ZA200308991B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100834232B1 (ko) * | 2004-01-30 | 2008-05-30 | 화이자 프로덕츠 인크. | 액체 투여형용 베타-시클로덱스트린을 사용하는 다수회투여 제형을 얻기 위한 항균 방부제 |
| JP2007519701A (ja) | 2004-01-30 | 2007-07-19 | ファイザー・プロダクツ・インク | 麻酔回復を改善するためのnk−1受容体拮抗剤 |
| MXPA06012504A (es) * | 2004-04-30 | 2006-12-15 | Schering Corp | Moduladores del receptor neuropeptido. |
| CN114403042A (zh) * | 2021-12-13 | 2022-04-29 | 深圳先进技术研究院 | 一种大动物焦虑症动物模型 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX18467A (es) * | 1988-11-23 | 1993-07-01 | Pfizer | Agentes terapeuticos de quinuclidinas |
| US5232929A (en) * | 1990-11-28 | 1993-08-03 | Pfizer Inc. | 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use |
| FR2677361A1 (fr) * | 1991-06-04 | 1992-12-11 | Adir | Nouveaux peptides et pseudopeptides, derives de tachykinines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| DE122006000066I2 (de) * | 1991-05-31 | 2007-12-06 | Pfizer | Chinuclidinderivate |
| BR9206161A (pt) * | 1991-06-20 | 1995-10-31 | Pfizer | Derivados fluoroalcoxibenzilamino de heterociclos contendo nitrogénio |
| US5688806A (en) * | 1993-03-04 | 1997-11-18 | Pfizer Inc. | Spiroazacyclic derivatives as substance P antagonists |
| EP0623344B1 (fr) * | 1993-05-04 | 2000-07-26 | Ceva Sante Animale | Utilisation de la Sélégiline en médecine vetérinaire |
| IL109646A0 (en) * | 1993-05-19 | 1994-08-26 | Pfizer | Heteroatom substituted alkyl benzylamino-quinuclidines |
| US5393762A (en) * | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
| EP0719266A1 (en) * | 1993-09-17 | 1996-07-03 | Pfizer Inc. | Heteroarylamino and heteroarylsulfonamido substituted 3-benzylaminomethyl piperidines and related compounds |
| US6083943A (en) * | 1993-09-17 | 2000-07-04 | Pfizer Inc | Substituted azaheterocyclecarboxylic acid |
| US5854262A (en) * | 1993-10-07 | 1998-12-29 | Pfizer Inc. | Aminomethylene substituted non-aromatic heterocycles and use as substance P antagonists |
| PE45195A1 (es) * | 1994-03-03 | 1996-01-17 | Boehringer Ingelheim Kg | Derivado de aminoacido, procedimiento para su preparacion y composicion farmaceutica que lo contiene |
| US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
| ATE279406T1 (de) * | 1995-01-12 | 2004-10-15 | Glaxo Group Ltd | Piperidinderivate mit tachykinin-antagonistischer wirkung |
| US5990125A (en) * | 1996-01-19 | 1999-11-23 | Pfizer Inc. | NK-1 receptor antagonists for the treatment of cancer |
| DE69736390T2 (de) * | 1996-10-07 | 2007-07-26 | Merck Sharp & Dohme Ltd., Hoddesdon | Zns-penetrierende nk-1 rezeptorantagonisten als antidepressivum und / oder anxiolytikum |
| US6117855A (en) * | 1996-10-07 | 2000-09-12 | Merck Sharp & Dohme Ltd. | Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent |
| DE69710921T2 (de) * | 1996-12-19 | 2002-09-19 | Aventis Pharmaceuticals Inc., Bridgewater | Heterocyclische substituierte pyrrolidinamid-derivate |
| US6156749A (en) * | 1997-12-01 | 2000-12-05 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating movement disorders |
| JP4669095B2 (ja) * | 1999-07-19 | 2011-04-13 | 太陽化学株式会社 | ペットの問題行動抑制組成物 |
| CA2280309C (en) * | 1999-08-13 | 2007-05-08 | William Norton Milgram | Use of adrafinil to treat behavioral problems in aged canines |
| CA2324813A1 (en) * | 1999-11-10 | 2001-05-10 | Susan Beth Sobolov-Jaynes | Combination treatment for depression and anxiety |
| US20020049211A1 (en) * | 2000-09-06 | 2002-04-25 | Sobolov-Jaynes Susan Beth | Combination treatment for depression and anxiety |
-
2002
- 2002-07-15 HU HU0401154A patent/HUP0401154A2/hu unknown
- 2002-07-15 CN CNA028141873A patent/CN1529600A/zh active Pending
- 2002-07-15 SK SK25-2004A patent/SK252004A3/sk not_active Application Discontinuation
- 2002-07-15 CZ CZ200434A patent/CZ200434A3/cs unknown
- 2002-07-15 EP EP02745741A patent/EP1411946A1/en not_active Withdrawn
- 2002-07-15 KR KR10-2004-7000901A patent/KR20040029375A/ko not_active Ceased
- 2002-07-15 JP JP2003515240A patent/JP2005504029A/ja not_active Withdrawn
- 2002-07-15 IL IL15899002A patent/IL158990A0/xx unknown
- 2002-07-15 CA CA002448722A patent/CA2448722A1/en not_active Abandoned
- 2002-07-15 PL PL02367944A patent/PL367944A1/xx not_active Application Discontinuation
- 2002-07-15 WO PCT/IB2002/002847 patent/WO2003009848A1/en not_active Ceased
- 2002-07-19 US US10/199,284 patent/US20030139443A1/en not_active Abandoned
-
2003
- 2003-11-19 ZA ZA200308991A patent/ZA200308991B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ200434A3 (cs) | 2005-02-16 |
| SK252004A3 (sk) | 2005-03-04 |
| PL367944A1 (en) | 2005-03-07 |
| US20030139443A1 (en) | 2003-07-24 |
| JP2005504029A (ja) | 2005-02-10 |
| CA2448722A1 (en) | 2003-02-06 |
| HUP0401154A2 (hu) | 2004-10-28 |
| ZA200308991B (en) | 2004-11-19 |
| EP1411946A1 (en) | 2004-04-28 |
| CN1529600A (zh) | 2004-09-15 |
| WO2003009848A1 (en) | 2003-02-06 |
| IL158990A0 (en) | 2004-05-12 |
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