KR20040019087A - 신규 비닐 카르복실산 유도체 및 항당뇨제 등으로서그들의 사용 - Google Patents
신규 비닐 카르복실산 유도체 및 항당뇨제 등으로서그들의 사용 Download PDFInfo
- Publication number
- KR20040019087A KR20040019087A KR10-2004-7001417A KR20047001417A KR20040019087A KR 20040019087 A KR20040019087 A KR 20040019087A KR 20047001417 A KR20047001417 A KR 20047001417A KR 20040019087 A KR20040019087 A KR 20040019087A
- Authority
- KR
- South Korea
- Prior art keywords
- phenyl
- allyloxy
- bis
- acetic acid
- chloro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200101154 | 2001-07-30 | ||
DKPA200101154 | 2001-07-30 | ||
PCT/DK2002/000471 WO2003011807A1 (en) | 2001-07-30 | 2002-07-05 | Novel vinyl carboxylic acid derivatives and their use as antidiabetics etc. |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20040019087A true KR20040019087A (ko) | 2004-03-04 |
Family
ID=8160643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR10-2004-7001417A KR20040019087A (ko) | 2001-07-30 | 2002-07-05 | 신규 비닐 카르복실산 유도체 및 항당뇨제 등으로서그들의 사용 |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP1414778A1 (zh) |
JP (1) | JP2004536150A (zh) |
KR (1) | KR20040019087A (zh) |
CN (1) | CN1537093A (zh) |
BR (1) | BR0211414A (zh) |
CA (1) | CA2452665A1 (zh) |
CZ (1) | CZ2004133A3 (zh) |
HU (1) | HUP0401575A2 (zh) |
IL (1) | IL159547A0 (zh) |
MX (1) | MXPA04000891A (zh) |
NO (1) | NO20040389L (zh) |
PL (1) | PL366401A1 (zh) |
RU (1) | RU2004105956A (zh) |
WO (1) | WO2003011807A1 (zh) |
ZA (1) | ZA200400161B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100693132B1 (ko) * | 2006-06-23 | 2007-03-14 | 동해전장 주식회사 | 정션박스내에 삽입된 릴레이의 동작 검사 장치 |
US20120168303A1 (en) * | 2011-01-05 | 2012-07-05 | Sueng-Nien Kao | Salt water activated emergency lighting device |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1688540A (zh) * | 2002-09-05 | 2005-10-26 | 诺沃挪第克公司 | 新颖的乙烯基羧酸衍生物以及它们的治疗用途 |
CA2503276A1 (en) * | 2002-10-28 | 2004-05-06 | Novo Nordisk A/S | Novel compounds useful in treating ppar mediated diseases |
DE60333211D1 (de) * | 2002-10-28 | 2010-08-12 | High Point Pharmaceuticals Llc | Neue verbindungen und deren verwendung als ppar-modulatoren |
ITRM20030305A1 (it) * | 2003-06-20 | 2004-12-21 | Sigma Tau Ind Farmaceuti | Preparazione di nuovi derivati di acidi fenil o fenossialchil mono e dicarbossilici utili nel trattamento dell'iperglicemia e dell'ipertrigliceridemia tipiche del diabete del tipo ii. |
EP2100877B1 (en) * | 2003-09-19 | 2012-01-25 | Janssen Pharmaceutica N.V. | 4-((Phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
EP2243766B1 (en) | 2003-09-19 | 2015-09-02 | Janssen Pharmaceutica N.V. | 4-((phenoxyalkyl)thio)-phenoxyacetic acids for use in treating PPAR-delta mediated conditions |
WO2005105736A1 (en) | 2004-05-05 | 2005-11-10 | Novo Nordisk A/S | Novel compounds, their preparation and use |
JO3006B1 (ar) | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
DK1942898T4 (da) | 2005-09-14 | 2014-06-02 | Takeda Pharmaceutical | Dipeptidylpeptidase-inhibitorer til behandling af diabetes |
KR101368988B1 (ko) | 2005-09-16 | 2014-02-28 | 다케다 야쿠힌 고교 가부시키가이샤 | 디펩티딜 펩티다제 억제제 |
EA201101085A1 (ru) * | 2005-12-22 | 2012-05-30 | ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Феноксиуксусные кислоты в качестве активаторов ppar дельта |
UY30288A1 (es) | 2006-04-18 | 2007-08-31 | Janssen Pharmaceutica Nv | Derivados del ácido benzoazepin-oxi-acético como agonistas de ppar-delta usados para aumentar hdl-c. reducir ldl-c y reducir colesterol |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
CN103467408B (zh) * | 2013-09-03 | 2015-01-21 | 浙江医药高等专科学校 | 一类四氮唑羧酸类化合物及其用途 |
CN103467407B (zh) * | 2013-09-03 | 2015-04-22 | 浙江医药高等专科学校 | 四氮唑羧酸类化合物及其用途 |
CN103467405B (zh) * | 2013-09-03 | 2015-01-07 | 浙江医药高等专科学校 | 一类四氮唑羧酸类化合物、其制备方法和用途 |
CN103467406B (zh) * | 2013-09-03 | 2014-12-17 | 浙江医药高等专科学校 | 卤素取代的四氮唑羧酸类化合物、其制备方法和用途 |
CN103467409B (zh) * | 2013-09-03 | 2015-01-07 | 浙江医药高等专科学校 | 取代的四氮唑羧酸类化合物及其用途 |
JP2023534835A (ja) | 2020-07-22 | 2023-08-14 | レネオ ファーマシューティカルズ,インク. | 結晶性pparデルタアゴニスト |
WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0098690B1 (en) * | 1982-06-14 | 1987-09-09 | Takeda Chemical Industries, Ltd. | Vinyl carboxylic acid derivatives, their production and use |
AU2652397A (en) * | 1996-05-13 | 1997-12-05 | Nippon Shinyaku Co. Ltd. | Substituted ethylene compounds and drugs |
IL145789A0 (en) * | 1999-04-20 | 2002-07-25 | Novo Nordisk As | Derivatives of propionic acid, their preparation and pharmaceutical compositions containing them |
WO2001055085A1 (en) * | 2000-01-28 | 2001-08-02 | Novo Nordisk A/S | Propionic acid derivatives and their use in the treatment of diabetes and obesity |
-
2002
- 2002-07-05 CN CNA028150996A patent/CN1537093A/zh active Pending
- 2002-07-05 RU RU2004105956/04A patent/RU2004105956A/ru not_active Application Discontinuation
- 2002-07-05 BR BR0211414-3A patent/BR0211414A/pt not_active IP Right Cessation
- 2002-07-05 WO PCT/DK2002/000471 patent/WO2003011807A1/en not_active Application Discontinuation
- 2002-07-05 CZ CZ2004133A patent/CZ2004133A3/cs unknown
- 2002-07-05 JP JP2003517001A patent/JP2004536150A/ja active Pending
- 2002-07-05 CA CA002452665A patent/CA2452665A1/en not_active Abandoned
- 2002-07-05 IL IL15954702A patent/IL159547A0/xx unknown
- 2002-07-05 PL PL02366401A patent/PL366401A1/xx not_active Application Discontinuation
- 2002-07-05 HU HU0401575A patent/HUP0401575A2/hu unknown
- 2002-07-05 MX MXPA04000891A patent/MXPA04000891A/es unknown
- 2002-07-05 KR KR10-2004-7001417A patent/KR20040019087A/ko not_active Application Discontinuation
- 2002-07-05 EP EP02745186A patent/EP1414778A1/en not_active Withdrawn
-
2004
- 2004-01-09 ZA ZA200400161A patent/ZA200400161B/en unknown
- 2004-01-29 NO NO20040389A patent/NO20040389L/no not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100693132B1 (ko) * | 2006-06-23 | 2007-03-14 | 동해전장 주식회사 | 정션박스내에 삽입된 릴레이의 동작 검사 장치 |
US20120168303A1 (en) * | 2011-01-05 | 2012-07-05 | Sueng-Nien Kao | Salt water activated emergency lighting device |
Also Published As
Publication number | Publication date |
---|---|
CN1537093A (zh) | 2004-10-13 |
ZA200400161B (en) | 2004-08-18 |
NO20040389L (no) | 2004-01-29 |
JP2004536150A (ja) | 2004-12-02 |
CZ2004133A3 (cs) | 2004-06-16 |
RU2004105956A (ru) | 2005-03-27 |
IL159547A0 (en) | 2004-06-01 |
BR0211414A (pt) | 2004-08-17 |
CA2452665A1 (en) | 2003-02-13 |
PL366401A1 (en) | 2005-01-24 |
HUP0401575A2 (hu) | 2004-11-29 |
EP1414778A1 (en) | 2004-05-06 |
MXPA04000891A (es) | 2004-05-21 |
WO2003011807A1 (en) | 2003-02-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR20040019087A (ko) | 신규 비닐 카르복실산 유도체 및 항당뇨제 등으로서그들의 사용 | |
KR20050036876A (ko) | 디카르복실산 유도체, 그것의 제제 및 치료에의 사용 | |
US7709528B2 (en) | Compounds, their preparation and use | |
JP4638229B2 (ja) | 新規ビニルカルボン酸誘導体およびその治療的使用 | |
JP4981662B2 (ja) | 新規の化合物、その製法と使用 | |
US7968723B2 (en) | Compounds, their preparation and use | |
JP4708184B2 (ja) | 新規の化合物、それらの調製及び使用 | |
EP1578716A1 (en) | Dicarboxylic acid derivatives as ppar-agonists | |
US6869967B2 (en) | Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives | |
EP1763511B1 (en) | Phenoxyacetic acid derivatives as ppar agonists | |
WO2003011814A1 (en) | Novel vinyl n-(2-benzoylphenyl)-l-tyrosine derivatives and their use as antidiabetics etc | |
US7067530B2 (en) | Compounds, their preparation and use | |
US7220877B2 (en) | Compounds, their preparation and use | |
JP2005503377A (ja) | 新規ビニルn−(2−ベンゾイルフェニル)−l−チロシン誘導体及び抗糖尿病剤等へのそれらの使用 | |
US7816385B2 (en) | Dimeric dicarboxylic acid derivatives, their preparation and use | |
US20030055076A1 (en) | Novel compounds, their preparation and use | |
AU2002316815A1 (en) | Novel vinyl carboxylic acid derivatives and their use as antidiabetics etc. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |