KR20040003923A - Preparation and it's method of functional food for low body fat. - Google Patents

Preparation and it's method of functional food for low body fat. Download PDF

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KR20040003923A
KR20040003923A KR1020020038764A KR20020038764A KR20040003923A KR 20040003923 A KR20040003923 A KR 20040003923A KR 1020020038764 A KR1020020038764 A KR 1020020038764A KR 20020038764 A KR20020038764 A KR 20020038764A KR 20040003923 A KR20040003923 A KR 20040003923A
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South Korea
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extract
weight
obesity
body fat
functional food
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KR1020020038764A
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Korean (ko)
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오광택
오호택
윤미자
전승일
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(주)바이오자임 인터내셔날
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Priority to KR1020020038764A priority Critical patent/KR20040003923A/en
Publication of KR20040003923A publication Critical patent/KR20040003923A/en

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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20Reducing nutritive value; Dietetic products with reduced nutritive value
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30Dietetic or nutritional methods, e.g. for losing weight
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00Function of food ingredients
    • A23V2200/30Foods, ingredients or supplements having a functional effect on health
    • A23V2200/332Promoters of weight control and weight loss

Abstract

PURPOSE: A functional food comprising an extract of herbal plants such as Salicornia herbacea and Siegesbeckia spp. as a main component is provided which inhibits obesity and promotes body fat consumption without adverse side effects. CONSTITUTION: A functional food contains 10 to 15% by weight of a Salicornia herbacea extract, 25 to 50% by weight of a Natrii Sulfas extract, 1.5 to 5.0% by weight of a Crataegi Fructus, 2.0 to 5.0% by weight of a Cassiae Semen extract, 1.5 to 5.0% by weight of a young leaves extract of Oenothera odorata Jacq., 5 to 15% by weight of a cascara sagrada extract, 5 to 15% by weight of an Angelicae Gigantis Radix extract, 5 to 15% by weight of a Siegesbeckia spp. extract, 5 to 15% by weight of an Atractylodis Rhizoma extract, 5 to 15% by weight of an Eucommiae Cortex extract, 5 to 15% by weight of a Hordei Fructus extract, 5 to 15% by weight of a Poria cocos extract, 5 to 15% by weight of an Astragali Radix extract, 5 to 15% by weight of a Saururus chinensis extract, 5 to 15% by weight of a Fructus Aurantii extract, 1 to 5% by weight of a Herba Taraxaci extract and 1 to 5% by weight of a Mori Cortex Radicis extract.

Description

체지방 감소에 효과적인 기능성 영양보충용 식품 및 그 제조 방법{Preparation and it's method of functional food for low body fat.}Functional nutritional supplement foods effective for reducing body fat and a method of manufacturing the same {Preparation and it's method of functional food for low body fat.}

ㆍ본 발명은 명함초,망초,결명자,산사자,연잎파리,달맞이꽃어린잎,황기,복령,율무,하수오,적소두,당귀.회첨,창출,맥아,두충,삼백초,민들레,뽕나무 등의 천연물질을 일정비율로 혼합하여 체지방 감소에 현격한 효과가 있는 기능성 영양보충용 식품의 제조 방법에 관한 것입니다. .ㆍ The present invention is a natural card, such as business card candles, forget-me-not, crystallizer, mountain lion, lotus leaf fly, evening primrose, young leaves, Astragalus, Fuling, Yulmu, sewage, red bean, donkey. It relates to a method of manufacturing functional nutritional supplement foods that have a significant effect on body fat reduction by mixing at a certain ratio. .

ㆍ경제발전과 이에 따른 식생활 패턴 및 생활양식의 변화에 따라 에너지가 높으며 인스턴트와 같은 가공식품의 섭취가 늘어나고 운동량의 부족 및 도시화에 따른 스트레스가 쌓임에 따라 비만증이 사회적으로 심긱한 문제로 떠오르고 있다.ㆍ Because of economic development and the changes in dietary patterns and lifestyles, the energy is high, the consumption of processed foods such as instant foods is increasing, and the lack of exercise and the stress caused by urbanization are causing the obesity to be a social problem.

비만(obesity)이란 지방이 과잉 축적된 상태의 대사장애(代謝障碍)이다.열량섭취가 소비를 초과함으로서 초과된 열량이 중성지방(中性脂肪)의 형태로 지방조직에 과잉 축적된 열량 불균형으로 일어난다.통상 이상적 체중치의 10-20%를 초과했을 때 비만증이라 하게 된다.즉 비만여부는 신장에 대한 체중증가비율로 판정케 한다. 비만증은 신체 모든 부의에 악순환을 가져다 준다.Obesity is a metabolic disorder in which fat is excessively accumulated. An excess of calorie intake due to excess calories in the form of triglycerides results in caloric imbalance in the fat tissue. It is usually referred to as obesity when it exceeds 10-20% of the ideal body weight, ie whether obesity is determined by the ratio of weight gain to height. Obesity brings a vicious cycle to all the wealth of the body.

흉복부에 지방이 현저히 축적되면 환기운동의 장애를 받아 환기량(換氣量)이감소하고 그 결과 운동량이 떨어지게 된다.그렇게되면 운동부족이 되고 이것이 비만의 원인이 되다. 비만은 비만증이 되기 쉬은 소질을 가진자가 생활환경과 당질계 식품의 과식과 비 활동적인 생활이 계속되면 섭취에너지가 소비를 크게 상회하여 지방축적이 현저하게 일어난다.Significant accumulation of fat in the chest abdomen results in impaired ventilation, resulting in a decrease in the amount of ventilation resulting in lack of exercise, which can lead to obesity. Obesity is a person with a tendency to become obese, if the living environment and overeating of sugar-based foods and inactive life continues, intake energy significantly exceeds consumption, fat accumulation occurs remarkably.

체내에는 4종류의 지방이 있다.콜레스테롤(cholesterol), 인지질(lipid),중성지방(triglyceride), 유리지방산(free fatty acide)이다.이들 지방이 과축적된 상태가 바로 비만이다.There are four types of fats in your body: cholesterol, lipids, triglycerides, and free fatty acids, which are overweight.

ㆍ콜레스테롤(cholesterol)은 체내 분포된 약 25%는 신경세포에 들어있고 기타근육,피하지방,부신,간장속에 들어있다.세포막을 형성하는데에 약 10%정도가 혈액중에 들어가는데 이중 약간이 결정 또는 혈청 콜레스테롤(cholesterol)이 된다.About 25% of cholesterol in the body is contained in nerve cells and in other muscles, subcutaneous fat, adrenal glands, and liver. About 10% of blood enters the blood to form cell membranes, some of which are crystals or serum. It is cholesterol.

ㆍ인지질(phospholipid)은 단백질과 지방을 결합시키는 역할을 하며 콜레스테롤과 마찬가지로 체세포의 세포막을 구성하는 중요성분이다.Phospholipid (phospholipid) plays a role in binding proteins and fats and, like cholesterol, is an important component of the cell membrane of somatic cells.

ㆍ중성지방(triglyceride), 유리지방산(free fatty acide)은 피하지방에 가장 많이 들어있다.유리지방산과 함께 몸의 에너지에 필요한 지방이다.Triglycerides and free fatty acids are most commonly found in subcutaneous fat. Together with free fatty acids, they are needed for your body's energy.

피하지방의 60%는 수분이고 30%정도가 중성지방(triglyceride)으로 구성된다.60% of subcutaneous fat is water and 30% is composed of triglycerides.

이것이 과도하게 축적이 되면 비만이 된다.중성지방의 역할은 에너지의 저장이고 유리지방산은 에너지를 일으키는 물질 그 자체이다.When it accumulates too much, it becomes obese: the role of triglycerides is the storage of energy and free fatty acids are the energy-producing substances themselves.

ㆍ지방은 주로 피하조직에 축적되는데 심장의 주의에 축적되어 심장기능에 장해 주기도 하며 비만한 사람은 당뇨병,동맥경화증,고혈압증,심장병,간장병,담색증,통풍,신장병의 발생률이 높고 수술시에도 위험성이 높아 대체로 단명하는 것으로 보고 되어있다.이와 같이 비만증은 생명과 직결되는 건강상의 문제일 뿐 아니라 특히 여성의 경우 미용상으로 중요한 문제로서 매년 체중감소를 위해 지출되는 비용이 사회적으로 문제가 되고 있는 실정이다.ㆍ Fat accumulates mainly in the subcutaneous tissues, and it can accumulate in the heart due to the attention of the heart. Obese people have a high incidence of diabetes, arteriosclerosis, hypertension, heart disease, liver disease, cholestasis, gout, and kidney disease. As a result, obesity is not only a health problem directly related to life, but also a cosmetic problem, especially for women, and the cost of losing weight every year is a social problem. .

ㆍ비만증을 억제하기 위해서는 음식물의 섭취를 줄이고 에너지 소비를 늘리며 지방의 체내축적을 억제하는 것이 필요하다.특히 음식물 섭취의 감소보다는 에너지 소모를 증가시키는 것이 비만증 억제에 효과적이라고 알려져 있다.실제로 많은 에너지의 소비가 심장혈관질환으로 인한 사망률 및 총사망률을 낮춘다는 보고도 있다.그러나 지속적으로 운동을 하기 어려운 현대사회의 특성으로 인해 비만 억제를 위한 주된 노력은 비만억제효과를 갖고 축적된 지방을 분해 및 촉진하는 기능성식품의 섭취에 초점이 맞춰져 있는 실정이다. 현재까지 국내외에 개발되어 있는 대부분의 비만억제기능성 식품은 주로 식이섬유나 아미노산을 주원료로 하여 체내의 수분,염류를 강제 배출시키는 이뇨제와 포만감을 일으켜 음식성취욕을 격감시키는 것이 대부분이었다.In order to control obesity, it is necessary to reduce food intake, increase energy consumption, and suppress fat accumulation in the body.In particular, increasing energy consumption rather than reducing food intake is known to be effective in suppressing obesity. It is reported that consumption lowers mortality and total mortality from cardiovascular disease, but due to the characteristics of modern society, which is difficult to continuously exercise, the main effort for suppressing obesity has the effect of suppressing obesity and decomposing and promoting accumulated fat. The situation is focused on the intake of functional foods. Most of the anti-obesity functional foods developed to date at home and abroad mainly use dietary fiber or amino acids as main ingredients to diuretic and satiety to force water and salts in the body.

이상과 같은 실정을 고려하여 본 발명자들은 생약재들 중 비만억제효과가 뛰어나며 체내 축적된 지방의 소비를 촉진시키는 물질을 탐색하고 이들의 추출방법 및 배합비율등의 최적화된 방법을 통하여 비만억제효과 및 체지방 소비촉진을 시키는 조성물을 제공함으로서 본 발명을 완성하였다.In view of the above situation, the present inventors search for substances that have excellent anti-obesity effect among herbal medicines and promote consumption of fat accumulated in the body, and optimize the anti-obesity effect and body fat by optimizing such extraction methods and compounding ratios. The present invention has been completed by providing a composition for promoting consumption.

따라서 본 발명의 목적은 비만억제효과가 우수하며 체지방소비를 촉진하는효과가 뛰어나며 생약재 추출물의 혼합물로 이루어지는 새로운 비만억제 및 체지방소비 촉진제를 제공하는 것이다.Accordingly, an object of the present invention is to provide a novel anti-obesity and body fat-stimulating accelerator consisting of a mixture of herbal extracts with excellent anti-obesity effect, excellent effect of promoting body fat consumption.

또한 본 발명은 상기에서 비만억제 및 체지방소비 촉진을 극대화 할 수 있는 생약재 추출법과 배합비율을 제공하는 것을 목적으로 한다.In another aspect, the present invention is to provide an herbal extract extraction method and a blending ratio that can maximize the inhibition of obesity and the promotion of body fat consumption.

상기목적을 달성하기 위하여,본 발명을 산사자,결명자,만삼,연잎파리,달맞이꽃어린잎,황기,복령,울무하수오,적소두,진피,함초,카스카라사그라다,당귀,회첨,창출,맥아,두충,삼백초,민들레,뽕나무의 열수추출물을 유효성분으로 함유하는 비만억제 및 체지방 소비 촉진제용 조성물을 제공한다.In order to achieve the above object, the present invention is a mountain lion, a locus, ginseng, lotus leaf fly, evening primrose young leaves, Astragalus, Fuling, Ulmu Sewage, red bean, dermis, seaweed, cascara sagrada, donkey, lottery, creation, malt, tofu Provides a composition for inhibiting obesity and body fat consumption promoting agent containing the hot water extract of three hundred seconds, dandelion, mulberry as an active ingredient.

이하 본 발명을 상세히 설명한다.Hereinafter, the present invention will be described in detail.

본 발명의 비만억제 및 체지방소비 촉진의 조성물은 함초추출물 10-15%, 망초추출물 25-50%, 산사자추출물1.5-5.0%,결명자추출물 2.0-5.0%,달맞이꽃어린잎추출물 1.5-5.0%,카스카라사그라다추출물5-15%와 당귀추출물 5-15%,회첨추출물 5-15%,창출추출물 5-15%,두충추출물 5-15%,맥아추출물 5-15% 복령추출물 5-15%,황기추출물 5-15%,삼백초추출물 5-15%,진피추출물 5-15%,민들레추출물 1-5%,뽕나무추출물 1-5%를 포함하는 것이다.Composition of the anti-obesity and body fat consumption promoting composition of the present invention is 10-15% of seaweed extract, 25-50% of forget-me-not extract, hawthorn extract 1.5-5.0%, sperm extract 2.0-5.0%, evening primrose leaf extract 1.5-5.0%, Kasu Carras Grada Extract 5-15%, Angelica Extract 5-15%, Root Extract 5-15%, Extract Extract 5-15%, Tobacco Extract 5-15%, Malt Extract 5-15%, Fuling Extract 5-15%, Astragalus extract 5-15%, trichoola extract 5-15%, dermis extract 5-15%, dandelion extract 1-5%, mulberry extract 1-5%.

본 발명의 조성물에서 생약재의 열수추출물은 함초,망초,산사자,결명자,만삼,황기,복령,연잎파리,달맞이꽃어린잎,카스카라사그라다 시료에 약 5-15배 바람직하게는 약 10배의 정제수를 혼합하여 85-95 ℃에서 5-7시간 동안 추출하여 얻는 것이 바람직하며 당귀,회첨,창출,두충,맥아,복령,황기,삼백초,진피민들레,뽕나무 시료에 약 7배의 정제수를 혼합하여 82-95 ℃에서 2-3시간 동안 추출,농축하여 얻는다.The hot water extract of the herbal medicine in the composition of the present invention is about 5-15 times preferably about 10-15 times the seaweed, forget-me-not, mountain lion, bladder, mansam, Astragalus, Bokyeong, lotus leaf, evening primrose and young cascara sagrada sample. It is preferable to obtain by extracting for 5-7 hours at 85-95 ℃ by mixing and mixed with about 7 times purified water to the sample of Angelica, rot, creation, tofu, malt, Bokryeong, Astragalus, three hundred seconds, dermis dandelion, mulberry 82 Obtained by extraction and concentration at -95 ° C for 2-3 hours.

상기 추출물의 비만억제와 체지방소비촉진의 관계를 조사한 결과 체중증가,열량섭취 복부지방,간 중성지방등 비만도의 각종 지표에 대해 1일 투여량이 체중 100g당2mg,5mg,10mg,20mg에 대해 투여한 경우 함초,망초의 경우 1일 5mg/체중100g/일로 투여한 경우에 효과가 좋았으며 당귀,회첨등의 추출물은 2mg/체중100g/일로 투여한 경우가 우수한 것으로 나타났다.As a result of investigating the relationship between the inhibition of obesity and the promotion of body fat consumption of the extract, the daily dose was administered to 2 mg, 5 mg, 10 mg, and 20 mg per 100 g of body weight for various indicators of obesity such as weight gain, calorie intake, abdominal fat, and liver triglyceride. In case of persimmon and forget-me-not, the effect was good when administered at 5mg / weight 100g / day per day, and the extracts such as Angelica, rot, and 2mg / weight 100g / day were found to be excellent.

한편 본 발명의 비만억제 및 체지방 소비촉진제의 조성물은 분말,캡슐,정제,과립,산제,액제등의 형태로 체형화 할수 있다.Meanwhile, the composition of the anti-obesity and body fat consumption promoting agent of the present invention can be shaped into a powder, capsule, tablets, granules, powders, liquids and the like.

본 발명은 본 발명에 따른 생약제 추출물의 혼합 조성물에 대하여 추가적으로 비독성,불활성,부평제 또는 담체를 포함할 수 있다.The present invention may further comprise a nontoxic, inactive, carrier, or carrier with respect to the mixed composition of the herbal extract according to the present invention.

또 본 발명의 조성물은 경구투여하는 것이 바람직하며 이를 위하여 복용이 간편한 캅셀제,정제의 형태가 유리하다.In addition, the composition of the present invention is preferably administered orally. For this purpose, the capsule is easy to take, the form of the tablet is advantageous.

본 발명의 추출물의 혼합조성물은 상기 체형에 있어서 전체혼합물의 약 0.1중량%내지 99.5중량%의으로 함유 할 수있다.The mixed composition of the extract of the present invention may contain from about 0.1% to 99.5% by weight of the total mixture in the body shape.

본 발명의 함초,망초등의 추출물의 혼합조성물은 유효성분투여량이 2-10mg/체중100g/일이고 당귀,회침 등의 혼합조성물은 1-5mg/체중100g/일로 비만억제 및 체지방 소비 촉진용 건강보조식품또는 기능성 식품으로 사용될수 있다.The mixed composition of the extracts of seaweeds, forages, etc. of the present invention has an active ingredient dose of 2-10mg / 100g body weight / day, and the mixed composition of Angelica, guinea pig, etc. 1-5mg / 100g / day weight to prevent obesity and promote body fat consumption It can be used as a supplement or a functional food.

이하 본 발명을 실시예에 의해 상세히 설명한다.Hereinafter, the present invention will be described in detail by way of examples.

단 하기 실시예는 본 발명을 예시하는 것일뿐 본 발명의 내용이 하기 실시에한정되는 것은 아니다.However, the following examples are merely to illustrate the present invention, but the content of the present invention is not limited to the following examples.

실시예1) 생약재 추출물의 제조Example 1 Preparation of Herbal Extracts

함초,망초,결명자,카스카라사그라다의 이물질을 제거하고 잘게 세절한후 10배의 정제수로 90 ℃에서 6시간동안 진탕하여 추출하고60 ℃에서 감압농축,건조하여 분말화하였다.(이하함초등혼합추물) 회첨,당귀,삼백초 또한 이물질을 제거하고 잘게 세절한후 7배의 정제수를 85 °에서 2시간동안 진탕하여 추출하고 60 ℃에서 감압농축,건조하여 분말화 하였다.(이하 회첨분 혼합추출물)Remove foreign substances of seaweed, forget-me-not, cassia, cascara sagrada, finely chopped, and extract by shaking for 10 hours at 90 ℃ with purified water of 10 times, concentrated under reduced pressure, dried at 60 ℃ and powdered. Mixed extract) Rotating, Angelica, and three hundred seconds Also, after removing the foreign matter and finely chopped, extracted 7 times purified water by shaking for 2 hours at 85 °, concentrated under reduced pressure and dried at 60 ℃ to powder. )

실시예2) 비만 억제 및 체지방 소비 촉진 효과Example 2 effect of inhibiting obesity and promoting body fat consumption

실시예1에서 얻어진 함초 등 혼합추출물과 희첨등 혼합추출물의 비만억제 효과를 조사하였다.The antiobesity effect of the mixed extracts such as seaweed and the rare extracts obtained in Example 1 was investigated.

먼저 4주령의 스프래그-다우리(Sprague-Dawley,SD)응성ㆍ쥐에 1주간 시판 펠렛(pellet) 사료를 급여한뒤 10마리씩 정상대조군, 비만대조군 및 상기 시료의 추출물에 공급할 대조군으로 나누었다. 정상 대조군은 계속 펠렛 사료만 급여하고 나머지 모듣 군은 펠렛 사료와 함께 사람에게 가장 흔히 발생하는 비만증 유형과 가장 가까운 비만증을 유발한다고 알려진 카페테리아 식이 (cafeteria diet)를 투여하였으며, 모듣 사료와 물은 자유롭게 섭취시켰다. 카페테리아 식이로는 쿠키, 비스켓, 초콜릿, 땅콩, 치즈, 감자칩, 아몬드, 소시지 및 햄을 투여하였으며, 에너지함량은 식품성분표를 이용하여 계산하였다.First, 4 weeks old Sprague-Dawley, SD rats were fed with a commercial pellet feed for 1 week, and then 10 rats were divided into a normal control group, an obese control group, and a control group to supply the extract of the sample. The normal control group continued to feed only pellets and the rest of the modal group received a pelleted diet along with a cafeteria diet, which is known to cause obesity closest to the most common types of obesity in humans. I was. In the cafeteria diet, cookies, biscuits, chocolate, peanuts, cheese, potato chips, almonds, sausages and ham were administered, and the energy content was calculated using a food ingredient table.

상기 시료의 추출물에 공급할 대조군은 카페테리아 식이를 2주간 급여한 후, 하루에 실험쥐 체중 100g에 대해 추출물 분말 10mg씩을 증류수에 혼합하여 경구투여하였으며 상기 시료의 급여를 7주간 지속하였다. 정상대조군 및 비만대조군은 같은 부피의 생리식염수를 경구투여하였다.The control group to be fed to the extract of the sample was fed a cafeteria diet for 2 weeks, and then administered orally by mixing 10mg of extract powder in distilled water for 100g of the rat body weight per day and the feeding of the sample was continued for 7 weeks. Normal and obese controls were orally administered the same volume of saline.

시료를 7주간 경구투여한 후 체중을 측정하고, 간 및 복부의 지질을 추출하여 효소법으로 간의 중성지방과 복부지방을 정량하였다.After oral administration of the sample for 7 weeks, body weight was measured, and liver and abdominal lipids were extracted, and liver triglycerides and abdominal fats were quantified by enzyme method.

상기와 같이 측정된 실험쥐의 비만도를 표 1에 나타내었다.Table 1 shows the obesity of the mice measured as described above.

표1. 각 대조군에 따른 비만 억제 및 체지방 감소 측정결과Table 1. Obesity inhibition and body fat reduction results

1) 복부지방측정법: 복부피하지방을 모두 떼어내 생리식염수로 혈액을 제거한 후 중량 측정1) Abdominal fat measurement method: Remove all the abdominal subcutaneous fat, remove blood with physiological saline and measure the weight

2) 간 중성지방 측정법: Folch법에 의해 총지질 추출후 효소법으로 함량2) Determination of liver triglyceride: content by enzyme method after total lipid extraction by Folch method

(Wako pure chewical end, ltd.., japan)(Wako pure chewical end, ltd .., japan)

상기표 1에서 알수 있듯이 함초등 혼합추출물과 희첨등 혼합추출물에서 카페테리아 식이로 체중이 증가한 비만 대조군에 비해 40% 이상의 체중 억제 효과를 보였으며 복부 지방 및 간의 중성지방과 같은 체지방의 편리한 감소 효과를 알수 있다.As can be seen in Table 1 above, the extracts of Hamcho and other extracts showed a 40% or more weight suppression effect compared to the obese control group who gained weight by the cafeteria diet and showed a convenient reduction effect of body fat such as abdominal fat and liver triglyceride. have.

비만 억제 및 체지방 감소 효과의 유효농도를 결정하기 위해 실시예2와 동일한 방법으로 각 시표의 투여량은 실험쥐 체중 100g에 대해 각각 2.5.10.20mg/100g 로 하여 7주간 투여하였다.In order to determine the effective concentration of the effect of inhibiting obesity and reducing body fat, the dose of each target was administered as 2.5.10.20mg / 100g for 7 weeks in the same manner as in Example 2.

상기 추출물의 투여량에 따른 비만억제 및 체지방 감소 효과를 실험쥐의 체중증가, 복부지방, 간 중성지방 지수로 측정하여 표2에 나타내었다.Obesity inhibition and body fat reduction effect according to the dosage of the extract is shown in Table 2 by measuring the weight gain, abdominal fat, liver triglyceride index of the mice.

표2 시료투여량에 따른 비만억제 및 체지방 감소 효과측정Table 2 Measurement of the effects of obesity inhibition and body fat reduction according to the sample dose

상기표 2에서 볼 수 있듯이 함초등 혼합추출물의 경우 1일투여량 5kg/100g에서 희첨등 혼합추출물의 경우 1일 투여량 2mg/100g에서 현저한 체중증가 감소와 복부지방, 간 중성지방의 수치가 현저한 감소를 가져왔다.As can be seen in Table 2, in the case of mixed extracts such as seaweed, the daily dose of 5kg / 100g is significantly reduced in weight gain and abdominal fat and liver triglycerides in the daily dose of 2mg / 100g. Brought a decline.

따라서 함초등 혼합추출물과 희첨등 혼합추출물에서 비만억제 및 체지방 감소에 효과적임을 확인하였다.Therefore, it was confirmed that the mixed extracts of Hamcho and other extracts were effective in suppressing obesity and reducing body fat.

ㆍ본 발명은 천연식물성 원료를 사용하여 비만억제 및 체지방 감소에 효과적이며 부작용이 없는 식품의 소재를 찾던중 함초등의 추출물(함초추출물 10-15%, 망초추출물 25-50%,산사자추출물 1. 5-5.0%,결명자추출물2.0-5.0%,달맞이꽃어린잎추출물1.5-5.0%,카스카라사그라다추출물5-15%)과 희첨등의 추출물(희첨추출물 5-15%,당귀추출물 5-15%,창출추출물 5-15%,두충추출물5-15%, 맥아추출물 5-15% 복령추출물 5-15%,황기추출물 5-15%,삼백초추출물 5-15%,진피추출물5-15%, 민들레추출물 1-5%, 뽕나무추출물 1-5%)에서 비만억제 및 체지방 감소 촉진 효과가 월등한 생약혼합물을 추출,농축, 건조, 분말화 하여정제 또는 캅셀제제화 하여 비만억제 및 체지방 감소에 효과 적인 기능성 특수영양보충용 식품을 개발 하였다.ㆍ The present invention is effective in suppressing obesity and reducing body fat using natural plant raw materials, and extracts of seaweed such as seaweed extract (10-15% of seaweed extract, 25-50% of maize extract, mountain lion extract 1. 5-5.0%, Cassia tora extract 2.0-5.0%, evening primrose young leaf extract 1.5-5.0%, cascara sagrada extract 5-15%) and rare extracts (rare extract 5-15%, Angelica extract 5-15%) , 5-15% of extract extract, 5-15% of larvae extract, 5-15% of malt extract, 5-15% of Fuling Extract, 5-15% of Astragalus extract, 5-15% of Triticale extract, 5-15% of dermis extract, Dandelion 1-5% extract, 1-5% of mulberry extract) extract, concentrate, dry, and powder extracts, concentrate, dry and powder to produce anti-obesity and body fat reduction. Special nutritional supplements have been developed.

Claims (1)

함초추출물 10-15%, 망초추출물 25-50%, 산사자추출물1.5-5.0%,결명자추출물 2.0-5.0%,달맞이꽃어린잎추출물 1.5-5.0%,카스카라사그라다추출물 5-15%와 당귀추출물 5-15%,회첨추출물 5-15%,창출추출물 5-15%,두충추출물 5-15%,맥아추출물 5-15%,복령추출물 5-15%,황기추출물 5-15%,삼백초추출물 5-15%,진피추출물 5-15%,민들레추출물 1-5%,뽕나무추출물 1-5%로 구성된 비만억제 및 체지방 감소에 효과가 있는 기능성 영양보충용 식품 및 그 조성물.Seaweed Extract 10-15%, Forget-me-not Extract 25-50%, Lioness Extract 1.5-5.0%, Cactus Extract 2.0-5.0%, Evening Primrose Leaf Extract 1.5-5.0%, Cascara Sagrada Extract 5-15% and Angelica Extract 5 -15%, rot extract 5-15%, creation extract 5-15%, tofu extract 5-15%, malt extract 5-15%, Bokryeong extract 5-15%, Astragalus extract 5-15%, triticale extract 5- 15%, dermal extract 5-15%, dandelion extract 1-5%, mulberry extract 1-5% functional dietary supplement foods and compositions effective in inhibiting obesity and reducing body fat.
KR1020020038764A 2002-07-04 2002-07-04 Preparation and it's method of functional food for low body fat. KR20040003923A (en)

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KR20040013666A (en) * 2002-08-08 2004-02-14 이준호 A health food composite contained hamcho extract
KR20040052160A (en) * 2002-12-13 2004-06-19 이경수 Non fat
KR100716066B1 (en) * 2004-02-21 2007-05-08 변상요 Diet Food Comprising Eucommia-ulmoides Oliver Extract and Morus-alba Linne Extract
US20100247691A1 (en) * 2009-03-31 2010-09-30 Industry Foundation Of Chonnam National University Anti-angiogenic agents and anti-obesity substances applied with anti-angiogenesis from natural products
KR101454970B1 (en) * 2012-11-06 2014-10-28 대구한의대학교산학협력단 A aromatic oil composition and cometic composition comprising the essential oil fraction from Angelica gigas Nakai for the prevention or reduction of body fats or cellulite
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Publication number Priority date Publication date Assignee Title
KR20040013666A (en) * 2002-08-08 2004-02-14 이준호 A health food composite contained hamcho extract
KR20040052160A (en) * 2002-12-13 2004-06-19 이경수 Non fat
KR100716066B1 (en) * 2004-02-21 2007-05-08 변상요 Diet Food Comprising Eucommia-ulmoides Oliver Extract and Morus-alba Linne Extract
US20100247691A1 (en) * 2009-03-31 2010-09-30 Industry Foundation Of Chonnam National University Anti-angiogenic agents and anti-obesity substances applied with anti-angiogenesis from natural products
US8753694B2 (en) * 2009-03-31 2014-06-17 Industry Foundation Of Chonnam National University Anti-angiogenic agents and anti-obesity substances applied with anti-angiogenesis from natural products
US9649351B2 (en) 2009-03-31 2017-05-16 Industry Foundation Of Chonnam National University Anti-angiogenic agents and anti-obesity substances applied with anti-angiogenesis from natural products
KR101454970B1 (en) * 2012-11-06 2014-10-28 대구한의대학교산학협력단 A aromatic oil composition and cometic composition comprising the essential oil fraction from Angelica gigas Nakai for the prevention or reduction of body fats or cellulite
KR20200060040A (en) * 2018-11-22 2020-05-29 경희대학교 산학협력단 Composition for lipolysis comprising Taraxacum platycarpum
KR20200098201A (en) * 2019-02-12 2020-08-20 (주)보인바이오컨버젼스 Composition for topical lipolysis comprising herbal extracts
WO2020166773A1 (en) * 2019-02-12 2020-08-20 (주)보인바이오컨버젼스 Composition for dissolving local fat, comprising crude drug extract as active ingredient
CN113194973A (en) * 2019-02-12 2021-07-30 补人生物融合股份有限公司 Composition for decomposing local fat comprising crude drug extract as effective component

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