KR20030068583A - 순수한 온단세트론 하이드로클로라이드 이수화물의 개선된제조 방법 - Google Patents

순수한 온단세트론 하이드로클로라이드 이수화물의 개선된제조 방법 Download PDF

Info

Publication number
KR20030068583A
KR20030068583A KR10-2003-7009221A KR20037009221A KR20030068583A KR 20030068583 A KR20030068583 A KR 20030068583A KR 20037009221 A KR20037009221 A KR 20037009221A KR 20030068583 A KR20030068583 A KR 20030068583A
Authority
KR
South Korea
Prior art keywords
solution
methyl
ondansetron
carbazolone
precipitate
Prior art date
Application number
KR10-2003-7009221A
Other languages
English (en)
Korean (ko)
Inventor
하다스라미리도르
바카르엘리에제르
Original Assignee
테바 파마슈티컬 인더스트리즈 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 테바 파마슈티컬 인더스트리즈 리미티드 filed Critical 테바 파마슈티컬 인더스트리즈 리미티드
Publication of KR20030068583A publication Critical patent/KR20030068583A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR10-2003-7009221A 2001-01-11 2002-01-11 순수한 온단세트론 하이드로클로라이드 이수화물의 개선된제조 방법 KR20030068583A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26105201P 2001-01-11 2001-01-11
US60/261,052 2001-01-11
PCT/US2002/000853 WO2002055492A2 (en) 2001-01-11 2002-01-11 An improved process for preparing pure ondansetron hydrochloride dihydrate

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1020067020069A Division KR20060113792A (ko) 2001-01-11 2002-01-11 순수한 온단세트론 하이드로클로라이드 이수화물의 개선된제조 방법
KR1020077010146A Division KR20070054749A (ko) 2001-01-11 2002-01-11 순수한 온단세트론 하이드로클로라이드 이수화물의 개선된제조 방법

Publications (1)

Publication Number Publication Date
KR20030068583A true KR20030068583A (ko) 2003-08-21

Family

ID=22991757

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020077010146A KR20070054749A (ko) 2001-01-11 2002-01-11 순수한 온단세트론 하이드로클로라이드 이수화물의 개선된제조 방법
KR10-2003-7009221A KR20030068583A (ko) 2001-01-11 2002-01-11 순수한 온단세트론 하이드로클로라이드 이수화물의 개선된제조 방법
KR1020067020069A KR20060113792A (ko) 2001-01-11 2002-01-11 순수한 온단세트론 하이드로클로라이드 이수화물의 개선된제조 방법

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020077010146A KR20070054749A (ko) 2001-01-11 2002-01-11 순수한 온단세트론 하이드로클로라이드 이수화물의 개선된제조 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020067020069A KR20060113792A (ko) 2001-01-11 2002-01-11 순수한 온단세트론 하이드로클로라이드 이수화물의 개선된제조 방법

Country Status (21)

Country Link
EP (1) EP1355881A4 (zh)
JP (1) JP2004526692A (zh)
KR (3) KR20070054749A (zh)
CN (2) CN1496350A (zh)
AU (1) AU2002236753B2 (zh)
CA (1) CA2433720A1 (zh)
CZ (1) CZ20032090A3 (zh)
DE (1) DE02703115T1 (zh)
ES (1) ES2219201T1 (zh)
HR (1) HRP20030631A2 (zh)
HU (1) HUP0400767A2 (zh)
IL (1) IL156835A0 (zh)
IS (1) IS6869A (zh)
MX (1) MXPA03006215A (zh)
NO (1) NO20033147L (zh)
PL (1) PL368837A1 (zh)
SK (1) SK9892003A3 (zh)
TR (1) TR200401460T3 (zh)
WO (1) WO2002055492A2 (zh)
YU (1) YU56103A (zh)
ZA (1) ZA200305338B (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040104654A (ko) 2002-04-29 2004-12-10 비오갈 기오기스제르갸르 알티. 1,2,3,9-테트라히드로-9-메틸-3-[(2-메틸-1ｈ-이미다졸-1-일)메틸]-4ｈ-카르바졸-4-온의 제조 방법
HU225885B1 (en) * 2002-10-17 2007-11-28 Richter Gedeon Nyrt Process for producing ondansetron hydrochlorid dihydrate of high purity
FI6164U1 (fi) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronmuotoja
GB2398071B (en) * 2003-01-24 2006-06-07 Synthon Bv Process for making ondansetron and intermediate thereof
US7696356B2 (en) 2004-08-17 2010-04-13 Taro Pharmaceutical Industries Limited Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
WO2006046253A1 (en) * 2004-10-26 2006-05-04 Ipca Laboratories Limited A one-pot process for the preparation of antiemetic agent, 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl)-1h-imidazole-1-yl)methyl]-4h-carbazol-4-o

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
GB8630071D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
MXPA03003761A (es) * 2000-10-30 2003-07-28 Teva Pharma Formas de cristales y solvatos de clorhidrato de ondansetron y procesos para su preparacion.

Also Published As

Publication number Publication date
WO2002055492A3 (en) 2003-02-13
JP2004526692A (ja) 2004-09-02
CA2433720A1 (en) 2002-07-18
EP1355881A4 (en) 2004-03-31
NO20033147D0 (no) 2003-07-09
PL368837A1 (en) 2005-04-04
DE02703115T1 (de) 2004-10-21
SK9892003A3 (en) 2004-05-04
HRP20030631A2 (en) 2005-06-30
CZ20032090A3 (cs) 2004-08-18
YU56103A (sh) 2006-05-25
ES2219201T1 (es) 2004-12-01
CN101045704A (zh) 2007-10-03
KR20060113792A (ko) 2006-11-02
WO2002055492A2 (en) 2002-07-18
NO20033147L (no) 2003-09-02
HUP0400767A2 (hu) 2004-07-28
KR20070054749A (ko) 2007-05-29
MXPA03006215A (es) 2005-02-17
CN1496350A (zh) 2004-05-12
AU2002236753B2 (en) 2007-06-28
ZA200305338B (en) 2004-07-12
IL156835A0 (en) 2004-02-08
EP1355881A2 (en) 2003-10-29
IS6869A (is) 2003-07-08
TR200401460T3 (zh) 2004-08-23

Similar Documents

Publication Publication Date Title
CN1315809C (zh) 喹啉衍生物和其作为5－ht6配体的用途
EP1781627B1 (en) A method for preparing irbesartan and intermediates thereof
JPS6364428B2 (zh)
CA2942301A1 (en) Clomiphene synthesis using a single solvent
WO2006018955A1 (ja) イソインドール誘導体の製造方法
JP2008511684A (ja) アナストロゾール中間体についての精製方法
JP2005507900A (ja) シタロプラムの製造方法
KR20070091617A (ko) 무스카린 수용체 길항 작용약의 제조방법 및 이의 중간체
KR20030068583A (ko) 순수한 온단세트론 하이드로클로라이드 이수화물의 개선된제조 방법
JP2004500324A (ja) ピペラジン環含有化合物の新規の合成及び結晶化
TWI291956B (en) Improved process
AU2002236753A1 (en) An improved process for preparing pure ondansetron hydrochloride dihydrate
JP2002155075A (ja) １，２，３，９−テトラヒドロ−９−メチル−３−［（２−メチル−１ｈ−イミダゾール−１−イル）メチル］−４ｈ−カルバゾール−４−オンの製造方法
JP2002544184A (ja) （１ｒ，２ｓ，４ｒ）−（−）−２−［（２’−｛ｎ，ｎ−ジメチルアミノ｝−エトキシ）］−２−［フェニル］−１，７，７−トリ−［メチル］−ビシクロ［２．２．１］ヘプタン及びその薬学上許容される酸付加塩の製法
US20020115707A1 (en) Process for preparing pure ondansetron hydrochloride dihydrate
JP2004514675A (ja) 新規デスロラタジン塩、その合成方法および医薬組成物
KR930003611B1 (ko) 퀴놀론 카복실산 유도체의 제조방법
HUT56050A (en) Process for resolving 2-amino-4phenyl-butane
EP1828141A1 (en) A one-pot process for the preparation of antiemetic agent, 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl)-1h-imidazole-1-yl)methyl]-4h-carbazol-4-o
NZ586521A (en) Process for the preparation of 5-(2-ethyl-dihydro-1h-inden-2-yl)-1h-imidazole and salts thereof
US4528297A (en) Neuroleptic 3-azetidinylethyl-1-phenyl-2-imidazolidinones
KR100377578B1 (ko) 온단세트론 및 그의 염의 제조방법
WO2023100110A1 (en) Process for preparing brivaracetam
WO1991017973A1 (en) 5H-DIBENZO(a,d)CYCLOHEPTENES AS MUSCARINIC RECEPTOR ANTAGONISTS
EP3759081A1 (en) An improved process for the preparation of propiomazine maleate

Legal Events

Date Code Title Description
A201 Request for examination
AMND Amendment
E902 Notification of reason for refusal
A107 Divisional application of patent
AMND Amendment
E601 Decision to refuse application
AMND Amendment
J201 Request for trial against refusal decision
A107 Divisional application of patent
AMND Amendment
E902 Notification of reason for refusal
B701 Decision to grant
NORF Unpaid initial registration fee