KR20020003138A - Vegetable Protective Agent for the skin moistening it - Google Patents

Abstract

PURPOSE: A botanical skin protective agent with moisturizing activity is provided, thereby protecting and moisturizing the skin and further more, treating the dermatitis. CONSTITUTION: The botanical skin protective agent with moisturizing activity contains a medical herb extract selected from Japanese medlar leaf, Lycium chinense MILL. or Glycyrrizae Radix; a compound selected from ethylene glycol, 1,3-butanediol, glycerine and propylene glycol; a hydroperoxide lipid inhibitor of vitamin E acetate; a humectant selected from phyto-collagen or Na-hyaluronate; a stimulation-decreasing agent selected from allantoin or dipotassium glycyrrhizate; and phytoesterol which is similar to lipid component of skin.

Description

Vegetal Protective Agent for the skin moistening it}

The present invention relates to a plant skin moisturizing agent and a protective agent, and in particular to a skin moisturizing and protecting agent useful for the treatment of dry dermatitis, especially the inhibition and alleviation of peroxidated lipid peroxidation using a herbal medicine plant.

Conventionally, as a skin moisturizer, a skin irritant, and a nutritional supplying agent, a skin moisturizer using a vegetable herbal medicine, in particular, contains a mixed herbal medicine selectively selected from jade porridge, lily, peony, lotus root, shihwang, loquat leaf, licorice and wolfberry. Skin moisturizer crudes that have been added to cosmetics by adding glycerin or 1.3-butylene glycol to the extracted extract have been registered in Korea Patent No. 10-0193105, US Patent No. 5,955,083 (1999.09.21), Republic of Korea Patent 198,116 (February 26, 1999) and Japanese Unexamined Patent Publication No. 6-24954 (1994.02.01),

Skin moisturizers made from the above herbal herbal medicines have only skin moisturizing and irritation-reducing effects, and it is not clear whether there is a treatment, prevention or alleviating effect on malignant dermatitis such as atopic dermatitis caused by environmental pollution and instant food. In particular, the protection, treatment or preventive effect of peroxidized skin due to air or food contamination could not be expected at all.

In particular, atopic dermatitis caused by recent environmental pollution and ingestion of instant foods is a disease in which eczema appears on the skin due to an allergic reaction to food and inhalable substances. The characteristic symptoms are itchy, rough and dry skin. It will be repeated, worsening or improvement of symptoms, and to treat atopic dermatitis with the above symptoms by using olive oil, skin lubricant or urea cream, clean the surrounding environment, clean the body, Prohibition of excision of antigenic foods, mental stability, etc. There were mainly environmental and hygienic therapies, but there were no drug slurs. Moreover, lipid peroxidation of skin due to air pollution has not been prevented or treated.

The present invention can improve the limit of the effect of the skin moisturizer by the conventional herbal herbal medicines to relieve, treat or prevent skin dermatitis, such as atopic dermatitis, as well as skin moisturizing effect, alleviation of skin irritation, soothing and irritation of skin irritation The present invention provides a skin moisturizing agent and a skin protection agent that has an effect of inhibiting lipid peroxidation and giving flexibility to the skin. Particularly, the present invention is used alone as a skin protection and moisturizing cosmetic or added during the manufacture of an existing cosmetic. To provide a skin moisturizing agent and a protective agent that also obtained a skin protection effect such as moisturizing effect, dermatitis healing, prevention and alleviation as a cosmetic as described in detail as an example.

Skin moisturizing and protective agent by adding a material selected from ethylene glycol, 1,3-butanediol, glycerin, and propylene glycol to a material selected arbitrarily from among non-leafed or goji berry or licorice extract, vitamin E acetate, phytocollagen, phytocollagen or Na-Hyaluronate, any one selected from Allantoin or Dipotassium Glycyrrhizate, and phytosterol is added in an appropriate amount. .

It is known that non-leaflets, goji berry and licorice have skin soothing, skin irritation and nutritional and moisturizing effects on the skin. Ethylene glycol, 1,3-butanediol, glycerin and propylene glycol are hygroscopic, nonvolatile and antiseptic. It is an excellent cosmetic additive with excellent compatibility with each extract, Vitamin E acetate acts to inhibit the formation of lipid peroxide in addition to the action of the composition, phytocollagen and sodium hyaluronic acid as a powerful moisturizing agent, It acts to reinforce the weak moisturizing effect of goji berry and licorice, and allatomin or dipotassium glycyritin has excellent stimulating effect, which further reinforces the weak stimulating effect of the non-leaflets, goji berry and licorice and phytosterol It is similar to the skin lipid component and gives elasticity to the skin It will have to.

In the above, the compounding amount of each component is not limited, and at any ratio, the respective properties are exerted to provide moisturizing and dermatitis healing effects.

The vegetable skin moisturizer and skin protectant of the present invention having the above-mentioned effect is a sofa test, an intradermal reaction test, a blood IgE test, a blood IgG4 test, or an induction test of actual dermatitis patients at an oriental medicine clinic operated by the inventor and the applicant. After diagnosing it, confirming that it is a dermatitis or dry skin such as atopic dermatitis, and then applying the present invention skin moisturizer and protective agent to the affected area, and after a certain period of time, a trans-epidermal water loss (Servo MED Evaporimeter). Eepidermal Water Loss (hereinafter referred to as TEWL) was measured to confirm the skin moisturizing effect.

That is, after applying the moisturizing agent and the protective agent of the present invention to the affected part of the skin uniformly, read the value with a moisture evaporation meter and set the initial value, and then apply the same method for 4 to 5 days and continue to apply the TEWL value with the moisture evaporation meter on the last day. Read the skin moisturizing effect was confirmed.

The results were as shown in Table 1 below.

Table 1 Clinical Trial Results

collection TEWL (g / h; gm) TEWL volume difference Initial (T1) 5 days later (T2) T1-T2 One 23.5 9.8 13.7 2 24.9 10.2 14.7 3 22.4 8.9 13.5 4 23.7 11.4 12.3 5 24.1 10.8 13.3 6 22.7 9.7 13.0. 7 23.8 8.9 14.9 8 22.5 11.0 11.5

As can be seen from the above results of the moisturizing effect test, the skin moisturizer and protective agent of the present invention was found to be remarkably different from the initial application to the affected area and subsequent application for 5 days.

In addition, as a result of inquiring the healing effect directly from the patients in the clinical trial, 20 out of 30 had excellent moisturizing and dermatitis treatment effect, 6 had better than existing moisturizing cosmetics, and only 4 had similar results. The moisturizer and protective agent of the present invention were confirmed to be excellent in treating and preventing dermatitis.

In order to grasp the performance of the skin moisturizing agent and protective agent of the present invention, the result of testing the skin moisturizing effect with the present invention in Yonsei University Youngdong Severance dermatology classroom was as follows.

Plant skin moisturizer efficacy test

Determination of Conjunctival Moisture Loss Through Nude Mice (TEWL)

The test results showed that the use of herbal vegetable skin moisturizers showed a faster recovery of transdermal moisture loss than unused skin.

Claims (1)

A skin moisturizing and protecting agent obtained by adding a material selected from ethylene glycol, 1,3-butanediol, glycerin, and propylene glycol to a material selected from non-leafed or goji berry or licorice extract, wherein the mixture contains vitamin E acetate and phytocollagen. Vegetable skin moisturizer characterized in that one of Na-Hyaluronate, any one selected from Allantoin or Dipotassium Glycyrrhizate, and phytosterol are added in an appropriate amount Cum protection agent.