CN111803431A - Antibacterial and anti-inflammatory lipstick and preparation method thereof - Google Patents
Antibacterial and anti-inflammatory lipstick and preparation method thereof Download PDFInfo
- Publication number
- CN111803431A CN111803431A CN202010842656.3A CN202010842656A CN111803431A CN 111803431 A CN111803431 A CN 111803431A CN 202010842656 A CN202010842656 A CN 202010842656A CN 111803431 A CN111803431 A CN 111803431A
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- lipstick
- bacteriostatic
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- inflammatory
- antibacterial
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Abstract
The invention provides antibacterial and anti-inflammatory lipstick and a preparation method thereof, and belongs to the technical field of lipstick preparation. The lipstick of the invention is mainly prepared by mixing the following raw materials in parts by weight: 2-4 parts of pitaya peel pigment powder, 8-12 parts of beeswax, 30-50 parts of olive oil, 0.1-0.3 part of jasmine essential oil, 2-3 parts of vitamin E and 0.004-0.007 part of plant antibacterial component. The invention takes the pitaya peel extract as the pigment, takes the extracts of the three traditional Chinese medicines of rush, hawthorn and loquat leaf as the antibacterial components, and adjusts the proportion of the three antibacterial components to ensure that the antibacterial activity of the three components is synergistic, thereby obtaining the lipstick which is safe and reliable and has better antibacterial and anti-inflammatory effects.
Description
[ technical field ] A method for producing a semiconductor device
The invention relates to the technical field of cosmetic preparation, in particular to antibacterial and anti-inflammatory lipstick and a preparation method thereof.
[ background of the invention ]
With the development of the beauty industry and the pursuit of people on beauty, the types of lipstick products on the market are more and more, but the quality of some lipstick products cannot be guaranteed, and the content of lead, mercury and other heavy metals in some lipstick products circulating on the market exceeds the standard, so that the lipstick products can generate adverse effects on human bodies and cannot be used for a long time. A large number of researches show that heavy metal elements such as lead and mercury can cause poisoning and even organ failure to endanger life if accumulated in a human body for a long time, and the harm of lipstick on the human body can be reduced to a great extent if natural pigment is used for replacing heavy metal to be applied to lipstick to achieve the purpose of brightening the skin color. In addition, the long-term application of lipstick containing heavy metal can cause allergy, cheilitis, lip and skin ulceration and other diseases, which are more unfavorable for oral ulcer patients. If the traditional Chinese medicine components with the antibacterial and anti-inflammatory effects are added into the lipstick, lip inflammation can be inhibited, meanwhile, the traditional Chinese medicine components are absorbed by lips and oral mucosa, oral ulcer can also be relieved, and good news is brought to beauty lovers suffering from the oral ulcer.
Lipstick containing traditional Chinese medicine components is hardly seen in the market of the lipstick abroad, and although some lipstick containing traditional Chinese medicine components appears in the market at home, the traditional Chinese medicine lipstick products aiming at diminishing inflammation are few, and related literature records and technical support are few. At present, the research on the traditional Chinese medicine lipstick with bacteriostasis and anti-inflammation mainly comprises the following steps: the studied extraction method of Zijin antiviral traditional Chinese medicine lipstick is researched, and the studied antiviral Zijin lipstick is mainly prepared from honeysuckle, radix puerariae, dandelion, liquorice, lithospermum and menthol which have the functions of clearing heat, cooling blood and resisting viruses, has the curative effect of preventing and assisting in treating herpes labialis, and can play the dual roles of preventing diseases and beautifying. Zhangrongxi, Tangnaihong, etc. have been studied to develop the traditional Chinese medicine radix arnebiae lipstick, which contains five traditional Chinese medicines of radix arnebiae, phellodendron, gallnut, indigo naturalis and borneol, and has the functions of clearing away heat and toxic material, diminishing inflammation and relieving pain through reasonable compatibility, and can treat lip and skin ulcer diseases. The inventor who has not disclosed researches an edible lipstick with good antibacterial property and a preparation method thereof, and the researched lipstick is prepared from aloe oil, lithospermum, phellodendron, gallnut, indigo naturalis, borneol and the like, has excellent antibacterial and health-care effects, can play the roles of beautifying and moistening lips of the lipstick, and can also play the role of treating lip ulcer diseases. Liu Ri Sheng researches a medicinal lipstick, which is prepared from aloe oil, purslane, honeysuckle, coptis, scutellaria, dandelion, hawthorn and the like, has good antibacterial and anti-inflammatory effects, prevents the dry lip and the peeling of the epidermis, and can effectively treat cheilitis and the like.
At present, no relevant report exists on lipstick which is prepared by taking an extract of pitaya peel as a pigment and taking extracts of three traditional Chinese medicines, namely rush, hawthorn and loquat leaf as antibacterial components.
[ summary of the invention ]
The invention aims to: aiming at the existing problems, the antibacterial and anti-inflammatory lipstick and the preparation method thereof are provided, the pitaya peel extract is used as a pigment, the extracts of the three traditional Chinese medicines of rush, hawthorn and loquat leaf are used as antibacterial components, and the antibacterial activity is synergistically enhanced by adjusting the proportion of the three antibacterial components, so that the safe and reliable lipstick with good antibacterial and anti-inflammatory effects is obtained.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the antibacterial and anti-inflammatory lipstick contains plant antibacterial components, wherein the plant antibacterial components are liquid medicine obtained by mixing rush alcohol extract, hawthorn alcohol extract and loquat leaf alcohol extract according to the weight ratio of 5-7: 1: 6-7. More preferably, the plant bacteriostatic component is a liquid medicine obtained by mixing rush alcohol extract, hawthorn alcohol extract and loquat leaf alcohol extract according to a weight ratio of 6:1: 7.
In the present invention, preferably, the rush alcohol extract, the hawthorn alcohol extract and the loquat leaf alcohol extract are obtained by performing ultrasonic-assisted extraction with ethanol, respectively.
In the invention, preferably, ethanol with volume fraction of 60-70% is adopted in the ultrasonic-assisted extraction, the extraction is carried out under the conditions that the material-liquid ratio is 1g: 10-20 mL and the temperature is 20-40 ℃, the ultrasonic-assisted extraction is carried out to obtain an initial extract, and the initial extract is concentrated to obtain an alcohol extract with final concentration of 1 g/mL.
In the invention, preferably, the pigment adopted by the lipstick is pitaya peel pigment powder.
In the invention, preferably, the lipstick is mainly prepared by mixing the following raw materials: beeswax, olive oil, jasmine essential oil, vitamin E, pitaya peel pigment powder and plant bacteriostatic components.
In the invention, preferably, the lipstick is mainly prepared by mixing the following raw materials in parts by weight: 2-4 parts of pitaya peel pigment powder, 8-12 parts of beeswax, 30-50 parts of olive oil, 0.1-0.3 part of jasmine essential oil, 2-3 parts of vitamin E and 0.004-0.007 part of plant antibacterial component.
In the invention, preferably, the lipstick is mainly prepared by mixing the following raw materials in parts by weight: 3 parts of pitaya peel pigment powder, 10 parts of beeswax, 40 parts of olive oil, 0.25 part of jasmine essential oil, 2.5 parts of vitamin E and 0.005 part of plant antibacterial component.
The invention also provides a preparation method of the antibacterial and anti-inflammatory lipstick, which comprises the following steps:
(1) heating and stirring beeswax and olive oil in a container until the beeswax and the olive oil are melted;
(2) after melting, cooling to 55-65 ℃, adding the pitaya peel pigment, the plant bacteriostatic component, the jasmine essential oil and the vitamin E, and then fully stirring by using a grinding device until no granular sensation exists, thus obtaining a lipstick stock solution;
(3) after fully stirring, quickly pouring the lipstick stock solution into a lipstick tube to prevent the beeswax from solidifying; pouring the liquid level to the convex lipstick tube to prevent the middle from being too large after cooling;
(4) after the lipstick stock solution is completely solidified, refrigerating the lipstick stock solution to help the lipstick stock solution to be solidified and prevent the lipstick stock solution from adhering to the wall of the tube; and finally, cleaning the outer wall of the lipstick tube, thus finishing the preparation.
The following describes the components of the invention:
the beeswax has the effect of solidifying the shape, can increase the touch feeling and the use feeling of lipstick, and nourish the skin.
The olive oil has the function of moistening lips, and can keep the wax soft enough so as to be easily smeared and prevent radiation.
The jasmine essential oil plays roles of nourishing skin, lightening lip wrinkles and increasing aroma in the invention.
The vitamin E plays roles of moistening the skin, keeping moisture and resisting oxidation in the invention.
The pitaya peel pigment powder is used as a lipstick pigment, the pitaya peel is a byproduct of industrial processing of the pitaya, contains a large amount of red pigment, is bright in color and good in tinting strength, and is an excellent resource of natural red pigment. The method for extracting the red pigment from the pitaya peel can fully utilize the processing byproducts of the pitaya, reduce the pollution to the environment and simultaneously can drive the development of the local pitaya industry, thereby driving the local economic development and improving the income level of people. The pitaya peel pigment powder has the functions of increasing color, diminishing inflammation and calming in the product.
The innovation of the invention is more shown in that the extracts of three Chinese medicinal materials of rush, hawthorn and loquat leaf are used as plant bacteriostatic components. The following are descriptions of their respective features:
the rush is dried stem and marrow of Juncus effusus L (Juncus effusus L) belonging to family Juncaceae, and is named as Juncus effusus, Juncus effusus and Juncus effusus. Rush is slightly cold, sweet and bland in nature and taste; it enters heart, lung and small intestine meridians and has the functions of clearing away heart-fire, promoting urination and reducing pathogenic fire. The rush contains phenanthrene, dihydrophenols, dehydrojunceylol, etc. and has antibacterial biological activity.
The hawthorn is dry mature fruit of Crataegus pinnatifida or Crataegus pinnatifida of Rosaceae, has the effects of promoting digestion, invigorating stomach, promoting qi circulation, removing blood stasis, eliminating turbidity, reducing blood fat and the like, is rich in flavonoid, polyphenol and other components, also has the functions of resisting inflammation and inhibiting bacteria, has obvious antibacterial action on common pathogenic bacteria such as staphylococcus aureus, escherichia coli, bacillus subtilis, proteus and the like, and particularly has strong antibacterial action on the bacillus subtilis and the escherichia coli.
The folium Eriobotryae is leaf of Eriobotrya japonica (Eriobotrya japonica) of Rosaceae, and has bitter, slightly pungent and cold properties, and has effects of relieving cough, clearing lung-heat and regulating stomach. The loquat leaves contain a plurality of antioxidant compounds including polyphenols, saponins and the like, and are proved to have good bacteriostatic action on escherichia coli and staphylococcus aureus.
Although the alcohol extracts of the rush, the hawthorn and the loquat leaf have certain antibacterial and bacteriostatic effects, the antibacterial and bacteriostatic effects of the three traditional Chinese medicines are still limited when the alcohol extracts are used independently, experiments show that when the ratio of the rush, the hawthorn and the loquat leaf liquid medicine is 5-7: 1: 6-7, particularly 6:1:7, the antibacterial and bacteriostatic effects on escherichia coli and staphylococcus aureus are the best, the synergistic effect is achieved, and the alcohol extracts have the effects of inhibiting bacteria, resisting inflammation, promoting skin elastin generation and wound healing when being applied to lipstick.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
1. the lipstick is prepared by mixing pitaya peel pigment powder, beeswax, olive oil, jasmine essential oil, vitamin E and plant bacteriostatic components through a certain process, and has good effects of moisturizing, lip moistening, nourishing and diminishing inflammation. Wherein, the olive oil can moisten skin, remove wrinkles, be fresh and not greasy, has fine essential oil molecules, has permeability which is more beneficial to the absorption of skin, and contains abundant squalane and oleic acid. The beeswax has good nourishing effect on skin, has no toxic or side effect, and can make lipstick have good moistening and skin caring effects. The jasmine essential oil has the effects of moistening and nourishing skin, lightening lip wrinkles and enhancing aroma. Vitamin E has effects of resisting oxidation and nourishing skin. The pitaya peel pigment has beautiful color; the antibacterial components of the combination of rush, hawthorn and loquat leaf are synergistic, and the composition has the outstanding effects of inhibiting bacteria, diminishing inflammation and promoting ulcer healing. Therefore, the lipstick with the effects of moisturizing, lip moistening, nourishing and diminishing inflammation is obtained by matching the raw materials.
2. The lipstick disclosed by the invention is not added with chemical pigments and preservatives, uses pure natural plant pigments and plant bacteriostatic components, integrates the traditional lipstick and bacteriostatic anti-inflammatory products, is safe and reliable in formula, convenient to use and remarkable in effect, has a more obvious effect on oral ulcer caused by frequent staying up all night, does not have any side effect, and is more popular with people.
3. The preparation process of the antibacterial anti-inflammatory lipstick is simple, feasible, safe and reliable.
[ description of the drawings ]
FIG. 1 shows rush: hawthorn fruit: the bacteriostatic effect graph of the loquat leaf alcohol extract on escherichia coli is shown when the weight ratio of the loquat leaf alcohol extract is 5:1:7 and 6:1: 7;
FIG. 2 shows rush: hawthorn fruit: the bacteriostatic effect graph on staphylococcus aureus when the weight ratio of the loquat leaf alcohol extract is 5:1:7 and 6:1: 7;
wherein, P4Is a 5:1:7 medicinal paper sheet, P5Is a 6:1:7 medicine paper sheet, L is a positive control streptomycin paper sheet, and Q is a positive control penicillin paper sheet.
[ detailed description ] embodiments
The invention aims to develop a lipstick which is safe to use, antibacterial and anti-inflammatory. In the development process, pitaya pigment is selected as the phytochrome of the lipstick, 3 Chinese herbal medicines are selected as the phytobacteriostatic components, and the 3 Chinese herbal medicines are found to have the antibacterial effect of synergistic interaction within a certain proportion range, so that an unexpected technical effect is obtained. In order that the invention may be more clearly expressed, the invention will now be further described by way of specific examples.
An antibacterial and anti-inflammatory lipstick contains plant antibacterial components, wherein the plant antibacterial components are liquid medicine obtained by mixing rush alcohol extract, hawthorn alcohol extract and loquat leaf alcohol extract according to a weight ratio of 5-7: 1: 6-7. The plant bacteriostatic component is prepared by matching extracts of 3 Chinese herbal medicines in a certain weight ratio range, has a synergistic effect, and the synergistic effect is independent of other components in the lipstick, namely, even if the other components in the lipstick such as pigment, grease and spice are changed, the bacteriostatic effect still exists.
In some preferred embodiments of the present invention, the rush alcohol extract, the hawthorn alcohol extract and the loquat leaf alcohol extract are obtained by performing ultrasonic-assisted extraction with ethanol respectively. By means of alcohol extraction, bacteriostatic active ingredients can be obtained from the alcohol extract.
In some preferred embodiments of the invention, ethanol with a volume fraction of 60% -70% is adopted for ultrasonic-assisted extraction, the extraction is carried out under the conditions that the material-liquid ratio is 1g: 10-20 mL and the temperature is 20-40 ℃, an initial extraction solution is obtained through ultrasonic-assisted extraction, and the initial extraction solution is concentrated to obtain an alcohol extraction solution with a final concentration of 1 g/mL. Ultrasonic extraction can accelerate the extraction process.
In some preferred embodiments of the present invention, the pigment used in the lipstick is pitaya peel pigment powder.
In some preferred embodiments of the present invention, the lipstick is mainly prepared by mixing the following raw materials: beeswax, olive oil, jasmine essential oil, vitamin E, pitaya peel pigment powder and plant bacteriostatic components. The complete formulation is a recommended formulation and those skilled in the art can make equivalent substitutions or optimizations with reference to the formulation using routine skill in the art.
In some preferred embodiments of the invention, the lipstick is mainly prepared by mixing the following raw materials in parts by weight: 2-4 parts of pitaya peel pigment powder, 8-12 parts of beeswax, 30-50 parts of olive oil, 0.1-0.3 part of jasmine essential oil, 2-3 parts of vitamin E and 0.004-0.007 part of plant antibacterial component.
In some preferred embodiments of the invention, the lipstick is mainly prepared by mixing the following raw materials in parts by weight: 3 parts of pitaya peel pigment powder, 10 parts of beeswax, 40 parts of olive oil, 0.25 part of jasmine essential oil, 2.5 parts of vitamin E and 0.005 part of plant antibacterial component.
In some preferred embodiments of the present invention, the preparation method of the bacteriostatic anti-inflammatory lipstick comprises the following steps:
(1) heating and stirring beeswax and olive oil in a container until the beeswax and the olive oil are melted;
(2) after melting, cooling to 55-65 ℃, adding the pitaya peel pigment, the plant bacteriostatic component, the jasmine essential oil and the vitamin E, and then fully stirring by using a grinding device until no granular sensation exists, thus obtaining a lipstick stock solution;
(3) after fully stirring, quickly pouring the lipstick stock solution into a lipstick tube to prevent the beeswax from solidifying; the liquid level is poured to be protruded, so that the middle depression is not too large after cooling;
(4) after the lipstick stock solution is completely solidified, refrigerating the lipstick stock solution to help the lipstick stock solution to be solidified and prevent the lipstick stock solution from adhering to the wall of the tube; and finally, cleaning the outer wall of the lipstick tube, thus finishing the preparation.
The following is illustrated by specific examples:
in the following examples, the pitaya peel pigment is prepared by the following method: cleaning the pitaya peel, removing green stems and leaves on the peel, drying in an oven at 50 ℃ for 5 hours until dry, crushing, and sieving with a 100-mesh sieve to obtain coarse pitaya peel powder. Weighing 5g of prepared crude pitaya peel powder into a conical flask, adding absolute ethyl alcohol according to the solid-to-liquid ratio of 1:20ml, carrying out ultrasonic treatment (the power is 100W, the frequency is 40kHz, the temperature is 40 ℃) for extraction for 30min, taking supernate, repeatedly extracting filter residues once, combining the two supernatants, and evaporating at low temperature in an evaporating dish to dryness to obtain the pitaya peel pigment powder.
Example 1
1. Preparing plant bacteriostatic components:
preparation of rush alcohol extract: taking dry rush, crushing, sieving by a 40-mesh sieve, taking 5g rush powder, adding 50mL of 60% ethanol, carrying out ultrasonic extraction for 30min, wherein the ultrasonic frequency is 40kHz, the ultrasonic power is 400W, the extraction temperature is 40 ℃, filtering the extracting solution by using filter paper to obtain a primary extracting solution, concentrating the primary extracting solution to obtain an alcohol extracting solution with the final concentration of 1g/mL, sterilizing the alcohol extracting solution at 121 ℃ for 15min, and storing the alcohol extracting solution in a refrigerator (4 ℃) for later use.
Preparing the hawthorn alcohol extract: taking dried hawthorn fruits, crushing, sieving by a 40-mesh sieve, respectively taking 5g of hawthorn powder, placing the hawthorn powder into two conical flasks, adding 50mL of 60% ethanol, carrying out ultrasonic extraction for 30min, wherein the ultrasonic frequency is 40kHz, the ultrasonic power is 400W, the extraction temperature is 40 ℃, filtering the extracting solution by using filter paper to obtain a primary extracting solution, concentrating the primary extracting solution to obtain an alcohol extracting solution with the final concentration of 1g/mL, sterilizing the alcohol extracting solution at 121 ℃ for 15min, and storing the alcohol extracting solution in a refrigerator (4 ℃) for later use.
Preparing loquat leaf alcohol extract: taking dried loquat leaves, crushing, sieving by a 40-mesh sieve, respectively weighing 5g of loquat leaf powder, placing the loquat leaf powder into two conical flasks, respectively adding 50mL of 60% ethanol for ultrasonic extraction for 30min, wherein the ultrasonic frequency is 40kHz, the ultrasonic power is 400W, the extraction temperature is 40 ℃, filtering the extracting solution by using filter paper to obtain a primary extracting solution, concentrating the primary extracting solution to obtain an alcohol extracting solution with the final concentration of 1g/mL, sterilizing the alcohol extracting solution at 121 ℃ for 15min, and placing the alcohol extracting solution in a refrigerator (4 ℃) for storage for later use.
2. Preparing the lipstick:
(1) the following raw materials were prepared: 2kg of pitaya peel pigment powder, 8kg of beeswax, 30kg of olive oil, 0.1kg of jasmine essential oil, 2kg of vitamin E and 0.004kg of plant bacteriostatic components. The plant bacteriostatic component is a liquid medicine obtained by mixing rush ethanol extract, hawthorn ethanol extract and loquat leaf ethanol extract according to the weight ratio of 5:1: 7.
(2) Heating and stirring beeswax and olive oil in a container until the beeswax and the olive oil are melted;
(3) after melting, cooling to 55 ℃, adding pitaya peel pigment, plant bacteriostatic components, jasmine essential oil and vitamin E, and then fully stirring by using a grinding device until no granular sensation exists to obtain a lipstick stock solution;
(4) after fully stirring, quickly pouring the lipstick stock solution into a lipstick tube to prevent the beeswax from solidifying; the liquid level is poured to be protruded, so that the middle depression is not too large after cooling;
(5) after the lipstick stock solution is completely solidified, refrigerating the lipstick stock solution to help the lipstick stock solution to be solidified and prevent the lipstick stock solution from adhering to the wall of the tube; and finally, cleaning the outer wall of the lipstick tube, thus finishing the preparation.
Example 2
1. Preparing plant bacteriostatic components:
preparation of rush alcohol extract: taking dry rush, crushing, sieving by a 40-mesh sieve, taking 5g rush powder, adding 75mL of 65% ethanol, carrying out ultrasonic extraction for 30min, wherein the ultrasonic frequency is 40kHz, the ultrasonic power is 400W, the extraction temperature is 40 ℃, filtering the extracting solution by using filter paper to obtain a primary extracting solution, concentrating the primary extracting solution to obtain an alcohol extracting solution with the final concentration of 1g/mL, sterilizing the alcohol extracting solution at 121 ℃ for 15min, and storing the alcohol extracting solution in a refrigerator (4 ℃) for later use.
The preparation method of the hawthorn alcohol extract and the loquat leaf alcohol extract is the same as that of the rush alcohol extract.
2. Preparing the lipstick:
(1) the following raw materials were prepared: 3kg of pitaya peel pigment powder, 10kg of beeswax, 40kg of olive oil, 0.25kg of jasmine essential oil, 2.5kg of vitamin E and 0.005kg of plant bacteriostatic components. The plant bacteriostatic component is a liquid medicine obtained by mixing rush alcohol extract, hawthorn alcohol extract and loquat leaf alcohol extract according to the weight ratio of 6:1: 7.
(2) Heating and stirring beeswax and olive oil in a container until the beeswax and the olive oil are melted;
(3) after melting, cooling to 60 ℃, adding pitaya peel pigment, plant bacteriostatic components, jasmine essential oil and vitamin E, and then fully stirring by using a grinding device until no granular sensation exists to obtain a lipstick stock solution;
(4) after fully stirring, quickly pouring the lipstick stock solution into a lipstick tube to prevent the beeswax from solidifying; the liquid level is poured to be protruded, so that the middle depression is not too large after cooling;
(5) after the lipstick stock solution is completely solidified, refrigerating the lipstick stock solution to help the lipstick stock solution to be solidified and prevent the lipstick stock solution from adhering to the wall of the tube; and finally, cleaning the outer wall of the lipstick tube, thus finishing the preparation.
Example 3
1. Preparing plant bacteriostatic components:
preparation of rush alcohol extract: taking dry rush, crushing, sieving by a 40-mesh sieve, taking 5g rush powder, adding 100mL 70% ethanol, carrying out ultrasonic extraction for 30min, wherein the ultrasonic frequency is 40kHz, the ultrasonic power is 400W, the extraction temperature is 40 ℃, filtering the extracting solution by using filter paper to obtain a primary extracting solution, concentrating the primary extracting solution to obtain an alcohol extracting solution with the final concentration of 1g/mL, sterilizing the alcohol extracting solution at 121 ℃ for 15min, and storing the alcohol extracting solution in a refrigerator (4 ℃) for later use.
The preparation method of the hawthorn alcohol extract and the loquat leaf alcohol extract is the same as that of the rush alcohol extract.
2. Preparing the lipstick:
(1) the following raw materials were prepared: 4kg of pitaya peel pigment powder, 12kg of beeswax, 50kg of olive oil, 0.3kg of jasmine essential oil, 3kg of vitamin E and 0.007kg of plant antibacterial components. The plant bacteriostatic component is a liquid medicine obtained by mixing rush alcohol extract, hawthorn alcohol extract and loquat leaf alcohol extract according to the weight ratio of 6:1: 6.
(2) Heating and stirring beeswax and olive oil in a container until the beeswax and the olive oil are melted;
(3) after melting, cooling to 65 ℃, adding pitaya peel pigment, plant bacteriostatic components, jasmine essential oil and vitamin E, and then fully stirring by using a grinding device until no granular sensation exists to obtain a lipstick stock solution;
(4) after fully stirring, quickly pouring the lipstick stock solution into a lipstick tube to prevent the beeswax from solidifying; the liquid level is poured to be protruded, so that the middle depression is not too large after cooling;
(5) after the lipstick stock solution is completely solidified, refrigerating the lipstick stock solution to help the lipstick stock solution to be solidified and prevent the lipstick stock solution from adhering to the wall of the tube; and finally, cleaning the outer wall of the lipstick tube, thus finishing the preparation.
The lipsticks prepared in examples 1-3 above were sticks in appearance, smooth in surface, free of air holes and no foreign substances visible to the naked eye. The color is rose red and the color is proper. The lipstick has no oil and fat peculiar smell, no traditional Chinese medicine smell and light jasmine flower faint scent.
Second, contrast bacteriostasis test
1. The bacteriostatic test method comprises the following steps:
(1) preparation of plate Medium
Per 100mL of distilled water according to the formula: sodium chloride: peptone: these reagents were added at a ratio of 0.3:0.5:1:2 agar. Mixing distilled water, beef extract, sodium chloride and peptone in a beaker, heating, adding agar while stirring after the beef extract, sodium chloride and peptone are fully dissolved, stirring until the agar is fully dissolved, putting into a conical flask, adding a cotton plug, wrapping the bottle mouth with kraft paper, and sterilizing for 20min at 121 ℃ by using a high-pressure steam sterilizer. After sterilization, placing the sterilized culture medium on a clean bench, cooling to 50-60 ℃, pouring the culture medium into plates (15 mL of each plate is poured) while the culture medium is hot, and standing the plates on the clean bench until the culture medium is cooled and solidified for later use.
(2) Activation and culture of strains
And (3) coating 100 mu L of the preserved test strain (escherichia coli and staphylococcus aureus) suspension onto the prepared solid culture medium, uniformly coating, and culturing in a constant-temperature incubator at 37 ℃ for 24h to fully recover the physiological properties of the strain.
(3) Preparation of test Strain suspension
And (3) putting the inoculating loop on an alcohol lamp, burning, sterilizing, then picking 2 loops of activated test strains into sterile water, uniformly dispersing, uniformly distributing into two sterile test tubes, and plugging the two tubes of bacteria liquid with tampons respectively and sealing for later use. And (3) determining the number of bacteria by adopting a plate culture counting method, and then diluting according to the required bacterial liquid concentration.
(4) Method for bacteriostasis experiment
Taking 0.1g/mL rush, hawthorn and loquat leaf alcohol extract as an experimental group solution, taking 0.5mg/mL penicillin solution and 0.5mg/mL streptomycin solution as a reference solution, respectively taking 5mL of the experimental group solution and the reference solution, respectively soaking sterilized filter paper sheets in a sample solution and the reference for 1h, respectively taking 100 mu L of suspension of escherichia coli and staphylococcus aureus (the concentration of the bacterial liquid is 10)6-107cfu/mL) was dropped in different media and spread evenly. Clamping the soaked filter paper with sterile forceps, sticking the paper to the coated culture medium after the solvent is volatilized, slightly pressing the paper to make the paper completely contact with agar, standing for 20min, culturing overnight at 37 ℃ in an incubator, and measuring and recording the diameter of the inhibition zone on day 2.
2. Results of bacteriostatic test
The antibacterial effect of the mixture of rush, hawthorn and loquat leaves in different proportions on the tested strains is tested by using the single rush alcohol extract, the single hawthorn alcohol extract and the single loquat leaf alcohol extract, and the test results are shown in the following tables 1 and 2:
TABLE 1 bacteriostatic effect on E.coli
TABLE 2 bacteriostatic effect on Staphylococcus aureus
As can be seen from experimental groups 1 to 10 in table 1, the antibacterial effect on escherichia coli is more obvious as the proportion of the loquat leaf extract is increased, but the rush: hawthorn fruit: when the weight ratio of the loquat leaves is 1:1:3, 1:1:4 and 1:1:5, the antibacterial effect on escherichia coli is not obviously different (P is greater than 0.05), but when the ratio is 1:1:5 to 1:1:6, the diameter of an antibacterial ring is obviously increased and suddenly increased, the diameter difference of the antibacterial ring between the groups 1:1:6 and 1:1:7 is obvious (P is less than 0.05) and the ratio is 1:1:3, 1:1:4 and 1:1:5, the antibacterial effect is better when the ratio is 1:1:7, and then the trend of gradual change is shown. As can be seen from the experimental groups 11-18 in Table 1, with the addition of the rush alcohol extract, the phenomenon that the diameter of the inhibition zone is suddenly increased is also shown in the ratio of 4:1:7 to 5:1:7, the ratio is best in the ratios of 6:1:7 and 7:1:7, and then the inhibition effect is in a trend of gentle change with the increase of the rush alcohol extract, which shows that the three Chinese herbal medicines have a synergistic effect on the inhibition effect of escherichia coli in a certain weight ratio.
As can be seen from the experimental groups 1-10 of Table 2, when rush: hawthorn fruit: when the loquat leaves are 1:1:3, 1:1:4, 1:1:5 and 1:1:6, the antibacterial effect on staphylococcus aureus is not obviously different (P >0.05) although the dosage of the loquat leaf extract is increased. When rush is used: hawthorn fruit: when the ratio of the loquat leaves is 1:1:7, the diameter of the inhibition zone is increased suddenly, and the diameter difference of the inhibition zone between the 1:1:7 group and the groups of 1:1:3, 1:1:4, 1:1:5 and 1:1:6 is obvious (P is less than 0.05). As can be seen from the experimental groups 11-18 of Table 2, rush: hawthorn fruit: the loquat leaves have obvious inhibition effect on escherichia coli and staphylococcus aureus when the ratio of the loquat leaves is 2:1:7, 3:1:7, 4:1:7, 5:1:7, 6:1:7, 7:1:7 and 8:1:7, the antibacterial effect is gradually enhanced along with the increase of the using amount of rush, the antibacterial effect is best when the using amount of the rush is increased to 6:1:7, and then the antibacterial effect is in a stable trend along with the increase of the using amount of the rush.
Therefore, the invention comprehensively takes the liquid medicine obtained by mixing the rush alcohol extract, the hawthorn alcohol extract and the loquat leaf alcohol extract according to the weight ratio of 5-7: 1: 6-7 as the plant bacteriostatic component, and has better bacteriostatic effect on escherichia coli and staphylococcus aureus.
Anti-inflammatory test for mice
1. Mouse injury skin test
Collecting 40 Kunming white mice (KM), removing back hair, and randomly dividing into 4 groups (sterile wound group A)1Group), vehicle control group (A)2Group, vaseline) and lipstick product group (A)3Group, administration of lipstick), positive control group (A)4Group, triamcinolone acetonide econazole cream). The dorsal lacerated dermis of each group of mice is in a shape of a 2cm long 'well', and is given as A2、A3、A4The skin surface of the mice of the group was painted with goldStaphylococcus aureus liquid and Escherichia coli liquid (liquid concentration 10)6-107cfu/mL)20 μ L, applying vaseline, lipstick and triamcinolone acetonide econazole cream on the back of each group of mice respectively, with the dose of 0.2g each mouse, administering 2 times per day, feeding in single cage, continuously for 8 days, and observing the healing condition of the back wound of the mice 4d and 8d after administration[24]. The wound healing degree is judged according to the standard, and the healing degree is divided into 4 conditions of deterioration, no change, improvement and recovery. The deterioration is characterized in that a wound area has a large amount of pus and exudates, the wound is enlarged, festered, and has less granulation tissues and larger tissue tension; the wound surface has pus or exudate without change, local swelling, no enlargement of the wound, new granulation and larger tissue tension; the local drying is improved, the wound is reduced, new granulation can be seen, and the local tension is small; the healing is local dryness, wound closure and small local tension. The test results are given in the table below.
TABLE 3 bacteriostatic action of lipstick on mouse skin injury
As can be seen from the above table, the wound infection degree of the aseptic wound group is obviously reduced compared with that of the model group animals, which indicates that the molding is successful. 4d, vehicle control group (A)2) 6 mice improved and 0 mice healed; lipstick set (A)3) 9 mice improved and 0 mice healed; triamcinolone acetonide econazole cream composition (A)4) 7 improved and 3 healed. Compared with the vehicle control group, the lipstick group and the triamcinolone acetonide econazole cream group have no significant effect and no statistically significant difference (P)>0.05). 8d, vehicle control group (A)2) 3 mice improved and 7 mice were cured; lipstick set (A)3) 1 mouse improved and 9 mice healed; triamcinolone acetonide econazole cream composition (A)4) 0 out of the cases and 10 out of the cases. Compared with the vehicle control group, the lipstick group and the triamcinolone acetonide econazole cream group have no significant effect and no statistically significant difference (P)>0.05). The results show that the effects of the vaseline, the lipstick finished product and the triamcinolone acetonide econazole cream on promoting the healing of the locally infected wounds are equivalent。
(2) Mouse ear swelling test
30 KM mice are randomly divided into 3 groups, each group comprises 10 mice, each mouse is 18-22 g, and the mice are male and female. B is1Group was the matrix group (negative control group): coating vaseline; b is2The group was triamcinolone acetonide econazole cream group (positive control group); b is3The group is lipstick finished product group. The ointment of vaseline, lipstick and triamcinolone acetonide econazole is applied to the right auricle of each group of mice respectively according to the dose of 0.1 g/mouse, and the administration is carried out 2 times per day, and the mice are raised in a single cage for 7 days continuously. Fasting is carried out for 12h before the last administration, 20 mu L of dimethylbenzene is smeared on the right ear of the mouse 45min after the administration, a puncher with the diameter of 6mm is used after 20min, the left ear and the right ear of the same part are taken, weighing is carried out by a ten-thousandth balance, and the mass difference of the two ears is used as the swelling degree of the auricle.
TABLE 4 anti-inflammatory action of lipstick on swelling of mouse ear
Note: and B1Comparing by P<0.01
As can be seen from Table 4, the lipstick product group (B)2) And triamcinolone acetonide econazole cream group (B)3) The difference between the quality of the two ears of the mouse is reduced compared with that of a vaseline control group, and the statistical significance is achieved (P)<0.01). The lipstick product has obvious inhibiting effect on mouse ear swelling caused by dimethylbenzene and is obviously superior to an excipient control group (P)<0.01)。
The above description is intended to describe in detail the preferred embodiments of the present invention, but the embodiments are not intended to limit the scope of the claims of the present invention, and all equivalent changes and modifications made within the technical spirit of the present invention should fall within the scope of the claims of the present invention.
Claims (9)
1. The bacteriostatic and anti-inflammatory lipstick contains plant bacteriostatic components and is characterized in that: the plant bacteriostatic component is a liquid medicine obtained by mixing rush alcohol extract, hawthorn alcohol extract and loquat leaf alcohol extract according to a weight ratio of 5-7: 1: 6-7.
2. The bacteriostatic and anti-inflammatory lipstick contains plant bacteriostatic components and is characterized in that: the plant bacteriostatic component is a liquid medicine obtained by mixing rush alcohol extract, hawthorn alcohol extract and loquat leaf alcohol extract according to the weight ratio of 6:1: 7.
3. A bacteriostatic and anti-inflammatory lipstick according to claim 1, characterized in that: the rush ethanol extract, the hawthorn ethanol extract and the loquat leaf ethanol extract are obtained by respectively adopting ethanol to carry out ultrasonic-assisted extraction.
4. A bacteriostatic and anti-inflammatory lipstick according to claim 1, characterized in that: the ultrasonic-assisted extraction adopts 60-70% volume fraction ethanol, the extraction is carried out under the conditions that the material-liquid ratio is 1g: 10-20 mL and the temperature is 20-40 ℃, the ultrasonic-assisted extraction is carried out to obtain an initial extract, and the initial extract is concentrated to obtain an alcohol extract with the final concentration of 1 g/mL.
5. A bacteriostatic and anti-inflammatory lipstick according to claim 1, characterized in that: the pigment adopted by the lipstick is pitaya peel pigment powder.
6. A bacteriostatic and anti-inflammatory lipstick according to claim 1, characterized in that: the lipstick is mainly prepared by mixing the following raw materials: beeswax, olive oil, jasmine essential oil, vitamin E, pitaya peel pigment powder and plant bacteriostatic components.
7. A bacteriostatic and anti-inflammatory lipstick according to claim 1, characterized in that: the lipstick is mainly prepared by mixing the following raw materials in parts by weight: 2-4 parts of pitaya peel pigment powder, 8-12 parts of beeswax, 30-50 parts of olive oil, 0.1-0.3 part of jasmine essential oil, 2-3 parts of vitamin E and 0.004-0.007 part of plant antibacterial component.
8. A bacteriostatic and anti-inflammatory lipstick according to claim 7, characterized in that: the lipstick is mainly prepared by mixing the following raw materials in parts by weight: 3 parts of pitaya peel pigment powder, 10 parts of beeswax, 40 parts of olive oil, 0.25 part of jasmine essential oil, 2.5 parts of vitamin E and 0.005 part of plant antibacterial component.
9. A method for preparing antibacterial and anti-inflammatory lipstick according to claim 6, 7 or 8, characterized in that: the method comprises the following steps:
(1) heating and stirring beeswax and olive oil in a container until the beeswax and the olive oil are melted;
(2) after melting, cooling to 55-65 ℃, adding the pitaya peel pigment, the plant bacteriostatic component, the jasmine essential oil and the vitamin E, and then fully stirring by using a grinding device until no granular sensation exists, thus obtaining a lipstick stock solution;
(3) after fully stirring, quickly pouring the lipstick stock solution into a lipstick tube to prevent the beeswax from solidifying; pouring the liquid level to the convex lipstick tube to prevent the middle from being too large after cooling;
(4) after the lipstick stock solution is completely solidified, refrigerating the lipstick stock solution to help the lipstick stock solution to be solidified and prevent the lipstick stock solution from adhering to the wall of the tube; and finally, cleaning the outer wall of the lipstick tube, thus finishing the preparation.
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