CN102813751A - Wound treatment agent - Google Patents
Wound treatment agent Download PDFInfo
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- CN102813751A CN102813751A CN2012102816250A CN201210281625A CN102813751A CN 102813751 A CN102813751 A CN 102813751A CN 2012102816250 A CN2012102816250 A CN 2012102816250A CN 201210281625 A CN201210281625 A CN 201210281625A CN 102813751 A CN102813751 A CN 102813751A
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Abstract
The invention relates to a wound treatment agent prepared by using traditional Chinese medicine materials. The wound treatment agent is used for treating wounds and promoting wound healing. The wound treatment agent provided by the invention is prepared from Taiwan beautyberry leaf, dry or fresh longleaf garden burnet root, rosewood heart wood, dry or fresh bunge corydalis herb, myrrh, ligusticum, salvia chinensis, prepared rehmannia root, redroot gromwell, and licorice root. The medicine materials are decocted according to a certain ratio; the obtained mixture is filtered; and the filtrate is concentrated, such that a traditional Chinese medicine liquid with a certain concentration is prepared. The medicine liquid has disinfecting and sterilizing effects of common wound sterilizing liquids, and has a fast haemostatic effect which can not be provided by current wound sterilizing liquids. Also, the wound treatment agent provided by the invention also has a wound healing promoting effect. The wound treatment agent provided by the invention is prepared by using pure natural traditional Chinese medicine materials, and does not contain hormone. The preparation method is simple, and the cost is low.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation that is used to handle wound, relate in particular to and a kind ofly be prepared from the wound treatment agent that be used to handle wound, promotes wound healing raw material of Chinese medicine.
Background technology
The product that is used for wound disinfection at present mainly is to be main with ethanol and iodine tincture; But such disinfectant can only be located general antibacterial or microorganism extremely, does not have anastalsis and to the healing of wound also not directly effect.Chinese patent CN102462732A has announced that " a kind of wound disinfection liquid and preparation method thereof " its active substance is medical alcohol 20-50 part, trichloro hydroxyl diphenyl ether 6-15 part, Herba Clinopodii Polycephali 10-25 part, oils and fats Radix Hyperici Monogyni (Herba Hyperici Monogyni) extract 5-18 part.Trichloro hydroxyl diphenyl ether wherein is the antimicrobial activity agent of using always, is usually used in the disinfecting articles for use, like medicated soap, body lotion, handwashing liquid etc.; Herba Clinopodii Polycephali wherein is used for hemostasis, oils and fats Radix Hyperici Monogyni (Herba Hyperici Monogyni) extract is used for blood circulation promoting and blood stasis dispelling, and this disinfectant solution is a kind of disinfectant solution that can promote wound healing.But because Herba Clinopodii Polycephali, oils and fats Radix Hyperici Monogyni (Herba Hyperici Monogyni) extractive content very little, can only play the preliminary astringent effect of wound that makes; After using this disinfectant solution to handle wound, also need smear the ointment that promotes wound healing.Therefore the contained Chinese medicine ingredients of Chinese patent CN102462732A " a kind of wound disinfection liquid and preparation method thereof " of announcing is few, can only be as the disinfectant solution of handling wound, and do not have the effect that quick-acting haemostatic powder is arranged and promote wound healing.
Summary of the invention
The purpose of this invention is to provide and a kind ofly process the wound treatment agent that be used to clear up the wound quick-acting haemostatic powder, promotes wound healing by the natural Chinese medicines material.
Technical scheme of the present invention:
A kind of wound treatment agent is raw material of Chinese medicine decocte with water, filtration, the concentrated water extract that forms by following weight parts; The weight of water extract is that 0.5-2.0 is doubly to the weight of medical material dry product; Folium Callicarpae Formosanae 10-30 part, Radix Sanguisorbae dry product 6-15 part or bright article 30-90 part, Lignum Dalbergiae Odoriferae 3-6 part, Herba Corydalis Bungeanae dry product 9-15 part or bright article 30-60 part, Myrrha 3-9 part, Radix Angelicae Sinensis 6-12 part, Herba Salviae Chinensis 6-12 part, Radix Rehmanniae Preparata 15-25 part, Radix Arnebiae (Radix Lithospermi) 6-12 part, Radix Glycyrrhizae 15-30 part.
Folium Callicarpae Formosanae: property is flat, distinguish the flavor of little suffering, hardship; Hemostasis and anti-inflammation, dissipating blood stasis for subsidence of swelling.Be used for traumatic hemorrhage, epistaxis, gingiva bleeding gingival hemorrhage, sprain swell and ache, suppurative skin ulcer, burn.
Radix Sanguisorbae: cold nature; Bitter in the mouth, acid, puckery; Return liver, large intestine channel; Cooling blood for hemostasis, skin ulcer is held back in detoxifcation.Be used for burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Lignum Dalbergiae Odoriferae: warm in nature; Acrid in the mouth; Return liver, spleen channel; Promoting flow of QI and blood, pain relieving, hemostasis.Be used for injury from falling down, traumatic hemorrhage.
Herba Corydalis Bungeanae: cold in nature; Bitter in the mouth, suffering; GUIXIN, spleen channel; The heat clearing away poison, subduing inflammation.
Myrrha: property is flat; Bitter in the mouth, suffering; GUIXIN, liver, spleen channel; Promoting blood circulation and stopping pain, detumescence and promoting granulation.Be used for the external wounds traumatic injury, skin infection carbuncle, all pain cards of stagnation of blood stasis.
Radix Angelicae Sinensis: warm in nature; Sweet in the mouth, suffering; Return liver, the heart, spleen channel; Enrich blood and invigorate blood circulation.Be used for rheumatic arthralgia, traumatic injury.
Herba Salviae Chinensis: property is flat, bitter in the mouth, suffering; Heat-clearing and toxic substances removing, the blood circulation promoting regulates qi pain relieving.
Radix Rehmanniae Preparata: slightly warm in nature; Sweet in the mouth; Return liver, kidney channel; The YIN nourishing of enriching blood, beneficial essence is filled out marrow.
Radix Arnebiae (Radix Lithospermi): cold in nature; Sweet in the mouth, salty; GUIXIN, Liver Channel; Removing heat from blood is invigorated blood circulation, the detoxifcation rash.Be used for the heat in blood poison and contain, macule is purple black, skin infection, eczema, burn due to hot liquid or fire.
Radix Glycyrrhizae: property is flat; Sweet; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, carbuncle sore tumefacting virus, cushion toxicity, strong.
Chinese medical discrimination: hinder then stagnation of QI and blood, stagnation of QI and blood is then obstructed, stagnation of QI and blood may bring about pain; General rule is wet not long-pending, wet long-pending then mould corruption; Its rule of treatment is blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, control malicious damp eliminating, removing the necrotic tissue and promoting granulation.Among the we, Folium Callicarpae Formosanae, Lignum Dalbergiae Odoriferae, Radix Arnebiae (Radix Lithospermi), Herba Corydalis Bungeanae are monarch drug; Wherein Folium Callicarpae Formosanae, Lignum Dalbergiae Odoriferae are used for hemostasis and anti-inflammation, dissipating blood stasis for subsidence of swelling, and Radix Arnebiae (Radix Lithospermi), Herba Corydalis Bungeanae are used for heat-clearing and toxic substances removing, promoting blood circulation and cooling blood.Radix Sanguisorbae, Myrrha, Radix Angelicae Sinensis, Radix Rehmanniae Preparata are ministerial drug, and wherein Myrrha promoting blood circulation and stopping pain, Radix Rehmanniae Preparata are enriched blood, and auxilliary Folium Callicarpae Formosanae, Lignum Dalbergiae Odoriferae are with blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic; The dehumidifying of invigorating blood circulation of Radix Sanguisorbae cooling blood for hemostasis, Radix Angelicae Sinensis, auxilliary Radix Arnebiae (Radix Lithospermi), Herba Corydalis Bungeanae are with removing damp-heat, blood circulation promoting regulates qi.Radix Glycyrrhizae is with heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong.
Contain the multi-flavor haemostatic medicament among the we, have good hemostasia effect; Therefore when the cleaning bleeding wounds, can play the effect of quick-acting haemostatic powder; Be particularly useful for open air or family emergency.
Also contain the medicine of multi-flavor blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, anti-inflammatory analgetic among the we, can promote the healing of wound; Therefore wound treatment agent of the present invention can be used as the drug use of healing of wound.Owing to contain the medicine that is mostly heat-clearing and toxic substances removing, removing heat from blood effect in the wound treatment agent of the present invention; Therefore the present invention is suitable equally to burn and scald.
In order to improve the effect of above-mentioned wound treatment agent healing of wound; Preferably, the weight portion of said raw material of Chinese medicine is: 10 parts of Folium Callicarpae Formosanaes, 6 parts of Radix Sanguisorbae dry products, 3 parts of Lignum Dalbergiae Odoriferaes, Herba Corydalis Bungeanae dry product 9-15 part, Myrrha 8-9 part, Radix Angelicae Sinensis 9-12 part, Herba Salviae Chinensis 8-12 part, Radix Rehmanniae Preparata 20-25 part, Radix Arnebiae (Radix Lithospermi) 6-9 part, Radix Glycyrrhizae 15-30 part; The weight of said water extract is that 0.5-0.8 is doubly to the weight of medicinal raw material.The wound treatment agent of this moment is applied in the wound with it and gets final product, every day 3-6 time as the drug use of healing of wound.
Because the amount of the needed wound treatment agent of cleaning wound can be bigger; But it is less demanding to its healing effect; So preferred, the weight portion of said raw material of Chinese medicine is: 30 parts of Folium Callicarpae Formosanaes, 15 parts of Radix Sanguisorbae dry products, 6 parts of Lignum Dalbergiae Odoriferaes, 12 parts of Herba Corydalis Bungeanae dry products, 3 parts of Myrrhas, 6 parts of Radix Angelicae Sinensis, 12 parts of Herba Salviae Chinensiss, 15 parts of Radix Rehmanniae Preparata, 12 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts in Radix Glycyrrhizae; The weight of said water extract is that 1.5-2.0 is doubly to the weight of medical material dry product.This moment, wound treatment agent used as wound cleaning liquid, can not cause waste.
Method for preparing: take by weighing raw material by above-mentioned weight portion, decocte with water, filtration, the concentrated water extract of processing.Can the water extract of gained be continued concentrate the interpolation adjuvant and process unguentum.
Bacteriostatic test:
Slant culture one ring of depletion Staphylococcus aureus, escherichia coli, Candida albicans, bacillus pyocyaneus is inoculated in the broth bouillon respectively; Cultivate after 24 hours for 37 ℃; Respectively get 0.2 milliliter and be inoculated in 3 plating mediums, get wound treatment agent prepared among the embodiment 1-3 of equivalent respectively, drip in 3 plating mediums respectively; Detect sterilization rate behind the effect 3min; Result such as table 1;
Table 1
| ? | Staphylococcus aureus | Escherichia coli | Candida albicans | Bacillus pyocyaneus |
| Embodiment 1 | 99.94 | 99.94 | 99.96 | 99.93 |
| Embodiment 2 | 99.94 | 99.95 | 99.95 | 99.94 |
| Embodiment 3 | 99.95 | 99.95 | 99.96 | 99.94 |
Animal experiment:
Mice is cut the influence in tail bleeding time: 60 of healthy Kunming mouses, male and female half and half, body weight are suitable, are divided into 6 groups, test group 1-3 group, matched group 1-2 and blank control group.Test 1-3 adopts wound treatment agent prepared among the embodiment 1-3 respectively; Wound disinfection liquid (to call disinfectant solution in the following text), medical alcohol that matched group 1-2 adopts Chinese patent CN102462732A to announce respectively; Blank control group is not carried out any processing to wound.
With very sharp shears in the mouse tail tip upwards about 1cm place cut off afterbody fast, and clock with stopwatch immediately, with wound treatment agent, medical alcohol, the disinfectant solution of same dose wound is cleaned respectively simultaneously, whenever separated 1min is once.Simultaneously constantly inhale effusive blood with filter paper.Begin to be mice during this period of time and cut the tail bleeding time from cutting tail to stopped bleeding.
Result of the test such as table 2;
Table 2
| ? | Test group 1 | Test group 2 | Test group 3 | Matched group 1 | Matched group 2 | Blank control group |
| Bleeding time | 522-615s | 469-518s | 465-517s | 967-1122s | Greater than 1500s | Greater than 1500s |
Table 2 explanation, the too late sterilizing effect that possesses medical alcohol of wound treatment agent of the present invention, and possess haemostatic effect; And its haemostatic effect is much larger than the haemostatic effect of disinfectant solution.
Treat that the wound of mice carries out suture operation after no longer hemorrhage, carries out the wound healing viewing test to test group 1-3 and matched group 1; Wherein test group 1-3 continues to adopt prepared wound treatment agent among the embodiment 1-3, smears wound every day 6 times; Matched group 1 adopts disinfectant solution to smear wound every day; Blank control group is only carried out sterilizing to wound and is handled.Treat that it is healing that wound covers no edema pain phenomenon fully by epidermis.Result of the test such as table 3;
Table 3
| ? | Test group 1 | Test group 2 | Test group 3 | Matched group 1 | Blank control group |
| Healing time | 16-19 days | 12-16 days | 12-16 days | Greater than 21 days | Greater than 21 days |
Table 3 explanation, wound treatment agent of the present invention also possesses the effect that promotes wound healing; And disinfectant solution does not have obvious facilitation to wound healing.
Beneficial effect of the present invention:
Wound treatment agent of the present invention adopts the natural Chinese medicine material to be prepared from, and does not contain hormone.Its preparation method is simple, and is with low cost.When its concentration is low, can be used for cleaning a wound, can sterilizing and can play anastalsis; When its concentration is higher, can be used as the drug use that promotes wound healing, can make wound healing.Therefore, wound treatment agent of the present invention is that a kind of collection antibacterial, sterilization, hemostasis, promotion wound healing function are one, wound treatment agent with low cost.
The specific embodiment
Embodiment 1
Get Folium Callicarpae Formosanae 30kg, Radix Sanguisorbae dry product 15kg, Lignum Dalbergiae Odoriferae 6kg, Herba Corydalis Bungeanae dry product 12kg, Myrrha 3kg, Radix Angelicae Sinensis 6kg, Herba Salviae Chinensis 12kg, Radix Rehmanniae Preparata 15kg, Radix Arnebiae (Radix Lithospermi) 12kg, Radix Glycyrrhizae 20kg, decocte with water, filter, be concentrated into 230kg; Cooling, encapsulation.
Embodiment 2
Get Folium Callicarpae Formosanae 10kg, Radix Sanguisorbae dry product 6kg, Lignum Dalbergiae Odoriferae 3kg, Herba Corydalis Bungeanae dry product 9kg, Myrrha 8kg, Radix Angelicae Sinensis 9kg, Herba Salviae Chinensis 8kg, Radix Rehmanniae Preparata 25kg, Radix Arnebiae (Radix Lithospermi) 6kg, Radix Glycyrrhizae 30kg, decocte with water, filter, be concentrated into 91kg; Cooling, encapsulation.
Embodiment 3
Get Folium Callicarpae Formosanae 10kg, Radix Sanguisorbae dry product 6kg, Lignum Dalbergiae Odoriferae 3kg, Herba Corydalis Bungeanae dry product 15kg, Myrrha 9kg, Radix Angelicae Sinensis 12kg, Herba Salviae Chinensis 12kg, Radix Rehmanniae Preparata 20kg, Radix Arnebiae (Radix Lithospermi) 9kg, Radix Glycyrrhizae 15kg, decocte with water, filter, be concentrated into 56kg; Cooling, encapsulation.
Claims (3)
1. a wound treatment agent is characterized in that, is raw material of Chinese medicine decocte with water, filtration, the concentrated water extract that forms by following weight parts; The weight of water extract is that 0.5-2.0 is doubly to the weight of medical material dry product; Folium Callicarpae Formosanae 10-30 part, Radix Sanguisorbae dry product 6-15 part or bright article 30-90 part, Lignum Dalbergiae Odoriferae 3-6 part, Herba Corydalis Bungeanae dry product 9-15 part or bright article 30-60 part, Myrrha 3-9 part, Radix Angelicae Sinensis 6-12 part, Herba Salviae Chinensis 6-12 part, Radix Rehmanniae Preparata 15-25 part, Radix Arnebiae (Radix Lithospermi) 6-12 part, Radix Glycyrrhizae 15-30 part.
2. wound treatment agent according to claim 1; It is characterized in that the weight portion of said raw material of Chinese medicine is: 10 parts of Folium Callicarpae Formosanaes, 6 parts of Radix Sanguisorbae dry products, 3 parts of Lignum Dalbergiae Odoriferaes, Herba Corydalis Bungeanae dry product 9-15 part, Myrrha 8-9 part, Radix Angelicae Sinensis 9-12 part, Herba Salviae Chinensis 8-12 part, Radix Rehmanniae Preparata 20-25 part, Radix Arnebiae (Radix Lithospermi) 6-9 part, Radix Glycyrrhizae 15-30 part;
The weight of said water extract is that 0.5-0.8 is doubly to the weight of medical material dry product.
3. wound treatment agent according to claim 1; It is characterized in that the weight portion of said raw material of Chinese medicine is: 30 parts of Folium Callicarpae Formosanaes, 15 parts of Radix Sanguisorbae dry products, 6 parts of Lignum Dalbergiae Odoriferaes, 12 parts of Herba Corydalis Bungeanae dry products, 3 parts of Myrrhas, 6 parts of Radix Angelicae Sinensis, 12 parts of Herba Salviae Chinensiss, 15 parts of Radix Rehmanniae Preparata, 12 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts in Radix Glycyrrhizae; The weight of said water extract is that 1.5-2.0 is doubly to the weight of medical material dry product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210281625.0A CN102813751B (en) | 2012-08-09 | 2012-08-09 | Wound treatment agent |
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| CN201210281625.0A CN102813751B (en) | 2012-08-09 | 2012-08-09 | Wound treatment agent |
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| CN102813751A true CN102813751A (en) | 2012-12-12 |
| CN102813751B CN102813751B (en) | 2014-04-09 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103751543A (en) * | 2014-01-15 | 2014-04-30 | 薛晓晓 | Chinese herbal medicine formula for wound care and preparation method thereof |
| CN105560620A (en) * | 2015-12-25 | 2016-05-11 | 马真真 | Trauma treatment traditional Chinese medicine preparation |
| CN105770382A (en) * | 2016-05-30 | 2016-07-20 | 孙兆玲 | Traditional Chinese medicine composition for nursing wounds of middle-aged and elderly people |
| CN105902701A (en) * | 2016-06-29 | 2016-08-31 | 山东大学第二医院 | Traditional Chinese medicine composition for treating infection at outlet of peritoneal dialysis tube |
| CN109200220A (en) * | 2018-11-29 | 2019-01-15 | 吴斌 | A kind for the treatment of of wounds Chinese medicine composition and preparation method thereof |
| CN111467433A (en) * | 2020-05-27 | 2020-07-31 | 中国人民解放军空军军医大学 | A topical Chinese medicinal composition and paste for promoting wound healing, and its preparation method |
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| CN101543565A (en) * | 2009-05-19 | 2009-09-30 | 卜继武 | Chinese medicine external-use preparation medicament for treating surgery wound infection and method for producing the same |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751543A (en) * | 2014-01-15 | 2014-04-30 | 薛晓晓 | Chinese herbal medicine formula for wound care and preparation method thereof |
| CN105560620A (en) * | 2015-12-25 | 2016-05-11 | 马真真 | Trauma treatment traditional Chinese medicine preparation |
| CN105770382A (en) * | 2016-05-30 | 2016-07-20 | 孙兆玲 | Traditional Chinese medicine composition for nursing wounds of middle-aged and elderly people |
| CN105902701A (en) * | 2016-06-29 | 2016-08-31 | 山东大学第二医院 | Traditional Chinese medicine composition for treating infection at outlet of peritoneal dialysis tube |
| CN109200220A (en) * | 2018-11-29 | 2019-01-15 | 吴斌 | A kind for the treatment of of wounds Chinese medicine composition and preparation method thereof |
| CN111467433A (en) * | 2020-05-27 | 2020-07-31 | 中国人民解放军空军军医大学 | A topical Chinese medicinal composition and paste for promoting wound healing, and its preparation method |
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| CN102813751B (en) | 2014-04-09 |
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