KR20010087413A - 헤르페스 바이러스의 아세트아마이드 및 치환아세트아마이드-함유 티오우레아 억제제 - Google Patents
헤르페스 바이러스의 아세트아마이드 및 치환아세트아마이드-함유 티오우레아 억제제 Download PDFInfo
- Publication number
- KR20010087413A KR20010087413A KR1020017007052A KR20017007052A KR20010087413A KR 20010087413 A KR20010087413 A KR 20010087413A KR 1020017007052 A KR1020017007052 A KR 1020017007052A KR 20017007052 A KR20017007052 A KR 20017007052A KR 20010087413 A KR20010087413 A KR 20010087413A
- Authority
- KR
- South Korea
- Prior art keywords
- phenyl
- carbon atoms
- chloro
- amino
- thioureido
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Furan Compounds (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20831698A | 1998-12-09 | 1998-12-09 | |
| US09/208,316 | 1998-12-09 | ||
| PCT/US1999/028844 WO2000034237A2 (en) | 1998-12-09 | 1999-12-06 | Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20010087413A true KR20010087413A (ko) | 2001-09-15 |
Family
ID=22774137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020017007052A KR20010087413A (ko) | 1998-12-09 | 1999-12-06 | 헤르페스 바이러스의 아세트아마이드 및 치환아세트아마이드-함유 티오우레아 억제제 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1137633A2 (ja) |
| JP (1) | JP2002531544A (ja) |
| KR (1) | KR20010087413A (ja) |
| CN (1) | CN1333750A (ja) |
| AU (1) | AU3111200A (ja) |
| BR (1) | BR9916041A (ja) |
| CA (1) | CA2350899A1 (ja) |
| CZ (1) | CZ20012060A3 (ja) |
| EA (1) | EA200100640A1 (ja) |
| HU (1) | HUP0104944A3 (ja) |
| IL (1) | IL143204A0 (ja) |
| NO (1) | NO20012834L (ja) |
| PL (1) | PL349131A1 (ja) |
| WO (1) | WO2000034237A2 (ja) |
| ZA (1) | ZA200104142B (ja) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6166028A (en) * | 1998-12-09 | 2000-12-26 | American Home Products Corporation | Diaminopuridine-containing thiourea inhibitors of herpes viruses |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| WO2001064642A2 (en) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| BR0315580A (pt) * | 2002-10-24 | 2005-08-30 | Merck Patent Gmbh | Derivados de metileno uréia |
| US7220768B2 (en) * | 2003-02-11 | 2007-05-22 | Wyeth Holdings Corp. | Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus |
| US7419801B2 (en) | 2003-08-08 | 2008-09-02 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
| US8158814B2 (en) | 2003-08-29 | 2012-04-17 | Mitsui Chemicals, Inc. | Insecticide for agricultural or horticultural use and method of use thereof |
| WO2005086915A2 (en) | 2004-03-09 | 2005-09-22 | Arriva Pharmaceuticals, Inc. | Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor |
| EP2074085A2 (en) * | 2006-10-13 | 2009-07-01 | Lica Pharmaceuticals A/S | Anti-infective thiourea compounds |
| EP2077995B1 (en) | 2006-11-02 | 2012-02-08 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing pharmaceutical salts of a factor xa inhibitor |
| CN108619123A (zh) * | 2018-03-13 | 2018-10-09 | 武汉威立得生物医药有限公司 | Tenovin-1在制备防治人类疱疹病毒感染药物中的应用 |
| WO2019193541A1 (en) * | 2018-04-06 | 2019-10-10 | Glaxosmithkline Intellectual Property Development Limited | Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors |
| CN112807294B (zh) * | 2019-11-18 | 2023-09-05 | 武汉大学 | 一种酰基硫脲类化合物在制备治疗或预防单纯疱疹病毒i型感染药物中的应用 |
| WO2022150962A1 (en) * | 2021-01-12 | 2022-07-21 | Westlake Pharmaceutical (Hangzhou) Co., Ltd. | Protease inhibitors, preparation, and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6783698A (en) * | 1997-04-10 | 1998-10-30 | Pharmacia & Upjohn Company | Polyaromatic antiviral compositions |
-
1999
- 1999-12-06 EP EP99965132A patent/EP1137633A2/en not_active Withdrawn
- 1999-12-06 IL IL14320499A patent/IL143204A0/xx unknown
- 1999-12-06 WO PCT/US1999/028844 patent/WO2000034237A2/en not_active Application Discontinuation
- 1999-12-06 JP JP2000586685A patent/JP2002531544A/ja active Pending
- 1999-12-06 KR KR1020017007052A patent/KR20010087413A/ko not_active Application Discontinuation
- 1999-12-06 CN CN99815640A patent/CN1333750A/zh active Pending
- 1999-12-06 BR BR9916041-2A patent/BR9916041A/pt not_active Application Discontinuation
- 1999-12-06 AU AU31112/00A patent/AU3111200A/en not_active Abandoned
- 1999-12-06 PL PL99349131A patent/PL349131A1/xx not_active Application Discontinuation
- 1999-12-06 CA CA002350899A patent/CA2350899A1/en not_active Abandoned
- 1999-12-06 HU HU0104944A patent/HUP0104944A3/hu unknown
- 1999-12-06 EA EA200100640A patent/EA200100640A1/ru unknown
- 1999-12-06 CZ CZ20012060A patent/CZ20012060A3/cs unknown
-
2001
- 2001-05-21 ZA ZA200104142A patent/ZA200104142B/en unknown
- 2001-06-08 NO NO20012834A patent/NO20012834L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20012834L (no) | 2001-08-07 |
| EP1137633A2 (en) | 2001-10-04 |
| IL143204A0 (en) | 2002-04-21 |
| HUP0104944A3 (en) | 2003-03-28 |
| NO20012834D0 (no) | 2001-06-08 |
| WO2000034237A3 (en) | 2000-11-23 |
| PL349131A1 (en) | 2002-07-01 |
| HUP0104944A2 (hu) | 2002-04-29 |
| CN1333750A (zh) | 2002-01-30 |
| BR9916041A (pt) | 2001-12-04 |
| EA200100640A1 (ru) | 2001-12-24 |
| AU3111200A (en) | 2000-06-26 |
| CZ20012060A3 (cs) | 2001-11-14 |
| WO2000034237A2 (en) | 2000-06-15 |
| JP2002531544A (ja) | 2002-09-24 |
| CA2350899A1 (en) | 2000-06-15 |
| ZA200104142B (en) | 2002-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |