KR20010074429A - 섬유 교체 단백질을 함유하는 변형된 아데노바이러스 - Google Patents
섬유 교체 단백질을 함유하는 변형된 아데노바이러스 Download PDFInfo
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- KR20010074429A KR20010074429A KR1020007008959A KR20007008959A KR20010074429A KR 20010074429 A KR20010074429 A KR 20010074429A KR 1020007008959 A KR1020007008959 A KR 1020007008959A KR 20007008959 A KR20007008959 A KR 20007008959A KR 20010074429 A KR20010074429 A KR 20010074429A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
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- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
- C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
- C12N2810/859—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from immunoglobulins
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| US20050095231A1 (en) * | 1998-02-17 | 2005-05-05 | Curiel David T. | Modified adenovirus containing a fiber replacement protein |
| US6815200B1 (en) * | 1998-02-17 | 2004-11-09 | The Uab Research Foundation | Modified adenovirus containing a fiber replacement protein |
| AU4070499A (en) | 1998-04-30 | 1999-11-16 | Cornell Research Foundation Inc. | Adenoviral vectors with tandem fiber proteins |
| AU767975B2 (en) | 1998-09-11 | 2003-11-27 | Genvec, Inc. | Alternatively targeted adenovirus |
| WO2000046364A1 (en) * | 1999-02-05 | 2000-08-10 | The Uab Research Foundation | Fiber receptor-independent system for the propagation of adenoviral vectors |
| CN1359391A (zh) * | 1999-07-06 | 2002-07-17 | 哥德－A－基因股份公司 | 重组腺病毒 |
| CA2407518A1 (en) * | 2000-04-26 | 2001-11-01 | Crucell Holland B.V. | Adenovirus vectors with knobless fibers, and their uses |
| US7332337B2 (en) * | 2000-05-16 | 2008-02-19 | Galapagos Nv | Viral vectors having tissue tropism for T-lymphocytes, B- and mast cells |
| EP1285079A2 (en) | 2000-05-31 | 2003-02-26 | University of Saskatchewan | Modified bovine adenovirus having altered tropism |
| JP3635462B2 (ja) * | 2000-05-31 | 2005-04-06 | 国立医薬品食品衛生研究所長 | アデノウイルスベクター |
| GB0017720D0 (en) * | 2000-07-19 | 2000-09-06 | Got A Gene Ab | Modified virus |
| JP4399255B2 (ja) | 2001-06-22 | 2010-01-13 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 細菌の形質転換体を迅速に選別する方法および新規なサルアデノウイルス蛋白質 |
| US6905678B2 (en) * | 2001-07-07 | 2005-06-14 | Crucell Holland B.V. | Gene delivery vectors with cell type specificity for mesenchymal stem cells |
| US20040002060A1 (en) * | 2002-01-24 | 2004-01-01 | Novartis Ag | Fiber shaft modifications for efficient targeting |
| CA2493254A1 (en) * | 2002-07-22 | 2004-01-29 | Vectorlogics, Inc. | Targeted adenoviral vector displaying immunoglobulin-binding domain and uses thereof |
| AU2003259199A1 (en) * | 2002-07-22 | 2004-02-09 | Vectorlogics, Inc. | Adenoviral vector incorporating zipper peptide-modified fiber protein and uses thereof |
| US20050003548A1 (en) * | 2002-07-22 | 2005-01-06 | Nikolay Korokhov | Targeted adenoviral vector displaying immunoglobulin-binding domain and uses thereof |
| EP1625222A2 (en) | 2003-05-14 | 2006-02-15 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Broadening adenovirus tropism |
| JP2007531507A (ja) * | 2003-06-11 | 2007-11-08 | ザ スクリップス リサーチ インスティテュート | 効率的な受容体結合のための修飾型線維タンパク質 |
| US7291498B2 (en) | 2003-06-20 | 2007-11-06 | The Trustees Of The University Of Pennsylvania | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses |
| JP6499825B2 (ja) * | 2010-06-10 | 2019-04-10 | ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャリゼーション | デスモグレイン２（ｄｓｇ２）とのアデノウイルスの相互作用のための方法およびシステム |
| JP6576326B2 (ja) | 2013-03-14 | 2019-09-18 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腫瘍溶解性アデノウイルス組成物 |
| WO2015161314A1 (en) | 2014-04-18 | 2015-10-22 | Washington University | Adenoviral targeting, compositions and methods therefor |
| CN107683289B (zh) * | 2015-01-26 | 2021-08-06 | 芝加哥大学 | IL13Rα2结合剂和其在癌症治疗中的用途 |
| JP7054527B2 (ja) | 2016-02-23 | 2022-04-14 | ソーク インスティテュート フォー バイオロジカル スタディーズ | アデノウイルスの複製動態を測定するための高スループットアッセイ |
| KR20220163505A (ko) | 2016-02-23 | 2022-12-09 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
| JP2019536468A (ja) | 2016-12-12 | 2019-12-19 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腫瘍を標的にする合成アデノウイルスおよびその使用 |
| WO2018118967A1 (en) | 2016-12-21 | 2018-06-28 | Memgen, Llc | Armed replication-competent oncolytic adenoviruses |
| AU2019251356B2 (en) | 2018-04-09 | 2025-06-12 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions with enhanced replication properties |
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| GB9223084D0 (en) * | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
| US5543328A (en) * | 1993-08-13 | 1996-08-06 | Genetic Therapy, Inc. | Adenoviruses having modified fiber proteins |
| US5846782A (en) * | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| US5559099A (en) * | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
| US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| AU726544B2 (en) * | 1995-12-08 | 2000-11-09 | University Of Alabama At Birmingham Research Foundation, The | Targeted adenovirus vectors |
| US5877011A (en) * | 1996-11-20 | 1999-03-02 | Genzyme Corporation | Chimeric adenoviral vectors |
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- 1999-02-16 KR KR1020007008959A patent/KR20010074429A/ko not_active Withdrawn
- 1999-02-16 CA CA002321135A patent/CA2321135A1/en not_active Abandoned
- 1999-02-16 US US09/250,580 patent/US6210946B1/en not_active Expired - Lifetime
- 1999-02-16 DE DE69933550T patent/DE69933550T2/de not_active Expired - Lifetime
- 1999-02-16 WO PCT/US1999/003233 patent/WO1999041359A1/en not_active Ceased
- 1999-02-16 IL IL13773098A patent/IL137730A0/xx unknown
- 1999-02-16 EP EP99932506A patent/EP1070118B1/en not_active Expired - Lifetime
- 1999-02-16 JP JP2000531540A patent/JP2002503459A/ja active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| CN1297479A (zh) | 2001-05-30 |
| AU751542B2 (en) | 2002-08-22 |
| DE69933550T2 (de) | 2007-06-28 |
| IL137730A0 (en) | 2001-10-31 |
| NO20004563D0 (no) | 2000-09-13 |
| EP1070118A1 (en) | 2001-01-24 |
| AU3294099A (en) | 1999-08-30 |
| ATE342350T1 (de) | 2006-11-15 |
| BR9908018A (pt) | 2000-10-24 |
| EP1070118B1 (en) | 2006-10-11 |
| US6210946B1 (en) | 2001-04-03 |
| ZA200004208B (en) | 2002-01-30 |
| NZ506451A (en) | 2003-06-30 |
| CA2321135A1 (en) | 1999-08-19 |
| NO20004563L (no) | 2000-09-13 |
| DE69933550D1 (de) | 2006-11-23 |
| JP2002503459A (ja) | 2002-02-05 |
| EP1070118A4 (en) | 2003-05-02 |
| WO1999041359A1 (en) | 1999-08-19 |
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