KR20010033737A - 3'-에피머성 Ｋ-252ａ 유도체 - Google Patents
3'-에피머성 Ｋ-252ａ 유도체 Download PDFInfo
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- KR20010033737A KR20010033737A KR1020007007260A KR20007007260A KR20010033737A KR 20010033737 A KR20010033737 A KR 20010033737A KR 1020007007260 A KR1020007007260 A KR 1020007007260A KR 20007007260 A KR20007007260 A KR 20007007260A KR 20010033737 A KR20010033737 A KR 20010033737A
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- KR
- South Korea
- Prior art keywords
- hydrogen
- unsubstituted
- lower alkyl
- substituted
- aryl
- Prior art date
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- KOZFSFOOLUUIGY-IYYJOCMQSA-N k-252a, nocardiopsis sp. Chemical compound C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@@H]1C[C@](C(=O)OC)(O)[C@@]4(C)O1 KOZFSFOOLUUIGY-IYYJOCMQSA-N 0.000 title description 32
- 150000001875 compounds Chemical class 0.000 claims abstract description 72
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- 230000002708 enhancing effect Effects 0.000 claims abstract description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 72
- 229910052739 hydrogen Inorganic materials 0.000 claims description 60
- 239000001257 hydrogen Substances 0.000 claims description 60
- 150000002431 hydrogen Chemical class 0.000 claims description 44
- 238000000034 method Methods 0.000 claims description 39
- 125000001072 heteroaryl group Chemical group 0.000 claims description 33
- 125000003118 aryl group Chemical group 0.000 claims description 30
- 125000003107 substituted aryl group Chemical group 0.000 claims description 20
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- 125000003710 aryl alkyl group Chemical group 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 16
- -1 wherein m is 0 to 4 Chemical compound 0.000 claims description 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
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- 108090000315 Protein Kinase C Proteins 0.000 claims description 12
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 11
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- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 8
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- 230000026731 phosphorylation Effects 0.000 claims description 5
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
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- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 2
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- 125000002102 aryl alkyloxo group Chemical group 0.000 claims description 2
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- IQZPDFORWZTSKT-UHFFFAOYSA-N nitrosulphonic acid Chemical compound OS(=O)(=O)[N+]([O-])=O IQZPDFORWZTSKT-UHFFFAOYSA-N 0.000 claims description 2
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 5
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7026397P | 1997-12-31 | 1997-12-31 | |
| US60/070,263 | 1997-12-31 | ||
| PCT/US1998/027644 WO1999033836A1 (en) | 1997-12-31 | 1998-12-30 | 3'-epimeric k-252a derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20010033737A true KR20010033737A (ko) | 2001-04-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020007007260A Withdrawn KR20010033737A (ko) | 1997-12-31 | 1998-12-30 | 3'-에피머성 Ｋ-252ａ 유도체 |
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| EP (1) | EP1044203B1 (enExample) |
| JP (1) | JP4405667B2 (enExample) |
| KR (1) | KR20010033737A (enExample) |
| CN (1) | CN1285836A (enExample) |
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| AU (1) | AU1947499A (enExample) |
| BR (1) | BR9814543A (enExample) |
| CA (1) | CA2315953C (enExample) |
| DE (1) | DE69812177T2 (enExample) |
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| ES (1) | ES2194385T3 (enExample) |
| NO (1) | NO20003397L (enExample) |
| PT (1) | PT1044203E (enExample) |
| WO (1) | WO1999033836A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE301661T1 (de) | 2000-12-08 | 2005-08-15 | Ortho Mcneil Pharm Inc | Makroheterocyclische verbindungen als kinase inhibitoren |
| DE60212836T2 (de) * | 2001-05-16 | 2007-01-25 | Gpc Biotech Ag | Pyridylpyrimidin-derivate als wirksame verbindungen gegen prionen-krankheiten |
| US7018999B2 (en) | 2001-05-16 | 2006-03-28 | Cephalon, Inc. | Methods for the treatment and prevention of pain |
| DE10161940A1 (de) | 2001-12-17 | 2003-07-03 | Nad Ag | N-Carbacyclus-monosubstitutierte Indolocarbazole als Proteinkinase-inhibitoren |
| US6723844B1 (en) * | 2003-02-27 | 2004-04-20 | Abbott Laboratories | Preparation of K-252a |
| DE102004025726B4 (de) * | 2004-05-26 | 2006-07-06 | Roder, Hanno, Dr. | Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit |
| US20060058250A1 (en) * | 2004-09-10 | 2006-03-16 | Cephalon, Inc. | Methods of treating proliferative skin diseases using carbazole derivatives |
| US20080021013A1 (en) * | 2006-07-21 | 2008-01-24 | Cephalon, Inc. | JAK inhibitors for treatment of myeloproliferative disorders |
| AU2007334381B2 (en) * | 2006-12-14 | 2014-02-13 | Tautatis, Inc. | Compositions and methods for the treatment of cancer |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62155284A (ja) * | 1985-12-27 | 1987-07-10 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質ｋ−２５２の誘導体 |
| JPH0826036B2 (ja) | 1987-01-22 | 1996-03-13 | 協和醗酵工業株式会社 | 生理活性物質ｋ−２５２の誘導体 |
| US4923986A (en) * | 1987-03-09 | 1990-05-08 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of physiologically active substance K-252 |
| US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
| US5621100A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
| WO1994027982A1 (en) | 1993-05-28 | 1994-12-08 | Cephalon, Inc. | Use of indolocarbazole derivatives to treat a pathological condition of the prostate |
| US5468872A (en) * | 1993-09-16 | 1995-11-21 | Cephalon, Inc. | K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders |
| CA2170888A1 (en) * | 1994-07-04 | 1996-01-18 | Masahiko Kinugawa | Process for producing indolocarbazole derivative |
| AU6657596A (en) | 1995-07-31 | 1997-02-26 | Ciba-Geigy Ag | Trindene compounds |
| WO1997007081A2 (en) | 1995-08-11 | 1997-02-27 | Yale University | Glycosylated indolocarbazole synthesis |
-
1998
- 1998-12-30 JP JP2000526515A patent/JP4405667B2/ja not_active Expired - Fee Related
- 1998-12-30 PT PT98964309T patent/PT1044203E/pt unknown
- 1998-12-30 AT AT98964309T patent/ATE234308T1/de not_active IP Right Cessation
- 1998-12-30 KR KR1020007007260A patent/KR20010033737A/ko not_active Withdrawn
- 1998-12-30 US US09/223,518 patent/US6093713A/en not_active Expired - Lifetime
- 1998-12-30 WO PCT/US1998/027644 patent/WO1999033836A1/en not_active Ceased
- 1998-12-30 AU AU19474/99A patent/AU1947499A/en not_active Abandoned
- 1998-12-30 ES ES98964309T patent/ES2194385T3/es not_active Expired - Lifetime
- 1998-12-30 DE DE69812177T patent/DE69812177T2/de not_active Expired - Lifetime
- 1998-12-30 BR BR9814543-6A patent/BR9814543A/pt not_active Application Discontinuation
- 1998-12-30 DK DK98964309T patent/DK1044203T3/da active
- 1998-12-30 CN CN98812812A patent/CN1285836A/zh active Pending
- 1998-12-30 CA CA2315953A patent/CA2315953C/en not_active Expired - Fee Related
- 1998-12-30 EP EP98964309A patent/EP1044203B1/en not_active Expired - Lifetime
-
2000
- 2000-02-15 US US09/503,812 patent/US6451786B1/en not_active Expired - Fee Related
- 2000-06-29 NO NO20003397A patent/NO20003397L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2194385T3 (es) | 2003-11-16 |
| WO1999033836A9 (en) | 2000-09-14 |
| JP2001527079A (ja) | 2001-12-25 |
| DE69812177T2 (de) | 2004-01-15 |
| PT1044203E (pt) | 2003-07-31 |
| CN1285836A (zh) | 2001-02-28 |
| US6451786B1 (en) | 2002-09-17 |
| DK1044203T3 (da) | 2003-07-14 |
| AU1947499A (en) | 1999-07-19 |
| CA2315953A1 (en) | 1999-07-08 |
| JP4405667B2 (ja) | 2010-01-27 |
| WO1999033836A1 (en) | 1999-07-08 |
| CA2315953C (en) | 2010-11-09 |
| DE69812177D1 (de) | 2003-04-17 |
| US6093713A (en) | 2000-07-25 |
| EP1044203B1 (en) | 2003-03-12 |
| EP1044203A1 (en) | 2000-10-18 |
| NO20003397L (no) | 2000-08-31 |
| NO20003397D0 (no) | 2000-06-29 |
| BR9814543A (pt) | 2000-10-10 |
| ATE234308T1 (de) | 2003-03-15 |
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