DE69812177D1 - 3'-epi k-252a derivate - Google Patents
3'-epi k-252a derivateInfo
- Publication number
- DE69812177D1 DE69812177D1 DE69812177T DE69812177T DE69812177D1 DE 69812177 D1 DE69812177 D1 DE 69812177D1 DE 69812177 T DE69812177 T DE 69812177T DE 69812177 T DE69812177 T DE 69812177T DE 69812177 D1 DE69812177 D1 DE 69812177D1
- Authority
- DE
- Germany
- Prior art keywords
- epi
- derivatives
- compounds
- survival
- enhancement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- KOZFSFOOLUUIGY-IYYJOCMQSA-N k-252a, nocardiopsis sp. Chemical compound C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@@H]1C[C@](C(=O)OC)(O)[C@@]4(C)O1 KOZFSFOOLUUIGY-IYYJOCMQSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000002932 cholinergic neuron Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 230000001228 trophic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7026397P | 1997-12-31 | 1997-12-31 | |
PCT/US1998/027644 WO1999033836A1 (en) | 1997-12-31 | 1998-12-30 | 3'-epimeric k-252a derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69812177D1 true DE69812177D1 (de) | 2003-04-17 |
DE69812177T2 DE69812177T2 (de) | 2004-01-15 |
Family
ID=22094212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69812177T Expired - Lifetime DE69812177T2 (de) | 1997-12-31 | 1998-12-30 | 3'-epi k-252a derivate |
Country Status (15)
Country | Link |
---|---|
US (2) | US6093713A (de) |
EP (1) | EP1044203B1 (de) |
JP (1) | JP4405667B2 (de) |
KR (1) | KR20010033737A (de) |
CN (1) | CN1285836A (de) |
AT (1) | ATE234308T1 (de) |
AU (1) | AU1947499A (de) |
BR (1) | BR9814543A (de) |
CA (1) | CA2315953C (de) |
DE (1) | DE69812177T2 (de) |
DK (1) | DK1044203T3 (de) |
ES (1) | ES2194385T3 (de) |
NO (1) | NO20003397L (de) |
PT (1) | PT1044203E (de) |
WO (1) | WO1999033836A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2737102A (en) * | 2000-12-08 | 2002-06-18 | Ortho Mcneil Pharm Inc | Macroheterocylic compounds useful as kinase inhibitors |
DE60212836T2 (de) * | 2001-05-16 | 2007-01-25 | Gpc Biotech Ag | Pyridylpyrimidin-derivate als wirksame verbindungen gegen prionen-krankheiten |
US7018999B2 (en) | 2001-05-16 | 2006-03-28 | Cephalon, Inc. | Methods for the treatment and prevention of pain |
DE10161940A1 (de) * | 2001-12-17 | 2003-07-03 | Nad Ag | N-Carbacyclus-monosubstitutierte Indolocarbazole als Proteinkinase-inhibitoren |
US6723844B1 (en) * | 2003-02-27 | 2004-04-20 | Abbott Laboratories | Preparation of K-252a |
DE102004025726B4 (de) * | 2004-05-26 | 2006-07-06 | Roder, Hanno, Dr. | Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit |
US20060058250A1 (en) * | 2004-09-10 | 2006-03-16 | Cephalon, Inc. | Methods of treating proliferative skin diseases using carbazole derivatives |
US20080021013A1 (en) * | 2006-07-21 | 2008-01-24 | Cephalon, Inc. | JAK inhibitors for treatment of myeloproliferative disorders |
ATE544455T1 (de) * | 2006-12-14 | 2012-02-15 | Tautatis Inc | Zusammensetzungen und verfahren für die krebsbehandlung |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62155284A (ja) * | 1985-12-27 | 1987-07-10 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質k−252の誘導体 |
JPH0826036B2 (ja) | 1987-01-22 | 1996-03-13 | 協和醗酵工業株式会社 | 生理活性物質k−252の誘導体 |
DE3752123T2 (de) * | 1987-03-09 | 1998-05-14 | Kyowa Hakko Kogyo Kk | Derivate des physiologisch aktiven mittels k-252 |
US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
US5621100A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
KR100201343B1 (ko) | 1993-05-28 | 1999-06-15 | 바바라 에스 쉴버그 | 인돌로카르바졸 유도체들의 전립선의 병적상태치료에의 용도 |
US5468872A (en) * | 1993-09-16 | 1995-11-21 | Cephalon, Inc. | K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders |
CA2170888A1 (en) * | 1994-07-04 | 1996-01-18 | Masahiko Kinugawa | Process for producing indolocarbazole derivative |
WO1997005140A1 (en) | 1995-07-31 | 1997-02-13 | Novartis Ag | Trindene compounds |
WO1997007081A2 (en) | 1995-08-11 | 1997-02-27 | Yale University | Glycosylated indolocarbazole synthesis |
-
1998
- 1998-12-30 CN CN98812812A patent/CN1285836A/zh active Pending
- 1998-12-30 AU AU19474/99A patent/AU1947499A/en not_active Abandoned
- 1998-12-30 ES ES98964309T patent/ES2194385T3/es not_active Expired - Lifetime
- 1998-12-30 DK DK98964309T patent/DK1044203T3/da active
- 1998-12-30 CA CA2315953A patent/CA2315953C/en not_active Expired - Fee Related
- 1998-12-30 US US09/223,518 patent/US6093713A/en not_active Expired - Lifetime
- 1998-12-30 DE DE69812177T patent/DE69812177T2/de not_active Expired - Lifetime
- 1998-12-30 KR KR1020007007260A patent/KR20010033737A/ko not_active Application Discontinuation
- 1998-12-30 BR BR9814543-6A patent/BR9814543A/pt not_active Application Discontinuation
- 1998-12-30 EP EP98964309A patent/EP1044203B1/de not_active Expired - Lifetime
- 1998-12-30 PT PT98964309T patent/PT1044203E/pt unknown
- 1998-12-30 WO PCT/US1998/027644 patent/WO1999033836A1/en not_active Application Discontinuation
- 1998-12-30 JP JP2000526515A patent/JP4405667B2/ja not_active Expired - Fee Related
- 1998-12-30 AT AT98964309T patent/ATE234308T1/de not_active IP Right Cessation
-
2000
- 2000-02-15 US US09/503,812 patent/US6451786B1/en not_active Expired - Fee Related
- 2000-06-29 NO NO20003397A patent/NO20003397L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU1947499A (en) | 1999-07-19 |
EP1044203B1 (de) | 2003-03-12 |
BR9814543A (pt) | 2000-10-10 |
DK1044203T3 (da) | 2003-07-14 |
US6093713A (en) | 2000-07-25 |
JP4405667B2 (ja) | 2010-01-27 |
JP2001527079A (ja) | 2001-12-25 |
EP1044203A1 (de) | 2000-10-18 |
CA2315953A1 (en) | 1999-07-08 |
ATE234308T1 (de) | 2003-03-15 |
WO1999033836A9 (en) | 2000-09-14 |
US6451786B1 (en) | 2002-09-17 |
CA2315953C (en) | 2010-11-09 |
NO20003397L (no) | 2000-08-31 |
NO20003397D0 (no) | 2000-06-29 |
ES2194385T3 (es) | 2003-11-16 |
WO1999033836A1 (en) | 1999-07-08 |
KR20010033737A (ko) | 2001-04-25 |
PT1044203E (pt) | 2003-07-31 |
DE69812177T2 (de) | 2004-01-15 |
CN1285836A (zh) | 2001-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CU23126A3 (es) | Inhibicion de kinasa raf usando ureas heterociclicas sustituidas | |
DE69616480D1 (de) | Piperidinderivate als neurokininantagonisten | |
ES2175079T3 (es) | Derivados de indol utiles como inhibidores de cgmp-pde. | |
ATE302005T1 (de) | N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren | |
WO1999057117A3 (de) | Indolderivate und deren verwendung zur behandlung von malignen und anderen, auf pathologischen zellproliferationen beruhenden erkrankungen | |
ES2067813T3 (es) | Derivados substituidos de valinamida. | |
ATE302606T1 (de) | N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren | |
WO1992007830A3 (en) | Oxindole peptide antagonists | |
DE69623472D1 (de) | Derivate von dolastatin, dreen herstellung un verwendung | |
BR9608789A (pt) | Compostos de tetralina com atividade de mdr | |
YU19499A (sh) | Benzonaftiridini kao bronhijalni terapeutici | |
DE69722656D1 (de) | Bicyclische arylcarboxamide und ihre therapeutische verwendung | |
DE69715010D1 (de) | Ausgewählte k-252a derivate | |
DE69812177T2 (de) | 3'-epi k-252a derivate | |
BR0016553A (pt) | 2-(1h-indol-3-il)-2-oxo-acetamidas com atividades antitumor | |
IS4367A (is) | CCK eða gastrín temprandi 5-heterósýklísk-1,5-bensódíazepín | |
DE69623819D1 (de) | Furan- und thiophencarbothioamid derivate, deren herstellung und deren verwendung als inhibitoren der replikation von hiv-1 und hiv-1 mutanten | |
DE3584652D1 (de) | 2,2,6,6-tetramethyl-4-piperidinyl-derivate und ihre verwendung als lichtstabilisatoren. | |
MX9603477A (es) | Acido micofenolico 4-amino 6-sustituido y derivados con actividad inmunosupresora. | |
ATE198192T1 (de) | Benzolsulfonamidderivate, ihre herstellung und ihre therapeutische verwendung | |
BG105549A (en) | Use of n-substituted azabicycloalkane derivatives for treating diseases of the central nervous system | |
SU1786802A1 (ru) | 2,4-ДИМЕТИЛ-9-ОКСИПИРИДО[1,2-a]ПИРИМИДИНИЙХЛОРИД, ОБЛАДАЮЩИЙ АНТИДЕПРЕССИВНОЙ АКТИВНОСТЬЮ | |
DE59809929D1 (de) | 6-substituierte 1,2,4a,5a,8a,8b-hexahydro- und 1,2,3,4,4a,5a,8a,8b-oktahydro-6h-pyrrolo[3',4':4,5]furo[3,2-b]pyrid-8(7h)-on derivate und ihre verwendung zur bekämpfung von endoparasiten | |
MX9603483A (es) | Acido micofenolico 6-sustituido y derivados. | |
ES2151820A1 (es) | Herbicidas a base de derivados de 1,3-oxazin-4-ona, composiciones que los contienen y procedimiento para su preparacion. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |