KR20010032251A - 약물이 로딩된 분말 형태의 가교 폴리머를 포함하는약학적 조성물 및 초임계 유체를 이용한 이의 제조방법 - Google Patents

약물이 로딩된 분말 형태의 가교 폴리머를 포함하는약학적 조성물 및 초임계 유체를 이용한 이의 제조방법 Download PDF

Info

Publication number
KR20010032251A
KR20010032251A KR1020007005454A KR20007005454A KR20010032251A KR 20010032251 A KR20010032251 A KR 20010032251A KR 1020007005454 A KR1020007005454 A KR 1020007005454A KR 20007005454 A KR20007005454 A KR 20007005454A KR 20010032251 A KR20010032251 A KR 20010032251A
Authority
KR
South Korea
Prior art keywords
crosslinked
supercritical fluid
polymer
drug
pharmaceutical composition
Prior art date
Application number
KR1020007005454A
Other languages
English (en)
Korean (ko)
Inventor
카를리파비오
콜롬보이탈로
알레씨파올로
키킥이레네오
코르테시안젤로
Original Assignee
추후제출
유란드 인터내셔날 에스.피.아.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 추후제출, 유란드 인터내셔날 에스.피.아. filed Critical 추후제출
Publication of KR20010032251A publication Critical patent/KR20010032251A/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020007005454A 1997-11-19 1998-11-16 약물이 로딩된 분말 형태의 가교 폴리머를 포함하는약학적 조성물 및 초임계 유체를 이용한 이의 제조방법 KR20010032251A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT97MI002571A IT1296464B1 (it) 1997-11-19 1997-11-19 Composizioni farmaceutiche in forma di polveri di polimeri reticolati caricati con farmaci e relativo processo di preparazione mediante
ITMI97A002571 1997-11-19
PCT/EP1998/007311 WO1999025322A2 (en) 1997-11-19 1998-11-16 Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids

Publications (1)

Publication Number Publication Date
KR20010032251A true KR20010032251A (ko) 2001-04-16

Family

ID=11378230

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007005454A KR20010032251A (ko) 1997-11-19 1998-11-16 약물이 로딩된 분말 형태의 가교 폴리머를 포함하는약학적 조성물 및 초임계 유체를 이용한 이의 제조방법

Country Status (9)

Country Link
EP (1) EP1033977A2 (it)
JP (1) JP2001522873A (it)
KR (1) KR20010032251A (it)
AU (1) AU738748B2 (it)
BR (1) BR9814656A (it)
CA (1) CA2310423A1 (it)
IT (1) IT1296464B1 (it)
NZ (1) NZ505290A (it)
WO (1) WO1999025322A2 (it)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100508518B1 (ko) * 2002-11-13 2005-08-17 한미약품 주식회사 초임계유체 공정을 이용한 파클리탁셀 고체분산체의 제조방법 및 이 방법으로 제조된 파클리탁셀 고체분산체

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
AU2001240515A1 (en) * 2000-01-17 2001-07-31 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Method for modifying the surfaces of fine-porous adsorbents
IT1318404B1 (it) * 2000-03-17 2003-08-25 Eurand Int Processo per la preparazione di formulazioni a rilascio accelerato conimpiego di fluidi compressi.
EP1258241A1 (en) * 2001-05-16 2002-11-20 BIOPROGRESS S.p.A. Method of increasing the bioavailability of nimesulide
CH695418A5 (de) * 2001-05-30 2006-05-15 Csir Verfahren zur Einkapselung eines Wirkstoffs.
US20030044514A1 (en) * 2001-06-13 2003-03-06 Richard Robert E. Using supercritical fluids to infuse therapeutic on a medical device
DE10132366A1 (de) * 2001-07-04 2003-01-30 Degussa Verfahren zur physikalischen Behandlung von Stärke(-Derivaten)
FR2830760B1 (fr) 2001-10-12 2004-06-04 Pf Medicament Procede de preparation d'un compose d'interaction de substances actives avec un support poreux par fluide supercritique
GB0127786D0 (en) * 2001-11-20 2002-01-09 Univ Nottingham Impregnation of antimicrobial substances
AU2003218685A1 (en) * 2002-03-07 2003-09-16 Eurand Pharmaceuticals Ltd Process for loading and thermodynamically activating drugs on polymers by means of supercritical fluids
FR2854079B1 (fr) 2003-04-25 2007-11-30 Pf Medicament Procede de preparation de complexes moleculaires
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
EP1611877A1 (en) 2004-06-28 2006-01-04 Universidade de Coimbra Method for preparing sustained-release therapeutic ophthalmic articles using compressed fluids for impregnation of drugs
GB2417900A (en) * 2004-09-11 2006-03-15 Medway Science Technologies Lt Composition for oral drug delivery
BRPI0618499A2 (pt) * 2005-11-09 2011-09-06 Novartis Ag processo para produção de composições farmacêuticas com um plastificante transitório
GB0812742D0 (en) 2008-07-11 2008-08-20 Critical Pharmaceuticals Ltd Process
FR2945449B1 (fr) * 2009-05-15 2012-10-05 Pf Medicament Procede d'impregnation par co2 supercritique
CN105687141A (zh) * 2016-03-04 2016-06-22 中国药科大学 超临界抗溶剂法制备尼美舒利-左旋聚乳酸(Nim-PLLA)复合微球的工艺研究
CN112812355B (zh) * 2020-12-31 2022-09-23 厦门天生爱科技有限公司 一种具有缓释挥发性中草药有效成分的功能高分子发泡材料、制备方法和用途
CN113425895A (zh) * 2021-07-12 2021-09-24 大连大学 一种载药骨修复内固定材料及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE63321B1 (en) * 1986-02-03 1995-04-05 Elan Corp Plc Drug delivery system
FR2635043B1 (fr) * 1988-08-05 1990-09-28 Michelin & Cie Appareil de fabrication d'un renforcement pour pneumatiques, ledit renforcement etant constitue a partir d'un seul fil
CH677876A5 (en) * 1988-10-21 1991-07-15 Siegfried Ag Prepn. of coronary active 1,4-di:hydro-pyridine(s) in sorbed form - by pptn. on and/or in polyacrylate particles to improve bio-availability
IT1252867B (it) * 1991-12-31 1995-06-28 Gentili Ist Spa Composizioni farmaceutiche contenenti progesterone ad elevata biodisponibilita'
DE4202320A1 (de) * 1992-01-29 1993-08-05 Dierk Dr Knittel Verfahren zum impraegnieren von substraten
US5340614A (en) * 1993-02-11 1994-08-23 Minnesota Mining And Manufacturing Company Methods of polymer impregnation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100508518B1 (ko) * 2002-11-13 2005-08-17 한미약품 주식회사 초임계유체 공정을 이용한 파클리탁셀 고체분산체의 제조방법 및 이 방법으로 제조된 파클리탁셀 고체분산체

Also Published As

Publication number Publication date
JP2001522873A (ja) 2001-11-20
EP1033977A2 (en) 2000-09-13
WO1999025322A3 (en) 1999-08-19
CA2310423A1 (en) 1999-05-27
WO1999025322A2 (en) 1999-05-27
BR9814656A (pt) 2000-10-03
IT1296464B1 (it) 1999-06-25
ITMI972571A1 (it) 1999-05-19
NZ505290A (en) 2002-08-28
AU2153199A (en) 1999-06-07
AU738748B2 (en) 2001-09-27

Similar Documents

Publication Publication Date Title
KR20010032251A (ko) 약물이 로딩된 분말 형태의 가교 폴리머를 포함하는약학적 조성물 및 초임계 유체를 이용한 이의 제조방법
CA2462338C (en) Powder processing with pressurized gaseous fluids
Bleich et al. Production of drug loaded microparticles by the use of supercritical gases with the aerosol solvent extraction system (ASES) process
Girotra et al. Supercritical fluid technology: a promising approach in pharmaceutical research
JP4374249B2 (ja) 超臨界的流体による処理方法：タンパク質微粒子の調製およびそれらの安定化
Thies et al. Size controlled production of biodegradable microparticles with supercritical gases
ES2228148T3 (es) Metodo de produccion de particulas de farmacos.
AU2002334935A1 (en) Powder processing with pressurized gaseous fluids
Deshpande et al. Supercritical fluid technology: concepts and pharmaceutical applications
JP2004511530A (ja) ホスト分子に包接された活性成分からなる微細粒子の製造方法
JP2005514341A6 (ja) 超臨界的流体による処理方法：タンパク質微粒子の調製およびそれらの安定化
EP1572315B1 (en) Apparatus and method for the isolation of produced particles as a suspension in a non-supercritical fluid
BRPI0620038A2 (pt) composto orgánicos
JP2003517373A (ja) 顆粒床におけるパーコレーションによって微細粒子を捕集する方法
EP1341525B1 (en) Granulation process using halogenated hydrocarbon
Duarte et al. Applications of supercritical expansion processes for particle formation
Leboeuf et al. Current Trends of Supercritical Fluid Technology in Pharmaceutical, Nutraceutical and Food Processing Industries, 2010, 97-115 97

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid