NZ505290A - Pharmaceutical compositions comprising cross-linked polymers loaded with drugs prepared by using supercritical fluids to solubilize and load the drugs on to the polymers - Google Patents

Pharmaceutical compositions comprising cross-linked polymers loaded with drugs prepared by using supercritical fluids to solubilize and load the drugs on to the polymers

Info

Publication number
NZ505290A
NZ505290A NZ505290A NZ50529098A NZ505290A NZ 505290 A NZ505290 A NZ 505290A NZ 505290 A NZ505290 A NZ 505290A NZ 50529098 A NZ50529098 A NZ 50529098A NZ 505290 A NZ505290 A NZ 505290A
Authority
NZ
New Zealand
Prior art keywords
drugs
polymers
cross
pharmaceutical compositions
drug
Prior art date
Application number
NZ505290A
Inventor
Fabio Carli
Italo Colombo
Paolo Alessi
Ireneo Kikic
Angelo Cortesi
Original Assignee
Eurand Internat S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand Internat S filed Critical Eurand Internat S
Publication of NZ505290A publication Critical patent/NZ505290A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Pharmaceutical compositions in powder form are prepared by loading drugs solubilized in supercritical fluids on cross-linked polymers. The loading process is carried out by means of two steps. In the first step the supercritical fluid is saturated with the drug in suitable temperature and pressure conditions. In the second step the supercritical fluid containing the drug is contacted with the cross-linked polymer. Owing to its particular properties the supercritical fluid penetrates into the polymer and allows the drug to impregnate the polymer itself. After the removal of the fluid the drug remains in the polymer itself.
NZ505290A 1997-11-19 1998-11-16 Pharmaceutical compositions comprising cross-linked polymers loaded with drugs prepared by using supercritical fluids to solubilize and load the drugs on to the polymers NZ505290A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI002571A IT1296464B1 (en) 1997-11-19 1997-11-19 PHARMACEUTICAL COMPOSITIONS IN THE FORM OF DRUG-LOADED CROSS-LINKED POLYMER POWDERS AND RELATED PREPARATION PROCESS BY MEANS
PCT/EP1998/007311 WO1999025322A2 (en) 1997-11-19 1998-11-16 Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids

Publications (1)

Publication Number Publication Date
NZ505290A true NZ505290A (en) 2002-08-28

Family

ID=11378230

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ505290A NZ505290A (en) 1997-11-19 1998-11-16 Pharmaceutical compositions comprising cross-linked polymers loaded with drugs prepared by using supercritical fluids to solubilize and load the drugs on to the polymers

Country Status (9)

Country Link
EP (1) EP1033977A2 (en)
JP (1) JP2001522873A (en)
KR (1) KR20010032251A (en)
AU (1) AU738748B2 (en)
BR (1) BR9814656A (en)
CA (1) CA2310423A1 (en)
IT (1) IT1296464B1 (en)
NZ (1) NZ505290A (en)
WO (1) WO1999025322A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
EP1250189B1 (en) * 2000-01-17 2005-06-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for modifying the surfaces of fine-porous adsorbents
IT1318404B1 (en) * 2000-03-17 2003-08-25 Eurand Int PROCESS FOR THE PREPARATION OF FORMULATIONS WITH ACCELERATED RELEASE WITH THE USE OF COMPRESSED FLUIDS.
EP1258241A1 (en) * 2001-05-16 2002-11-20 BIOPROGRESS S.p.A. Method of increasing the bioavailability of nimesulide
ES2305250T3 (en) 2001-05-30 2008-11-01 Csir ENCAPSULATION PROCEDURE OF AN ACTIVE SUBSTANCE.
US20030044514A1 (en) * 2001-06-13 2003-03-06 Richard Robert E. Using supercritical fluids to infuse therapeutic on a medical device
DE10132366A1 (en) * 2001-07-04 2003-01-30 Degussa Process for the physical treatment of starch (derivatives)
FR2830760B1 (en) 2001-10-12 2004-06-04 Pf Medicament PROCESS FOR THE PREPARATION OF AN INTERACTION COMPOUND OF ACTIVE SUBSTANCES WITH A POROUS SUPPORT BY SUPERCRITICAL FLUID
GB0127786D0 (en) * 2001-11-20 2002-01-09 Univ Nottingham Impregnation of antimicrobial substances
DK1515699T3 (en) * 2002-03-07 2009-05-04 Eurand Pharmaceuticals Ltd Process for charge and thermodynamic activation of drugs on polymers by supercritical fluids
KR100508518B1 (en) * 2002-11-13 2005-08-17 한미약품 주식회사 Method for the preparation of paclitaxel solid dispersion by using the supercritical fluid process and paclitaxel solid dispersion prepared thereby
FR2854079B1 (en) 2003-04-25 2007-11-30 Pf Medicament PROCESS FOR THE PREPARATION OF MOLECULAR COMPLEXES
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
EP1611877A1 (en) 2004-06-28 2006-01-04 Universidade de Coimbra Method for preparing sustained-release therapeutic ophthalmic articles using compressed fluids for impregnation of drugs
GB2417900A (en) * 2004-09-11 2006-03-15 Medway Science Technologies Lt Composition for oral drug delivery
JP5284101B2 (en) * 2005-11-09 2013-09-11 ノバルティス アーゲー Method for producing pharmaceutical composition using temporary plasticizer
GB0812742D0 (en) 2008-07-11 2008-08-20 Critical Pharmaceuticals Ltd Process
FR2945449B1 (en) * 2009-05-15 2012-10-05 Pf Medicament SUPERCRITICAL CO2 IMPREGNATION PROCESS
CN105687141A (en) * 2016-03-04 2016-06-22 中国药科大学 Technical study for preparing Nim-PLLA (nimesulide-poly-l-lactic acid) composite microsphere with supercritical anti-solvent method
CN112812355B (en) * 2020-12-31 2022-09-23 厦门天生爱科技有限公司 Functional polymer foaming material with slow-release volatile Chinese herbal medicine effective components, preparation method and application
CN113425895A (en) * 2021-07-12 2021-09-24 大连大学 Drug-loaded bone repair internal fixation material and preparation method thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE63321B1 (en) * 1986-02-03 1995-04-05 Elan Corp Plc Drug delivery system
FR2635043B1 (en) * 1988-08-05 1990-09-28 Michelin & Cie APPARATUS FOR MANUFACTURING A REINFORCEMENT FOR TIRES, SAID REINFORCEMENT MADE FROM A SINGLE THREAD
CH677876A5 (en) * 1988-10-21 1991-07-15 Siegfried Ag Prepn. of coronary active 1,4-di:hydro-pyridine(s) in sorbed form - by pptn. on and/or in polyacrylate particles to improve bio-availability
IT1252867B (en) * 1991-12-31 1995-06-28 Gentili Ist Spa PHARMACEUTICAL COMPOSITIONS CONTAINING HIGH-BIOAVAILABILITY PROGESTERONE
DE4202320A1 (en) * 1992-01-29 1993-08-05 Dierk Dr Knittel Impregnating substrate by contact with supercritical fluid contg. impregnant - followed by conversion of fluid to subcritical state
US5340614A (en) * 1993-02-11 1994-08-23 Minnesota Mining And Manufacturing Company Methods of polymer impregnation

Also Published As

Publication number Publication date
WO1999025322A3 (en) 1999-08-19
CA2310423A1 (en) 1999-05-27
JP2001522873A (en) 2001-11-20
WO1999025322A2 (en) 1999-05-27
ITMI972571A1 (en) 1999-05-19
BR9814656A (en) 2000-10-03
EP1033977A2 (en) 2000-09-13
IT1296464B1 (en) 1999-06-25
AU2153199A (en) 1999-06-07
KR20010032251A (en) 2001-04-16
AU738748B2 (en) 2001-09-27

Similar Documents

Publication Publication Date Title
NZ505290A (en) Pharmaceutical compositions comprising cross-linked polymers loaded with drugs prepared by using supercritical fluids to solubilize and load the drugs on to the polymers
Dang et al. Morphological characterization of polyanhydride biodegradable implant Gliadel® during in vitro and in vivo erosion using scanning electron microscopy
Gutowska et al. Squeezing hydrogels for controlled oral drug delivery
CN100509858C (en) Cross-linked polysaccharide composition
EP1455832B1 (en) Pulsed bio-agent delivery systems based on in vivo degradable and swellable modified dextran hydrogels
CN100584314C (en) Composition having gelling properties for the prolonged delivery of bioactive substances
SE8503486D0 (en) CROSS-GELED GELES OF HYALURONIC ACID, METHOD FOR PREPARING SUDAN GELLS AND PRODUCTS CONTAINING SUDAN GEL
US5044091B1 (en) Method of preparing a freeze-dried formulation of a drug
US20050037079A1 (en) Temperature sensitive state-changing hydrogel composition and method for preparation
WO1995024430A3 (en) Block and graft copolymers and methods relating thereto
NZ218948A (en) Pharmaceutical preparations containing viscous gels for administration by syringe
JPH0269414A (en) Controlled release coating compound to biological substance
GT199900151A (en) DRUG CONTROLLED DELIVERY SYSTEM ORALALLY ADMINISTERED, PROVIDING TEMPORARY AND SPACE CONTROL.
MXPA02001243A (en) Means for creating a mass having structural integrity.
WO1997006787A3 (en) Controlled release products
IL149572A0 (en) Film preparation for biphasic release of pharmacologically active or other substances
DE69324442T2 (en) Medicinal compositions containing a drug, a cross-linked polymer, an oil, and a surfactant
PL329285A1 (en) Pharmaceutic tablets of controllable active substance release containing an active substance carrier based on crosslinked amylase and hydroxypropylmethylllcellulose
EP1036568A4 (en) Vacuum syringe and method of manufacturing the same
Hashim et al. Improving the release characteristics of water-soluble drugs from hydrophilic sustained release matrices by in situ gas generation
Wolff et al. In vitro and in vivo-release of nitroglycerin from a new transdermal therapeutic system
Clelik et al. Formulation and compaction of microspheres
US6074664A (en) Medicament form for the delivery of collagenase to wounds and process for the preparation thereof
Veiga et al. Oral controlled release dosage forms. II. Glassy polymers in hydrophilic matrices
AU4555993A (en) Cross-linked polyhydroxylic material for enzymatically controlled drug release

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)