ITMI972571A1 - PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CROSS-LINKED POLYMER POWDERS LOADED WITH DRUGS AND RELATED PROCESS OF PREPARATION BY MEANS OF SUPERCRITICAL FLUIDS - Google Patents

PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CROSS-LINKED POLYMER POWDERS LOADED WITH DRUGS AND RELATED PROCESS OF PREPARATION BY MEANS OF SUPERCRITICAL FLUIDS

Info

Publication number
ITMI972571A1
ITMI972571A1 IT002571A ITMI972571A ITMI972571A1 IT MI972571 A1 ITMI972571 A1 IT MI972571A1 IT 002571 A IT002571 A IT 002571A IT MI972571 A ITMI972571 A IT MI972571A IT MI972571 A1 ITMI972571 A1 IT MI972571A1
Authority
IT
Italy
Prior art keywords
drugs
preparation
cross
pharmaceutical compositions
linked polymer
Prior art date
Application number
IT002571A
Other languages
Italian (it)
Inventor
Paolo Alessi
Fabio Carli
Italo Colombo
Angelo Cortesi
Ireneo Kikic
Original Assignee
Vectorpharma Internat S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT97MI002571A priority Critical patent/IT1296464B1/en
Application filed by Vectorpharma Internat S P A filed Critical Vectorpharma Internat S P A
Priority to EP98965674A priority patent/EP1033977A2/en
Priority to JP2000520756A priority patent/JP2001522873A/en
Priority to BR9814656-4A priority patent/BR9814656A/en
Priority to CA002310423A priority patent/CA2310423A1/en
Priority to AU21531/99A priority patent/AU738748B2/en
Priority to NZ505290A priority patent/NZ505290A/en
Priority to KR1020007005454A priority patent/KR20010032251A/en
Priority to PCT/EP1998/007311 priority patent/WO1999025322A2/en
Publication of ITMI972571A1 publication Critical patent/ITMI972571A1/en
Application granted granted Critical
Publication of IT1296464B1 publication Critical patent/IT1296464B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
IT97MI002571A 1997-11-19 1997-11-19 PHARMACEUTICAL COMPOSITIONS IN THE FORM OF DRUG-LOADED CROSS-LINKED POLYMER POWDERS AND RELATED PREPARATION PROCESS BY MEANS IT1296464B1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT97MI002571A IT1296464B1 (en) 1997-11-19 1997-11-19 PHARMACEUTICAL COMPOSITIONS IN THE FORM OF DRUG-LOADED CROSS-LINKED POLYMER POWDERS AND RELATED PREPARATION PROCESS BY MEANS
JP2000520756A JP2001522873A (en) 1997-11-19 1998-11-16 Pharmaceutical compositions having crosslinked polymers in powder form bearing pharmaceuticals and related supercritical fluid preparation methods
BR9814656-4A BR9814656A (en) 1997-11-19 1998-11-16 Pharmaceutical compositions in the form of powders, and process for the preparation of pharmaceutical compositions
CA002310423A CA2310423A1 (en) 1997-11-19 1998-11-16 Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids
EP98965674A EP1033977A2 (en) 1997-11-19 1998-11-16 Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids
AU21531/99A AU738748B2 (en) 1997-11-19 1998-11-16 Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids
NZ505290A NZ505290A (en) 1997-11-19 1998-11-16 Pharmaceutical compositions comprising cross-linked polymers loaded with drugs prepared by using supercritical fluids to solubilize and load the drugs on to the polymers
KR1020007005454A KR20010032251A (en) 1997-11-19 1998-11-16 Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids
PCT/EP1998/007311 WO1999025322A2 (en) 1997-11-19 1998-11-16 Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI002571A IT1296464B1 (en) 1997-11-19 1997-11-19 PHARMACEUTICAL COMPOSITIONS IN THE FORM OF DRUG-LOADED CROSS-LINKED POLYMER POWDERS AND RELATED PREPARATION PROCESS BY MEANS

Publications (2)

Publication Number Publication Date
ITMI972571A1 true ITMI972571A1 (en) 1999-05-19
IT1296464B1 IT1296464B1 (en) 1999-06-25

Family

ID=11378230

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI002571A IT1296464B1 (en) 1997-11-19 1997-11-19 PHARMACEUTICAL COMPOSITIONS IN THE FORM OF DRUG-LOADED CROSS-LINKED POLYMER POWDERS AND RELATED PREPARATION PROCESS BY MEANS

Country Status (9)

Country Link
EP (1) EP1033977A2 (en)
JP (1) JP2001522873A (en)
KR (1) KR20010032251A (en)
AU (1) AU738748B2 (en)
BR (1) BR9814656A (en)
CA (1) CA2310423A1 (en)
IT (1) IT1296464B1 (en)
NZ (1) NZ505290A (en)
WO (1) WO1999025322A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
EP1250189B1 (en) * 2000-01-17 2005-06-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for modifying the surfaces of fine-porous adsorbents
IT1318404B1 (en) * 2000-03-17 2003-08-25 Eurand Int PROCESS FOR THE PREPARATION OF FORMULATIONS WITH ACCELERATED RELEASE WITH THE USE OF COMPRESSED FLUIDS.
EP1258241A1 (en) * 2001-05-16 2002-11-20 BIOPROGRESS S.p.A. Method of increasing the bioavailability of nimesulide
ES2305250T3 (en) 2001-05-30 2008-11-01 Csir ENCAPSULATION PROCEDURE OF AN ACTIVE SUBSTANCE.
US20030044514A1 (en) * 2001-06-13 2003-03-06 Richard Robert E. Using supercritical fluids to infuse therapeutic on a medical device
DE10132366A1 (en) * 2001-07-04 2003-01-30 Degussa Process for the physical treatment of starch (derivatives)
FR2830760B1 (en) 2001-10-12 2004-06-04 Pf Medicament PROCESS FOR THE PREPARATION OF AN INTERACTION COMPOUND OF ACTIVE SUBSTANCES WITH A POROUS SUPPORT BY SUPERCRITICAL FLUID
GB0127786D0 (en) * 2001-11-20 2002-01-09 Univ Nottingham Impregnation of antimicrobial substances
DK1515699T3 (en) * 2002-03-07 2009-05-04 Eurand Pharmaceuticals Ltd Process for charge and thermodynamic activation of drugs on polymers by supercritical fluids
KR100508518B1 (en) * 2002-11-13 2005-08-17 한미약품 주식회사 Method for the preparation of paclitaxel solid dispersion by using the supercritical fluid process and paclitaxel solid dispersion prepared thereby
FR2854079B1 (en) 2003-04-25 2007-11-30 Pf Medicament PROCESS FOR THE PREPARATION OF MOLECULAR COMPLEXES
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
EP1611877A1 (en) 2004-06-28 2006-01-04 Universidade de Coimbra Method for preparing sustained-release therapeutic ophthalmic articles using compressed fluids for impregnation of drugs
GB2417900A (en) * 2004-09-11 2006-03-15 Medway Science Technologies Lt Composition for oral drug delivery
JP5284101B2 (en) * 2005-11-09 2013-09-11 ノバルティス アーゲー Method for producing pharmaceutical composition using temporary plasticizer
GB0812742D0 (en) 2008-07-11 2008-08-20 Critical Pharmaceuticals Ltd Process
FR2945449B1 (en) * 2009-05-15 2012-10-05 Pf Medicament SUPERCRITICAL CO2 IMPREGNATION PROCESS
CN105687141A (en) * 2016-03-04 2016-06-22 中国药科大学 Technical study for preparing Nim-PLLA (nimesulide-poly-l-lactic acid) composite microsphere with supercritical anti-solvent method
CN112812355B (en) * 2020-12-31 2022-09-23 厦门天生爱科技有限公司 Functional polymer foaming material with slow-release volatile Chinese herbal medicine effective components, preparation method and application
CN113425895A (en) * 2021-07-12 2021-09-24 大连大学 Drug-loaded bone repair internal fixation material and preparation method thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE63321B1 (en) * 1986-02-03 1995-04-05 Elan Corp Plc Drug delivery system
FR2635043B1 (en) * 1988-08-05 1990-09-28 Michelin & Cie APPARATUS FOR MANUFACTURING A REINFORCEMENT FOR TIRES, SAID REINFORCEMENT MADE FROM A SINGLE THREAD
CH677876A5 (en) * 1988-10-21 1991-07-15 Siegfried Ag Prepn. of coronary active 1,4-di:hydro-pyridine(s) in sorbed form - by pptn. on and/or in polyacrylate particles to improve bio-availability
IT1252867B (en) * 1991-12-31 1995-06-28 Gentili Ist Spa PHARMACEUTICAL COMPOSITIONS CONTAINING HIGH-BIOAVAILABILITY PROGESTERONE
DE4202320A1 (en) * 1992-01-29 1993-08-05 Dierk Dr Knittel Impregnating substrate by contact with supercritical fluid contg. impregnant - followed by conversion of fluid to subcritical state
US5340614A (en) * 1993-02-11 1994-08-23 Minnesota Mining And Manufacturing Company Methods of polymer impregnation

Also Published As

Publication number Publication date
NZ505290A (en) 2002-08-28
WO1999025322A3 (en) 1999-08-19
CA2310423A1 (en) 1999-05-27
JP2001522873A (en) 2001-11-20
WO1999025322A2 (en) 1999-05-27
BR9814656A (en) 2000-10-03
EP1033977A2 (en) 2000-09-13
IT1296464B1 (en) 1999-06-25
AU2153199A (en) 1999-06-07
KR20010032251A (en) 2001-04-16
AU738748B2 (en) 2001-09-27

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Legal Events

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0001 Granted