BR9814656A - Pharmaceutical compositions in the form of powders, and process for the preparation of pharmaceutical compositions - Google Patents

Pharmaceutical compositions in the form of powders, and process for the preparation of pharmaceutical compositions

Info

Publication number
BR9814656A
BR9814656A BR9814656-4A BR9814656A BR9814656A BR 9814656 A BR9814656 A BR 9814656A BR 9814656 A BR9814656 A BR 9814656A BR 9814656 A BR9814656 A BR 9814656A
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
drug
polymer
preparation
supercritical fluid
Prior art date
Application number
BR9814656-4A
Other languages
Portuguese (pt)
Inventor
Fabio Carli
Italo Colombo
Paolo Alessi
Ireneo Kikic
Angelo Cortesi
Original Assignee
Eurand Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand Int filed Critical Eurand Int
Publication of BR9814656A publication Critical patent/BR9814656A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DAS COMPOSIçõES FARMACêUTICAS, E, COMPOSIçãO FARMACêUTICA". Composições farmacêuticas em forma de pó são preparadas através do carregamento das drogas solubilizadas em fluidos supercríticos sobre polímeros reticulados. O processo de carga é executado por meio de duas etapas. Na primeira etapa o fluido supercrítico é saturado com a droga em condições adequadas de temperatura e pressão. Na segunda etapa o fluido supercrítico contendo a droga é contatado com o polímero reticulado. Devido a suas propriedades particulares o fluido supercrítico penetra no polímero e permite a droga impregnar o polímero propriamente dito. Após a remoção do fluido a droga permanece no polímero propriamente dito."PROCESS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS, AND PHARMACEUTICAL COMPOSITION". Pharmaceutical compositions in powder form are prepared by loading drugs solubilized in supercritical fluids over cross-linked polymers. The loading process is carried out in two steps. In the first stage, the supercritical fluid is saturated with the drug under appropriate conditions of temperature and pressure. In the second stage, the supercritical fluid containing the drug is contacted with the cross-linked polymer. Due to its particular properties, the supercritical fluid penetrates the polymer and allows the drug to impregnate the polymer itself. After removing the fluid, the drug remains in the polymer itself.

BR9814656-4A 1997-11-19 1998-11-16 Pharmaceutical compositions in the form of powders, and process for the preparation of pharmaceutical compositions BR9814656A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI002571A IT1296464B1 (en) 1997-11-19 1997-11-19 PHARMACEUTICAL COMPOSITIONS IN THE FORM OF DRUG-LOADED CROSS-LINKED POLYMER POWDERS AND RELATED PREPARATION PROCESS BY MEANS
PCT/EP1998/007311 WO1999025322A2 (en) 1997-11-19 1998-11-16 Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids

Publications (1)

Publication Number Publication Date
BR9814656A true BR9814656A (en) 2000-10-03

Family

ID=11378230

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814656-4A BR9814656A (en) 1997-11-19 1998-11-16 Pharmaceutical compositions in the form of powders, and process for the preparation of pharmaceutical compositions

Country Status (9)

Country Link
EP (1) EP1033977A2 (en)
JP (1) JP2001522873A (en)
KR (1) KR20010032251A (en)
AU (1) AU738748B2 (en)
BR (1) BR9814656A (en)
CA (1) CA2310423A1 (en)
IT (1) IT1296464B1 (en)
NZ (1) NZ505290A (en)
WO (1) WO1999025322A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
ATE298266T1 (en) * 2000-01-17 2005-07-15 Fraunhofer Ges Forschung METHOD FOR MODIFYING THE SURFACES OF FINE POROUS ADSORBENTS
IT1318404B1 (en) * 2000-03-17 2003-08-25 Eurand Int PROCESS FOR THE PREPARATION OF FORMULATIONS WITH ACCELERATED RELEASE WITH THE USE OF COMPRESSED FLUIDS.
EP1258241A1 (en) * 2001-05-16 2002-11-20 BIOPROGRESS S.p.A. Method of increasing the bioavailability of nimesulide
CN1255099C (en) * 2001-05-30 2006-05-10 South African Scientific and Industrial Research Center Method for encapsulating active substance
US20030044514A1 (en) * 2001-06-13 2003-03-06 Richard Robert E. Using supercritical fluids to infuse therapeutic on a medical device
DE10132366A1 (en) * 2001-07-04 2003-01-30 Degussa Process for the physical treatment of starch (derivatives)
FR2830760B1 (en) 2001-10-12 2004-06-04 Pf Medicament PROCESS FOR THE PREPARATION OF AN INTERACTION COMPOUND OF ACTIVE SUBSTANCES WITH A POROUS SUPPORT BY SUPERCRITICAL FLUID
GB0127786D0 (en) * 2001-11-20 2002-01-09 Univ Nottingham Impregnation of antimicrobial substances
ATE422156T1 (en) * 2002-03-07 2009-02-15 Eurand Pharmaceuticals Ltd METHOD FOR LOADING AND THERMODYNAMIC ACTIVATION OF DRUGS ON POLYMERS USING SUPERCRITICAL LIQUIDS
KR100508518B1 (en) * 2002-11-13 2005-08-17 한미약품 주식회사 Method for the preparation of paclitaxel solid dispersion by using the supercritical fluid process and paclitaxel solid dispersion prepared thereby
FR2854079B1 (en) 2003-04-25 2007-11-30 Pf Medicament PROCESS FOR THE PREPARATION OF MOLECULAR COMPLEXES
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
EP1611877A1 (en) 2004-06-28 2006-01-04 Universidade de Coimbra Method for preparing sustained-release therapeutic ophthalmic articles using compressed fluids for impregnation of drugs
GB2417900A (en) * 2004-09-11 2006-03-15 Medway Science Technologies Lt Composition for oral drug delivery
AU2006340003A1 (en) * 2005-11-09 2007-09-20 Novartis Ag Process for making pharmaceutical compositions with a transient plasticizer
GB0812742D0 (en) 2008-07-11 2008-08-20 Critical Pharmaceuticals Ltd Process
FR2945449B1 (en) * 2009-05-15 2012-10-05 Pf Medicament SUPERCRITICAL CO2 IMPREGNATION PROCESS
CN105687141A (en) * 2016-03-04 2016-06-22 中国药科大学 Technical study for preparing Nim-PLLA (nimesulide-poly-l-lactic acid) composite microsphere with supercritical anti-solvent method
CN112812355B (en) * 2020-12-31 2022-09-23 厦门天生爱科技有限公司 Functional polymer foaming material with slow-release volatile Chinese herbal medicine effective components, preparation method and application
CN113425895A (en) * 2021-07-12 2021-09-24 大连大学 Drug-loaded bone repair internal fixation material and preparation method thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE63321B1 (en) * 1986-02-03 1995-04-05 Elan Corp Plc Drug delivery system
FR2635043B1 (en) * 1988-08-05 1990-09-28 Michelin & Cie APPARATUS FOR MANUFACTURING A REINFORCEMENT FOR TIRES, SAID REINFORCEMENT MADE FROM A SINGLE THREAD
CH677876A5 (en) * 1988-10-21 1991-07-15 Siegfried Ag Prepn. of coronary active 1,4-di:hydro-pyridine(s) in sorbed form - by pptn. on and/or in polyacrylate particles to improve bio-availability
IT1252867B (en) * 1991-12-31 1995-06-28 Gentili Ist Spa PHARMACEUTICAL COMPOSITIONS CONTAINING HIGH-BIOAVAILABILITY PROGESTERONE
DE4202320A1 (en) * 1992-01-29 1993-08-05 Dierk Dr Knittel Impregnating substrate by contact with supercritical fluid contg. impregnant - followed by conversion of fluid to subcritical state
US5340614A (en) * 1993-02-11 1994-08-23 Minnesota Mining And Manufacturing Company Methods of polymer impregnation

Also Published As

Publication number Publication date
WO1999025322A2 (en) 1999-05-27
CA2310423A1 (en) 1999-05-27
ITMI972571A1 (en) 1999-05-19
KR20010032251A (en) 2001-04-16
NZ505290A (en) 2002-08-28
AU738748B2 (en) 2001-09-27
WO1999025322A3 (en) 1999-08-19
AU2153199A (en) 1999-06-07
IT1296464B1 (en) 1999-06-25
JP2001522873A (en) 2001-11-20
EP1033977A2 (en) 2000-09-13

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1912 DE 28/08/2007.