AU2001266033A1 - Formulation based on heparin, glycosaminoglycan or heparinoid, use of the formulation and the formulation base - Google Patents
Formulation based on heparin, glycosaminoglycan or heparinoid, use of the formulation and the formulation baseInfo
- Publication number
- AU2001266033A1 AU2001266033A1 AU2001266033A AU6603301A AU2001266033A1 AU 2001266033 A1 AU2001266033 A1 AU 2001266033A1 AU 2001266033 A AU2001266033 A AU 2001266033A AU 6603301 A AU6603301 A AU 6603301A AU 2001266033 A1 AU2001266033 A1 AU 2001266033A1
- Authority
- AU
- Australia
- Prior art keywords
- formulation
- heparinoid
- glycosaminoglycan
- heparin
- formulations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
The present invention relates to formulations based on at least one heparin, glycosaminoglycan or heparinoid and on a formulation base with a lipid component and a polymer component. The use of this formulation as drug form for oral administration of at least one heparin, glycosaminoglycan or heparinoid, and also a process for producing the formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as drug form, advantageously using melt extrusion, are described. The lipid component advantageously has active ingredient-promoting properties, while the polymer component is soluble or swellable. At least parts of the lipid component are embedded in a polymer matrix, preferably in the form of a molecular dispersion. The formulations can form emulsions in water or aqueous liquids.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10026699A DE10026699A1 (en) | 2000-05-30 | 2000-05-30 | Formulation based on heparin, glycosaminoglycan or heparinoid and use of the formulation and the formulation base |
DE10026699 | 2000-05-30 | ||
PCT/EP2001/006115 WO2001091729A1 (en) | 2000-05-30 | 2001-05-29 | Formulation based on heparin, glycosaminoglycan or heparinoid, use of the formulation and the formulation base |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001266033A1 true AU2001266033A1 (en) | 2001-12-11 |
Family
ID=7644040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001266033A Abandoned AU2001266033A1 (en) | 2000-05-30 | 2001-05-29 | Formulation based on heparin, glycosaminoglycan or heparinoid, use of the formulation and the formulation base |
Country Status (13)
Country | Link |
---|---|
US (1) | US7393840B2 (en) |
EP (1) | EP1284717B1 (en) |
JP (1) | JP5198708B2 (en) |
CN (1) | CN100391440C (en) |
AT (1) | ATE349202T1 (en) |
AU (1) | AU2001266033A1 (en) |
BR (1) | BR0111257A (en) |
CA (1) | CA2409828C (en) |
DE (2) | DE10026699A1 (en) |
ES (1) | ES2278750T3 (en) |
NO (2) | NO20025755D0 (en) |
RU (1) | RU2278658C2 (en) |
WO (1) | WO2001091729A1 (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE329579T1 (en) * | 1999-11-12 | 2006-07-15 | Abbott Lab | SOLID DISPERSION WITH RITONAVIR, FENOFIBRATE OR GRISEOFULVIN |
US7364752B1 (en) | 1999-11-12 | 2008-04-29 | Abbott Laboratories | Solid dispersion pharamaceutical formulations |
DE10026698A1 (en) * | 2000-05-30 | 2001-12-06 | Basf Ag | Self-emulsifying active ingredient formulation and use of this formulation |
WO2002047696A1 (en) * | 2000-12-16 | 2002-06-20 | Aventis Pharma Deutschland Gmbh | Use of low molecular heparin for treating osteoarthritis |
GB0205868D0 (en) * | 2002-03-13 | 2002-04-24 | Univ Nottingham | Polymer composite with internally distributed deposition matter |
AU2003303301B2 (en) | 2002-05-03 | 2008-08-07 | Massachusetts Institute Of Technology | Delta4,5 glycuronidase and uses thereof |
SE0201922D0 (en) * | 2002-06-20 | 2002-06-20 | Ltp Lipid Technologies Provide | Anticoagulant Composition |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
CA2543617A1 (en) * | 2003-10-23 | 2005-05-12 | The University Of Nottingham | Preparing active polymer extrudates |
ES2297516T3 (en) * | 2003-12-02 | 2008-05-01 | Universiteit Gent | USE OF POLYSULPHATED ALGINATE IN CELLULAR MATRICES. |
EP1537871A1 (en) * | 2003-12-04 | 2005-06-08 | Aventis Pharma S.A. | Enoxaparin for the treatment of cancer |
US7563780B1 (en) * | 2004-06-18 | 2009-07-21 | Advanced Cardiovascular Systems, Inc. | Heparin prodrugs and drug delivery stents formed therefrom |
JP5258144B2 (en) * | 2004-12-21 | 2013-08-07 | 株式会社分子生理化学研究所 | Method for producing solid coenzyme Q10 oral preparation with improved absorbability |
US7691830B2 (en) * | 2005-02-17 | 2010-04-06 | Clive Elson | Method and composition for treatment of a mucosal tissue disorder |
MY148074A (en) * | 2005-05-10 | 2013-02-28 | Novartis Ag | Pharmaceutical compositions comprising imatinib and a release retardant |
US8802156B2 (en) | 2007-11-14 | 2014-08-12 | Laboratorios Farmacéuticos Rovi, S.A. | Pharmaceutical forms for the release of active compounds |
GB0812742D0 (en) | 2008-07-11 | 2008-08-20 | Critical Pharmaceuticals Ltd | Process |
US20110305658A1 (en) * | 2008-12-11 | 2011-12-15 | L'oreal S.A. | Lengthening mascara composition |
WO2010113176A2 (en) * | 2009-03-31 | 2010-10-07 | Reliance Life Sciences Pvt. Ltd. | Novel copolymers for controlled release delivery system |
ES2363964B1 (en) | 2009-11-20 | 2012-08-22 | Gp Pharm, S.A. | CAPSULES OF PHARMACEUTICAL ACTIVE PRINCIPLES AND ESTERS OF POLYINSATURATED FATTY ACIDS. |
WO2011088418A2 (en) * | 2010-01-15 | 2011-07-21 | Mount Sinai School Of Medicine | Inhibition of tnf-alpha induced activation of nfkb by pentosan polysulfate |
WO2014142938A1 (en) * | 2013-03-15 | 2014-09-18 | Aihol Corporation | Pharmaceutical formulation containing glycosaminoglycan |
US9539265B2 (en) | 2013-03-15 | 2017-01-10 | Aihol Corporation | Pharmaceutical formulation containing glycosaminoglycan |
US10897918B1 (en) * | 2013-03-15 | 2021-01-26 | Mccormick & Company, Incorporated | Extrusion encapsulation with narrow particle size and shape distribution, high solubility, and low surface oil |
JP6877996B2 (en) * | 2016-12-27 | 2021-05-26 | 小林製薬株式会社 | Topical composition |
JP6877997B2 (en) * | 2016-12-27 | 2021-05-26 | 小林製薬株式会社 | Topical composition |
CN113164430A (en) * | 2018-06-03 | 2021-07-23 | 格莱科米拉治疗公司 | Methods for preventing severe health consequences and/or tissue damage following exposure to ionizing radiation and/or chemotherapy |
WO2021050320A1 (en) * | 2019-09-09 | 2021-03-18 | Harrow Ip, Llc | Pharmaceutical compositions comprising heparinoids and methods for preparing thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1107041A (en) * | 1913-10-25 | 1914-08-11 | Benjamin H Cook | Coupling device. |
JPS58101311A (en) * | 1981-12-11 | 1983-06-16 | Toshiba Corp | Polyphase voltage and current converting circuit |
DE3331009A1 (en) * | 1983-08-27 | 1985-03-14 | Basf Ag, 6700 Ludwigshafen | METHOD FOR INCREASING THE ENTERAL RESORBABILITY OF HEPARIN OR. HEPARINOIDS AND THE SO AVAILABLE HEPARIN OR HEPARINOID PREPARATION |
JPS6054313A (en) * | 1983-09-01 | 1985-03-28 | Terumo Corp | Heparin composition absorbable through intestine |
EP0318512B1 (en) | 1986-08-18 | 1998-06-17 | Emisphere Technologies, Inc. | Delivery systems for pharmacological agents |
SE9200951D0 (en) * | 1992-03-27 | 1992-03-27 | Kabi Pharmacia Ab | PHARMACEUTICAL COMPOSITION CONTAINING A DEFINED LIPID SYSTEM |
US5346701A (en) * | 1993-02-22 | 1994-09-13 | Theratech, Inc. | Transmucosal delivery of macromolecular drugs |
SE9302135D0 (en) * | 1993-06-18 | 1993-06-18 | Kabi Pharmacia Ab | NEW PHARMACEUTICAL COMPOSITION |
CA2176927C (en) * | 1993-11-17 | 2010-03-23 | Seang H. Yiv | Transparent liquid for encapsulated drug delivery |
DE19531277A1 (en) | 1995-08-25 | 1997-02-27 | Basf Ag | Use of lipids as an aid in the production of solid dosage forms by the melt extrusion process |
FR2775188B1 (en) | 1998-02-23 | 2001-03-09 | Lipha | IMMEDIATE RELEASE ORAL EXTENDED RELEASE GALENIC FORM COMPRISING AN ABSORPTION PROMOTING AGENT AND USE OF THE ABSORPTION PROMOTING AGENT |
DE69917609T2 (en) | 1998-03-05 | 2005-06-09 | Phares Pharmaceutical Research N.V., Curaçao | MEDICINES AND ITS USE |
US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
US6309663B1 (en) * | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
-
2000
- 2000-05-30 DE DE10026699A patent/DE10026699A1/en not_active Withdrawn
-
2001
- 2001-05-29 US US10/296,441 patent/US7393840B2/en not_active Expired - Fee Related
- 2001-05-29 AU AU2001266033A patent/AU2001266033A1/en not_active Abandoned
- 2001-05-29 JP JP2001587745A patent/JP5198708B2/en not_active Expired - Fee Related
- 2001-05-29 CA CA2409828A patent/CA2409828C/en not_active Expired - Fee Related
- 2001-05-29 CN CNB018133312A patent/CN100391440C/en not_active Expired - Fee Related
- 2001-05-29 BR BR0111257-0A patent/BR0111257A/en not_active Application Discontinuation
- 2001-05-29 DE DE50111738T patent/DE50111738D1/en not_active Expired - Lifetime
- 2001-05-29 RU RU2002135623/15A patent/RU2278658C2/en not_active IP Right Cessation
- 2001-05-29 WO PCT/EP2001/006115 patent/WO2001091729A1/en active IP Right Grant
- 2001-05-29 ES ES01943457T patent/ES2278750T3/en not_active Expired - Lifetime
- 2001-05-29 AT AT01943457T patent/ATE349202T1/en not_active IP Right Cessation
- 2001-05-29 EP EP01943457A patent/EP1284717B1/en not_active Expired - Lifetime
-
2002
- 2002-11-29 NO NO20025755A patent/NO20025755D0/en unknown
- 2002-11-29 NO NO20025759A patent/NO20025759L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ES2278750T3 (en) | 2007-08-16 |
NO20025759L (en) | 2003-01-14 |
NO20025755D0 (en) | 2002-11-29 |
NO20025759D0 (en) | 2002-11-29 |
RU2278658C2 (en) | 2006-06-27 |
JP2003534370A (en) | 2003-11-18 |
DE50111738D1 (en) | 2007-02-08 |
WO2001091729A1 (en) | 2001-12-06 |
CN100391440C (en) | 2008-06-04 |
ATE349202T1 (en) | 2007-01-15 |
US7393840B2 (en) | 2008-07-01 |
CA2409828C (en) | 2010-08-03 |
JP5198708B2 (en) | 2013-05-15 |
CA2409828A1 (en) | 2001-12-06 |
BR0111257A (en) | 2003-06-10 |
CN1450891A (en) | 2003-10-22 |
EP1284717A1 (en) | 2003-02-26 |
EP1284717B1 (en) | 2006-12-27 |
DE10026699A1 (en) | 2001-12-06 |
US20030161884A1 (en) | 2003-08-28 |
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