KR20000064716A - 약학적으로유용한화합물 - Google Patents

약학적으로유용한화합물 Download PDF

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Publication number
KR20000064716A
KR20000064716A KR1019980707441A KR19980707441A KR20000064716A KR 20000064716 A KR20000064716 A KR 20000064716A KR 1019980707441 A KR1019980707441 A KR 1019980707441A KR 19980707441 A KR19980707441 A KR 19980707441A KR 20000064716 A KR20000064716 A KR 20000064716A
Authority
KR
South Korea
Prior art keywords
pyrazolo
bond
hydroxy
formula
methyl
Prior art date
Application number
KR1019980707441A
Other languages
English (en)
Korean (ko)
Inventor
존 밴틱
로저 보너트
피터 케이지
데이빗 도널드
마크 퍼버
시몬 허스트
매튜 페리
에이피온 필립스
Original Assignee
니콜라스 피터 비가르트 (니크 비가르트), 콜린 레드롭
아스트라 파마슈티칼스 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605803.7A external-priority patent/GB9605803D0/en
Priority claimed from GBGB9610474.0A external-priority patent/GB9610474D0/en
Priority claimed from GBGB9610894.9A external-priority patent/GB9610894D0/en
Priority claimed from GBGB9700862.7A external-priority patent/GB9700862D0/en
Application filed by 니콜라스 피터 비가르트 (니크 비가르트), 콜린 레드롭, 아스트라 파마슈티칼스 리미티드 filed Critical 니콜라스 피터 비가르트 (니크 비가르트), 콜린 레드롭
Publication of KR20000064716A publication Critical patent/KR20000064716A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019980707441A 1996-03-20 1997-03-20 약학적으로유용한화합물 KR20000064716A (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GBGB9605803.7A GB9605803D0 (en) 1996-03-20 1996-03-20 Pharmaceutically-active compound
GB9605803.7 1996-03-20
GB9610474.0 1996-05-18
GBGB9610474.0A GB9610474D0 (en) 1996-05-18 1996-05-18 Pharmaceutically active compounds
GB9610894.9 1996-05-24
GBGB9610894.9A GB9610894D0 (en) 1996-05-24 1996-05-24 Pharmaceutically useful compounds
GB9700862.7 1997-01-16
GBGB9700862.7A GB9700862D0 (en) 1997-01-16 1997-01-16 Pharmaceutically useful compounds
PCT/SE1997/000471 WO1997034893A1 (en) 1996-03-20 1997-03-20 Pharmaceutically useful compounds

Publications (1)

Publication Number Publication Date
KR20000064716A true KR20000064716A (ko) 2000-11-06

Family

ID=27451427

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019980707441A KR20000064716A (ko) 1996-03-20 1997-03-20 약학적으로유용한화합물

Country Status (19)

Country Link
EP (1) EP0888347A1 (xx)
JP (1) JP2000506884A (xx)
KR (1) KR20000064716A (xx)
CN (1) CN1218472A (xx)
AR (1) AR006520A1 (xx)
AU (1) AU712141B2 (xx)
BR (1) BR9708103A (xx)
CA (1) CA2247814A1 (xx)
CZ (1) CZ297798A3 (xx)
EE (1) EE9800298A (xx)
ID (1) ID16283A (xx)
IL (1) IL126271A0 (xx)
IS (1) IS4848A (xx)
NO (1) NO984290L (xx)
NZ (1) NZ331614A (xx)
PL (1) PL328921A1 (xx)
SK (1) SK118798A3 (xx)
TR (1) TR199801861T2 (xx)
WO (1) WO1997034893A1 (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10110749A1 (de) * 2001-03-07 2002-09-12 Bayer Ag Substituierte Aminodicarbonsäurederivate
JP2003002863A (ja) * 2001-06-25 2003-01-08 Nippon Soda Co Ltd 安息香酸類の製造方法および新規化合物
US6642249B2 (en) 2001-07-04 2003-11-04 Active Biotech Ab Immunomodulating compounds
SE0102404D0 (sv) * 2001-07-04 2001-07-04 Active Biotech Ab Novel immunomodulating compounds
DE10229762A1 (de) * 2002-07-03 2004-01-22 Aventis Pharma Deutschland Gmbh Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase
US7081456B2 (en) * 2002-11-22 2006-07-25 Active Biotech Ab Immunomodulatory compounds
WO2004055014A1 (en) * 2002-12-16 2004-07-01 Active Biotech Ab Tetracyclic immunomodulatory compounds
EA009680B1 (ru) * 2003-03-14 2008-02-28 Эвидекс Лимитед Иммуномодулирующие гетероциклические соединения
GB0325644D0 (en) 2003-11-04 2003-12-10 Avidex Ltd Immuno ihibitory pyrazolone compounds
CA2547518A1 (en) 2003-12-12 2005-06-30 Wyeth Quinolines useful in treating cardiovascular disease
FR2870239B1 (fr) * 2004-05-11 2006-06-16 Sanofi Synthelabo Derives de carbamate de 2h- ou 3h-benzo[e]indazol-1-yle, leur preparation et leur application en therapeutique.
GB0411770D0 (en) * 2004-05-26 2004-06-30 Avidex Ltd Immuno inhibitory heterocyclic compouds
JP4763697B2 (ja) * 2004-08-09 2011-08-31 メディジーン リミテッド Ｃｄ８０抑制剤としての免疫調整性オキソピラゾロシンノリン類
RS20090208A (xx) 2006-10-31 2010-06-30 Pfizer Products Inc. Pirazolin jedinjenja kao antagonisti mineralokortikoid receptora
CN102372710A (zh) * 2010-08-18 2012-03-14 山东轩竹医药科技有限公司 作为盐皮质激素受体拮抗剂的并环类化合物
EP2674423A4 (en) 2011-02-09 2014-07-30 Nissan Chemical Ind Ltd PYRAZONE DERIVATIVE AND PESTICIDES
CN112654396A (zh) * 2018-09-07 2021-04-13 默克专利股份公司 5-吗啉-4-基-吡唑并[4,3-b]吡啶衍生物
WO2021257863A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Pyrrolotriazine compounds as jak2 v617f inhibitors
US11691971B2 (en) 2020-06-19 2023-07-04 Incyte Corporation Naphthyridinone compounds as JAK2 V617F inhibitors
WO2022006456A1 (en) 2020-07-02 2022-01-06 Incyte Corporation Tricyclic pyridone compounds as jak2 v617f inhibitors
TW202216713A (zh) 2020-07-02 2022-05-01 美商英塞特公司 作為ｊａｋ２ ｖ６１７ｆ抑制劑之三環脲化合物
WO2022046989A1 (en) 2020-08-27 2022-03-03 Incyte Corporation Tricyclic urea compounds as jak2 v617f inhibitors
WO2022140231A1 (en) 2020-12-21 2022-06-30 Incyte Corporation Deazaguaine compounds as jak2 v617f inhibitors
US11958861B2 (en) 2021-02-25 2024-04-16 Incyte Corporation Spirocyclic lactams as JAK2 V617F inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524146A (en) * 1982-12-08 1985-06-18 Ciba-Geigy Corporation Certain -2-heterocycle substituted pyrazoloquinolines
JPS61112075A (ja) * 1984-11-05 1986-05-30 Shionogi & Co Ltd チエニルピラゾロキノリン誘導体
SE8903564D0 (sv) * 1989-10-26 1989-10-26 Pharmacia Ab New use condensed quinoline compound
JPH05194515A (ja) * 1991-07-31 1993-08-03 Kyowa Hakko Kogyo Co Ltd 縮合ナフチリジン誘導体

Also Published As

Publication number Publication date
CA2247814A1 (en) 1997-09-25
AU2186797A (en) 1997-10-10
ID16283A (id) 1997-09-18
IS4848A (is) 1998-09-16
IL126271A0 (en) 1999-05-09
BR9708103A (pt) 1999-07-27
AR006520A1 (es) 1999-09-08
CN1218472A (zh) 1999-06-02
NZ331614A (en) 2000-07-28
EP0888347A1 (en) 1999-01-07
JP2000506884A (ja) 2000-06-06
TR199801861T2 (xx) 1998-12-21
AU712141B2 (en) 1999-10-28
EE9800298A (et) 1999-02-15
NO984290L (no) 1998-10-27
NO984290D0 (no) 1998-09-16
SK118798A3 (en) 1999-03-12
CZ297798A3 (cs) 1999-03-17
PL328921A1 (en) 1999-03-01
WO1997034893A1 (en) 1997-09-25

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