KR19990022712A - ａＰＬ 면역반응성 펩티드, 그것의 콘주게이트 및 ａＰＬ항체-매개병변의 치료방법 - Google Patents
ａＰＬ 면역반응성 펩티드, 그것의 콘주게이트 및 ａＰＬ항체-매개병변의 치료방법Info
- Publication number
- KR19990022712A KR19990022712A KR1019970709154A KR19970709154A KR19990022712A KR 19990022712 A KR19990022712 A KR 19990022712A KR 1019970709154 A KR1019970709154 A KR 1019970709154A KR 19970709154 A KR19970709154 A KR 19970709154A KR 19990022712 A KR19990022712 A KR 19990022712A
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- apl
- phage
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- peptide
- binding
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Classifications
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- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
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- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
- A61K2039/645—Dendrimers; Multiple antigen peptides
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Mycology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US8/482651 | 1995-06-07 | ||
| US08/482,651 US5874409A (en) | 1995-06-07 | 1995-06-07 | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
Publications (1)
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|---|---|
| KR19990022712A true KR19990022712A (ko) | 1999-03-25 |
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| KR1019970709154A Ceased KR19990022712A (ko) | 1995-06-07 | 1996-06-06 | ａＰＬ 면역반응성 펩티드, 그것의 콘주게이트 및 ａＰＬ항체-매개병변의 치료방법 |
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| Country | Link |
|---|---|
| US (2) | US5874409A (enExample) |
| EP (1) | EP0833648A4 (enExample) |
| JP (1) | JPH11507822A (enExample) |
| KR (1) | KR19990022712A (enExample) |
| CN (1) | CN1326557C (enExample) |
| AU (1) | AU711192B2 (enExample) |
| CA (1) | CA2223687A1 (enExample) |
| WO (1) | WO1996040197A1 (enExample) |
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| US5268454A (en) * | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
| KR100361933B1 (ko) * | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
| US6410775B1 (en) | 1995-06-07 | 2002-06-25 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
| US5874409A (en) | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
| EP0954531A1 (en) * | 1996-06-06 | 1999-11-10 | Lajolla Pharmaceutical Company | aPL IMMUNOREACTIVE PEPTIDES, CONJUGATES THEREOF AND METHODS OF TREATMENT FOR aPL ANTIBODY-MEDIATED PATHOLOGIES |
| US5817752A (en) * | 1996-06-06 | 1998-10-06 | La Jolla Pharmaceutical Company | Cyclic polypeptides comprising a thioether linkage and methods for their preparation |
| US6812327B1 (en) * | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
| US8212004B2 (en) * | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
| US6858210B1 (en) | 1998-06-09 | 2005-02-22 | La Jolla Pharmaceutical Co. | Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same |
| US20050197283A1 (en) * | 1998-10-04 | 2005-09-08 | Vascular Biogenics Ltd. | Compositions containing beta 2-glycoprotein I for the prevention and/or treatment of vascular disease |
| IL126447A (en) * | 1998-10-04 | 2004-09-27 | Vascular Biogenics Ltd | An immune preparation that confers tolerance in oral administration and its use in the prevention and / or treatment of atherosclerosis |
| US6458953B1 (en) | 1998-12-09 | 2002-10-01 | La Jolla Pharmaceutical Company | Valency platform molecules comprising carbamate linkages |
| US6399578B1 (en) | 1998-12-09 | 2002-06-04 | La Jolla Pharmaceutical Company | Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same |
| US20010010818A1 (en) * | 1998-12-09 | 2001-08-02 | Engle Steven B. | Methods and formulations for reducing circulating antibodies |
| CA2376057A1 (en) * | 1999-06-08 | 2000-12-14 | La Jolla Pharmaceutical Company | Valency platform molecules comprising aminooxy groups |
| AUPQ272699A0 (en) * | 1999-09-09 | 1999-09-30 | Unisearch Limited | Use of beta2GPI in diagnostic tests for autoimmune diseases |
| EP1233791A2 (en) | 1999-11-28 | 2002-08-28 | La Jolla Pharmaceutical Company | Methods of treating lupus based on antibody affinity and screening methods and compositions for use thereof |
| PT2857516T (pt) * | 2000-04-11 | 2017-08-28 | Genentech Inc | Anticorpos multivalentes e utilizações dos mesmos |
| AU2001268228A1 (en) | 2000-06-08 | 2001-12-17 | La Jolla Pharmaceutical Company | Multivalent platform molecules comprising high molecular weight polyethylene oxide |
| KR20060088905A (ko) * | 2000-06-16 | 2006-08-07 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 면역특이적으로 ＢＬｙＳ에 결합하는 항체 |
| US7879328B2 (en) * | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
| EP2267015A3 (en) * | 2000-08-18 | 2011-04-20 | Human Genome Sciences, Inc. | Binding polypeptides for B lymphocyte stimulator protein (BLyS) |
| US20030091565A1 (en) * | 2000-08-18 | 2003-05-15 | Beltzer James P. | Binding polypeptides and methods based thereon |
| US7319012B2 (en) * | 2001-05-30 | 2008-01-15 | Gene Therapy Systems, Inc. | Protein arrays and methods and systems for producing the same |
| AU2002345847B2 (en) | 2001-06-21 | 2008-05-29 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same |
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| EP0954531A1 (en) | 1996-06-06 | 1999-11-10 | Lajolla Pharmaceutical Company | aPL IMMUNOREACTIVE PEPTIDES, CONJUGATES THEREOF AND METHODS OF TREATMENT FOR aPL ANTIBODY-MEDIATED PATHOLOGIES |
| CN1225015A (zh) * | 1996-06-06 | 1999-08-04 | 拉卓拉药物公司 | aPL免疫反应性肽、其缀合物以及aPL抗体介导的疾病的治疗方法 |
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1995
- 1995-06-07 US US08/482,651 patent/US5874409A/en not_active Expired - Fee Related
-
1996
- 1996-06-06 KR KR1019970709154A patent/KR19990022712A/ko not_active Ceased
- 1996-06-06 JP JP9502123A patent/JPH11507822A/ja active Pending
- 1996-06-06 AU AU62710/96A patent/AU711192B2/en not_active Ceased
- 1996-06-06 WO PCT/US1996/009976 patent/WO1996040197A1/en not_active Ceased
- 1996-06-06 CN CNB96196006XA patent/CN1326557C/zh not_active Expired - Fee Related
- 1996-06-06 US US08/660,092 patent/US6207160B1/en not_active Expired - Fee Related
- 1996-06-06 CA CA002223687A patent/CA2223687A1/en not_active Abandoned
- 1996-06-06 EP EP96921498A patent/EP0833648A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11507822A (ja) | 1999-07-13 |
| WO1996040197A1 (en) | 1996-12-19 |
| AU711192B2 (en) | 1999-10-07 |
| CN1326557C (zh) | 2007-07-18 |
| CN1192153A (zh) | 1998-09-02 |
| EP0833648A1 (en) | 1998-04-08 |
| US5874409A (en) | 1999-02-23 |
| CA2223687A1 (en) | 1996-12-19 |
| AU6271096A (en) | 1996-12-30 |
| EP0833648A4 (en) | 1999-10-13 |
| US6207160B1 (en) | 2001-03-27 |
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