KR102976378B1 - 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도 - Google Patents

결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도

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Publication number
KR102976378B1
KR102976378B1 KR1020247029228A KR20247029228A KR102976378B1 KR 102976378 B1 KR102976378 B1 KR 102976378B1 KR 1020247029228 A KR1020247029228 A KR 1020247029228A KR 20247029228 A KR20247029228 A KR 20247029228A KR 102976378 B1 KR102976378 B1 KR 102976378B1
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antibody
nivolumab
ctla
patients
tumor
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KR1020247029228A
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Korean (ko)
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KR20240134249A (ko
Inventor
마이클 액셀슨
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브리스톨-마이어스 스큅 컴퍼니
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Priority to KR1020267018101A priority Critical patent/KR20260093438A/ko
Publication of KR20240134249A publication Critical patent/KR20240134249A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020247029228A 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도 Active KR102976378B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020267018101A KR20260093438A (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662345662P 2016-06-03 2016-06-03
US62/345,662 2016-06-03
KR1020237010151A KR102702675B1 (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도
PCT/US2017/035822 WO2017210637A1 (en) 2016-06-03 2017-06-02 Use of anti-pd-1 antibody in the treatment of patients with colorectal cancer

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020237010151A Division KR102702675B1 (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020267018101A Division KR20260093438A (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도

Publications (2)

Publication Number Publication Date
KR20240134249A KR20240134249A (ko) 2024-09-06
KR102976378B1 true KR102976378B1 (ko) 2026-06-11

Family

ID=59078186

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020247029228A Active KR102976378B1 (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도
KR1020187038115A Active KR102515509B1 (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도
KR1020237010151A Active KR102702675B1 (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도
KR1020267018101A Pending KR20260093438A (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR1020187038115A Active KR102515509B1 (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도
KR1020237010151A Active KR102702675B1 (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도
KR1020267018101A Pending KR20260093438A (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도

Country Status (7)

Country Link
US (3) US11332529B2 (enExample)
EP (2) EP3988570A1 (enExample)
JP (3) JP2019517512A (enExample)
KR (4) KR102976378B1 (enExample)
CN (1) CN109476754A (enExample)
ES (1) ES2897964T3 (enExample)
WO (1) WO2017210637A1 (enExample)

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HRP20201334T1 (hr) * 2015-04-17 2020-11-27 Bristol-Myers Squibb Company Kompozicije koje sadrže kombinaciju ipilimumaba i nivolumaba
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GB201912107D0 (en) * 2019-08-22 2019-10-09 Amazentis Sa Combination
CN110656179A (zh) * 2019-10-29 2020-01-07 至本医疗科技（上海）有限公司 免疫敏感性预测的生物标志组成物及用途、试剂盒设备存储介质
AR122043A1 (es) * 2020-05-12 2022-08-03 Bristol Myers Squibb Co Dosificación y administración del anticuerpo anti-ctla-4 activable
CN113995835A (zh) * 2021-10-09 2022-02-01 山东新创生物科技有限公司 戈氏梭菌芽孢联合pd-1抗体的应用
JP2026502785A (ja) * 2022-10-31 2026-01-27 アジェナス インコーポレイテッド 抗ｃｔｌａ４抗体を用いて大腸癌を治療する方法
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Also Published As

Publication number Publication date
KR20190015406A (ko) 2019-02-13
KR20260093438A (ko) 2026-06-19
CN109476754A (zh) 2019-03-15
KR20240134249A (ko) 2024-09-06
EP3464373A1 (en) 2019-04-10
US20190153100A1 (en) 2019-05-23
US20250026831A1 (en) 2025-01-23
WO2017210637A1 (en) 2017-12-07
KR20230047498A (ko) 2023-04-07
JP7721494B2 (ja) 2025-08-12
EP3988570A1 (en) 2022-04-27
JP2023002567A (ja) 2023-01-10
JP2025143276A (ja) 2025-10-01
JP2019517512A (ja) 2019-06-24
KR102702675B1 (ko) 2024-09-05
KR102515509B1 (ko) 2023-03-28
US20220356254A1 (en) 2022-11-10
US11332529B2 (en) 2022-05-17
ES2897964T3 (es) 2022-03-03
EP3464373B1 (en) 2021-10-27

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