KR102959196B1 - 포스포-타우 항체 및 사용 방법 - Google Patents

포스포-타우 항체 및 사용 방법

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Publication number
KR102959196B1
KR102959196B1 KR1020247011209A KR20247011209A KR102959196B1 KR 102959196 B1 KR102959196 B1 KR 102959196B1 KR 1020247011209 A KR1020247011209 A KR 1020247011209A KR 20247011209 A KR20247011209 A KR 20247011209A KR 102959196 B1 KR102959196 B1 KR 102959196B1
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South Korea
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amino acid
sequence
acid sequence
antibody
seq
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Korean (ko)
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KR20240067082A (ko
Inventor
안드레아스 제로민
크리시 벤카트
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알즈패스, 인크.
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Priority to KR1020267013080A priority Critical patent/KR20260069776A/ko
Priority to KR1020257022547A priority patent/KR102888596B1/ko
Publication of KR20240067082A publication Critical patent/KR20240067082A/ko
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G01N2333/4704—Inhibitors; Supressors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96402—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals
    • G01N2333/96405—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general
    • G01N2333/96408—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general with EC number
    • G01N2333/96416—Aspartic endopeptidases (3.4.23)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/14—Post-translational modifications [PTMs] in chemical analysis of biological material phosphorylation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020247011209A 2021-09-09 2022-09-08 포스포-타우 항체 및 사용 방법 Active KR102959196B1 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020267013080A KR20260069776A (ko) 2021-09-09 2022-09-08 포스포-타우 항체 및 사용 방법
KR1020257022547A KR102888596B1 (ko) 2021-09-09 2022-09-08 포스포-타우 항체 및 사용 방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163242437P 2021-09-09 2021-09-09
US63/242,437 2021-09-09
PCT/US2022/042963 WO2023039107A2 (en) 2021-09-09 2022-09-08 Phospho-tau antibodies and methods of use

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1020257022547A Division KR102888596B1 (ko) 2021-09-09 2022-09-08 포스포-타우 항체 및 사용 방법
KR1020267013080A Division KR20260069776A (ko) 2021-09-09 2022-09-08 포스포-타우 항체 및 사용 방법

Publications (2)

Publication Number Publication Date
KR20240067082A KR20240067082A (ko) 2024-05-16
KR102959196B1 true KR102959196B1 (ko) 2026-04-30

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KR1020247011209A Active KR102959196B1 (ko) 2021-09-09 2022-09-08 포스포-타우 항체 및 사용 방법
KR1020257022547A Active KR102888596B1 (ko) 2021-09-09 2022-09-08 포스포-타우 항체 및 사용 방법
KR1020267013080A Pending KR20260069776A (ko) 2021-09-09 2022-09-08 포스포-타우 항체 및 사용 방법

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KR1020267013080A Pending KR20260069776A (ko) 2021-09-09 2022-09-08 포스포-타우 항체 및 사용 방법

Country Status (7)

Country Link
US (3) US12276671B2 (enExample)
EP (1) EP4399524A4 (enExample)
JP (3) JP7836885B2 (enExample)
KR (3) KR102959196B1 (enExample)
CN (1) CN118235043A (enExample)
CA (1) CA3231228A1 (enExample)
WO (1) WO2023039107A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3231228A1 (en) 2021-09-09 2023-03-16 Andreas Jeromin Phospho-tau antibodies and methods of use
CN122525130A (zh) * 2023-03-16 2026-08-07 阿尔茨帕斯公司 诊断和治疗神经退行性病症的方法
CN119470917A (zh) * 2024-11-14 2025-02-18 苏州智研医康医疗科技有限公司 一种检测人血中阿尔茨海默病相关蛋白的试剂盒及检测方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190169275A1 (en) 2012-08-16 2019-06-06 Ipierian, Inc. Methods of Treating a Tauopathy
CN112505322A (zh) 2020-10-16 2021-03-16 威海纽普生物技术有限公司 阿尔茨海默病标志物p-Tau217检测试剂盒及其制造方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4694778A (en) 1984-05-04 1987-09-22 Anicon, Inc. Chemical vapor deposition wafer boat
US20040219509A1 (en) 2001-08-20 2004-11-04 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7604956B2 (en) 2004-03-01 2009-10-20 Biotraces, Inc. Supersensitive immunoassays
WO2005113798A2 (en) 2004-04-15 2005-12-01 University Of Florida Research Foundation, Inc. Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining
AU2008352940B2 (en) 2007-12-19 2014-06-05 Singulex, Inc. Scanning analyzer for single molecule detection and methods of use
WO2010011506A2 (en) 2008-07-23 2010-01-28 The Washington University Risk factors and a therapeutic target for neurodegenerative disorders
WO2010144358A1 (en) 2009-06-08 2010-12-16 Singulex, Inc. Highly sensitive biomarker panels
KR20130043088A (ko) * 2010-02-09 2013-04-29 브리스톨-마이어스 스큅 컴퍼니 면역검정 표준물 및 검정내 보정 표준물을 사용한 임상 바이오마커의 측정
WO2012142300A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury resulting from a hypoxic event
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
GB201112056D0 (en) 2011-07-14 2011-08-31 Univ Leuven Kath Antibodies
JP6358953B2 (ja) 2011-10-07 2018-07-18 エーシー イミューン エス．エー． タウを認識するホスホ特異的抗体
CA2859665C (en) 2011-12-20 2024-05-21 Janssen Biotech, Inc. Anti-phf-tau antibodies and their uses
AR100978A1 (es) * 2014-06-26 2016-11-16 Hoffmann La Roche LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS
NZ775762A (en) * 2015-06-05 2025-02-28 Genentech Inc Anti-tau antibodies and methods of use
GB201518675D0 (en) * 2015-10-21 2015-12-02 Cellcap Technologies Ltd Detection of structural forms of proteins
US20180080945A1 (en) * 2016-09-20 2018-03-22 Nanosomix, Inc. Biomarkers and diagnostic methods for alzheimer's disease and other neurodegenerative disorders
KR102048987B1 (ko) * 2017-02-22 2019-11-27 한국과학기술연구원 신경퇴행성 장애의 진단을 위한 정보 제공 방법
JP7029718B2 (ja) * 2017-07-31 2022-03-04 国立研究開発法人量子科学技術研究開発機構 リン酸化タウタンパク質の測定方法
CN109932509B (zh) 2017-11-02 2021-08-24 和其瑞医药(南京)有限公司 检测或抑制细胞外游离mg53的方法和用途
CN111587123A (zh) 2017-11-09 2020-08-25 品通治疗有限公司 用于生成和使用人源化构象特异性磷酸化的τ抗体的方法和组合物
EP3752531A1 (en) 2018-02-14 2020-12-23 Kite Pharma, Inc. Anti-idiotypic antibodies directed to the antigen-binding portion of an bcma-binding molecule
WO2020105700A1 (ja) 2018-11-22 2020-05-28 富士レビオ株式会社 抗体コンジュゲート
KR102905634B1 (ko) 2019-05-31 2025-12-30 일라이 릴리 앤드 캄파니 인간 타우를 표적화하는 화합물 및 방법
US20210285965A1 (en) 2020-03-03 2021-09-16 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Proteomic screening for diseases
WO2022115705A2 (en) 2020-11-30 2022-06-02 Enigma Biointelligence, Inc. Non-invasive assessment of alzheimer's disease
TWI843040B (zh) 2021-01-11 2024-05-21 美商美國禮來大藥廠 抗N3pGlu類澱粉β抗體及其用途
CA3231228A1 (en) 2021-09-09 2023-03-16 Andreas Jeromin Phospho-tau antibodies and methods of use
CN122525130A (zh) 2023-03-16 2026-08-07 阿尔茨帕斯公司 诊断和治疗神经退行性病症的方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190169275A1 (en) 2012-08-16 2019-06-06 Ipierian, Inc. Methods of Treating a Tauopathy
CN112505322A (zh) 2020-10-16 2021-03-16 威海纽普生物技术有限公司 阿尔茨海默病标志物p-Tau217检测试剂盒及其制造方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Dabramo Cristina et al, Journal of Personalized Medicine, (2020.09.08.), Vol 10, No 3, pp 1-39.
Ercan Herbst Ebru et al, Acta Neuropathologica Communications, (2019.12.01.), Vol 7, No 1, pp1-19.
Triana Baltzer Gallen et al, Journal of Alzheimer Disease, (2020.10.13.), Vol 77, No 4, pp 1417-1430.

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EP4399524A2 (en) 2024-07-17
JP7836885B2 (ja) 2026-03-27
US12339290B2 (en) 2025-06-24
CA3231228A1 (en) 2023-03-16
JP2025137567A (ja) 2025-09-19
JP7828500B2 (ja) 2026-03-11
WO2023039107A3 (en) 2023-10-05
EP4399524A4 (en) 2025-10-08
JP2024534348A (ja) 2024-09-20
WO2023039107A2 (en) 2023-03-16
JP2026034506A (ja) 2026-02-27
KR20240067082A (ko) 2024-05-16
US20240360206A1 (en) 2024-10-31
US20250277799A1 (en) 2025-09-04
US20240353428A1 (en) 2024-10-24
KR20260069776A (ko) 2026-05-15
US12276671B2 (en) 2025-04-15
KR102888596B1 (ko) 2025-11-20
CN118235043A (zh) 2024-06-21
KR20250108128A (ko) 2025-07-15

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