KR102883631B1 - 감마-델타 t 세포 및 자연 살해 세포의 치료 제제 및 제조 및 사용 방법 - Google Patents

감마-델타 t 세포 및 자연 살해 세포의 치료 제제 및 제조 및 사용 방법

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KR102883631B1
KR102883631B1 KR1020217006025A KR20217006025A KR102883631B1 KR 102883631 B1 KR102883631 B1 KR 102883631B1 KR 1020217006025 A KR1020217006025 A KR 1020217006025A KR 20217006025 A KR20217006025 A KR 20217006025A KR 102883631 B1 KR102883631 B1 KR 102883631B1
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cells
delete delete
cell
delta
gamma
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콘세타 친타렐리
안젤리스 비아조 드
프랑코 로카텔리
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오스페달레 페디아트리코 밤비노 제수
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    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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KR1020217006025A 2018-07-26 2019-07-25 감마-델타 t 세포 및 자연 살해 세포의 치료 제제 및 제조 및 사용 방법 Active KR102883631B1 (ko)

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US201862703654P 2018-07-26 2018-07-26
US62/703,654 2018-07-26
PCT/EP2019/070125 WO2020021045A2 (en) 2018-07-26 2019-07-25 Therapeutic preparations of gamma-delta t cells and natural killer cells and methods for manufacture and use

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KR102883631B1 true KR102883631B1 (ko) 2025-11-10

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JP (2) JP7565271B2 (https=)
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CN (1) CN112912494B (https=)
AU (1) AU2019311290B2 (https=)
CA (1) CA3106056A1 (https=)
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Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11293021B1 (en) 2016-06-23 2022-04-05 Inscripta, Inc. Automated cell processing methods, modules, instruments, and systems
US9982279B1 (en) 2017-06-23 2018-05-29 Inscripta, Inc. Nucleic acid-guided nucleases
US10011849B1 (en) 2017-06-23 2018-07-03 Inscripta, Inc. Nucleic acid-guided nucleases
MX2019015505A (es) 2017-06-30 2020-07-28 Inscripta Inc Metodos, modulos, instrumentos y sistemas de procesamiento de celulas automatizados.
US10526598B2 (en) 2018-04-24 2020-01-07 Inscripta, Inc. Methods for identifying T-cell receptor antigens
US10858761B2 (en) 2018-04-24 2020-12-08 Inscripta, Inc. Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells
AU2019292919A1 (en) 2018-06-30 2021-03-11 Inscripta, Inc. Instruments, modules, and methods for improved detection of edited sequences in live cells
US11142740B2 (en) 2018-08-14 2021-10-12 Inscripta, Inc. Detection of nuclease edited sequences in automated modules and instruments
US11214781B2 (en) 2018-10-22 2022-01-04 Inscripta, Inc. Engineered enzyme
CN109517793B (zh) * 2018-11-30 2022-05-10 广州长峰生物技术有限公司 一种NK细胞和γδT细胞共培养的建立方法
CN113631713A (zh) 2019-03-25 2021-11-09 因思科瑞普特公司 酵母中的同时多重基因组编辑
US11001831B2 (en) 2019-03-25 2021-05-11 Inscripta, Inc. Simultaneous multiplex genome editing in yeast
AU2020288623A1 (en) 2019-06-06 2022-01-06 Inscripta, Inc. Curing for recursive nucleic acid-guided cell editing
US11203762B2 (en) 2019-11-19 2021-12-21 Inscripta, Inc. Methods for increasing observed editing in bacteria
EP4069851A4 (en) 2019-12-18 2023-11-22 Inscripta, Inc. Cascade/dcas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells
GB202000934D0 (en) * 2020-01-22 2020-03-04 Ucl Business Ltd Engineered immune cells
AU2021213705A1 (en) 2020-01-27 2022-06-16 Inscripta, Inc. Electroporation modules and instrumentation
US20210238535A1 (en) * 2020-02-02 2021-08-05 Inscripta, Inc. Automated production of car-expressing cells
WO2021221766A2 (en) * 2020-02-19 2021-11-04 Barron Annelise E A method of treating cancer by upregulating cathelicidin gene expression and infusing natural killer cells
CN115516085A (zh) * 2020-02-28 2022-12-23 Avm生物技术有限责任公司 淋巴细胞群体以及用于产生所述淋巴细胞群体的方法
US20210332388A1 (en) 2020-04-24 2021-10-28 Inscripta, Inc. Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
US11787841B2 (en) 2020-05-19 2023-10-17 Inscripta, Inc. Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli
WO2022060749A1 (en) 2020-09-15 2022-03-24 Inscripta, Inc. Crispr editing to embed nucleic acid landing pads into genomes of live cells
US11512297B2 (en) 2020-11-09 2022-11-29 Inscripta, Inc. Affinity tag for recombination protein recruitment
US20230414720A1 (en) * 2020-11-23 2023-12-28 University Of Florida Research Foundation, Incorporated Use of insulin-like growth factors with gamma-chain cytokines to induce homeostatic proliferation of lymphocytes
IT202000030266A1 (it) * 2020-12-10 2022-06-10 Ospedale Pediatrico Bambino Gesù Car t cells for treating cd19+, cd20+ or cd22+ tumors.
CN112501127B (zh) * 2020-12-21 2023-10-10 广东昭泰细胞生物科技有限公司 一种重编程nk细胞的培养方法
AU2021415461A1 (en) 2021-01-04 2023-08-17 Inscripta, Inc. Mad nucleases
US20240376451A1 (en) 2021-01-07 2024-11-14 Inscripta, Inc. Mad nucleases
US11884924B2 (en) 2021-02-16 2024-01-30 Inscripta, Inc. Dual strand nucleic acid-guided nickase editing
EP4334361A1 (en) 2021-05-05 2024-03-13 Immatics Biotechnologies GmbH Antigen binding proteins specifically binding prame
GB202115389D0 (en) * 2021-10-26 2021-12-08 XNK Therapeutics AB Methods
CN114107200B (zh) * 2021-11-29 2023-04-21 华东师范大学 一种高纯度CD56+γδT细胞及其制备方法和用途
KR20250079220A (ko) * 2022-10-10 2025-06-04 카이트 파마 인코포레이티드 렌티바이러스 벡터 형질감염을 사용한 신규한 대규모 car-t 면역 세포 제조 방법
CN115651903B (zh) * 2022-11-14 2023-03-17 四川新生命干细胞科技股份有限公司 高杀伤力的免疫细胞群及其培养方法、试剂组合物和应用
JP2025541237A (ja) * 2022-12-13 2025-12-18 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 免疫療法を強化するためのチェックポイントモジュレーター
ES3034332A1 (es) * 2025-05-21 2025-08-14 Univ Madrid Complutense Método de expansión selectiva in vitro y adquisición de fenotipo residente en tejido decélulas T Yo Vo1+ derivadas de sangre periférica

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1317108B1 (it) 2000-12-06 2003-05-26 Philogen Srl Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso.
JP2010220479A (ja) * 2007-06-15 2010-10-07 Medeinetto:Kk Nk細胞の培養方法及びnk細胞の利用
CN103635573B (zh) * 2011-05-19 2016-05-11 分子医学研究所 包含γδT细胞的淋巴细胞系、其组合物及生产方法
CA3197849A1 (en) * 2014-12-29 2016-07-07 Novartis Ag Methods of making chimeric antigen receptor-expressing cells
AU2016297014B2 (en) * 2015-07-21 2021-06-17 Novartis Ag Methods for improving the efficacy and expansion of immune cells
EP3454870A4 (en) * 2016-05-12 2020-03-04 Adicet Bio Inc. METHOD FOR SELECTIVE EXPANSION OF GAMMA DELTA T CELL POPULATIONS AND COMPOSITIONS THEREOF

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BMC Immunology, vol.16(61), pp.1~10(2015)*

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CN112912494A (zh) 2021-06-04
KR20210042119A (ko) 2021-04-16
AU2019311290B2 (en) 2025-11-27
CA3106056A1 (en) 2020-01-30
WO2020021045A3 (en) 2020-03-12
SG11202100320QA (en) 2021-02-25
EP3827074A2 (en) 2021-06-02
CN112912494B (zh) 2024-12-17
AU2019311290A1 (en) 2021-01-28
WO2020021045A2 (en) 2020-01-30
JP2025011150A (ja) 2025-01-23
JP2021532829A (ja) 2021-12-02
JP7565271B2 (ja) 2024-10-10
WO2020021045A9 (en) 2021-03-04

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