KR102817897B1 - γ-히드록시부티르산의 선택 아미드 및 알코올 오남용의 치료에서의 이의 용도 - Google Patents

γ-히드록시부티르산의 선택 아미드 및 알코올 오남용의 치료에서의 이의 용도 Download PDF

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KR102817897B1
KR102817897B1 KR1020187006231A KR20187006231A KR102817897B1 KR 102817897 B1 KR102817897 B1 KR 102817897B1 KR 1020187006231 A KR1020187006231 A KR 1020187006231A KR 20187006231 A KR20187006231 A KR 20187006231A KR 102817897 B1 KR102817897 B1 KR 102817897B1
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formula
compound
alcohol
treatment
acget61
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KR20180066033A (ko
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로베르토 카치아그리아
안토넬라 로체
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라보라토리오 파르마체우티코 치. 티. 에쎄. 에레. 엘레.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020187006231A 2015-08-04 2016-08-03 γ-히드록시부티르산의 선택 아미드 및 알코올 오남용의 치료에서의 이의 용도 Active KR102817897B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT102015000041820 2015-08-04
ITUB2015A002860A ITUB20152860A1 (it) 2015-08-04 2015-08-04 Selezionata amide dell?acido ?-idrossibutirrico e suoi usi nel trattamento dell?abuso da alcool
PCT/EP2016/068517 WO2017021438A1 (en) 2015-08-04 2016-08-03 SELECTED AMIDE OF γ -HYDROXYBUTYRIC ACID AND USES THEREOF IN THE TREATMENT OF ALCOHOL MISUSE

Publications (2)

Publication Number Publication Date
KR20180066033A KR20180066033A (ko) 2018-06-18
KR102817897B1 true KR102817897B1 (ko) 2025-06-05

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KR1020187006231A Active KR102817897B1 (ko) 2015-08-04 2016-08-03 γ-히드록시부티르산의 선택 아미드 및 알코올 오남용의 치료에서의 이의 용도

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US (1) US10336687B2 (enExample)
EP (1) EP3331853B1 (enExample)
JP (1) JP6832336B2 (enExample)
KR (1) KR102817897B1 (enExample)
CN (1) CN108026029B (enExample)
AU (1) AU2016302869B2 (enExample)
CA (1) CA2994599C (enExample)
CL (1) CL2018000282A1 (enExample)
CO (1) CO2018002428A2 (enExample)
DK (1) DK3331853T3 (enExample)
EA (1) EA033769B9 (enExample)
ES (1) ES2776628T3 (enExample)
GE (1) GEP20207107B (enExample)
IL (1) IL257314B (enExample)
IT (1) ITUB20152860A1 (enExample)
MX (1) MX2018001239A (enExample)
MY (1) MY185942A (enExample)
PH (1) PH12018550008A1 (enExample)
PL (1) PL3331853T3 (enExample)
PT (1) PT3331853T (enExample)
SM (1) SMT202000337T1 (enExample)
UA (1) UA121994C2 (enExample)
WO (1) WO2017021438A1 (enExample)
ZA (1) ZA201801402B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11878001B2 (en) 2017-07-31 2024-01-23 Novartis Ag Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use
AU2018310882C1 (en) 2017-07-31 2021-12-09 Novartis Ag Use of mavoglurant in the reduction of alcohol use or in preventing relapse into alcohol use
CN113185403A (zh) * 2021-07-02 2021-07-30 山东国邦药业有限公司 一种甲醚制备环丙胺中间体环丙甲酸甲酯的方法
WO2023126076A1 (en) * 2022-01-03 2023-07-06 Laboratorio Farmaceutico C.T. S.R.L. Medical use of an amide of y-hydroxybutyric acid in the treatment of fragile x syndrome

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006690A1 (en) 1996-08-09 1998-02-19 Laboratorio Farmaceutico C.T. S.R.L. USE OF η-HYDROXYBUTYRIC ACID AMIDES IN THE TREATMENT OF DRUG ADDICTION AND IN PARTICULAR OF ALCOHOLISM

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006690A1 (en) 1996-08-09 1998-02-19 Laboratorio Farmaceutico C.T. S.R.L. USE OF η-HYDROXYBUTYRIC ACID AMIDES IN THE TREATMENT OF DRUG ADDICTION AND IN PARTICULAR OF ALCOHOLISM

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Publication number Publication date
PL3331853T3 (pl) 2020-06-15
CO2018002428A2 (es) 2018-07-10
UA121994C2 (uk) 2020-08-25
EA201890419A1 (ru) 2018-07-31
PT3331853T (pt) 2020-02-25
US20180230086A1 (en) 2018-08-16
CA2994599C (en) 2023-08-29
BR112018002245A2 (pt) 2018-09-18
IL257314B (en) 2020-04-30
MY185942A (en) 2021-06-14
JP2018523644A (ja) 2018-08-23
JP6832336B2 (ja) 2021-02-24
GEAP202014717A (en) 2020-01-27
US10336687B2 (en) 2019-07-02
IL257314A (en) 2018-03-29
CN108026029B (zh) 2020-12-04
EA033769B1 (ru) 2019-11-22
ITUB20152860A1 (it) 2017-02-04
AU2016302869B2 (en) 2020-10-22
ZA201801402B (en) 2019-01-30
CA2994599A1 (en) 2017-02-09
EA033769B9 (ru) 2020-04-10
SMT202000337T1 (it) 2020-07-08
KR20180066033A (ko) 2018-06-18
GEP20207107B (en) 2020-05-11
ES2776628T3 (es) 2020-07-31
MX2018001239A (es) 2018-07-06
CL2018000282A1 (es) 2018-07-13
AU2016302869A1 (en) 2018-03-15
EP3331853A1 (en) 2018-06-13
PH12018550008A1 (en) 2018-07-09
CN108026029A (zh) 2018-05-11
DK3331853T3 (da) 2020-03-16
WO2017021438A1 (en) 2017-02-09
EP3331853B1 (en) 2019-12-11

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