EA033769B9 - Отселектированный амид -гидроксимасляной кислоты и его применения при лечении злоупотребления алкоголем - Google Patents

Отселектированный амид -гидроксимасляной кислоты и его применения при лечении злоупотребления алкоголем

Info

Publication number
EA033769B9
EA033769B9 EA201890419A EA201890419A EA033769B9 EA 033769 B9 EA033769 B9 EA 033769B9 EA 201890419 A EA201890419 A EA 201890419A EA 201890419 A EA201890419 A EA 201890419A EA 033769 B9 EA033769 B9 EA 033769B9
Authority
EA
Eurasian Patent Office
Prior art keywords
hydroxybutyric acid
treatment
alcohol misuse
selected amide
amide
Prior art date
Application number
EA201890419A
Other languages
English (en)
Other versions
EA033769B1 (ru
EA201890419A1 (ru
Inventor
Роберто Каччалья
Антонелла Локе
Original Assignee
Лабораторио Фармачеутико С.Т. С.Р.Л.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лабораторио Фармачеутико С.Т. С.Р.Л. filed Critical Лабораторио Фармачеутико С.Т. С.Р.Л.
Publication of EA201890419A1 publication Critical patent/EA201890419A1/ru
Publication of EA033769B1 publication Critical patent/EA033769B1/ru
Publication of EA033769B9 publication Critical patent/EA033769B9/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Изобретение относится к отселектированному амиду -гидроксимасляной кислоты формулы (I), способу его производства и применениям. Изобретение также включает фармацевтическую композицию, содержащую эффективное количество отселектированного соединения изобретения для применения в предупреждении или лечении наркотической зависимости, в особенности злоупотребления алкоголем, или алкогольной зависимости
EA201890419A 2015-08-04 2016-08-03 Отселектированный амид -гидроксимасляной кислоты и его применения при лечении злоупотребления алкоголем EA033769B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITUB2015A002860A ITUB20152860A1 (it) 2015-08-04 2015-08-04 Selezionata amide dell?acido ?-idrossibutirrico e suoi usi nel trattamento dell?abuso da alcool
PCT/EP2016/068517 WO2017021438A1 (en) 2015-08-04 2016-08-03 SELECTED AMIDE OF γ -HYDROXYBUTYRIC ACID AND USES THEREOF IN THE TREATMENT OF ALCOHOL MISUSE

Publications (3)

Publication Number Publication Date
EA201890419A1 EA201890419A1 (ru) 2018-07-31
EA033769B1 EA033769B1 (ru) 2019-11-22
EA033769B9 true EA033769B9 (ru) 2020-04-10

Family

ID=54542363

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201890419A EA033769B9 (ru) 2015-08-04 2016-08-03 Отселектированный амид -гидроксимасляной кислоты и его применения при лечении злоупотребления алкоголем

Country Status (23)

Country Link
US (1) US10336687B2 (ru)
EP (1) EP3331853B1 (ru)
JP (1) JP6832336B2 (ru)
KR (1) KR20180066033A (ru)
CN (1) CN108026029B (ru)
AU (1) AU2016302869B2 (ru)
CA (1) CA2994599C (ru)
CL (1) CL2018000282A1 (ru)
CO (1) CO2018002428A2 (ru)
DK (1) DK3331853T3 (ru)
EA (1) EA033769B9 (ru)
ES (1) ES2776628T3 (ru)
GE (1) GEP20207107B (ru)
IL (1) IL257314B (ru)
IT (1) ITUB20152860A1 (ru)
MX (1) MX2018001239A (ru)
MY (1) MY185942A (ru)
PH (1) PH12018550008A1 (ru)
PL (1) PL3331853T3 (ru)
PT (1) PT3331853T (ru)
UA (1) UA121994C2 (ru)
WO (1) WO2017021438A1 (ru)
ZA (1) ZA201801402B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110891564A (zh) * 2017-07-31 2020-03-17 诺华股份有限公司 玛沃谷兰在减少酒精使用或在预防复用酒精中的用途
US11878001B2 (en) 2017-07-31 2024-01-23 Novartis Ag Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use
CN113185403A (zh) * 2021-07-02 2021-07-30 山东国邦药业有限公司 一种甲醚制备环丙胺中间体环丙甲酸甲酯的方法
WO2023126076A1 (en) * 2022-01-03 2023-07-06 Laboratorio Farmaceutico C.T. S.R.L. Medical use of an amide of y-hydroxybutyric acid in the treatment of fragile x syndrome

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006690A1 (en) * 1996-08-09 1998-02-19 Laboratorio Farmaceutico C.T. S.R.L. USE OF η-HYDROXYBUTYRIC ACID AMIDES IN THE TREATMENT OF DRUG ADDICTION AND IN PARTICULAR OF ALCOHOLISM

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006690A1 (en) * 1996-08-09 1998-02-19 Laboratorio Farmaceutico C.T. S.R.L. USE OF η-HYDROXYBUTYRIC ACID AMIDES IN THE TREATMENT OF DRUG ADDICTION AND IN PARTICULAR OF ALCOHOLISM

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
L FERRARO, LOCHE A, BEGGIATO S, TOMASINI M C, ANTONELLI T, COLOMBO G, LOBINA C, CARAI M A M, PORCU A, CASTELLI M P, CLERICI F, BOR: "The New Compound GET73, N-[(4-trifluoromethyl)benzyl]4-metho- xybutyramide, Regulates Hippocampal Aminoacidergic Transmission Possibly Via an Allosteric Modulation of mGlu5 Receptor. Behavioural Evidence of its "Anti-Alcohol" and Anxiolytic Properties", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE, vol. 20, no. 27, 1 January 2013 (2013-01-01), pages 3339 - 3357, XP055330421 *

Also Published As

Publication number Publication date
GEP20207107B (en) 2020-05-11
UA121994C2 (uk) 2020-08-25
PH12018550008A1 (en) 2018-07-09
CN108026029A (zh) 2018-05-11
US10336687B2 (en) 2019-07-02
EA033769B1 (ru) 2019-11-22
MY185942A (en) 2021-06-14
AU2016302869B2 (en) 2020-10-22
CL2018000282A1 (es) 2018-07-13
MX2018001239A (es) 2018-07-06
ZA201801402B (en) 2019-01-30
EP3331853A1 (en) 2018-06-13
JP6832336B2 (ja) 2021-02-24
AU2016302869A1 (en) 2018-03-15
EP3331853B1 (en) 2019-12-11
CA2994599C (en) 2023-08-29
GEAP202014717A (en) 2020-01-27
CA2994599A1 (en) 2017-02-09
ES2776628T3 (es) 2020-07-31
IL257314B (en) 2020-04-30
BR112018002245A2 (pt) 2018-09-18
US20180230086A1 (en) 2018-08-16
WO2017021438A1 (en) 2017-02-09
ITUB20152860A1 (it) 2017-02-04
JP2018523644A (ja) 2018-08-23
PL3331853T3 (pl) 2020-06-15
DK3331853T3 (da) 2020-03-16
KR20180066033A (ko) 2018-06-18
CN108026029B (zh) 2020-12-04
PT3331853T (pt) 2020-02-25
EA201890419A1 (ru) 2018-07-31
CO2018002428A2 (es) 2018-07-10
IL257314A (en) 2018-03-29

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

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