BR112018002245A2 - amida selecionado do ácido g-hidroxybutírico e sua utilização no tratamento na dependência de álcool. - Google Patents

amida selecionado do ácido g-hidroxybutírico e sua utilização no tratamento na dependência de álcool.

Info

Publication number
BR112018002245A2
BR112018002245A2 BR112018002245-4A BR112018002245A BR112018002245A2 BR 112018002245 A2 BR112018002245 A2 BR 112018002245A2 BR 112018002245 A BR112018002245 A BR 112018002245A BR 112018002245 A2 BR112018002245 A2 BR 112018002245A2
Authority
BR
Brazil
Prior art keywords
hydroxybutyric acid
alcohol dependence
amide selected
dependence treatment
amide
Prior art date
Application number
BR112018002245-4A
Other languages
English (en)
Other versions
BR112018002245B1 (pt
Inventor
Cacciaglia Robert
Loche Antonella
Original Assignee
Laboratorio Farmaceutico C.T. S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorio Farmaceutico C.T. S.R.L. filed Critical Laboratorio Farmaceutico C.T. S.R.L.
Publication of BR112018002245A2 publication Critical patent/BR112018002245A2/pt
Publication of BR112018002245B1 publication Critical patent/BR112018002245B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

a presente invenção se refere a uma amida selecionada do ácido ¿-hidroxibutírico, um processo de fabricação e suas utilizações. a invenção também inclui uma composição farmacêutica compreendendo uma quantidade eficaz do composto selecionado da invenção para utilização na prevenção ou tratamento de dependência de drogas, especialmente, abuso ou dependência de álcool.
BR112018002245-4A 2015-08-04 2016-08-03 Composto amida selecionado do ácido ?-hidroxybutírico, processo para a preparação do referido composto, uso do referido composto e composição farmacêutica compreendendo o referido composto BR112018002245B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITUB2015A002860A ITUB20152860A1 (it) 2015-08-04 2015-08-04 Selezionata amide dell?acido ?-idrossibutirrico e suoi usi nel trattamento dell?abuso da alcool
IT102015000041820 2015-08-04
PCT/EP2016/068517 WO2017021438A1 (en) 2015-08-04 2016-08-03 SELECTED AMIDE OF γ -HYDROXYBUTYRIC ACID AND USES THEREOF IN THE TREATMENT OF ALCOHOL MISUSE

Publications (2)

Publication Number Publication Date
BR112018002245A2 true BR112018002245A2 (pt) 2018-09-18
BR112018002245B1 BR112018002245B1 (pt) 2023-07-11

Family

ID=

Also Published As

Publication number Publication date
ES2776628T3 (es) 2020-07-31
CN108026029B (zh) 2020-12-04
ITUB20152860A1 (it) 2017-02-04
EP3331853A1 (en) 2018-06-13
EA033769B1 (ru) 2019-11-22
JP6832336B2 (ja) 2021-02-24
CL2018000282A1 (es) 2018-07-13
KR20180066033A (ko) 2018-06-18
JP2018523644A (ja) 2018-08-23
GEP20207107B (en) 2020-05-11
MY185942A (en) 2021-06-14
EA201890419A1 (ru) 2018-07-31
PT3331853T (pt) 2020-02-25
CA2994599C (en) 2023-08-29
WO2017021438A1 (en) 2017-02-09
MX2018001239A (es) 2018-07-06
AU2016302869A1 (en) 2018-03-15
UA121994C2 (uk) 2020-08-25
US10336687B2 (en) 2019-07-02
ZA201801402B (en) 2019-01-30
PL3331853T3 (pl) 2020-06-15
PH12018550008A1 (en) 2018-07-09
GEAP202014717A (en) 2020-01-27
EP3331853B1 (en) 2019-12-11
AU2016302869B2 (en) 2020-10-22
CA2994599A1 (en) 2017-02-09
CO2018002428A2 (es) 2018-07-10
EA033769B9 (ru) 2020-04-10
CN108026029A (zh) 2018-05-11
IL257314A (en) 2018-03-29
US20180230086A1 (en) 2018-08-16
DK3331853T3 (da) 2020-03-16
IL257314B (en) 2020-04-30

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Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: LABORATORIO FARMACEUTICO C.T. S.R.L. (IT)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/08/2016, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REFERENTE A RPI 2740 DE 11/07/2023, QUANTO AO ITEM (54) TITULO E AO ITEM (72) NOME DO INVENTOR.