KR102811263B1 - 릴루졸의 설하 제제 - Google Patents

릴루졸의 설하 제제 Download PDF

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Publication number
KR102811263B1
KR102811263B1 KR1020237031525A KR20237031525A KR102811263B1 KR 102811263 B1 KR102811263 B1 KR 102811263B1 KR 1020237031525 A KR1020237031525 A KR 1020237031525A KR 20237031525 A KR20237031525 A KR 20237031525A KR 102811263 B1 KR102811263 B1 KR 102811263B1
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South Korea
Prior art keywords
disorders
riluzole
sublingual
disorder
disease
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KR1020237031525A
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Korean (ko)
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KR20230135183A (ko
Inventor
블라디미르 코릭
로버트 엠. 버만
로날드 사무엘 블라디카
암가드 살레
대니 유
Original Assignee
바이오하벤 파마슈티컬 홀딩 컴퍼니 엘티디.
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Publication of KR20230135183A publication Critical patent/KR20230135183A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020237031525A 2014-11-21 2015-11-17 릴루졸의 설하 제제 Active KR102811263B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462083094P 2014-11-21 2014-11-21
US62/083,094 2014-11-21
PCT/US2015/061114 WO2016081472A1 (en) 2014-11-21 2015-11-17 Sublingual formulation of riluzole
KR1020177016906A KR102580378B1 (ko) 2014-11-21 2015-11-17 릴루졸의 설하 제제

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020177016906A Division KR102580378B1 (ko) 2014-11-21 2015-11-17 릴루졸의 설하 제제

Publications (2)

Publication Number Publication Date
KR20230135183A KR20230135183A (ko) 2023-09-22
KR102811263B1 true KR102811263B1 (ko) 2025-05-23

Family

ID=55085882

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020237031525A Active KR102811263B1 (ko) 2014-11-21 2015-11-17 릴루졸의 설하 제제
KR1020177016906A Active KR102580378B1 (ko) 2014-11-21 2015-11-17 릴루졸의 설하 제제

Family Applications After (1)

Application Number Title Priority Date Filing Date
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Country Status (23)

Country Link
US (3) US11660267B2 (https=)
EP (3) EP4039247B1 (https=)
JP (3) JP6753860B2 (https=)
KR (2) KR102811263B1 (https=)
CN (1) CN107249567B (https=)
AU (2) AU2015350148B2 (https=)
BR (1) BR112017010423B1 (https=)
CY (1) CY1122469T1 (https=)
DK (1) DK3220891T3 (https=)
EA (1) EA038518B1 (https=)
ES (3) ES3060532T3 (https=)
HR (1) HRP20191892T8 (https=)
HU (1) HUE046869T2 (https=)
IL (2) IL278188B2 (https=)
LT (1) LT3220891T (https=)
MX (1) MX368838B (https=)
PH (1) PH12017500934B1 (https=)
PL (1) PL3220891T3 (https=)
PT (1) PT3220891T (https=)
RS (1) RS59490B1 (https=)
SG (1) SG11201703896QA (https=)
SI (1) SI3220891T1 (https=)
WO (1) WO2016081472A1 (https=)

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US12589097B2 (en) 2018-02-21 2026-03-31 OrphAl Therapeutics Inc. Apilimod compositions and methods of use
MX2020012377A (es) * 2018-05-27 2021-04-12 Biohaven Therapeutics Ltd Uso de tabletas de desintegracion orales de riluzol para el tratamiento de enfermedades.
US20210315865A1 (en) * 2018-08-16 2021-10-14 Biohaven Therapeutics Ltd. Use of riluzole oral disintigrating tablets for treating diseases
KR20220087482A (ko) * 2019-10-22 2022-06-24 아비나스 오퍼레이션스, 인코포레이티드 전립선암 치료 방법
CR20220630A (es) 2020-05-09 2023-01-23 Arvinas Operations Inc Métodos para fabricar un compuesto bifuncional, formas ultrapuras del compuesto bifuncional y formas de dosificación que comprenden el mismo
US20240016783A1 (en) * 2020-10-05 2024-01-18 Icahn School Of Medicine At Mount Sinai Riluzole for the treatment of alzheimer's disease
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CN115475145A (zh) * 2021-06-16 2022-12-16 山东新时代药业有限公司 一种利鲁唑分散片及其制备方法
CN113876735B (zh) * 2021-10-20 2023-05-12 陇南市第一人民医院 一种利鲁唑微球制剂及其制备方法
KR102625977B1 (ko) 2021-11-24 2024-01-17 부산대학교 산학협력단 리루졸을 유효성분으로 포함하는 염증성 장질환 예방 또는 치료용 조성물
TW202535392A (zh) 2023-12-08 2025-09-16 美商亞文納營運公司 使用雄性素受體降解劑治療脊髓延髓性肌肉萎縮

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EA201790958A1 (ru) 2018-01-31
EP4039247C0 (en) 2025-11-05
IL252285B (en) 2020-10-29
PT3220891T (pt) 2019-10-31
AU2015350148A1 (en) 2017-06-15
CN107249567A (zh) 2017-10-13
EP3616686B8 (en) 2021-06-23
DK3220891T3 (da) 2019-11-04
US20250114301A1 (en) 2025-04-10
LT3220891T (lt) 2019-11-11
PH12017500934B1 (en) 2024-06-28
US20210038499A1 (en) 2021-02-11
EP3220891B1 (en) 2019-07-24
RS59490B1 (sr) 2019-12-31
JP2023065398A (ja) 2023-05-12
EA038518B1 (ru) 2021-09-09
CA2967662A1 (en) 2016-05-26
MX368838B (es) 2019-10-18
HUE046869T2 (hu) 2020-04-28
AU2021201034B2 (en) 2023-07-06
BR112017010423A2 (pt) 2017-12-26
KR20170137032A (ko) 2017-12-12
BR112017010423B1 (pt) 2023-09-26
EP4039247A3 (en) 2022-11-16
AU2021201034A1 (en) 2021-03-11
IL278188B1 (en) 2024-11-01
US11660267B2 (en) 2023-05-30
ES2751300T3 (es) 2020-03-31
EP4039247B1 (en) 2025-11-05
CY1122469T1 (el) 2021-01-27
US12121609B2 (en) 2024-10-22
EP3616686A1 (en) 2020-03-04
CN107249567B (zh) 2021-08-03
EP3616686B1 (en) 2021-05-19
WO2016081472A1 (en) 2016-05-26
PH12017500934A1 (en) 2017-11-20
MX2017006446A (es) 2018-02-12
KR20230135183A (ko) 2023-09-22
JP6753860B2 (ja) 2020-09-09
HRP20191892T1 (hr) 2020-01-10
JP2017535613A (ja) 2017-11-30
KR102580378B1 (ko) 2023-09-19
IL278188A (en) 2020-11-30
SG11201703896QA (en) 2017-06-29
PL3220891T3 (pl) 2020-08-24
JP2021001173A (ja) 2021-01-07
ES2882783T3 (es) 2021-12-02
IL278188B2 (en) 2025-03-01
EP4039247A2 (en) 2022-08-10
EP3220891A1 (en) 2017-09-27
IL252285A0 (en) 2017-07-31
US20180153794A1 (en) 2018-06-07
SI3220891T1 (sl) 2020-02-28
ES3060532T3 (en) 2026-03-26
AU2015350148B2 (en) 2020-11-26
HRP20191892T8 (hr) 2020-09-18

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