KR102782810B1 - sGC 자극제의 결정질 형태 - Google Patents

sGC 자극제의 결정질 형태 Download PDF

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KR102782810B1
KR102782810B1 KR1020207028170A KR20207028170A KR102782810B1 KR 102782810 B1 KR102782810 B1 KR 102782810B1 KR 1020207028170 A KR1020207028170 A KR 1020207028170A KR 20207028170 A KR20207028170 A KR 20207028170A KR 102782810 B1 KR102782810 B1 KR 102782810B1
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ray powder
powder diffraction
diffraction peaks
angles
fluorobenzyl
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KR20200128708A (ko
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크웨임 더블유. 엔티-아대
리나 쿠마리 프라사드
토마스 스토르츠
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티센토 쎄라퓨틱스 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020207028170A 2018-03-07 2019-03-07 sGC 자극제의 결정질 형태 Active KR102782810B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862639846P 2018-03-07 2018-03-07
US62/639,846 2018-03-07
PCT/US2019/021080 WO2019173551A1 (en) 2018-03-07 2019-03-07 Crystalline forms of an sgc stimulator

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KR20200128708A KR20200128708A (ko) 2020-11-16
KR102782810B1 true KR102782810B1 (ko) 2025-03-14

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US (3) US11466015B2 (https=)
EP (1) EP3762389B1 (https=)
JP (1) JP7423539B2 (https=)
KR (1) KR102782810B1 (https=)
CN (1) CN111836812A (https=)
AU (1) AU2019231724B2 (https=)
BR (1) BR112020018212A2 (https=)
CA (1) CA3092683A1 (https=)
CL (5) CL2020002284A1 (https=)
CO (1) CO2020012493A2 (https=)
CR (1) CR20200458A (https=)
EA (1) EA202092109A1 (https=)
ES (1) ES2980256T3 (https=)
IL (1) IL276853B1 (https=)
MA (1) MA54638A (https=)
MX (5) MX2023004858A (https=)
PE (1) PE20210124A1 (https=)
PH (1) PH12020551394A1 (https=)
SG (1) SG11202008641WA (https=)
TW (1) TWI823903B (https=)
WO (1) WO2019173551A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019231724B2 (en) 2018-03-07 2024-06-27 Tisento Therapeutics Inc. Crystalline forms of an sGC stimulator
KR20210031931A (ko) * 2018-07-11 2021-03-23 사이클리온 테라퓨틱스, 인크. 미토콘드리아 장애의 치료를 위한 sGC 자극제의 용도
US20230130739A1 (en) * 2020-03-26 2023-04-27 Cyclerion Therapeutics, Inc. DEUTERATED sGC STIMULATORS
EP4640676A1 (en) * 2022-12-21 2025-10-29 Sunshine Lake Pharma Co., Ltd. Crystal form of fluorine-substituted indazole compound and use thereof
AU2023412238A1 (en) * 2022-12-21 2025-07-03 Sunshine Lake Pharma Co., Ltd. Crystal form of fluorine-substituted indazole compound and use thereof

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WO2015187470A1 (en) 2014-06-04 2015-12-10 Merck Sharp & Dohme Corp. Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators
JP2016533361A (ja) 2013-10-17 2016-10-27 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． ピラゾロピリジン化合物の固体形態
WO2018045276A1 (en) 2016-09-02 2018-03-08 Ironwood Pharmaceuticals, Inc. Fused bicyclic sgc stimulators

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JP2928079B2 (ja) 1994-02-14 1999-07-28 永信薬品工業股▲ふん▼有限公司 １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途
DE19744026A1 (de) 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
CN1332943C (zh) 1998-07-08 2007-08-22 萨诺费－阿文蒂斯德国有限公司 硫取代的磺酰基氨基羧酸n－芳基酰胺,其制备方法、用途以及含有该化合物的药物制剂
DE19830430A1 (de) 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
GB9824310D0 (en) 1998-11-05 1998-12-30 Univ London Activators of soluble guanylate cyclase
DE19942809A1 (de) 1999-09-08 2001-03-15 Bayer Ag Verfahren zur Herstellung substituierter Pyrimidinderivate
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10216145A1 (de) 2002-04-12 2003-10-23 Bayer Ag Verwendung von Stimulatoren der löslichen Guanylatcyclase zur Behandlung von Glaukom
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
KR20100059952A (ko) 2007-09-06 2010-06-04 머크 샤프 앤드 돔 코포레이션 가용성 구아닐레이트 사이클라제 활성제
WO2009094242A1 (en) 2008-01-24 2009-07-30 Merck & Co., Inc. Angiotensin ii receptor antagonists
AU2009322836B2 (en) 2008-11-25 2013-04-04 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
CN102414194A (zh) 2009-02-26 2012-04-11 默沙东公司 可溶性鸟苷酸环化酶激活剂
US9284301B2 (en) 2010-03-25 2016-03-15 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
UA107112C2 (uk) 2010-05-27 2014-11-25 Мерк Шарп Енд Доме Корп. Активатори розчинної гуанілатциклази
AR088020A1 (es) 2010-06-30 2014-05-07 Ironwood Pharmaceuticals Inc Compuestos heterociclicos como estimuladores de sgc
EP2632551B1 (en) 2010-10-28 2016-07-06 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
EP2637659B1 (en) 2010-11-09 2016-05-18 Ironwood Pharmaceuticals, Inc. Sgc stimulators
CA2891976C (en) 2012-11-30 2020-07-21 Astellas Pharma Inc. Imidazopyridine compounds
US9776997B2 (en) 2013-06-04 2017-10-03 Bayer Pharma Aktiengesellschaft 3-aryl-substituted imidazo[1,2-A]pyridines and their use
EP3194386A2 (en) 2014-09-17 2017-07-26 Ironwood Pharmaceuticals, Inc. Sgc stimulators
CN107257796A (zh) * 2014-12-02 2017-10-17 拜耳医药股份有限公司 取代的吡唑并[1,5‑a]吡啶和咪唑并[1,2‑a]吡嗪及其用途
AU2019231724B2 (en) 2018-03-07 2024-06-27 Tisento Therapeutics Inc. Crystalline forms of an sGC stimulator

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016533361A (ja) 2013-10-17 2016-10-27 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． ピラゾロピリジン化合物の固体形態
WO2015187470A1 (en) 2014-06-04 2015-12-10 Merck Sharp & Dohme Corp. Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators
WO2018045276A1 (en) 2016-09-02 2018-03-08 Ironwood Pharmaceuticals, Inc. Fused bicyclic sgc stimulators

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JP7423539B2 (ja) 2024-01-29
MX2023004856A (es) 2023-11-24
US20230095799A1 (en) 2023-03-30
MX2023004858A (es) 2023-11-24
US20250115611A1 (en) 2025-04-10
CR20200458A (es) 2020-11-09
AU2019231724B2 (en) 2024-06-27
CL2021003530A1 (es) 2022-08-19
KR20200128708A (ko) 2020-11-16
EP3762389B1 (en) 2024-02-28
IL276853B1 (en) 2026-01-01
MX2020009183A (es) 2020-10-08
CL2021003531A1 (es) 2022-08-19
CL2021003536A1 (es) 2022-08-19
MX2023004857A (es) 2023-11-24
CL2020002284A1 (es) 2020-11-27
TW201940487A (zh) 2019-10-16
CN111836812A (zh) 2020-10-27
WO2019173551A1 (en) 2019-09-12
PH12020551394A1 (en) 2021-11-22
MX2023004855A (es) 2023-11-24
CO2020012493A2 (es) 2020-10-30
CA3092683A1 (en) 2019-09-12
US12122782B2 (en) 2024-10-22
MA54638A (fr) 2021-11-10
TWI823903B (zh) 2023-12-01
BR112020018212A2 (pt) 2020-12-29
IL276853A (en) 2020-10-29
US11466015B2 (en) 2022-10-11
EP3762389A1 (en) 2021-01-13
PE20210124A1 (es) 2021-01-19
CL2021000301A1 (es) 2021-06-18
JP2021515015A (ja) 2021-06-17
US20210115050A1 (en) 2021-04-22
AU2019231724A1 (en) 2020-10-08
WO2019173551A8 (en) 2020-06-11
EA202092109A1 (ru) 2021-03-04
SG11202008641WA (en) 2020-10-29
ES2980256T3 (es) 2024-09-30

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