MX2023004855A - Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc). - Google Patents

Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).

Info

Publication number
MX2023004855A
MX2023004855A MX2023004855A MX2023004855A MX2023004855A MX 2023004855 A MX2023004855 A MX 2023004855A MX 2023004855 A MX2023004855 A MX 2023004855A MX 2023004855 A MX2023004855 A MX 2023004855A MX 2023004855 A MX2023004855 A MX 2023004855A
Authority
MX
Mexico
Prior art keywords
crystalline forms
sgc stimulator
present disclosure
sgc
stimulator
Prior art date
Application number
MX2023004855A
Other languages
English (en)
Inventor
Kwame W Nti-Addae
Thomas Storz
Leena Kumari Prasad
Original Assignee
Cyclerion Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cyclerion Therapeutics Inc filed Critical Cyclerion Therapeutics Inc
Publication of MX2023004855A publication Critical patent/MX2023004855A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente descripción se relaciona con formas cristalinas de 8-(2-fluorobencil)-6-(3-(trifluorometil)-1H-1,2,4-triazol-5-il)im idazo[1,2-a]pirazina, que son útiles como estimuladores de guanilato ciclasa soluble (sGC). La presente descripción también provee composiciones farmacéuticamente aceptables que comprenden las formas cristalinas y métodos para usar las composiciones en el tratamiento de diversas afecciones.
MX2023004855A 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc). MX2023004855A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862639846P 2018-03-07 2018-03-07
PCT/US2019/021080 WO2019173551A1 (en) 2018-03-07 2019-03-07 Crystalline forms of an sgc stimulator

Publications (1)

Publication Number Publication Date
MX2023004855A true MX2023004855A (es) 2023-11-24

Family

ID=65818696

Family Applications (5)

Application Number Title Priority Date Filing Date
MX2023004857A MX2023004857A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).
MX2023004858A MX2023004858A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).
MX2023004855A MX2023004855A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).
MX2023004856A MX2023004856A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).
MX2020009183A MX2020009183A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2023004857A MX2023004857A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).
MX2023004858A MX2023004858A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2023004856A MX2023004856A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).
MX2020009183A MX2020009183A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).

Country Status (20)

Country Link
US (2) US11466015B2 (es)
EP (1) EP3762389B1 (es)
JP (1) JP7423539B2 (es)
KR (1) KR20200128708A (es)
CN (1) CN111836812A (es)
AU (1) AU2019231724B2 (es)
BR (1) BR112020018212A2 (es)
CA (1) CA3092683A1 (es)
CL (5) CL2020002284A1 (es)
CO (1) CO2020012493A2 (es)
CR (1) CR20200458A (es)
EA (1) EA202092109A1 (es)
IL (1) IL276853A (es)
MA (1) MA54638A (es)
MX (5) MX2023004857A (es)
PE (1) PE20210124A1 (es)
PH (1) PH12020551394A1 (es)
SG (1) SG11202008641WA (es)
TW (1) TWI823903B (es)
WO (1) WO2019173551A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019301683A1 (en) * 2018-07-11 2021-02-11 Tisento Therapeutics Inc. Use of sGC stimulators for the treatment of mitochonrial disorders
WO2021195403A1 (en) * 2020-03-26 2021-09-30 Cyclerion Therapeutics, Inc. Deuterated sgc stimulators

Family Cites Families (22)

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JP2928079B2 (ja) 1994-02-14 1999-07-28 永信薬品工業股▲ふん▼有限公司 １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途
DE19744026A1 (de) 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
ID26773A (id) 1998-07-08 2001-02-08 Aventis Pharma Gmbh Sulfur tersubstitusi pada asam sulfonilaminokarboksilat n-arilamida, persiapan, penggunaan dan persiapan pembuatan obat yang menyertainya
DE19830430A1 (de) 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
GB9824310D0 (en) 1998-11-05 1998-12-30 Univ London Activators of soluble guanylate cyclase
DE19942809A1 (de) 1999-09-08 2001-03-15 Bayer Ag Verfahren zur Herstellung substituierter Pyrimidinderivate
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10216145A1 (de) 2002-04-12 2003-10-23 Bayer Ag Verwendung von Stimulatoren der löslichen Guanylatcyclase zur Behandlung von Glaukom
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
AU2008296974B2 (en) 2007-09-06 2013-10-10 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
JP2011510082A (ja) 2008-01-24 2011-03-31 メルク・シャープ・エンド・ドーム・コーポレイション アンジオテンシンｉｉ受容体拮抗薬
AU2009322836B2 (en) 2008-11-25 2013-04-04 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
BRPI1008793A2 (pt) 2009-02-26 2016-03-08 Merck Sharp & Dohme composto, uso de um composto, e, composição farmacêutica
WO2011119518A1 (en) 2010-03-25 2011-09-29 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
KR101499308B1 (ko) 2010-05-27 2015-03-05 머크 샤프 앤드 돔 코포레이션 가용성 구아닐레이트 시클라제 활성화제
WO2012058132A1 (en) 2010-10-28 2012-05-03 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
CN104327107A (zh) * 2013-10-17 2015-02-04 广东东阳光药业有限公司 一种氟喹诺酮类抗菌药物的制备方法
EP3152214B1 (en) * 2014-06-04 2020-01-29 Merck Sharp & Dohme Corp. Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators
EP3227286B1 (de) 2014-12-02 2018-12-26 Bayer Pharma Aktiengesellschaft Substituierte pyrazolo[1,5-a]pyridine und imidazo[1,2-a]pyrazine und ihre verwendung
SI3507291T1 (sl) * 2016-09-02 2021-11-30 Cyclerion Therapeutics, Inc. Kondenzirani biciklični SGS stimulatorji

Also Published As

Publication number Publication date
CL2021003531A1 (es) 2022-08-19
TWI823903B (zh) 2023-12-01
MA54638A (fr) 2021-11-10
EA202092109A1 (ru) 2021-03-04
US20210115050A1 (en) 2021-04-22
US20230095799A1 (en) 2023-03-30
TW201940487A (zh) 2019-10-16
EP3762389B1 (en) 2024-02-28
CL2021003530A1 (es) 2022-08-19
WO2019173551A8 (en) 2020-06-11
CA3092683A1 (en) 2019-09-12
PE20210124A1 (es) 2021-01-19
JP2021515015A (ja) 2021-06-17
KR20200128708A (ko) 2020-11-16
CN111836812A (zh) 2020-10-27
MX2023004856A (es) 2023-11-24
SG11202008641WA (en) 2020-10-29
IL276853A (en) 2020-10-29
AU2019231724A1 (en) 2020-10-08
MX2020009183A (es) 2020-10-08
US11466015B2 (en) 2022-10-11
MX2023004858A (es) 2023-11-24
CL2021003536A1 (es) 2022-08-19
BR112020018212A2 (pt) 2020-12-29
CR20200458A (es) 2020-11-09
EP3762389A1 (en) 2021-01-13
WO2019173551A1 (en) 2019-09-12
JP7423539B2 (ja) 2024-01-29
CL2020002284A1 (es) 2020-11-27
AU2019231724B2 (en) 2024-06-27
CO2020012493A2 (es) 2020-10-30
MX2023004857A (es) 2023-11-24
CL2021000301A1 (es) 2021-06-18
PH12020551394A1 (en) 2021-11-22

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