PE20210124A1 - FORMAS CRISTALINAS DE UN ESTIMULANTE DE LA GUANILIL CICLASA SOLUBLE (sGC) - Google Patents
FORMAS CRISTALINAS DE UN ESTIMULANTE DE LA GUANILIL CICLASA SOLUBLE (sGC)Info
- Publication number
- PE20210124A1 PE20210124A1 PE2020001347A PE2020001347A PE20210124A1 PE 20210124 A1 PE20210124 A1 PE 20210124A1 PE 2020001347 A PE2020001347 A PE 2020001347A PE 2020001347 A PE2020001347 A PE 2020001347A PE 20210124 A1 PE20210124 A1 PE 20210124A1
- Authority
- PE
- Peru
- Prior art keywords
- crystalline forms
- crystalline
- powder
- ray diffraction
- diffraction peaks
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invencion se refiere a Formas Cristalinas de estimulantes de la Guanililciclasa soluble, dichos compuestos son formas cristalinas del 8-(2-fluorobencil)-6-(3-(trifluorometil)-1H-1,2,4-triazol-5-il)imidazo[1,2-a]pirazina. Las Formas Cristalinas comprenden: a)Una forma cristalina A caracterizada por picos de difraccion de rayos x en polvo a angulos 2 theta: 7,0°, 8,3°, 11,1°, 14,3°, 15,0°, 15,9°, 16,7°, 17,6°, 19,1°, 20,2°, 21,6°, 24,9°, y 25,8° ; b)Una forma cristalina B caracterizada por picos de difraccion de rayos x en polvo a angulos 2 theta: 8,9°, 12,2°, 13,6°, 14,5°, 15,7°, 17,2°, 17,7°, 21,0°,22,7°, 23,9°, 25,0°, 26,7°, y 27,6° ; c)Un hidrato cristalino 1 caracterizado por picos de difraccion de rayos x en polvo a angulos 2 theta: 11,5°, 13,5°, 15,2°, 17,0°, 17,7°, 18,3°, 19,1°, 22,1°, 23,1°, 23,3°, 24,2°, 24,9°, y 29,4°; d) Un hidrato cristalino 2 caracterizado por picos de difraccion de rayos x en polvo a angulos 2 theta: 10,4°, 15,5°, 18,4°, 18,7°, 20,7°, 21,2°, 21,9°, 22,7°, 24,6°, 25,9°, 26,3°, y 27,4°; e) Un hidrato cristalino 3 caracterizado por picos de difraccion de rayos x en polvo a angulos 2 theta: 10,3°, 12,1°, 13,5°, 15,9°, 16,9°, 17,6°, 22,0°, 22,9°, 24,4°, y 28,9°. Estas formas cristalinas son utiles en el tratamiento de enfermedades del SNC.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862639846P | 2018-03-07 | 2018-03-07 | |
| PCT/US2019/021080 WO2019173551A1 (en) | 2018-03-07 | 2019-03-07 | Crystalline forms of an sgc stimulator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20210124A1 true PE20210124A1 (es) | 2021-01-19 |
Family
ID=65818696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2020001347A PE20210124A1 (es) | 2018-03-07 | 2019-03-07 | FORMAS CRISTALINAS DE UN ESTIMULANTE DE LA GUANILIL CICLASA SOLUBLE (sGC) |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11466015B2 (es) |
| EP (1) | EP3762389B1 (es) |
| JP (1) | JP7423539B2 (es) |
| KR (1) | KR20200128708A (es) |
| CN (1) | CN111836812A (es) |
| AU (1) | AU2019231724A1 (es) |
| BR (1) | BR112020018212A2 (es) |
| CA (1) | CA3092683A1 (es) |
| CL (5) | CL2020002284A1 (es) |
| CO (1) | CO2020012493A2 (es) |
| CR (1) | CR20200458A (es) |
| EA (1) | EA202092109A1 (es) |
| IL (1) | IL276853A (es) |
| MA (1) | MA54638A (es) |
| MX (5) | MX2023004855A (es) |
| PE (1) | PE20210124A1 (es) |
| PH (1) | PH12020551394A1 (es) |
| SG (1) | SG11202008641WA (es) |
| TW (1) | TWI823903B (es) |
| WO (1) | WO2019173551A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210177846A1 (en) * | 2018-07-11 | 2021-06-17 | Cyclerion Therapeutics, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF MITOCHONDRIAL DISORDERS |
| US20230130739A1 (en) * | 2020-03-26 | 2023-04-27 | Cyclerion Therapeutics, Inc. | DEUTERATED sGC STIMULATORS |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2928079B2 (ja) | 1994-02-14 | 1999-07-28 | 永信薬品工業股▲ふん▼有限公司 | １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途 |
| DE19744026A1 (de) | 1997-10-06 | 1999-04-08 | Hoechst Marion Roussel De Gmbh | Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| HU228111B1 (en) | 1998-07-08 | 2012-11-28 | Sanofi Aventis Deutschland | Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them |
| DE19830430A1 (de) | 1998-07-08 | 2000-01-13 | Hoechst Marion Roussel De Gmbh | Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| GB9824310D0 (en) | 1998-11-05 | 1998-12-30 | Univ London | Activators of soluble guanylate cyclase |
| DE19942809A1 (de) | 1999-09-08 | 2001-03-15 | Bayer Ag | Verfahren zur Herstellung substituierter Pyrimidinderivate |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE10216145A1 (de) | 2002-04-12 | 2003-10-23 | Bayer Ag | Verwendung von Stimulatoren der löslichen Guanylatcyclase zur Behandlung von Glaukom |
| DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
| BRPI0816382A2 (pt) | 2007-09-06 | 2015-02-24 | Merck Sharp & Dohme | Composto, composição, e, métodos para ativar a guanilato ciclase solúvel e para tratar ou previnir doenças |
| JP2011510082A (ja) | 2008-01-24 | 2011-03-31 | メルク・シャープ・エンド・ドーム・コーポレイション | アンジオテンシンｉｉ受容体拮抗薬 |
| AU2009322836B2 (en) | 2008-11-25 | 2013-04-04 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| AU2010218224B2 (en) | 2009-02-26 | 2013-06-27 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| WO2011119518A1 (en) | 2010-03-25 | 2011-09-29 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| EP2575473B1 (en) | 2010-05-27 | 2016-01-20 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| WO2012058132A1 (en) | 2010-10-28 | 2012-05-03 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| CN104327107A (zh) * | 2013-10-17 | 2015-02-04 | 广东东阳光药业有限公司 | 一种氟喹诺酮类抗菌药物的制备方法 |
| EP3152214B1 (en) | 2014-06-04 | 2020-01-29 | Merck Sharp & Dohme Corp. | Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators |
| EP3227286B1 (de) | 2014-12-02 | 2018-12-26 | Bayer Pharma Aktiengesellschaft | Substituierte pyrazolo[1,5-a]pyridine und imidazo[1,2-a]pyrazine und ihre verwendung |
| CR20220309A (es) | 2016-09-02 | 2022-09-16 | Cyclerion Therapeutics Inc | Estimuladores de sgc |
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2019
- 2019-03-07 PE PE2020001347A patent/PE20210124A1/es unknown
- 2019-03-07 US US16/976,430 patent/US11466015B2/en active Active
- 2019-03-07 EA EA202092109A patent/EA202092109A1/ru unknown
- 2019-03-07 MX MX2023004855A patent/MX2023004855A/es unknown
- 2019-03-07 CA CA3092683A patent/CA3092683A1/en active Pending
- 2019-03-07 CR CR20200458A patent/CR20200458A/es unknown
- 2019-03-07 MX MX2023004857A patent/MX2023004857A/es unknown
- 2019-03-07 SG SG11202008641WA patent/SG11202008641WA/en unknown
- 2019-03-07 JP JP2020546378A patent/JP7423539B2/ja active Active
- 2019-03-07 MX MX2020009183A patent/MX2020009183A/es unknown
- 2019-03-07 MA MA054638A patent/MA54638A/fr unknown
- 2019-03-07 TW TW108107664A patent/TWI823903B/zh active
- 2019-03-07 MX MX2023004856A patent/MX2023004856A/es unknown
- 2019-03-07 BR BR112020018212-5A patent/BR112020018212A2/pt unknown
- 2019-03-07 AU AU2019231724A patent/AU2019231724A1/en active Pending
- 2019-03-07 KR KR1020207028170A patent/KR20200128708A/ko not_active Application Discontinuation
- 2019-03-07 MX MX2023004858A patent/MX2023004858A/es unknown
- 2019-03-07 WO PCT/US2019/021080 patent/WO2019173551A1/en unknown
- 2019-03-07 CN CN201980017657.XA patent/CN111836812A/zh active Pending
- 2019-03-07 EP EP19712427.4A patent/EP3762389B1/en active Active
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2020
- 2020-08-20 IL IL276853A patent/IL276853A/en unknown
- 2020-09-03 CL CL2020002284A patent/CL2020002284A1/es unknown
- 2020-09-05 PH PH12020551394A patent/PH12020551394A1/en unknown
- 2020-10-06 CO CONC2020/0012493A patent/CO2020012493A2/es unknown
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2021
- 2021-02-04 CL CL2021000301A patent/CL2021000301A1/es unknown
- 2021-12-28 CL CL2021003530A patent/CL2021003530A1/es unknown
- 2021-12-28 CL CL2021003531A patent/CL2021003531A1/es unknown
- 2021-12-28 CL CL2021003536A patent/CL2021003536A1/es unknown
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2022
- 2022-09-28 US US17/954,713 patent/US20230095799A1/en active Pending
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