MX2020009183A - Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc). - Google Patents

Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).

Info

Publication number
MX2020009183A
MX2020009183A MX2020009183A MX2020009183A MX2020009183A MX 2020009183 A MX2020009183 A MX 2020009183A MX 2020009183 A MX2020009183 A MX 2020009183A MX 2020009183 A MX2020009183 A MX 2020009183A MX 2020009183 A MX2020009183 A MX 2020009183A
Authority
MX
Mexico
Prior art keywords
crystalline forms
sgc stimulator
present disclosure
sgc
stimulator
Prior art date
Application number
MX2020009183A
Other languages
English (en)
Inventor
Kwame W Nti-Addae
Thomas Storz
Leena Kumari Prasad
Original Assignee
Cyclerion Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cyclerion Therapeutics Inc filed Critical Cyclerion Therapeutics Inc
Publication of MX2020009183A publication Critical patent/MX2020009183A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente descripción se relaciona con formas cristalinas de 8-(2-fluorobencil)-6-(3-(trifluorometil)-1H- 1,2,4-triazol-5-il)im idazo[1,2-a]pirazina, que son útiles como estimuladores de guanilato ciclasa soluble (sGC). La presente descripción también provee composiciones farmacéuticamente aceptables que comprenden las formas cristalinas y métodos para usar las composiciones en el tratamiento de diversas afecciones.
MX2020009183A 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc). MX2020009183A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862639846P 2018-03-07 2018-03-07
PCT/US2019/021080 WO2019173551A1 (en) 2018-03-07 2019-03-07 Crystalline forms of an sgc stimulator

Publications (1)

Publication Number Publication Date
MX2020009183A true MX2020009183A (es) 2020-10-08

Family

ID=65818696

Family Applications (5)

Application Number Title Priority Date Filing Date
MX2023004858A MX2023004858A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).
MX2023004857A MX2023004857A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).
MX2023004855A MX2023004855A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).
MX2023004856A MX2023004856A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).
MX2020009183A MX2020009183A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).

Family Applications Before (4)

Application Number Title Priority Date Filing Date
MX2023004858A MX2023004858A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).
MX2023004857A MX2023004857A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).
MX2023004855A MX2023004855A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).
MX2023004856A MX2023004856A (es) 2018-03-07 2019-03-07 Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).

Country Status (20)

Country Link
US (2) US11466015B2 (es)
EP (1) EP3762389B1 (es)
JP (1) JP7423539B2 (es)
KR (1) KR20200128708A (es)
CN (1) CN111836812A (es)
AU (1) AU2019231724A1 (es)
BR (1) BR112020018212A2 (es)
CA (1) CA3092683A1 (es)
CL (5) CL2020002284A1 (es)
CO (1) CO2020012493A2 (es)
CR (1) CR20200458A (es)
EA (1) EA202092109A1 (es)
IL (1) IL276853A (es)
MA (1) MA54638A (es)
MX (5) MX2023004858A (es)
PE (1) PE20210124A1 (es)
PH (1) PH12020551394A1 (es)
SG (1) SG11202008641WA (es)
TW (1) TWI823903B (es)
WO (1) WO2019173551A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210177846A1 (en) * 2018-07-11 2021-06-17 Cyclerion Therapeutics, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF MITOCHONDRIAL DISORDERS
US20230130739A1 (en) * 2020-03-26 2023-04-27 Cyclerion Therapeutics, Inc. DEUTERATED sGC STIMULATORS

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2928079B2 (ja) 1994-02-14 1999-07-28 永信薬品工業股▲ふん▼有限公司 １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途
DE19744026A1 (de) 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
CA2336807C (en) 1998-07-08 2010-04-13 Aventis Pharma Deutschland Gmbh Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them
DE19830430A1 (de) 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
GB9824310D0 (en) 1998-11-05 1998-12-30 Univ London Activators of soluble guanylate cyclase
DE19942809A1 (de) 1999-09-08 2001-03-15 Bayer Ag Verfahren zur Herstellung substituierter Pyrimidinderivate
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10216145A1 (de) 2002-04-12 2003-10-23 Bayer Ag Verwendung von Stimulatoren der löslichen Guanylatcyclase zur Behandlung von Glaukom
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
CA2698332C (en) 2007-09-06 2012-08-21 Merck Sharp & Dohme Corp. Pyrazole derivatives as soluble guanylate cyclase activators
EP2244575B1 (en) 2008-01-24 2013-07-17 Merck Sharp & Dohme Corp. Angiotensin ii receptor antagonists
EP2373317B1 (en) 2008-11-25 2016-12-14 Merck Sharp & Dohme Corp. 4-amino-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one or 4-amino-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one derivatives as activators of the soluble guanylat cyclase for the treatment of cardiovascular diseases
CN102414194A (zh) 2009-02-26 2012-04-11 默沙东公司 可溶性鸟苷酸环化酶激活剂
US9284301B2 (en) 2010-03-25 2016-03-15 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
US9365574B2 (en) 2010-05-27 2016-06-14 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
WO2012058132A1 (en) 2010-10-28 2012-05-03 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
CN104327107A (zh) 2013-10-17 2015-02-04 广东东阳光药业有限公司 一种氟喹诺酮类抗菌药物的制备方法
US9796733B2 (en) 2014-06-04 2017-10-24 Merck Sharp & Dohme Corp. Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators
JP2017537922A (ja) 2014-12-02 2017-12-21 バイエル・ファルマ・アクティエンゲゼルシャフト 置換ピラゾロ［１，５−ａ］ピリジンおよびイミダゾ［１，２−ａ］ピラジンならびにそれらの使用
CR20190101A (es) 2016-09-02 2019-07-04 Ironwood Pharmaceuticals Inc Estimuladores de sgc

Also Published As

Publication number Publication date
US20210115050A1 (en) 2021-04-22
EA202092109A1 (ru) 2021-03-04
PE20210124A1 (es) 2021-01-19
TWI823903B (zh) 2023-12-01
CN111836812A (zh) 2020-10-27
BR112020018212A2 (pt) 2020-12-29
EP3762389B1 (en) 2024-02-28
MA54638A (fr) 2021-11-10
CL2021003536A1 (es) 2022-08-19
MX2023004856A (es) 2023-11-24
WO2019173551A1 (en) 2019-09-12
CA3092683A1 (en) 2019-09-12
CL2020002284A1 (es) 2020-11-27
WO2019173551A8 (en) 2020-06-11
IL276853A (en) 2020-10-29
PH12020551394A1 (en) 2021-11-22
CL2021003530A1 (es) 2022-08-19
JP7423539B2 (ja) 2024-01-29
CL2021003531A1 (es) 2022-08-19
CR20200458A (es) 2020-11-09
AU2019231724A1 (en) 2020-10-08
MX2023004855A (es) 2023-11-24
US11466015B2 (en) 2022-10-11
JP2021515015A (ja) 2021-06-17
TW201940487A (zh) 2019-10-16
MX2023004858A (es) 2023-11-24
CO2020012493A2 (es) 2020-10-30
EP3762389A1 (en) 2021-01-13
KR20200128708A (ko) 2020-11-16
SG11202008641WA (en) 2020-10-29
US20230095799A1 (en) 2023-03-30
MX2023004857A (es) 2023-11-24
CL2021000301A1 (es) 2021-06-18

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