KR102777995B1 - 11형 인유두종 바이러스 엘1 단백질의 돌연변이체 - Google Patents

11형 인유두종 바이러스 엘1 단백질의 돌연변이체 Download PDF

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KR102777995B1
KR102777995B1 KR1020187018923A KR20187018923A KR102777995B1 KR 102777995 B1 KR102777995 B1 KR 102777995B1 KR 1020187018923 A KR1020187018923 A KR 1020187018923A KR 20187018923 A KR20187018923 A KR 20187018923A KR 102777995 B1 KR102777995 B1 KR 102777995B1
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hpv11
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KR20180084139A (ko
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샤오웨이 리
다닝 왕
신린 리우
지하이 리
준 장
닝샤오 시아
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시아먼 유니버시티
시아맨 이노박스 바이오테크 코. 엘티디.
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
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    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/20043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20071—Demonstrated in vivo effect

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020187018923A 2015-12-04 2016-12-02 11형 인유두종 바이러스 엘1 단백질의 돌연변이체 Active KR102777995B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510887801.9 2015-12-04
CN201510887801 2015-12-04
PCT/CN2016/108349 WO2017092711A1 (zh) 2015-12-04 2016-12-02 一种人乳头瘤病毒11型l1蛋白的突变体

Publications (2)

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KR20180084139A KR20180084139A (ko) 2018-07-24
KR102777995B1 true KR102777995B1 (ko) 2025-03-10

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US (1) US10513541B2 (https=)
EP (1) EP3385274B1 (https=)
JP (1) JP6920694B2 (https=)
KR (1) KR102777995B1 (https=)
CN (1) CN106831958B (https=)
WO (1) WO2017092711A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114127095B (zh) * 2019-07-19 2024-04-09 神州细胞工程有限公司 嵌合的人乳头瘤病毒11型l1蛋白
WO2021013067A1 (zh) * 2019-07-19 2021-01-28 神州细胞工程有限公司 嵌合的人乳头瘤病毒6型l1蛋白
BR112022022719A2 (pt) 2020-05-14 2023-02-14 Inovio Pharmaceuticals Inc Vacinas para papilomatose respiratória recorrente e métodos de usar a mesma
CN114539363B (zh) * 2020-11-26 2023-12-01 中国医学科学院基础医学研究所 一种c端改造的人乳头瘤病毒11型l1蛋白及其用途
KR102833970B1 (ko) 2022-02-23 2025-07-17 충남대학교산학협력단 핵수송 신호 펩타이드가 접합된 핵산 전달용 2세대 폴리아미도아민 덴드리머 고분자 유도체
CN116041445B (zh) * 2023-01-06 2023-09-05 北京康乐卫士生物技术股份有限公司 一种人乳头瘤病毒51型l1蛋白突变体及减少重组蛋白降解的方法及应用

Citations (2)

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Publication number Priority date Publication date Assignee Title
US20050058988A1 (en) * 1998-12-17 2005-03-17 Jansen Kathrin U. Synthetic virus-like particles with heterologous epitopes
US20100291141A1 (en) * 2007-05-29 2010-11-18 Jun Zhang Truncated l1 protein of human papillomavirus type 11

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IL117591A0 (en) 1995-03-30 1996-07-23 Merck & Co Inc Synthetic DNA encoding human papillomavirus type 11 L1 protein
US5795754A (en) * 1995-07-19 1998-08-18 Merck & Co., Inc. Synthetic HPV11 virus-like particles
ATE258222T1 (de) * 1995-11-15 2004-02-15 Merck & Co Inc Synthetische hpv11 virusartige partikel
US5738853A (en) * 1995-11-15 1998-04-14 Merck & Co., Inc. Synthetic HPV11 virus-like particles
AUPP765398A0 (en) * 1998-12-11 1999-01-14 University Of Queensland, The Treatment of papillomavirus infections
DK2154149T3 (da) * 2007-05-29 2019-10-14 Univ Xiamen En trunkeret l1-protein af human papillomavirus 6
CN101518647A (zh) * 2008-02-29 2009-09-02 江阴艾托金生物技术有限公司 人乳头瘤病毒预防性疫苗、构建方法及应用
NO2324113T3 (https=) * 2008-08-08 2018-07-28
CN102229660B (zh) * 2011-05-25 2015-04-22 厦门大学 截短的人乳头瘤病毒33型l1蛋白
CN102747047B (zh) * 2012-02-28 2016-03-23 厦门大学 人乳头瘤病毒型别杂合病毒样颗粒及其制备方法
CN104211782B (zh) * 2013-06-04 2017-11-17 厦门大学 截短的人乳头瘤病毒45型l1蛋白

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050058988A1 (en) * 1998-12-17 2005-03-17 Jansen Kathrin U. Synthetic virus-like particles with heterologous epitopes
US20100291141A1 (en) * 2007-05-29 2010-11-18 Jun Zhang Truncated l1 protein of human papillomavirus type 11

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Steven W Ludmerer et al., ‘HPV11 Mutant Virus-like Particles Elicit Immune Responses That Neutralize Virus and Delineate a Novel Neutralizing Domain’, Virology, Vol. 266, pp. 237-245, 2000.*

Also Published As

Publication number Publication date
US20190062379A1 (en) 2019-02-28
EP3385274A4 (en) 2019-08-14
BR112018011331A2 (pt) 2019-04-30
JP2019502404A (ja) 2019-01-31
EP3385274B1 (en) 2021-09-22
JP6920694B2 (ja) 2021-08-18
US10513541B2 (en) 2019-12-24
CN106831958B (zh) 2020-12-29
WO2017092711A1 (zh) 2017-06-08
KR20180084139A (ko) 2018-07-24
CN106831958A (zh) 2017-06-13
EP3385274A1 (en) 2018-10-10

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