KR102768284B1 - Jak 패밀리의 키나제의 소분자 억제제 - Google Patents

Jak 패밀리의 키나제의 소분자 억제제 Download PDF

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KR102768284B1
KR102768284B1 KR1020217000012A KR20217000012A KR102768284B1 KR 102768284 B1 KR102768284 B1 KR 102768284B1 KR 1020217000012 A KR1020217000012 A KR 1020217000012A KR 20217000012 A KR20217000012 A KR 20217000012A KR 102768284 B1 KR102768284 B1 KR 102768284B1
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jak
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KR20210021342A (ko
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필리페 페르난데스
마크 에스. 티치노르
폴 제이. 크라우스주크
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얀센 파마슈티카 엔브이
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
KR1020217000012A 2018-06-15 2019-06-14 Jak 패밀리의 키나제의 소분자 억제제 Active KR102768284B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862685737P 2018-06-15 2018-06-15
US62/685,737 2018-06-15
US201962846290P 2019-05-10 2019-05-10
US62/846,290 2019-05-10
PCT/IB2019/055005 WO2019239387A1 (en) 2018-06-15 2019-06-14 Small molecule inhibitors of the jak family of kinases

Publications (2)

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KR20210021342A KR20210021342A (ko) 2021-02-25
KR102768284B1 true KR102768284B1 (ko) 2025-02-13

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US (3) US20200017498A1 (enExample)
EP (1) EP3807277A1 (enExample)
JP (1) JP2021528391A (enExample)
KR (1) KR102768284B1 (enExample)
CN (1) CN112313233A (enExample)
AU (1) AU2019286641A1 (enExample)
BR (1) BR112020024744A2 (enExample)
CA (1) CA3101438A1 (enExample)
CL (1) CL2020003227A1 (enExample)
CO (1) CO2020015396A2 (enExample)
CR (1) CR20200603A (enExample)
EC (1) ECSP20080817A (enExample)
IL (1) IL279314A (enExample)
JO (1) JOP20200311A1 (enExample)
MA (1) MA52900A (enExample)
MX (1) MX2020013688A (enExample)
NI (1) NI202000100A (enExample)
PE (1) PE20212113A1 (enExample)
PH (1) PH12020551984A1 (enExample)
SG (1) SG11202011691PA (enExample)
TW (1) TW202016110A (enExample)
UY (1) UY38262A (enExample)
WO (1) WO2019239387A1 (enExample)

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JOP20190144A1 (ar) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
JP7291077B2 (ja) 2016-12-16 2023-06-14 ヤンセン ファーマシューティカ エヌ．ベー． Ｊａｋファミリーのキナーゼの低分子阻害物質
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
MX2023010642A (es) 2021-03-11 2023-11-28 Janssen Pharmaceutica Nv Lorpucitinib para uso en el tratamiento de trastornos mediados por jak.
CN113292561A (zh) * 2021-05-22 2021-08-24 中国药科大学 一种二吡咯并吡啶结构的化合物、制备方法和医药用途

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RU2012132278A (ru) * 2010-01-12 2014-02-20 Ф. Хоффманн-Ля Рош Аг Трициклические гетероциклические соединения, содержащие их композиции и способы их применения
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ES2753159T3 (es) 2015-05-28 2020-04-07 Theravance Biopharma R&D Ip Llc Compuestos de naftiridina como inhibidores de quinasa JAK
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JOP20190053A1 (ar) 2016-09-23 2019-03-21 Novartis Ag مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط
EP3640251B1 (en) 2016-10-24 2021-12-08 Astrazeneca AB 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer
JOP20190144A1 (ar) * 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
KR102314286B1 (ko) 2016-12-16 2021-10-21 화이자 인코포레이티드 Glp-1 수용체 작용제 및 이의 용도
ES2941631T3 (es) 2016-12-16 2023-05-24 Lilly Co Eli Compuestos de Pirido[4,3-d][1,3]oxazin-2-ona como inhibidores de IDH1 e IDH2 mutantes
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TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
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ECSP20080817A (es) 2021-01-29
US11787807B2 (en) 2023-10-17
IL279314A (en) 2021-01-31
US20200017498A1 (en) 2020-01-16
CL2020003227A1 (es) 2021-05-14
NI202000100A (es) 2021-06-30
MA52900A (fr) 2021-04-21
SG11202011691PA (en) 2020-12-30
WO2019239387A1 (en) 2019-12-19
PE20212113A1 (es) 2021-11-04
CA3101438A1 (en) 2019-12-19
UY38262A (es) 2019-12-31
EP3807277A1 (en) 2021-04-21
US11066406B2 (en) 2021-07-20
CN112313233A (zh) 2021-02-02
MX2020013688A (es) 2021-02-26
TW202016110A (zh) 2020-05-01
BR112020024744A2 (pt) 2021-03-23
US20210340144A1 (en) 2021-11-04
CO2020015396A2 (es) 2021-03-08
US20200165250A1 (en) 2020-05-28
PH12020551984A1 (en) 2021-08-02
CR20200603A (es) 2021-01-20
KR20210021342A (ko) 2021-02-25
JP2021528391A (ja) 2021-10-21
JOP20200311A1 (ar) 2020-11-30
AU2019286641A1 (en) 2020-12-10

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