KR102750931B1 - 리보시클립 정제 - Google Patents

리보시클립 정제 Download PDF

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Publication number
KR102750931B1
KR102750931B1 KR1020177029433A KR20177029433A KR102750931B1 KR 102750931 B1 KR102750931 B1 KR 102750931B1 KR 1020177029433 A KR1020177029433 A KR 1020177029433A KR 20177029433 A KR20177029433 A KR 20177029433A KR 102750931 B1 KR102750931 B1 KR 102750931B1
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South Korea
Prior art keywords
tablet
ribociclib
tablets
delete delete
coating
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KR1020177029433A
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English (en)
Korean (ko)
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KR20170137101A (ko
Inventor
빈두마다반 구루라잔
아르노 그랑듀리
루이 코스타
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노파르티스 아게
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55806565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR102750931(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Priority to KR1020257000051A priority Critical patent/KR20250009572A/ko
Publication of KR20170137101A publication Critical patent/KR20170137101A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020177029433A 2015-04-16 2016-04-14 리보시클립 정제 Active KR102750931B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257000051A KR20250009572A (ko) 2015-04-16 2016-04-14 리보시클립 정제

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562148240P 2015-04-16 2015-04-16
US62/148,240 2015-04-16
PCT/IB2016/052136 WO2016166703A1 (en) 2015-04-16 2016-04-14 Ribociclib tablet

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020257000051A Division KR20250009572A (ko) 2015-04-16 2016-04-14 리보시클립 정제

Publications (2)

Publication Number Publication Date
KR20170137101A KR20170137101A (ko) 2017-12-12
KR102750931B1 true KR102750931B1 (ko) 2025-01-09

Family

ID=55806565

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020177029433A Active KR102750931B1 (ko) 2015-04-16 2016-04-14 리보시클립 정제
KR1020257000051A Pending KR20250009572A (ko) 2015-04-16 2016-04-14 리보시클립 정제

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020257000051A Pending KR20250009572A (ko) 2015-04-16 2016-04-14 리보시클립 정제

Country Status (31)

Country Link
US (6) US10799506B2 (https=)
EP (3) EP4197530B1 (https=)
JP (1) JP2018514523A (https=)
KR (2) KR102750931B1 (https=)
CN (2) CN107530292B (https=)
AR (1) AR104257A1 (https=)
AU (5) AU2016248017A1 (https=)
BR (1) BR112017021283A2 (https=)
CA (1) CA2982425C (https=)
CL (1) CL2017002593A1 (https=)
CO (1) CO2017010510A2 (https=)
DK (2) DK3283058T3 (https=)
EA (1) EA201792290A1 (https=)
EC (1) ECSP17075052A (https=)
ES (2) ES3062263T3 (https=)
FI (2) FI3283058T3 (https=)
HR (2) HRP20230053T1 (https=)
HU (1) HUE061213T2 (https=)
IL (1) IL254818A0 (https=)
LT (1) LT4197530T (https=)
MX (1) MX2017013350A (https=)
PE (1) PE20180035A1 (https=)
PH (1) PH12017501820A1 (https=)
PL (2) PL3283058T3 (https=)
PT (2) PT3283058T (https=)
RS (1) RS67697B1 (https=)
SG (1) SG11201708084PA (https=)
SI (2) SI3283058T1 (https=)
TN (1) TN2017000422A1 (https=)
TW (1) TW201642864A (https=)
WO (1) WO2016166703A1 (https=)

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CN105828822B (zh) 2013-08-14 2019-10-18 诺华股份有限公司 用于治疗癌症的组合疗法
CN107530292B (zh) * 2015-04-16 2022-11-01 诺华股份有限公司 瑞博西尼片剂
CA3048036A1 (en) 2018-07-02 2020-01-02 Apotex Inc Crystalline form of ribociclib succinate
KR20220054347A (ko) 2019-08-26 2022-05-02 아비나스 오퍼레이션스, 인코포레이티드 에스트로겐 수용체 분해제로서의 테트라히드로나프탈렌 유도체로 유방암을 치료하는 방법
CN118652252A (zh) 2019-12-16 2024-09-17 卢内拉生物技术有限公司 选择性cdk4/6抑制剂型癌症治疗药物
AU2020405427B2 (en) 2019-12-16 2025-01-09 Lunella Biotech, Inc. Selective CDK4/6 inhibitor cancer therapeutics
US20230310327A1 (en) * 2020-08-03 2023-10-05 Natco Pharma Limited Pharmaceutical compositions comprising ribociclib
MX2022015336A (es) * 2020-09-29 2023-01-11 Laboratorios Silanes S A De C V Combinaciones farmaceuticas de estatinas y fibratos para el tratamiento y prevencion de hiperlipidemias y enfermedades cardiovasculares.
WO2022162122A1 (en) 2021-01-29 2022-08-04 Biotx.Ai Gmbh Genetically verified netosis inhibitor for use in the treatment of a sars-cov2 infection
CN117396208A (zh) 2021-07-16 2024-01-12 达纳－法伯癌症研究所公司 细胞周期蛋白依赖性激酶4/6(cdk4/6)和ikzf2(helios)的小分子降解剂及其使用方法
TWI848533B (zh) 2022-01-25 2024-07-11 瑞士商諾華公司 瑞博西尼藥物組成物
CN120112291A (zh) 2022-08-31 2025-06-06 阿尔维纳斯运营股份有限公司 雌激素受体降解剂的给药方案
EP4626890A1 (en) 2022-12-01 2025-10-08 KRKA, d.d., Novo mesto Ribociclib salts and formulations thereof
CN121358477A (zh) 2023-03-27 2026-01-16 诺华股份有限公司 使用瑞波西利与芳香化酶抑制剂组合治疗早期乳腺癌的方法
TW202602868A (zh) 2024-04-15 2026-01-16 瑞士商諾華公司 瑞波西利的藥物組成物

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WO2014097125A1 (en) * 2012-12-20 2014-06-26 Novartis Ag Pharmaceutical combination comprising binimetinib

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JPS5428812A (en) * 1977-08-09 1979-03-03 Yoshitomi Pharmaceut Ind Ltd Preparation of coated tablet
GB9414045D0 (en) 1994-07-12 1994-08-31 Berwind Pharma Service Moisture barrier film coating composition, method, and coated form
EP0771339B1 (en) * 1994-07-12 2003-10-15 BPSI Holdings, Inc. Dry moisture barrier film coating composition, method of coating substrates using the same and pharmaceutical tablets coated therewith
US6448323B1 (en) * 1999-07-09 2002-09-10 Bpsi Holdings, Inc. Film coatings and film coating compositions based on polyvinyl alcohol
ES2522346T3 (es) 2008-08-22 2014-11-14 Novartis Ag Compuestos de pirrolopirimidina como inhibidores de CDK
US8784781B2 (en) * 2009-09-24 2014-07-22 Mcneil-Ppc, Inc. Manufacture of chewing gum product with radiofrequency
US20120115878A1 (en) 2010-11-10 2012-05-10 John Vincent Calienni Salt(s) of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and processes of making thereof
JP5898701B2 (ja) * 2011-02-11 2016-04-13 ウィスタ ラボラトリーズ リミテッド フェノチアジンジアミニウム塩およびそれらの使用
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EP2742940B1 (en) * 2012-12-13 2017-07-26 IP Gesellschaft für Management mbH Fumarate salt of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-l-aza-bicyclo-[2.2.2]octane for adminstration once daily, twice daily or thrice daily
MA38522A1 (fr) * 2013-03-21 2017-10-31 Novartis Ag Thérapie de combinaison comprenant un inhibiteur de b-raf et un second inhibiteur.
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JP7347388B2 (ja) 2020-09-25 2023-09-20 信越化学工業株式会社 紫外線硬化型有機変性シリコーン組成物および硬化物

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Also Published As

Publication number Publication date
LT4197530T (lt) 2026-02-25
PT3283058T (pt) 2023-02-03
CA2982425C (en) 2023-10-31
AU2020250190A1 (en) 2020-11-05
EP3283058A1 (en) 2018-02-21
HRP20230053T1 (hr) 2023-03-03
US20250134893A1 (en) 2025-05-01
PH12017501820A1 (en) 2018-04-23
EP4620458A2 (en) 2025-09-24
CA2982425A1 (en) 2016-10-20
AU2024227794A1 (en) 2024-11-21
TW201642864A (zh) 2016-12-16
PE20180035A1 (es) 2018-01-09
IL254818A0 (en) 2017-12-31
KR20250009572A (ko) 2025-01-17
AU2016248017A1 (en) 2017-10-19
CL2017002593A1 (es) 2018-05-18
US10799506B2 (en) 2020-10-13
HUE061213T2 (hu) 2023-05-28
EP3283058B1 (en) 2022-11-16
SI3283058T1 (sl) 2023-03-31
PT4197530T (pt) 2026-02-05
ES3062263T3 (en) 2026-04-09
CN115554257A (zh) 2023-01-03
BR112017021283A2 (pt) 2018-06-26
US20200390771A1 (en) 2020-12-17
WO2016166703A1 (en) 2016-10-20
CN107530292A (zh) 2018-01-02
FI4197530T3 (fi) 2026-02-03
US20250090531A1 (en) 2025-03-20
SI4197530T1 (sl) 2026-03-31
US20250127785A1 (en) 2025-04-24
KR20170137101A (ko) 2017-12-12
AR104257A1 (es) 2017-07-05
SG11201708084PA (en) 2017-10-30
PL3283058T3 (pl) 2023-03-20
ES2938261T3 (es) 2023-04-05
AU2022215155B2 (en) 2024-08-01
MX2017013350A (es) 2018-01-25
AU2022215155A1 (en) 2022-09-01
AU2019201929B2 (en) 2020-07-09
FI3283058T3 (fi) 2023-03-01
AU2019201929A1 (en) 2019-04-11
HRP20260123T1 (hr) 2026-03-13
EP4197530A1 (en) 2023-06-21
EP4620458A3 (en) 2025-10-22
EP4197530B1 (en) 2025-11-12
US12064434B2 (en) 2024-08-20
CO2017010510A2 (es) 2018-03-20
US12419894B2 (en) 2025-09-23
US20180071292A1 (en) 2018-03-15
ECSP17075052A (es) 2018-02-28
US20230104792A1 (en) 2023-04-06
TN2017000422A1 (en) 2019-01-16
DK3283058T3 (da) 2023-02-13
JP2018514523A (ja) 2018-06-07
PL4197530T3 (pl) 2026-03-23
RS67697B1 (sr) 2026-02-27
CN107530292B (zh) 2022-11-01
EA201792290A1 (ru) 2018-02-28
DK4197530T3 (da) 2026-02-09

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