KR102745611B1 - 식도 염증 치료를 위한 ecm 하이드로겔 - Google Patents

식도 염증 치료를 위한 ecm 하이드로겔 Download PDF

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Publication number
KR102745611B1
KR102745611B1 KR1020197026981A KR20197026981A KR102745611B1 KR 102745611 B1 KR102745611 B1 KR 102745611B1 KR 1020197026981 A KR1020197026981 A KR 1020197026981A KR 20197026981 A KR20197026981 A KR 20197026981A KR 102745611 B1 KR102745611 B1 KR 102745611B1
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ecm
hydrogel
esophageal
esophagus
composition
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KR20190120258A (ko
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스티븐 프란시스 베이디락
후안 디에고 나랑호 구티아레즈
린지 타미코 살딘
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유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020197026981A 2017-03-02 2018-03-02 식도 염증 치료를 위한 ecm 하이드로겔 Active KR102745611B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762465985P 2017-03-02 2017-03-02
US62/465,985 2017-03-02
PCT/US2018/020758 WO2018161028A1 (en) 2017-03-02 2018-03-02 Ecm hydrogel for treating esophageal inflammation

Publications (2)

Publication Number Publication Date
KR20190120258A KR20190120258A (ko) 2019-10-23
KR102745611B1 true KR102745611B1 (ko) 2024-12-20

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KR1020197026981A Active KR102745611B1 (ko) 2017-03-02 2018-03-02 식도 염증 치료를 위한 ecm 하이드로겔

Country Status (9)

Country Link
US (4) US11213545B2 (cg-RX-API-DMAC7.html)
EP (2) EP3589292B1 (cg-RX-API-DMAC7.html)
JP (3) JP7203428B2 (cg-RX-API-DMAC7.html)
KR (1) KR102745611B1 (cg-RX-API-DMAC7.html)
CN (1) CN110352061A (cg-RX-API-DMAC7.html)
AU (2) AU2018226867B2 (cg-RX-API-DMAC7.html)
CA (1) CA3052489A1 (cg-RX-API-DMAC7.html)
ES (2) ES2957291T3 (cg-RX-API-DMAC7.html)
WO (1) WO2018161028A1 (cg-RX-API-DMAC7.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015231110B2 (en) 2014-03-21 2019-03-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix
AU2017227790B2 (en) 2016-03-02 2023-03-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Matrix bound nanovesicles and their use
CA3049990A1 (en) 2017-03-02 2018-09-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Extracellular matrix (ecm) hydrogel and soluble fraction thereof for the treatment of cancer
EP3589292B1 (en) 2017-03-02 2023-08-23 University of Pittsburgh - Of the Commonwealth System of Higher Education Ecm hydrogel for treating esophageal inflammation
KR102872720B1 (ko) 2017-05-05 2025-10-16 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 기질 결합 소낭의 안구에의 적용
KR20210005942A (ko) 2018-05-03 2021-01-15 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 Il-33을 포함하는 매트릭스 결합 소포 (mbvs) 및 그 용도
CN115671410B (zh) * 2018-06-21 2024-06-18 联邦高等教育系统匹兹堡大学 膀胱ecm水凝胶作为食管粘膜下层流体垫的用途
CN115487364B (zh) 2018-06-21 2024-02-23 联邦高等教育系统匹兹堡大学 细胞外基质(ecm)水凝胶作为粘膜下流体垫
AU2019288586B2 (en) 2018-06-21 2024-06-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Use of an extracellular matrix (ECM) hydrogel as an esophageal submucosal fluid cushion
AU2020235627B2 (en) 2019-03-13 2026-01-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Acoustic extracellular matrix hydrogels and their use
JP2023514821A (ja) 2020-02-28 2023-04-11 テキサス メディカル センター 癒着阻止および組織治癒向上のための噴霧可能刺激応答性マイクロヒドロゲル
WO2022108313A1 (ko) * 2020-11-17 2022-05-27 연세대학교 산학협력단 식도 오가노이드 배양 및 이식을 위한 탈세포 식도 조직 유래 지지체 및 이의 제조방법
EP4706694A1 (en) 2024-09-06 2026-03-11 Georgia Tech Research Corporation Hydrogels for cargo delivery to tubular epithelial structures

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008109407A2 (en) * 2007-03-02 2008-09-12 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Extracellular matrix-derived gels and related methods

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155095A (en) 1961-02-07 1964-11-03 Adolph M Brown Anastomosis method and means
US4294241A (en) 1977-06-09 1981-10-13 Teruo Miyata Collagen skin dressing
US4582640A (en) 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
US4563350A (en) 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
US4978668A (en) 1986-09-02 1990-12-18 Purdue Research Foundation Treatment to reduce ischemic tissue injury
US4956178A (en) 1988-07-11 1990-09-11 Purdue Research Foundation Tissue graft composition
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US5007927A (en) 1989-10-24 1991-04-16 Purdue Research Foundation Muscle-powered cardiac assist device
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5354274A (en) 1992-08-20 1994-10-11 Methodist Hospital Of Indiana, Inc. Device for oral administration of liquids
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US6653291B1 (en) 1992-11-13 2003-11-25 Purdue Research Foundation Composition and method for production of transformed cells
US5641518A (en) 1992-11-13 1997-06-24 Purdue Research Foundation Method of repairing bone tissue
US5352463A (en) 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
US6475232B1 (en) 1996-12-10 2002-11-05 Purdue Research Foundation Stent with reduced thrombogenicity
US5693085A (en) 1994-04-29 1997-12-02 Scimed Life Systems, Inc. Stent with collagen
US6485723B1 (en) 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
WO1996031232A1 (en) 1995-04-07 1996-10-10 Purdue Research Foundation Tissue graft and method for urinary bladder reconstruction
US5711969A (en) 1995-04-07 1998-01-27 Purdue Research Foundation Large area submucosal tissue graft constructs
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
CA2160647C (en) 1995-10-16 2002-05-28 Thomas William Garay Helical bearing anchor catcher
US5755791A (en) 1996-04-05 1998-05-26 Purdue Research Foundation Perforated submucosal tissue graft constructs
SK22499A3 (en) 1996-08-23 1999-10-08 Cook Biotech Inc Graft prosthesis, materials and methods
DK0925067T3 (da) 1996-09-16 2004-05-03 Purdue Research Foundation Graft fra submucosavæv til reparation af neurologisk væv
WO1998019719A1 (en) 1996-11-05 1998-05-14 Purdue Research Foundation Myocardial graft constructs
TW510803B (en) 1996-11-20 2002-11-21 Yasuhiko Shimizu Man-made esophagus and its manufacturing method
JP2001505807A (ja) 1996-12-10 2001-05-08 パーデュー・リサーチ・ファウンデーション 人工血管弁
US6696270B2 (en) 1996-12-10 2004-02-24 Purdue Research Foundation Gastric submucosal tissue as a novel diagnostic tool
DE69720252T2 (de) 1996-12-10 2003-12-04 Purdue Research Foundation, West Lafayette Gewebetransplantat aus der magensubmukosa
ATE249182T1 (de) 1996-12-10 2003-09-15 Purdue Research Foundation Rohrförmige transplantatkonstruktionen aus submucosalem gewebe
JP4046358B2 (ja) 1996-12-10 2008-02-13 パーデュー・リサーチ・ファウンデーション 粘膜下組織抽出物
AU732726B2 (en) 1996-12-10 2001-04-26 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
DE69802815T2 (de) 1997-09-11 2002-08-01 Purdue Research Foundation, West Lafayette Durch galactosidase modifiziertes submucosales gewebe
WO1999043786A2 (en) 1998-02-27 1999-09-02 Purdue Research Foundation Submucosa gel compositions
US6448076B2 (en) 1998-09-15 2002-09-10 The Regents Of The University Of Michigan Method for chemically acellularizing a biological tissue sample
US6918396B1 (en) 1998-12-01 2005-07-19 Purdue Research Foundation Method for vocal cord reconstruction
GB2361187A (en) 1998-12-01 2001-10-17 Purdue Research Foundation Submucosa modulation of mammalian immune response
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US6579538B1 (en) 1999-12-22 2003-06-17 Acell, Inc. Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof
WO2002014480A2 (en) 2000-08-16 2002-02-21 Duke University Decellularized tissue engineered constructs and tissues
EP1609468A3 (en) * 2000-11-22 2006-01-25 Rxkinetix, Inc. A composition on the basis of a sulfur-containing antioxidant and its use for the manufacture of a medicament for treating mucositis
WO2003059061A1 (en) 2002-01-11 2003-07-24 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
AU2003210474A1 (en) 2002-01-11 2003-07-30 Purdue Research Foundation Composition and method for inhibiting hypersensitivity
EP1503652A4 (en) 2002-05-02 2006-02-08 Purdue Research Foundation HYBRID GRAFTS WITH IMPROVED VASCULARIZATION
WO2003092381A1 (en) 2002-05-02 2003-11-13 Purdue Research Foundation Vascularization enhanced graft constructs
CN1665527A (zh) 2002-05-02 2005-09-07 普渡研究基金会 血管化增强的移植构造物
US7402319B2 (en) 2002-09-27 2008-07-22 Board Of Regents, The University Of Texas System Cell-free tissue replacement for tissue engineering
US20040187877A1 (en) 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of liver tissue
US20040191226A1 (en) 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of body wall
US20040175366A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
US20040176855A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
CA2530490A1 (en) 2003-06-25 2005-01-13 Stephen F. Badylak Conditioned matrix compositions for tissue restoration
US7326571B2 (en) 2003-07-17 2008-02-05 Boston Scientific Scimed, Inc. Decellularized bone marrow extracellular matrix
US8741352B2 (en) 2003-08-25 2014-06-03 Cook Biotech Incorporated Graft materials containing ECM components, and methods for their manufacture
DE112004001553T5 (de) 2003-08-25 2006-08-10 Cook Biotech, Inc., West Lafayette Verpflanzungsmaterialien, die bioaktive Substanzen enthalten, und Methoden zu deren Herstellung
ATE489251T1 (de) 2004-03-19 2010-12-15 Tamura Plastic Mfg Co Ltd Blende für ein kraftfahrzeug
US7905826B2 (en) 2004-11-03 2011-03-15 Cook Incorporated Methods for modifying vascular vessel walls
US8874204B2 (en) 2004-12-20 2014-10-28 Cardiac Pacemakers, Inc. Implantable medical devices comprising isolated extracellular matrix
US9138445B2 (en) 2005-03-09 2015-09-22 Cook Biotech Incorporated Medical graft materials with adherent extracellular matrix fibrous mass
US8029774B2 (en) 2005-07-01 2011-10-04 University Of Pittsburgh Wound healing polymeric networks
WO2007084278A2 (en) 2006-01-06 2007-07-26 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Extracellular matrix based gastroesophageal junction reinforcement device
US8241908B2 (en) 2006-05-16 2012-08-14 Becton, Dickinson And Company Extracellular matrix coated surface for culturing cells
WO2008008266A2 (en) 2006-07-07 2008-01-17 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Biohybrid elastomeric scaffolds and methods of use thereof
EP2079490B1 (en) 2006-10-23 2012-08-29 Cook Biotech Incorporated Processed ecm materials with enhanced component profiles
US20110184439A1 (en) 2008-05-09 2011-07-28 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Biological Matrix for Cardiac Repair
WO2010099463A2 (en) 2009-02-27 2010-09-02 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Joint bioscaffolds
WO2011044443A2 (en) 2009-10-09 2011-04-14 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Matricryptic ecm peptides for tissue reconstruction
US9814744B2 (en) 2009-12-22 2017-11-14 University of Pittsburg—Of the Commonwealth System of Higher Education Decellularized adipose cell growth scaffold
US9421307B2 (en) 2010-08-17 2016-08-23 University of Pittsburgh—of the Commonwealth System of Higher Education Biohybrid composite scaffold
PL2696687T3 (pl) 2011-04-12 2017-06-30 Novo Nordisk A/S Pochodne podwójnie acylowanej GLP-1
WO2013009595A2 (en) 2011-07-08 2013-01-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Injectable cns-derived ecm for tissue reconstruction
KR20180074818A (ko) 2013-02-08 2018-07-03 아셀, 인크. 세포외 기질 재료로부터의 생리활성 겔의 제조 방법
ES2703785T3 (es) 2013-04-08 2019-03-12 Regentys Corp Método y composición para tratar una enfermedad inflamatoria intestinal sin colectomía
US9861662B2 (en) 2013-07-03 2018-01-09 University of Pittsburgh—of the Commonwealth System of Higher Education Bone-derived extra cellular matrix gel
ITMI20131924A1 (it) 2013-11-20 2015-05-21 Cosmo Technologies Ltd Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica
US10286119B2 (en) 2014-01-24 2019-05-14 University of Pittsburgh—of the Commonwealth System of Higher Education Extracellular matrix mesh coating
AU2015231110B2 (en) 2014-03-21 2019-03-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix
WO2015164728A1 (en) * 2014-04-24 2015-10-29 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fractionating extracellular matrix to modulate bioactivity and the host response
EP3319653A4 (en) 2015-07-10 2019-03-27 University of Pittsburgh - Of the Commonwealth System of Higher Education METHOD FOR PRODUCING ECM EQUIPMENT AND HYDROGELS FROM COLON
EP3347063B1 (en) 2015-09-10 2025-11-19 University of Pittsburgh - of the Commonwealth System of Higher Education Bi-layer extra cellular matrix scaffolds and uses therefor
EP3349814B1 (en) 2015-09-18 2021-03-17 University of Pittsburgh- Of the Commonwealth System of Higher Education Non-gelling soluble extracellular matrix with biological activity
CA3011294A1 (en) 2016-01-13 2017-07-20 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Vascular extracellular matrix hydrogel
AU2017227790B2 (en) 2016-03-02 2023-03-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Matrix bound nanovesicles and their use
JP2019513038A (ja) 2016-03-14 2019-05-23 リージェンティーズ コーポレイション 炎症性腸疾患を処置するための方法および組成物
EP3589292B1 (en) 2017-03-02 2023-08-23 University of Pittsburgh - Of the Commonwealth System of Higher Education Ecm hydrogel for treating esophageal inflammation
CA3049990A1 (en) 2017-03-02 2018-09-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Extracellular matrix (ecm) hydrogel and soluble fraction thereof for the treatment of cancer
US11389569B2 (en) 2017-04-03 2022-07-19 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable, porous, thermally responsive injectable hydrogel as soft tissue defect filler
KR102872720B1 (ko) 2017-05-05 2025-10-16 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 기질 결합 소낭의 안구에의 적용
CN111263647A (zh) 2017-10-24 2020-06-09 达沃有限公司 含羟基丁酸根的软组织修复植入物
KR20210005942A (ko) 2018-05-03 2021-01-15 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 Il-33을 포함하는 매트릭스 결합 소포 (mbvs) 및 그 용도

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008109407A2 (en) * 2007-03-02 2008-09-12 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Extracellular matrix-derived gels and related methods

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US20200009187A1 (en) 2020-01-09
EP4252842B1 (en) 2025-06-25
EP3589292A1 (en) 2020-01-08
JP7203428B2 (ja) 2023-01-13
JP2020509048A (ja) 2020-03-26
JP7681909B2 (ja) 2025-05-23
JP2025019254A (ja) 2025-02-06
AU2018226867B2 (en) 2023-11-02
US11707485B2 (en) 2023-07-25
ES3039679T3 (en) 2025-10-23
US11213545B2 (en) 2022-01-04
CN110352061A (zh) 2019-10-18
US20220249549A1 (en) 2022-08-11
EP3589292B1 (en) 2023-08-23
AU2024200617A1 (en) 2024-02-22
EP4252842A2 (en) 2023-10-04
EP3589292A4 (en) 2020-12-09
US12303533B2 (en) 2025-05-20
WO2018161028A1 (en) 2018-09-07
JP2023024578A (ja) 2023-02-16
US20240189349A1 (en) 2024-06-13
EP4252842A3 (en) 2023-10-25
AU2024200617B2 (en) 2025-10-23
CA3052489A1 (en) 2018-09-07
AU2018226867A1 (en) 2019-08-22
US20260053850A1 (en) 2026-02-26
KR20190120258A (ko) 2019-10-23
ES2957291T3 (es) 2024-01-16

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