JP7203428B2 - 食道の炎症を処置するためのｅｃｍヒドロゲル - Google Patents

食道の炎症を処置するためのｅｃｍヒドロゲル Download PDF

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JP7203428B2
JP7203428B2 JP2019547483A JP2019547483A JP7203428B2 JP 7203428 B2 JP7203428 B2 JP 7203428B2 JP 2019547483 A JP2019547483 A JP 2019547483A JP 2019547483 A JP2019547483 A JP 2019547483A JP 7203428 B2 JP7203428 B2 JP 7203428B2
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ecm
hydrogel
esophageal
esophagus
composition
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JP2020509048A5 (cg-RX-API-DMAC7.html
JP2020509048A (ja
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スティーブン フランシス バディラック，
グティエレス， フアン ディエゴ ナランホ
リンジー タミコ サルディン，
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University of Pittsburgh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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JP2019547483A 2017-03-02 2018-03-02 食道の炎症を処置するためのｅｃｍヒドロゲル Active JP7203428B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022202955A JP7681909B2 (ja) 2017-03-02 2022-12-20 食道の炎症を処置するためのｅｃｍヒドロゲル
JP2024205576A JP2025019254A (ja) 2017-03-02 2024-11-26 食道の炎症を処置するためのｅｃｍヒドロゲル

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US201762465985P 2017-03-02 2017-03-02
US62/465,985 2017-03-02
PCT/US2018/020758 WO2018161028A1 (en) 2017-03-02 2018-03-02 Ecm hydrogel for treating esophageal inflammation

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JP2022202955A Division JP7681909B2 (ja) 2017-03-02 2022-12-20 食道の炎症を処置するためのｅｃｍヒドロゲル

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JP2020509048A JP2020509048A (ja) 2020-03-26
JP2020509048A5 JP2020509048A5 (cg-RX-API-DMAC7.html) 2021-03-25
JP7203428B2 true JP7203428B2 (ja) 2023-01-13

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JP2019547483A Active JP7203428B2 (ja) 2017-03-02 2018-03-02 食道の炎症を処置するためのｅｃｍヒドロゲル
JP2022202955A Active JP7681909B2 (ja) 2017-03-02 2022-12-20 食道の炎症を処置するためのｅｃｍヒドロゲル
JP2024205576A Pending JP2025019254A (ja) 2017-03-02 2024-11-26 食道の炎症を処置するためのｅｃｍヒドロゲル

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JP2024205576A Pending JP2025019254A (ja) 2017-03-02 2024-11-26 食道の炎症を処置するためのｅｃｍヒドロゲル

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US (3) US11213545B2 (cg-RX-API-DMAC7.html)
EP (2) EP4252842B1 (cg-RX-API-DMAC7.html)
JP (3) JP7203428B2 (cg-RX-API-DMAC7.html)
KR (1) KR102745611B1 (cg-RX-API-DMAC7.html)
CN (1) CN110352061A (cg-RX-API-DMAC7.html)
AU (2) AU2018226867B2 (cg-RX-API-DMAC7.html)
CA (1) CA3052489A1 (cg-RX-API-DMAC7.html)
ES (2) ES3039679T3 (cg-RX-API-DMAC7.html)
WO (1) WO2018161028A1 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015231110B2 (en) 2014-03-21 2019-03-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix
US20190117837A1 (en) 2016-03-02 2019-04-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Matrix bound nanovesicles and their use
US11213545B2 (en) 2017-03-02 2022-01-04 University of Pittsburgh—of the Commonwealth System of Higher Education ECM hydrogel for treating esophageal inflammation
JP7282380B2 (ja) 2017-03-02 2023-05-29 ユニバーシティ オブ ピッツバーグ － オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション がんを処置するための細胞外マトリクス（ｅｃｍ）ヒドロゲルおよびその可溶性画分
AU2018261022B2 (en) 2017-05-05 2024-02-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Ocular applications of matrix bound vesicles (MBVs)
EP3787642A4 (en) 2018-05-03 2022-09-21 University of Pittsburgh - of the Commonwealth System of Higher Education IL-33 CONTAINING MATRIX-BONDED VESICLES (MBVS) AND THEIR USE
JP2021527518A (ja) * 2018-06-21 2021-10-14 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 食道粘膜下流体クッションとしての膀胱ｅｃｍヒドロゲルの使用
JP2021529024A (ja) * 2018-06-21 2021-10-28 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 食道粘膜下流体クッションとしての細胞外マトリックス（ｅｃｍ）ヒドロゲルの使用
ES2966711T3 (es) * 2018-06-21 2024-04-23 Univ Pittsburgh Commonwealth Sys Higher Education Hidrogel de matriz extracelular (ECM) como almohadilla líquida submucosa
KR20210142003A (ko) 2019-03-13 2021-11-23 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 음향 세포외 기질 하이드로겔 및 이의 용도
WO2021174085A1 (en) 2020-02-28 2021-09-02 Texas Medical Center Sprayable stimuli-responsive micro-hydrogels for adhesion prevention and enhanced tissue healing
US20230374465A1 (en) * 2020-11-17 2023-11-23 Cellartgen Inc. Esophagus extracellular matrix-derived scaffold for culture and transplantation of esophageal organoid, and method of preparing the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008109407A2 (en) 2007-03-02 2008-09-12 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Extracellular matrix-derived gels and related methods
WO2015164728A1 (en) 2014-04-24 2015-10-29 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fractionating extracellular matrix to modulate bioactivity and the host response

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155095A (en) 1961-02-07 1964-11-03 Adolph M Brown Anastomosis method and means
US4294241A (en) 1977-06-09 1981-10-13 Teruo Miyata Collagen skin dressing
US4582640A (en) 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
US4563350A (en) 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
US4978668A (en) 1986-09-02 1990-12-18 Purdue Research Foundation Treatment to reduce ischemic tissue injury
US4956178A (en) 1988-07-11 1990-09-11 Purdue Research Foundation Tissue graft composition
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US5007927A (en) 1989-10-24 1991-04-16 Purdue Research Foundation Muscle-powered cardiac assist device
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5354274A (en) 1992-08-20 1994-10-11 Methodist Hospital Of Indiana, Inc. Device for oral administration of liquids
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5352463A (en) 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
US5641518A (en) 1992-11-13 1997-06-24 Purdue Research Foundation Method of repairing bone tissue
US6653291B1 (en) 1992-11-13 2003-11-25 Purdue Research Foundation Composition and method for production of transformed cells
DE69527141T2 (de) 1994-04-29 2002-11-07 Scimed Life Systems, Inc. Stent mit kollagen
US6475232B1 (en) 1996-12-10 2002-11-05 Purdue Research Foundation Stent with reduced thrombogenicity
US6485723B1 (en) 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
CA2214407C (en) 1995-04-07 2008-06-17 Purdue Research Foundation Tissue graft and method for urinary bladder reconstruction
US5711969A (en) 1995-04-07 1998-01-27 Purdue Research Foundation Large area submucosal tissue graft constructs
CA2160647C (en) 1995-10-16 2002-05-28 Thomas William Garay Helical bearing anchor catcher
US5755791A (en) 1996-04-05 1998-05-26 Purdue Research Foundation Perforated submucosal tissue graft constructs
US6206931B1 (en) 1996-08-23 2001-03-27 Cook Incorporated Graft prosthesis materials
DE69739928D1 (de) 1996-09-16 2010-08-19 Purdue Research Foundation Gewebetransplantat aus der Magensubmukosa zur Reparatur neurologischen Gewebes
US6096347A (en) 1996-11-05 2000-08-01 Purdue Research Foundation Myocardial graft constructs
TW510803B (en) 1996-11-20 2002-11-21 Yasuhiko Shimizu Man-made esophagus and its manufacturing method
SK71399A3 (en) 1996-12-10 2000-05-16 Purdue Research Foundation Tubular submucosal graft constructs
JP4638562B2 (ja) 1996-12-10 2011-02-23 パーデュー・リサーチ・ファウンデーション 脊椎動物肝臓組織由来の生物材料
AU728949C (en) 1996-12-10 2007-03-29 Purdue Research Foundation Submucosa extracts
WO1998025549A1 (en) 1996-12-10 1998-06-18 Purdue Research Foundation Artificial vascular valves
AU720274B2 (en) 1996-12-10 2000-05-25 Purdue Research Foundation Stomach submucosa derived tissue graft
US6696270B2 (en) 1996-12-10 2004-02-24 Purdue Research Foundation Gastric submucosal tissue as a novel diagnostic tool
DE69802815T2 (de) 1997-09-11 2002-08-01 Purdue Research Foundation, West Lafayette Durch galactosidase modifiziertes submucosales gewebe
US6444229B2 (en) 1998-02-27 2002-09-03 Purdue Research Foundation Submucosa gel compositions
US6448076B2 (en) 1998-09-15 2002-09-10 The Regents Of The University Of Michigan Method for chemically acellularizing a biological tissue sample
AU759272B2 (en) 1998-12-01 2003-04-10 Medical College Of Ohio At Toledo Submucosa modulation of mammalian immune response
US6918396B1 (en) 1998-12-01 2005-07-19 Purdue Research Foundation Method for vocal cord reconstruction
US6579538B1 (en) 1999-12-22 2003-06-17 Acell, Inc. Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
EP1315796B1 (en) 2000-08-16 2006-07-12 Duke University Decellularized tissue engineered constructs and tissues
DE60117043T2 (de) * 2000-11-22 2006-07-13 Rxkinetix, Inc., Louisville Behandlung von mukositis
WO2003059284A2 (en) 2002-01-11 2003-07-24 Purdue Research Foundation Composition and method for inhibiting hypersensitivity
US7919121B2 (en) 2002-01-11 2011-04-05 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
WO2003092381A1 (en) 2002-05-02 2003-11-13 Purdue Research Foundation Vascularization enhanced graft constructs
AU2003234317B2 (en) 2002-05-02 2009-04-09 Purdue Research Foundation Vascularization enhanced graft constructs
CA2483913C (en) 2002-05-02 2014-07-15 Purdue Research Foundation Vascularization enhanced graft constructs comprising basement membrane
US7402319B2 (en) 2002-09-27 2008-07-22 Board Of Regents, The University Of Texas System Cell-free tissue replacement for tissue engineering
US20040191226A1 (en) 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of body wall
US20040187877A1 (en) 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of liver tissue
US20040175366A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
US20040176855A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
EP1644011A1 (en) 2003-06-25 2006-04-12 Stephen F. Badylak Conditioned matrix compositions for tissue restoration
US7326571B2 (en) 2003-07-17 2008-02-05 Boston Scientific Scimed, Inc. Decellularized bone marrow extracellular matrix
US8741352B2 (en) 2003-08-25 2014-06-03 Cook Biotech Incorporated Graft materials containing ECM components, and methods for their manufacture
WO2005020847A2 (en) 2003-08-25 2005-03-10 Cook Biotech Incorporated Graft materials containing bioactive substances, and methods for their manufacture
JP4724114B2 (ja) 2004-03-19 2011-07-13 田村プラスチック製品株式会社 自動車用バイザー
US7905826B2 (en) 2004-11-03 2011-03-15 Cook Incorporated Methods for modifying vascular vessel walls
US8874204B2 (en) 2004-12-20 2014-10-28 Cardiac Pacemakers, Inc. Implantable medical devices comprising isolated extracellular matrix
US9138445B2 (en) 2005-03-09 2015-09-22 Cook Biotech Incorporated Medical graft materials with adherent extracellular matrix fibrous mass
WO2007005792A2 (en) 2005-07-01 2007-01-11 University Of Pittsburgh Wound healing polymeric networks
US20070166396A1 (en) 2006-01-06 2007-07-19 University Of Pittsburgh Extracellular matrix based gastroesophageal junction reinforcement device
US8241908B2 (en) 2006-05-16 2012-08-14 Becton, Dickinson And Company Extracellular matrix coated surface for culturing cells
WO2008008266A2 (en) 2006-07-07 2008-01-17 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Biohybrid elastomeric scaffolds and methods of use thereof
EP2079490B1 (en) 2006-10-23 2012-08-29 Cook Biotech Incorporated Processed ecm materials with enhanced component profiles
US20110184439A1 (en) 2008-05-09 2011-07-28 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Biological Matrix for Cardiac Repair
WO2010099463A2 (en) 2009-02-27 2010-09-02 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Joint bioscaffolds
US8716438B2 (en) 2009-10-09 2014-05-06 University of Pittsburgh—of the Commonwealth System of Higher Education Matricryptic ECM peptides for tissue reconstruction
WO2011087743A2 (en) 2009-12-22 2011-07-21 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Decellularized adipose cell growth scaffold
US9421307B2 (en) 2010-08-17 2016-08-23 University of Pittsburgh—of the Commonwealth System of Higher Education Biohybrid composite scaffold
EP3225631B1 (en) 2011-04-12 2019-01-09 Novo Nordisk A/S Double-acylated glp-1 derivatives
WO2013009595A2 (en) 2011-07-08 2013-01-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Injectable cns-derived ecm for tissue reconstruction
KR101750349B1 (ko) 2013-02-08 2017-06-23 아셀, 인크. 세포외 기질 재료로부터의 생리활성 겔의 제조 방법
PL2983616T3 (pl) 2013-04-08 2019-05-31 Regentys Corp Sposób i kompozycja do leczenia nieswoistego zapalenia jelit bez kolektomii
US9861662B2 (en) 2013-07-03 2018-01-09 University of Pittsburgh—of the Commonwealth System of Higher Education Bone-derived extra cellular matrix gel
ITMI20131924A1 (it) 2013-11-20 2015-05-21 Cosmo Technologies Ltd Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica
US10286119B2 (en) 2014-01-24 2019-05-14 University of Pittsburgh—of the Commonwealth System of Higher Education Extracellular matrix mesh coating
AU2015231110B2 (en) 2014-03-21 2019-03-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix
US20180200405A1 (en) 2015-07-10 2018-07-19 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Methods of preparing ecm scaffolds and hydrogels from colon
EP3347063B1 (en) 2015-09-10 2025-11-19 University of Pittsburgh - of the Commonwealth System of Higher Education Bi-layer extra cellular matrix scaffolds and uses therefor
ES2873519T3 (es) 2015-09-18 2021-11-03 Univ Pittsburgh Commonwealth Sys Higher Education Matriz extracelular soluble no gelificante con actividad biológica
US11406736B2 (en) 2016-01-13 2022-08-09 University of Pittsburgh—Of the Commonwealth Systems of Higher Education Vascular extracellular matrix hydrogel
US20190117837A1 (en) 2016-03-02 2019-04-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Matrix bound nanovesicles and their use
JP2019513038A (ja) 2016-03-14 2019-05-23 リージェンティーズ コーポレイション 炎症性腸疾患を処置するための方法および組成物
JP7282380B2 (ja) 2017-03-02 2023-05-29 ユニバーシティ オブ ピッツバーグ － オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション がんを処置するための細胞外マトリクス（ｅｃｍ）ヒドロゲルおよびその可溶性画分
US11213545B2 (en) 2017-03-02 2022-01-04 University of Pittsburgh—of the Commonwealth System of Higher Education ECM hydrogel for treating esophageal inflammation
US11389569B2 (en) 2017-04-03 2022-07-19 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable, porous, thermally responsive injectable hydrogel as soft tissue defect filler
AU2018261022B2 (en) 2017-05-05 2024-02-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Ocular applications of matrix bound vesicles (MBVs)
US12329883B2 (en) 2017-10-24 2025-06-17 Davol Inc. Soft tissue repair implants comprising hydroxybutyrate
EP3787642A4 (en) 2018-05-03 2022-09-21 University of Pittsburgh - of the Commonwealth System of Higher Education IL-33 CONTAINING MATRIX-BONDED VESICLES (MBVS) AND THEIR USE

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008109407A2 (en) 2007-03-02 2008-09-12 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Extracellular matrix-derived gels and related methods
WO2015164728A1 (en) 2014-04-24 2015-10-29 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fractionating extracellular matrix to modulate bioactivity and the host response

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Tissue Engineering: Part A, 2015, Vol.21, No.17-18, pp.2293-2300

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Publication number Publication date
EP4252842B1 (en) 2025-06-25
WO2018161028A1 (en) 2018-09-07
US20240189349A1 (en) 2024-06-13
KR20190120258A (ko) 2019-10-23
US11213545B2 (en) 2022-01-04
EP4252842A2 (en) 2023-10-04
KR102745611B1 (ko) 2024-12-20
CN110352061A (zh) 2019-10-18
US20200009187A1 (en) 2020-01-09
JP2023024578A (ja) 2023-02-16
CA3052489A1 (en) 2018-09-07
EP3589292A4 (en) 2020-12-09
AU2024200617A1 (en) 2024-02-22
US20220249549A1 (en) 2022-08-11
AU2018226867B2 (en) 2023-11-02
JP2020509048A (ja) 2020-03-26
EP3589292B1 (en) 2023-08-23
EP4252842A3 (en) 2023-10-25
ES3039679T3 (en) 2025-10-23
AU2024200617B2 (en) 2025-10-23
JP2025019254A (ja) 2025-02-06
AU2018226867A1 (en) 2019-08-22
ES2957291T3 (es) 2024-01-16
US12303533B2 (en) 2025-05-20
EP3589292A1 (en) 2020-01-08
JP7681909B2 (ja) 2025-05-23
US11707485B2 (en) 2023-07-25

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