KR102732835B1 - 파르네소이드 x 수용체 조정제로서의 가교된 비시클릭 화합물 - Google Patents

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Publication number

KR102732835B1

KR102732835B1 KR1020207015270A KR20207015270A KR102732835B1 KR 102732835 B1 KR102732835 B1 KR 102732835B1 KR 1020207015270 A KR1020207015270 A KR 1020207015270A KR 20207015270 A KR20207015270 A KR 20207015270A KR 102732835 B1 KR102732835 B1 KR 102732835B1

Authority

KR

South Korea

Prior art keywords

methoxy

cyclopropyl

isoxazol

octan

bicyclo

Prior art date

2017-11-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 125000002619 bicyclic group Chemical group 0.000 title claims description 7
• 102100038495 Bile acid receptor Human genes 0.000 title abstract description 85
• 101000603876 Homo sapiens Bile acid receptor Proteins 0.000 title abstract description 85
• 150000001875 compounds Chemical class 0.000 claims abstract description 294
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 65
• 150000003839 salts Chemical class 0.000 claims abstract description 55
• 239000012453 solvate Substances 0.000 claims abstract description 37
• 206010016654 Fibrosis Diseases 0.000 claims abstract description 27
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 27
• 201000010099 disease Diseases 0.000 claims abstract description 25
• 230000004761 fibrosis Effects 0.000 claims abstract description 25
• 230000001575 pathological effect Effects 0.000 claims abstract description 4
• -1 1,5-naphthyridinyl Chemical group 0.000 claims description 247
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 61
• 125000000217 alkyl group Chemical group 0.000 claims description 55
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 53
• 125000001072 heteroaryl group Chemical group 0.000 claims description 39
• 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 38
• WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 36
• 239000005711 Benzoic acid Substances 0.000 claims description 34
• 235000010233 benzoic acid Nutrition 0.000 claims description 34
• 125000003566 oxetanyl group Chemical group 0.000 claims description 28
• 229910052801 chlorine Inorganic materials 0.000 claims description 26
• 229910052731 fluorine Inorganic materials 0.000 claims description 22
• 125000004076 pyridyl group Chemical group 0.000 claims description 22
• 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims description 21
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 20
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 16
• 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims description 14
• 208000036971 interstitial lung disease 2 Diseases 0.000 claims description 14
• 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims description 13
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 13
• 239000003937 drug carrier Substances 0.000 claims description 13
• 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 13
• 125000002757 morpholinyl group Chemical group 0.000 claims description 13
• 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 13
• 125000004193 piperazinyl group Chemical group 0.000 claims description 12
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 12
• 125000002393 azetidinyl group Chemical group 0.000 claims description 11
• 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims description 10
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
• 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 10
• 238000002560 therapeutic procedure Methods 0.000 claims description 10
• 208000033222 Biliary cirrhosis primary Diseases 0.000 claims description 9
• 208000012654 Primary biliary cholangitis Diseases 0.000 claims description 9
• 125000005873 benzo[d]thiazolyl group Chemical group 0.000 claims description 8
• 208000019425 cirrhosis of liver Diseases 0.000 claims description 8
• 125000003226 pyrazolyl group Chemical group 0.000 claims description 8
• 125000003831 tetrazolyl group Chemical group 0.000 claims description 8
• 208000007342 Diabetic Nephropathies Diseases 0.000 claims description 7
• 208000033679 diabetic kidney disease Diseases 0.000 claims description 7
• 201000002793 renal fibrosis Diseases 0.000 claims description 7
• 125000000335 thiazolyl group Chemical group 0.000 claims description 7
• 208000020832 chronic kidney disease Diseases 0.000 claims description 6
• 125000001041 indolyl group Chemical group 0.000 claims description 6
• 125000001715 oxadiazolyl group Chemical group 0.000 claims description 6
• 125000002971 oxazolyl group Chemical group 0.000 claims description 6
• MSKHYVHBBFEAMY-BQYQJAHWSA-N 2-[4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]phenyl]acetic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)/C=C/C1=CC=C(C=C1)CC(=O)O MSKHYVHBBFEAMY-BQYQJAHWSA-N 0.000 claims description 5
• MJLYHUGEXSTFAI-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1SC2=C(N=1)C(=CC(=C2)C(=O)O)F MJLYHUGEXSTFAI-UHFFFAOYSA-N 0.000 claims description 5
• OEFRRNDOWOKWSE-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-6-cyclopropyloxypyridine-2-carboxylic acid Chemical compound C1(CC1)OC1=CC(=CC(=N1)C(=O)O)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC=1C(=NOC=1C1CC1)C1=C(C=NC=C1Cl)Cl OEFRRNDOWOKWSE-UHFFFAOYSA-N 0.000 claims description 5
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 5
• 125000002883 imidazolyl group Chemical group 0.000 claims description 5
• 208000010157 sclerosing cholangitis Diseases 0.000 claims description 5
• 201000009594 Systemic Scleroderma Diseases 0.000 claims description 4
• 206010042953 Systemic sclerosis Diseases 0.000 claims description 4
• 230000009787 cardiac fibrosis Effects 0.000 claims description 4
• 125000001624 naphthyl group Chemical group 0.000 claims description 4
• 125000003386 piperidinyl group Chemical group 0.000 claims description 4
• 125000003373 pyrazinyl group Chemical group 0.000 claims description 4
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 4
• 125000001425 triazolyl group Chemical group 0.000 claims description 4
• KNOCEIYOPWHYEO-UHFFFAOYSA-N 1-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methyl]pyrazole-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)CN1N=CC(=C1)C(=O)O KNOCEIYOPWHYEO-UHFFFAOYSA-N 0.000 claims description 3
• HYRHTCHZQGGIKB-UHFFFAOYSA-N 2-[2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyridin-4-yl]acetic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=NC=CC(=C1)CC(=O)O HYRHTCHZQGGIKB-UHFFFAOYSA-N 0.000 claims description 3
• OKIYJIPJCMIEJY-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C=1SC2=C(N=1)C=CC=C2C(=O)O OKIYJIPJCMIEJY-UHFFFAOYSA-N 0.000 claims description 3
• SGUJKFFAWLLIGZ-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,3-oxazole-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C=1OC=C(N=1)C(=O)O SGUJKFFAWLLIGZ-UHFFFAOYSA-N 0.000 claims description 3
• ORGFARYSIXOFLS-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-5-(trifluoromethyl)-1,3-benzothiazole-7-carboxamide Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1SC2=C(N=1)C=C(C=C2C(=O)N)C(F)(F)F ORGFARYSIXOFLS-UHFFFAOYSA-N 0.000 claims description 3
• PXUKANRLSFFNRC-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)C(F)(F)F)COC12CCC(CC1)(CC2)C=1SC2=C(N=1)C=CC(=C2)C(=O)O PXUKANRLSFFNRC-UHFFFAOYSA-N 0.000 claims description 3
• BQZVTXZADJYSTG-UHFFFAOYSA-N 2-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]acetic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)CC(=O)O BQZVTXZADJYSTG-UHFFFAOYSA-N 0.000 claims description 3
• DBZIYVDYGIFKFQ-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-hydroxymethyl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(C=1SC2=C(N=1)C(=CC(=C2)C(=O)O)F)O DBZIYVDYGIFKFQ-UHFFFAOYSA-N 0.000 claims description 3
• PAOITBRBSLDZKC-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]methoxy]-1,3-thiazole-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)COC=1SC=C(N=1)C(=O)O PAOITBRBSLDZKC-UHFFFAOYSA-N 0.000 claims description 3
• XUKKVJLGZVCGLP-UHFFFAOYSA-N 3-[2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C#CC=1C=C(C(=O)O)C=CC=1 XUKKVJLGZVCGLP-UHFFFAOYSA-N 0.000 claims description 3
• WPGMGJQJZMZVPU-UHFFFAOYSA-N 3-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-6-fluoroimidazo[1,2-a]pyridine-8-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C#CC1=CN=C2N1C=C(C=C2C(=O)O)F WPGMGJQJZMZVPU-UHFFFAOYSA-N 0.000 claims description 3
• WPNCTCCEACQUDU-UHFFFAOYSA-N 3-[4-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]triazol-1-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1N=NN(C=1)C=1C=C(C(=O)O)C=CC=1 WPNCTCCEACQUDU-UHFFFAOYSA-N 0.000 claims description 3
• MWOZFTAXBUAODT-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2,6-difluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C(=C(C(=O)O)C(=CC=1)F)F MWOZFTAXBUAODT-UHFFFAOYSA-N 0.000 claims description 3
• KPNRGTCZVFGEMY-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 KPNRGTCZVFGEMY-UHFFFAOYSA-N 0.000 claims description 3
• MCNALCXWQXEAJX-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 MCNALCXWQXEAJX-UHFFFAOYSA-N 0.000 claims description 3
• JKMJWOGBGIGBGG-UHFFFAOYSA-N 3-[5-[4-[[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]amino]methyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)NCC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 JKMJWOGBGIGBGG-UHFFFAOYSA-N 0.000 claims description 3
• ZPFDGMFKVKTCSJ-UHFFFAOYSA-N 3-chloro-4-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]bicyclo[2.2.2]octane-1-carbonyl]amino]benzoic acid Chemical compound ClC=1C=C(C(=O)O)C=CC=1NC(=O)C12CCC(CC1)(CC2)COCC=1C(=NOC=1C1CC1)C1=C(C=CC=C1Cl)Cl ZPFDGMFKVKTCSJ-UHFFFAOYSA-N 0.000 claims description 3
• RIFGMDROEVYTMA-UHFFFAOYSA-N 3-chloro-4-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]bicyclo[2.2.2]octane-1-carbothioyl]amino]benzoic acid Chemical compound ClC=1C=C(C(=O)O)C=CC=1NC(=S)C12CCC(CC1)(CC2)COCC=1C(=NOC=1C1CC1)C1=C(C=CC=C1Cl)Cl RIFGMDROEVYTMA-UHFFFAOYSA-N 0.000 claims description 3
• MMYAZTHOHJSTKC-UHFFFAOYSA-N 4-(1-chloro-3-hydroxypropan-2-yl)oxy-6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]quinoline-2-carboxylic acid Chemical compound ClCC(CO)OC1=CC(=NC2=CC=C(C=C12)OCC12CCC(CC1)(CC2)OCC=1C(=NOC=1C1CC1)C1=C(C=NC=C1Cl)Cl)C(=O)O MMYAZTHOHJSTKC-UHFFFAOYSA-N 0.000 claims description 3
• VLDXYEYYQPWZHV-UHFFFAOYSA-N 4-[4-[[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]amino]methyl]-2-oxabicyclo[2.2.2]octan-1-yl]benzamide Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)NCC12COC(CC1)(CC2)C1=CC=C(C(=O)N)C=C1 VLDXYEYYQPWZHV-UHFFFAOYSA-N 0.000 claims description 3
• NYFKOGMAHZAFET-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-N-methylsulfonylbenzamide Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=CC=C(C(=O)NS(=O)(=O)C)C=C1 NYFKOGMAHZAFET-UHFFFAOYSA-N 0.000 claims description 3
• AJHHQPYCALNQJL-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=CC=C(C(=O)O)C=C1 AJHHQPYCALNQJL-UHFFFAOYSA-N 0.000 claims description 3
• OGENKUKIJQYNGK-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)COCC12COC(CC1)(CC2)C1=NC(=NO1)C1=CC=C(C(=O)O)C=C1 OGENKUKIJQYNGK-UHFFFAOYSA-N 0.000 claims description 3
• UXTOVNAWKRFEQM-UHFFFAOYSA-N 4-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]isoquinoline-1-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=CN=C(C2=CC=CC=C12)C(=O)O UXTOVNAWKRFEQM-UHFFFAOYSA-N 0.000 claims description 3
• RPJVJLNMEAKYTJ-UHFFFAOYSA-N 4-cyclopropyl-6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=CC(=NC2=CC=C(C=C12)OCC12CCC(CC1)(CC2)OCC=1C(=NOC=1C1CC1)C1=C(C=NC=C1Cl)Cl)C(=O)O RPJVJLNMEAKYTJ-UHFFFAOYSA-N 0.000 claims description 3
• YDLTVBMEPKCJNY-UHFFFAOYSA-N 5-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-6-(3-fluoroazetidin-1-yl)pyridine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C#CC=1C(=NC=C(C(=O)O)C=1)N1CC(C1)F YDLTVBMEPKCJNY-UHFFFAOYSA-N 0.000 claims description 3
• RWXJVDQCJRWGRT-UHFFFAOYSA-N 5-[3-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NOC(=N1)C=1C=CC(=C(C(=O)O)C=1)OC RWXJVDQCJRWGRT-UHFFFAOYSA-N 0.000 claims description 3
• LCCVQASEJONYNN-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2,3-dimethoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=C(C(=O)O)C=1)OC)OC LCCVQASEJONYNN-UHFFFAOYSA-N 0.000 claims description 3
• XOIYZDBLHCTKEX-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-fluoro-3-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=C(C(=O)O)C=1)F)OC XOIYZDBLHCTKEX-UHFFFAOYSA-N 0.000 claims description 3
• NLNAQGCGEJRVNM-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzamide Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)N)C=1)OC NLNAQGCGEJRVNM-UHFFFAOYSA-N 0.000 claims description 3
• BXIKWFBTWHVRFY-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)O)C=1)OC BXIKWFBTWHVRFY-UHFFFAOYSA-N 0.000 claims description 3
• TWOYCPCUYQNBGB-UHFFFAOYSA-N 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-[[4-[6-(2H-tetrazol-5-yl)-1,3-benzothiazol-2-yl]-1-bicyclo[2.2.2]octanyl]oxymethyl]-1,2-oxazole Chemical compound N1N=NN=C1C1=CC2=C(N=C(S2)C23CCC(CC2)(CC3)OCC=2C(=NOC=2C2CC2)C2=C(C=CC=C2Cl)Cl)C=C1 TWOYCPCUYQNBGB-UHFFFAOYSA-N 0.000 claims description 3
• VISHNRLBZQHURE-UHFFFAOYSA-N 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-[[4-[[3-(2H-tetrazol-5-yl)phenoxy]methyl]-1-bicyclo[2.2.2]octanyl]oxymethyl]-1,2-oxazole Chemical compound N=1NN=NC=1C=1C=C(OCC23CCC(CC2)(CC3)OCC=2C(=NOC=2C2CC2)C2=C(C=CC=C2Cl)Cl)C=CC=1 VISHNRLBZQHURE-UHFFFAOYSA-N 0.000 claims description 3
• HMZNRSPTDAWOQF-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-4-methoxy-N,N-dimethylquinoline-2-carboxamide Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C#CC=1C=C2C(=CC(=NC2=CC=1)C(=O)N(C)C)OC HMZNRSPTDAWOQF-UHFFFAOYSA-N 0.000 claims description 3
• FCASJJSUWLUYHQ-UHFFFAOYSA-N 6-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=NC=C(C(=O)O)C=C1 FCASJJSUWLUYHQ-UHFFFAOYSA-N 0.000 claims description 3
• DHOWRLMYESJZOE-UHFFFAOYSA-N 6-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-3-methoxypyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=CC=C(C(=N1)C(=O)O)OC DHOWRLMYESJZOE-UHFFFAOYSA-N 0.000 claims description 3
• OVWVWBRVVVSXMN-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C=CC(=NC2=CC=1)C(=O)O OVWVWBRVVVSXMN-UHFFFAOYSA-N 0.000 claims description 3
• NXVPVIBWFNWSDO-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-(trifluoromethyl)pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=CC(=CC(=N1)C(=O)O)C(F)(F)F NXVPVIBWFNWSDO-UHFFFAOYSA-N 0.000 claims description 3
• GAOCCZMZVDWTGZ-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-(trifluoromethyl)quinoline-2-carboxamide Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=CC=1)C(=O)N)C(F)(F)F GAOCCZMZVDWTGZ-UHFFFAOYSA-N 0.000 claims description 3
• BQPMJMLIAHSHRG-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-5-(trifluoromethyl)pyridine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=NC=C(C(=O)O)C=C1C(F)(F)F BQPMJMLIAHSHRG-UHFFFAOYSA-N 0.000 claims description 3
• CAKHNNKSADIIGV-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-8-fluoro-4-methoxyquinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=C(C=1)F)C(=O)O)OC CAKHNNKSADIIGV-UHFFFAOYSA-N 0.000 claims description 3
• QHDRAKFSJWHEJN-VOTSOKGWSA-N 7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-1-methoxyisoquinoline-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)/C=C/C1=CC=C2C=C(N=C(C2=C1)OC)C(=O)O QHDRAKFSJWHEJN-VOTSOKGWSA-N 0.000 claims description 3
• IQGADFDUFVKCSW-BQYQJAHWSA-N 7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-1-propan-2-yloxyisoquinoline-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)/C=C/C1=CC=C2C=C(N=C(C2=C1)OC(C)C)C(=O)O IQGADFDUFVKCSW-BQYQJAHWSA-N 0.000 claims description 3
• GXWPZVUYCRTCQI-UHFFFAOYSA-N 7-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1-(4-methylpiperazin-1-yl)isoquinoline-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C#CC1=CC=C2C=C(N=C(C2=C1)N1CCN(CC1)C)C(=O)O GXWPZVUYCRTCQI-UHFFFAOYSA-N 0.000 claims description 3
• IEUYBFDAAWBQOJ-UHFFFAOYSA-N 7-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-1-propan-2-yloxyisoquinoline-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=CC=C2C=C(N=C(C2=C1)OC(C)C)C(=O)O IEUYBFDAAWBQOJ-UHFFFAOYSA-N 0.000 claims description 3
• 206010004664 Biliary fibrosis Diseases 0.000 claims description 3
• 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims description 3
• 208000005069 pulmonary fibrosis Diseases 0.000 claims description 3
• 125000002098 pyridazinyl group Chemical group 0.000 claims description 3
• 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims description 3
• 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims description 3
• 125000001113 thiadiazolyl group Chemical group 0.000 claims description 3
• 206010019668 Hepatic fibrosis Diseases 0.000 claims description 2
• CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims description 2
• 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 2
• WXBLLCUINBKULX-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1 WXBLLCUINBKULX-UHFFFAOYSA-N 0.000 claims 18
• KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 8
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 5
• DMPZJACLHDWUFS-UHFFFAOYSA-N 1,3-benzothiazole-6-carboxylic acid Chemical compound OC(=O)C1=CC=C2N=CSC2=C1 DMPZJACLHDWUFS-UHFFFAOYSA-N 0.000 claims 4
• FWZOJLZJEACICV-UHFFFAOYSA-N 2-[4-[2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-7-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1SC(=N2)C12CCC(CC1)(CC2)C=CC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 FWZOJLZJEACICV-UHFFFAOYSA-N 0.000 claims 4
• QQCOSZYRAHCCTO-UHFFFAOYSA-N 2-[4-[2-[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-7-carboxylic acid Chemical compound C1CC1C2=C(C(=NO2)C3=CC=CC=C3OC(F)(F)F)C=CC45CCC(CC4)(CC5)C6=NC7=CC=CC(=C7S6)C(=O)O QQCOSZYRAHCCTO-UHFFFAOYSA-N 0.000 claims 4
• VXXJEQJGJCXXES-UHFFFAOYSA-N 3-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-2-methoxybenzoic acid Chemical compound COC1=C(C=CC=C1C(O)=O)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 VXXJEQJGJCXXES-UHFFFAOYSA-N 0.000 claims 4
• PVGLYQXOHNMBFM-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C(=C(C(=O)O)C=CC=1)OC PVGLYQXOHNMBFM-UHFFFAOYSA-N 0.000 claims 4
• FVHPLBPMZJNGCZ-UHFFFAOYSA-N 3-[[4-[2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]bicyclo[2.2.2]octane-1-carbonyl]amino]benzoic acid Chemical compound OC(=O)C1=CC=CC(NC(=O)C23CCC(CC2)(CC3)C=CC2=C(ON=C2C2=C(Cl)C=CC=C2Cl)C2CC2)=C1 FVHPLBPMZJNGCZ-UHFFFAOYSA-N 0.000 claims 4
• QNCUSMLZWUPDEV-UHFFFAOYSA-N 4-[5-[4-[2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.1]heptanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)C=CC12CCC(CC1)(C2)C1=NC(=NO1)C1=CC=C(C(=O)O)C=C1 QNCUSMLZWUPDEV-UHFFFAOYSA-N 0.000 claims 4
• YCAPXSMYWUQRGA-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-6-methoxypyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=CC(=NC(=C1)OC)C(=O)O YCAPXSMYWUQRGA-UHFFFAOYSA-N 0.000 claims 4
• AMOBTAXYXRZTCM-UHFFFAOYSA-N 5-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]pyrazolo[1,5-a]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=C2C=C(C=CN2N=C1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 AMOBTAXYXRZTCM-UHFFFAOYSA-N 0.000 claims 4
• OMMFZYRVNFAUHZ-UHFFFAOYSA-N 7-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methyl]-6,8-dihydro-5H-imidazo[1,2-a]pyrazine-2-carboxylic acid Chemical compound OC(=O)C1=CN2CCN(CC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=CC=C3Cl)C3CC3)CC2=N1 OMMFZYRVNFAUHZ-UHFFFAOYSA-N 0.000 claims 4
• NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 claims 4
• ORSZGLLQNYSMNO-UHFFFAOYSA-N 1,3-benzothiazole-7-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1SC=N2 ORSZGLLQNYSMNO-UHFFFAOYSA-N 0.000 claims 3
• MZKGPWOMKIOYOR-AATRIKPKSA-N 2-[4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-3-fluorophenoxy]acetic acid Chemical compound OC(=O)COC1=CC(F)=C(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1 MZKGPWOMKIOYOR-AATRIKPKSA-N 0.000 claims 3
• YNUYDKHIIIRLKZ-UHFFFAOYSA-N 1-(azetidin-1-yl)-7-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]isoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C(C=C2)C#CC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(=N1)N1CCC1 YNUYDKHIIIRLKZ-UHFFFAOYSA-N 0.000 claims 2
• UASJWEHTQXRDCF-UHFFFAOYSA-N 1-(cyclopropylamino)-7-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]isoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C(C=C2)C#CC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(NC2CC2)=N1 UASJWEHTQXRDCF-UHFFFAOYSA-N 0.000 claims 2
• MIKSITSFBHXCLH-UHFFFAOYSA-N 1-[3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-hydroxymethyl]phenyl]cyclopropane-1-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(C=1C=C(C=CC=1)C1(CC1)C(=O)O)O MIKSITSFBHXCLH-UHFFFAOYSA-N 0.000 claims 2
• OAYASYFORALBMA-UHFFFAOYSA-N 1-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]cyclopropane-1-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1(CC1)C(=O)O OAYASYFORALBMA-UHFFFAOYSA-N 0.000 claims 2
• GIKNQEQASOSMSW-UHFFFAOYSA-N 1-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methyl]-5-(difluoromethyl)pyrazole-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)CN1N=CC(=C1C(F)F)C(=O)O GIKNQEQASOSMSW-UHFFFAOYSA-N 0.000 claims 2
• DLKATGBZWZVTLK-UHFFFAOYSA-N 1-anilino-7-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]isoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C(C=C2)C#CC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(NC2=CC=CC=C2)=N1 DLKATGBZWZVTLK-UHFFFAOYSA-N 0.000 claims 2
• WTHSRRCOVIDHTL-AATRIKPKSA-N 1-chloro-7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]isoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C(\C=C\C34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2)C(Cl)=N1 WTHSRRCOVIDHTL-AATRIKPKSA-N 0.000 claims 2
• COKATMFAAIHOFX-CMDGGOBGSA-N 1-cyclobutyloxy-7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]isoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C(\C=C\C34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2)C(OC2CCC2)=N1 COKATMFAAIHOFX-CMDGGOBGSA-N 0.000 claims 2
• QVJYKNGWBFDKHY-MDZDMXLPSA-N 1-cyclopentyloxy-7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]isoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C(\C=C\C34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2)C(OC2CCCC2)=N1 QVJYKNGWBFDKHY-MDZDMXLPSA-N 0.000 claims 2
• MBGAXGKHADNKCF-UHFFFAOYSA-N 1-cyclopropyl-5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyrazole-3-carboxylic acid Chemical compound OC(=O)C1=NN(C2CC2)C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1 MBGAXGKHADNKCF-UHFFFAOYSA-N 0.000 claims 2
• VZFHILQNKSNOBP-UHFFFAOYSA-N 2-[1-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]bicyclo[2.2.2]octane-1-carbonyl]piperidin-4-yl]acetic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(=O)N1CCC(CC1)CC(=O)O VZFHILQNKSNOBP-UHFFFAOYSA-N 0.000 claims 2
• NSSYCGXGDFDAML-UHFFFAOYSA-N 2-[2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]pyridine-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C#CC=1C=C(C(=O)O)C=CN=1 NSSYCGXGDFDAML-UHFFFAOYSA-N 0.000 claims 2
• VIJZNJQUTQIPIL-UHFFFAOYSA-N 2-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C#CC=1SC2=C(N=1)C(=CC(=C2)C(=O)O)F VIJZNJQUTQIPIL-UHFFFAOYSA-N 0.000 claims 2
• XXCHIJLFLLIORN-UHFFFAOYSA-N 2-[2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]phenyl]acetic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=C(C=CC=C1)CC(=O)O XXCHIJLFLLIORN-UHFFFAOYSA-N 0.000 claims 2
• GMOMKEOJVFSVDE-UHFFFAOYSA-N 2-[2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methylamino]-4-methyl-1,3-thiazol-5-yl]acetic acid Chemical compound Cc1nc(NCC23CCC(CC2)(CC3)OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)sc1CC(O)=O GMOMKEOJVFSVDE-UHFFFAOYSA-N 0.000 claims 2
• OYYYXAPLNZADQI-VOTSOKGWSA-N 2-[3-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]phenyl]acetic acid Chemical compound OC(=O)CC1=CC=CC(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1 OYYYXAPLNZADQI-VOTSOKGWSA-N 0.000 claims 2
• FGCVFKBIRAIUQW-UHFFFAOYSA-N 2-[3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]phenyl]acetic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C=CC=1)CC(=O)O FGCVFKBIRAIUQW-UHFFFAOYSA-N 0.000 claims 2
• GASIPMLUHJGRDS-UHFFFAOYSA-N 2-[3-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-5-ethylpyrazol-1-yl]acetic acid Chemical compound CCC1=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=NN1CC(O)=O GASIPMLUHJGRDS-UHFFFAOYSA-N 0.000 claims 2
• LPZUOUFFLBGESV-UHFFFAOYSA-N 2-[3-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methylamino]pyrazol-1-yl]acetic acid Chemical compound OC(=O)Cn1ccc(NCC23CCC(CC2)(CC3)OCc2c(onc2-c2c(Cl)cncc2Cl)C2CC2)n1 LPZUOUFFLBGESV-UHFFFAOYSA-N 0.000 claims 2
• KXMVLIDXEPLILP-AATRIKPKSA-N 2-[4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-2-fluorophenyl]acetic acid Chemical compound OC(=O)CC1=CC=C(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1F KXMVLIDXEPLILP-AATRIKPKSA-N 0.000 claims 2
• TWLKAAFQTSOUNU-AATRIKPKSA-N 2-[4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-3-(trifluoromethyl)phenyl]acetic acid Chemical compound OC(=O)Cc1ccc(\C=C\C23CCC(CC2)(CC3)OCc2c(onc2-c2c(Cl)cncc2Cl)C2CC2)c(c1)C(F)(F)F TWLKAAFQTSOUNU-AATRIKPKSA-N 0.000 claims 2
• MJQZKZWQWOSOOH-AATRIKPKSA-N 2-[4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-3-fluorophenyl]acetic acid Chemical compound OC(=O)CC1=CC(F)=C(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1 MJQZKZWQWOSOOH-AATRIKPKSA-N 0.000 claims 2
• JMHHCBCASLRABU-BQYQJAHWSA-N 2-[4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]phenyl]-1,3-thiazole-4-carboxylic acid Chemical compound OC(=O)C1=CSC(=N1)C1=CC=C(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1 JMHHCBCASLRABU-BQYQJAHWSA-N 0.000 claims 2
• PIYJSXJPHLJSDL-MDZDMXLPSA-N 2-[4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]phenyl]-N,N-dimethylacetamide Chemical compound CN(C)C(=O)CC1=CC=C(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1 PIYJSXJPHLJSDL-MDZDMXLPSA-N 0.000 claims 2
• MORPYGNWNGUWCK-CMDGGOBGSA-N 2-[4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]phenyl]-N-methylacetamide Chemical compound CNC(=O)CC1=CC=C(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1 MORPYGNWNGUWCK-CMDGGOBGSA-N 0.000 claims 2
• XFLKGOONVOYBFA-HWKANZROSA-N 2-[4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]pyridin-2-yl]oxyacetic acid Chemical compound OC(=O)COC1=NC=CC(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1 XFLKGOONVOYBFA-HWKANZROSA-N 0.000 claims 2
• AFIOBOUXPNRWNF-UHFFFAOYSA-N 2-[4-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-2-fluorophenyl]acetic acid Chemical compound OC(=O)CC1=CC=C(C=C1F)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 AFIOBOUXPNRWNF-UHFFFAOYSA-N 0.000 claims 2
• SIGZLXFDGVPTJK-UHFFFAOYSA-N 2-[4-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-3-(trifluoromethyl)phenyl]acetic acid Chemical compound OC(=O)Cc1ccc(C#CC23CCC(CC2)(CC3)OCc2c(onc2-c2c(Cl)cncc2Cl)C2CC2)c(c1)C(F)(F)F SIGZLXFDGVPTJK-UHFFFAOYSA-N 0.000 claims 2
• KZXVHNOKQURXGC-UHFFFAOYSA-N 2-[4-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-3-fluorophenoxy]acetic acid Chemical compound OC(=O)COC1=CC=C(C#CC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(F)=C1 KZXVHNOKQURXGC-UHFFFAOYSA-N 0.000 claims 2
• IVTUQNIKNGOFTD-UHFFFAOYSA-N 2-[4-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]pyridin-2-yl]oxyacetic acid Chemical compound OC(=O)COC1=NC=CC(=C1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 IVTUQNIKNGOFTD-UHFFFAOYSA-N 0.000 claims 2
• LYEIIEQYNIJWFN-UHFFFAOYSA-N 2-[4-[2-[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]ethyl]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)CCC12CCC(CC1)(CC2)C=1SC2=C(N=1)C=CC=C2C(=O)O LYEIIEQYNIJWFN-UHFFFAOYSA-N 0.000 claims 2
• SJQJDPIBWCASQW-UHFFFAOYSA-N 2-[4-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]phenoxy]propanoic acid Chemical compound CC(OC1=CC=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1)C(O)=O SJQJDPIBWCASQW-UHFFFAOYSA-N 0.000 claims 2
• FNMVSJWDWYCICG-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,2-difluoro-1-methylcyclopropyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]quinoline-5-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1(C(C1)(F)F)C)COC12CCC(CC1)(CC2)C1=NC=2C=CC=C(C=2C=C1)C(=O)O FNMVSJWDWYCICG-UHFFFAOYSA-N 0.000 claims 2
• GRWMHEKFBZLRJM-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-6-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C1)N=C(S2)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 GRWMHEKFBZLRJM-UHFFFAOYSA-N 0.000 claims 2
• CFLWZKKOSLLPFS-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]pyridine-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1C=C(C(=O)O)C=CN=1 CFLWZKKOSLLPFS-UHFFFAOYSA-N 0.000 claims 2
• VDWVQQGOPBOGRE-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]quinazoline-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC2=CC=C(C=C2C=N1)C(=O)O VDWVQQGOPBOGRE-UHFFFAOYSA-N 0.000 claims 2
• WGPXBGGTZUUQQC-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]quinoline-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC2=CC=C(C=C2C=C1)C(=O)O WGPXBGGTZUUQQC-UHFFFAOYSA-N 0.000 claims 2
• VJSAXAGDGVUHLQ-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-2-oxabicyclo[2.2.2]octan-1-yl]-1,3-benzothiazole-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12COC(CC1)(CC2)C=1SC2=C(N=1)C=CC=C2C(=O)O VJSAXAGDGVUHLQ-UHFFFAOYSA-N 0.000 claims 2
• GXWUJQPIBXQGMQ-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]bicyclo[2.2.2]octane-1-carbonyl]-3,4-dihydro-1H-isoquinoline-5-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(=O)N1CC=2C=CC=C(C=2CC1)C(=O)O GXWUJQPIBXQGMQ-UHFFFAOYSA-N 0.000 claims 2
• WLLQLLQIMFKEHZ-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]bicyclo[2.2.2]octane-1-carbonyl]-3,4-dihydro-1H-isoquinoline-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(=O)N1CC2=CC=C(C=C2CC1)C(=O)O WLLQLLQIMFKEHZ-UHFFFAOYSA-N 0.000 claims 2
• ZBRXAPRGIYZWBP-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]bicyclo[2.2.2]octane-1-carbonyl]-3,4-dihydro-1H-isoquinoline-8-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(=O)N1CC2=C(C=CC=C2CC1)C(=O)O ZBRXAPRGIYZWBP-UHFFFAOYSA-N 0.000 claims 2
• UGALHDBBHDUBMX-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C=1SC2=C(N=1)C=CC(=C2)C(=O)O UGALHDBBHDUBMX-UHFFFAOYSA-N 0.000 claims 2
• ZSSCUJNLDKCRQQ-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,3-benzoxazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C=1OC2=C(N=1)C=CC(=C2)C(=O)O ZSSCUJNLDKCRQQ-UHFFFAOYSA-N 0.000 claims 2
• PNYIICMNDMXEGB-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,3-thiazole-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C=1SC=C(N=1)C(=O)O PNYIICMNDMXEGB-UHFFFAOYSA-N 0.000 claims 2
• CYCLZAVSVDDBDM-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-4-methyl-1,3-thiazole-5-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C=1SC(=C(N=1)C)C(=O)O CYCLZAVSVDDBDM-UHFFFAOYSA-N 0.000 claims 2
• YXVSTHAINMSHLT-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-1,3-thiazole-4-carboxylic acid Chemical compound OC(=O)C1=CSC(=N1)C12CCC(COCC3=C(ON=C3C3=C(Cl)C=CC=C3Cl)C3CC3)(CC1)CO2 YXVSTHAINMSHLT-UHFFFAOYSA-N 0.000 claims 2
• SKARHFXXQRDVED-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1SC2=C(N=1)C=CC=C2C(=O)O SKARHFXXQRDVED-UHFFFAOYSA-N 0.000 claims 2
• DIOMJYZUMUEJOD-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1SC2=C(N=1)C(=CC(=C2)C(=O)O)F DIOMJYZUMUEJOD-UHFFFAOYSA-N 0.000 claims 2
• XKJVRZKELVRCDG-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-5-(trifluoromethyl)-1,3-benzothiazole-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1SC2=C(N=1)C=C(C=C2C(=O)O)C(F)(F)F XKJVRZKELVRCDG-UHFFFAOYSA-N 0.000 claims 2
• BGRBSSFDFYXYPH-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-5-(trifluoromethyl)quinoline-7-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=CC(=N2)C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(=C1)C(F)(F)F BGRBSSFDFYXYPH-UHFFFAOYSA-N 0.000 claims 2
• DXUBXDHUOMYKBZ-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-6-fluoro-1,3-benzothiazole-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1SC2=C(N=1)C=CC(=C2C(=O)O)F DXUBXDHUOMYKBZ-UHFFFAOYSA-N 0.000 claims 2
• VZLGSTKSUYAQNZ-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-6-methoxyquinoline-5-carboxylic acid Chemical compound COC1=C(C(O)=O)C2=C(C=C1)N=C(C=C2)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 VZLGSTKSUYAQNZ-UHFFFAOYSA-N 0.000 claims 2
• WZDQHEVIWLCSLF-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-7-(trifluoromethyl)quinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC(=CC2=C1C=CC(=N2)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(F)(F)F WZDQHEVIWLCSLF-UHFFFAOYSA-N 0.000 claims 2
• FKBKIWNUCUBWAN-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(2-hydroxy-2-methylpropoxy)quinoline-5-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC=2C(=CC=C(C=2C=C1)C(=O)O)OCC(C)(C)O FKBKIWNUCUBWAN-UHFFFAOYSA-N 0.000 claims 2
• KUDDWIOSXRMZPP-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(3-methoxypropoxy)quinoline-6-carboxylic acid Chemical compound COCCCOC1=CC(=CC2=C1N=C(C=C2)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O KUDDWIOSXRMZPP-UHFFFAOYSA-N 0.000 claims 2
• ISQFLTCJDFBHHA-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(4-methylpiperazin-1-yl)quinoline-5-carboxylic acid Chemical compound CN1CCN(CC1)C1=CC=C(C(O)=O)C2=CC=C(N=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 ISQFLTCJDFBHHA-UHFFFAOYSA-N 0.000 claims 2
• YULOLRRJARARHD-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(cyclopropylmethoxy)quinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=C(OCC2CC2)C2=NC(=CC=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 YULOLRRJARARHD-UHFFFAOYSA-N 0.000 claims 2
• MTNUKQZXOCAOIR-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(oxan-4-yloxy)quinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=C(OC2CCOCC2)C2=NC(=CC=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 MTNUKQZXOCAOIR-UHFFFAOYSA-N 0.000 claims 2
• AXJWXWHTELKSOZ-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(oxetan-3-yloxy)quinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=C(OC2COC2)C2=NC(=CC=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 AXJWXWHTELKSOZ-UHFFFAOYSA-N 0.000 claims 2
• FHBSBBXQLLGBBP-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(oxetan-3-yloxy)quinoline-6-carboxylic acid Chemical compound OC(=O)C1=CC2=C(N=C(C=C2)C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(OC2COC2)=C1 FHBSBBXQLLGBBP-UHFFFAOYSA-N 0.000 claims 2
• MEPPIPGTOKSMRR-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(oxolan-3-yloxy)quinoline-6-carboxylic acid Chemical compound OC(=O)C1=CC2=C(N=C(C=C2)C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(OC2CCOC2)=C1 MEPPIPGTOKSMRR-UHFFFAOYSA-N 0.000 claims 2
• OIRVTLYUXMHOIV-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(trifluoromethyl)quinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=C(C2=NC(=CC=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(F)(F)F OIRVTLYUXMHOIV-UHFFFAOYSA-N 0.000 claims 2
• PGZFNBBQFNMPQR-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(trifluoromethyl)quinoline-6-carboxylic acid Chemical compound OC(=O)C1=CC2=CC=C(N=C2C(=C1)C(F)(F)F)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 PGZFNBBQFNMPQR-UHFFFAOYSA-N 0.000 claims 2
• WPYWIOPLTFLQGN-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-fluoroquinoline-6-carboxylic acid Chemical compound OC(=O)C1=CC2=CC=C(N=C2C(F)=C1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 WPYWIOPLTFLQGN-UHFFFAOYSA-N 0.000 claims 2
• SIRVQDTVVSUCLG-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-hydroxyquinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=C(O)C2=NC(=CC=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 SIRVQDTVVSUCLG-UHFFFAOYSA-N 0.000 claims 2
• OXVJUKFVDFFXMA-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-methoxyquinoline-5-carboxylic acid Chemical compound COC1=CC=C(C(O)=O)C2=CC=C(N=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 OXVJUKFVDFFXMA-UHFFFAOYSA-N 0.000 claims 2
• OOMFPJKYLUBFCO-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-methylquinoline-5-carboxylic acid Chemical compound CC1=CC=C(C(O)=O)C2=CC=C(N=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 OOMFPJKYLUBFCO-UHFFFAOYSA-N 0.000 claims 2
• FLZAXVLXEIAVEY-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-morpholin-4-ylquinoline-5-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC=2C(=CC=C(C=2C=C1)C(=O)O)N1CCOCC1 FLZAXVLXEIAVEY-UHFFFAOYSA-N 0.000 claims 2
• GQZQHOANKCWOCK-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-morpholin-4-ylquinoline-6-carboxylic acid Chemical compound OC(=O)C1=CC2=C(N=C(C=C2)C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(=C1)N1CCOCC1 GQZQHOANKCWOCK-UHFFFAOYSA-N 0.000 claims 2
• PMEZLPBEMUVZTI-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-propan-2-yloxyquinoline-5-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC=2C(=CC=C(C=2C=C1)C(=O)O)OC(C)C PMEZLPBEMUVZTI-UHFFFAOYSA-N 0.000 claims 2
• WAMGLBALJXEOHI-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-pyrrolidin-1-ylquinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=C(N2CCCC2)C2=NC(=CC=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 WAMGLBALJXEOHI-UHFFFAOYSA-N 0.000 claims 2
• UDSKFKJXXCUHST-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]quinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=NC(=CC=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 UDSKFKJXXCUHST-UHFFFAOYSA-N 0.000 claims 2
• FOYMVMLVLIIZOS-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(dicyclopropylmethyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-7-(trifluoromethyl)quinoline-5-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C(C1CC1)C1CC1)COC12CCC(CC1)(CC2)C1=NC=2C=C(C=C(C=2C=C1)C(=O)O)C(F)(F)F FOYMVMLVLIIZOS-UHFFFAOYSA-N 0.000 claims 2
• BSHYILBOKGIEIN-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-6-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C1)N=C(S2)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 BSHYILBOKGIEIN-UHFFFAOYSA-N 0.000 claims 2
• XMRUTTLFGJEBEM-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)COC12CCC(CC1)(CC2)C=1SC2=C(N=1)C(=CC(=C2)C(=O)O)F XMRUTTLFGJEBEM-UHFFFAOYSA-N 0.000 claims 2
• QMYDZSITTJBTTH-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]quinazoline-6-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C1)N=C(N=C2)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 QMYDZSITTJBTTH-UHFFFAOYSA-N 0.000 claims 2
• ZNYYFNOKZWCJII-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-1,3-thiazole-4-carboxylic acid Chemical compound OC(=O)C1=CSC(=N1)C12CCC(COCC3=C(ON=C3C3=C(OC(F)(F)F)C=CC=C3)C3CC3)(CC1)CO2 ZNYYFNOKZWCJII-UHFFFAOYSA-N 0.000 claims 2
• UBJLWZIZLGZQPR-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid Chemical compound OC(=O)C1=CC2=C(N=C(S2)C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=CC=CC=C2C(F)(F)F)C2CC2)C(F)=C1 UBJLWZIZLGZQPR-UHFFFAOYSA-N 0.000 claims 2
• CLJMUWUBOGWZGS-AATRIKPKSA-N 2-[5-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]pyridin-2-yl]acetic acid Chemical compound OC(=O)CC1=CC=C(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=N1 CLJMUWUBOGWZGS-AATRIKPKSA-N 0.000 claims 2
• DLRBUARSOFLKGN-AATRIKPKSA-N 2-[5-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]pyridin-2-yl]oxyacetic acid Chemical compound OC(=O)COC1=CC=C(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=N1 DLRBUARSOFLKGN-AATRIKPKSA-N 0.000 claims 2
• QVGDSDQMNKCFLT-UHFFFAOYSA-N 2-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]cyclopropane-1-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1C(C1)C(=O)O QVGDSDQMNKCFLT-UHFFFAOYSA-N 0.000 claims 2
• NAXDZGAMYZVHKL-UHFFFAOYSA-N 2-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CN=1 NAXDZGAMYZVHKL-UHFFFAOYSA-N 0.000 claims 2
• MTBVJYHELGSHOV-UHFFFAOYSA-N 2-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]cyclopropane-1-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1C(C1)C(=O)O MTBVJYHELGSHOV-UHFFFAOYSA-N 0.000 claims 2
• ALUZIFDFSMWCNQ-BQYQJAHWSA-N 2-[[4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]phenyl]methoxy]acetic acid Chemical compound OC(=O)COCC1=CC=C(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1 ALUZIFDFSMWCNQ-BQYQJAHWSA-N 0.000 claims 2
• NZNFNUOIGFQZFF-UHFFFAOYSA-N 2-[[4-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]phenyl]methoxy]acetic acid Chemical compound OC(=O)COCC1=CC=C(C=C1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 NZNFNUOIGFQZFF-UHFFFAOYSA-N 0.000 claims 2
• BLIHJPCDANQCPJ-UHFFFAOYSA-N 2-[[4-[2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]methoxy]-1,3-benzothiazole-6-carboxylic acid Chemical compound OC(=O)C1=CC=C2N=C(OCC34CCC(CC3)(CC4)C=CC3=C(ON=C3C3=C(Cl)C=CC=C3Cl)C3CC3)SC2=C1 BLIHJPCDANQCPJ-UHFFFAOYSA-N 0.000 claims 2
• QYDJRIBEWYNZSD-UHFFFAOYSA-N 2-[[4-[2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]methoxy]-4-fluoro-1,3-benzothiazole-6-carboxylic acid Chemical compound OC(=O)C1=CC(F)=C2N=C(OCC34CCC(CC3)(CC4)C=CC3=C(ON=C3C3=C(Cl)C=CC=C3Cl)C3CC3)SC2=C1 QYDJRIBEWYNZSD-UHFFFAOYSA-N 0.000 claims 2
• APCNPQASXSVHHU-UHFFFAOYSA-N 2-[[4-[[3-(3-chloro-5-methoxypyridin-4-yl)-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-methoxyquinoline-6-carboxylic acid Chemical compound ClC=1C=NC=C(C=1C1=NOC(=C1COC12CCC(CC1)(CC2)COC1=NC2=CC=C(C=C2C(=C1)OC)C(=O)O)C1CC1)OC APCNPQASXSVHHU-UHFFFAOYSA-N 0.000 claims 2
• BIBKQUNGQCLUJX-UHFFFAOYSA-N 2-[[4-[[3-(3-chloro-5-methoxypyridin-4-yl)-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-8-cyclopropylquinoline-6-carboxylic acid Chemical compound ClC=1C=NC=C(C=1C1=NOC(=C1COC12CCC(CC1)(CC2)COC1=NC2=C(C=C(C=C2C=C1)C(=O)O)C1CC1)C1CC1)OC BIBKQUNGQCLUJX-UHFFFAOYSA-N 0.000 claims 2
• BJAUQRZOTFDMFP-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-hydroxymethyl]-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(C=1SC2=C(N=1)C=CC(=C2)C(=O)O)O BJAUQRZOTFDMFP-UHFFFAOYSA-N 0.000 claims 2
• RRMNLDUMZOJPHY-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-hydroxymethyl]-4-fluoro-1,3-benzothiazole-6-carboxamide Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(C=1SC2=C(N=1)C(=CC(=C2)C(=O)N)F)O RRMNLDUMZOJPHY-UHFFFAOYSA-N 0.000 claims 2
• XZPJFFTVOYYYDS-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyridine-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=O)O)C=CN=1 XZPJFFTVOYYYDS-UHFFFAOYSA-N 0.000 claims 2
• AKARZHRKWSJNCE-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyrimidine-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=NC=CC(=N1)C(=O)O AKARZHRKWSJNCE-UHFFFAOYSA-N 0.000 claims 2
• LQWJTXSONPLUMD-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methyl]-3,4-dihydro-1H-isoquinoline-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)CN1CC2=CC(=CC=C2CC1)C(=O)O LQWJTXSONPLUMD-UHFFFAOYSA-N 0.000 claims 2
• DFWMAUFKEPCZOJ-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-1,3-thiazole-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1SC=C(N=1)C(=O)O DFWMAUFKEPCZOJ-UHFFFAOYSA-N 0.000 claims 2
• SSEYHKOQIGHGPR-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid Chemical compound OC(=O)C1=C(N=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)S1)C(F)(F)F SSEYHKOQIGHGPR-UHFFFAOYSA-N 0.000 claims 2
• VDJQPWHDAUTVIX-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-methyl-1,3-thiazole-5-carboxylic acid Chemical compound CC1=C(SC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=N1)C(O)=O VDJQPWHDAUTVIX-UHFFFAOYSA-N 0.000 claims 2
• JUCFVLHGIBHNEX-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-5-fluoro-1,3-benzothiazole-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1SC2=C(N=1)C=C(C=C2C(=O)O)F JUCFVLHGIBHNEX-UHFFFAOYSA-N 0.000 claims 2
• HYFNLAKDEHXKCP-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-8-methoxyquinoline-5-carboxylic acid Chemical compound COC1=CC=C(C(O)=O)C2=C1N=C(OCC13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2 HYFNLAKDEHXKCP-UHFFFAOYSA-N 0.000 claims 2
• YLRPVGNOQAKVMP-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-8-methoxyquinoline-6-carboxylic acid Chemical compound COC1=CC(=CC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)N=C12)C(O)=O YLRPVGNOQAKVMP-UHFFFAOYSA-N 0.000 claims 2
• FVVZROMHBWABBO-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]imidazo[1,2-a]pyridine-7-carboxylic acid Chemical compound OC(=O)C1=CC2=NC(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)=CN2C=C1 FVVZROMHBWABBO-UHFFFAOYSA-N 0.000 claims 2
• HMGRJAXOGQJXPW-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]quinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1C=CC(OCC13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)=N2 HMGRJAXOGQJXPW-UHFFFAOYSA-N 0.000 claims 2
• PLHOKKPKPZKPEH-UHFFFAOYSA-N 2-[[5-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]pyridin-2-yl]methoxy]acetic acid Chemical compound OC(=O)COCC1=CC=C(C=N1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 PLHOKKPKPZKPEH-UHFFFAOYSA-N 0.000 claims 2
• ARGJZKHOYUFENQ-UHFFFAOYSA-N 2-[[6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]pyridin-3-yl]methoxy]acetic acid Chemical compound OC(=O)COCC1=CC=C(N=C1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 ARGJZKHOYUFENQ-UHFFFAOYSA-N 0.000 claims 2
• BBABMYPSSZSIBI-UHFFFAOYSA-N 2-[[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]bicyclo[2.2.2]octane-1-carbonyl]-methylamino]methyl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(=O)N(C)CC1=C(C(=O)O)C=CC=C1 BBABMYPSSZSIBI-UHFFFAOYSA-N 0.000 claims 2
• TYOXRISAXXIVAF-UHFFFAOYSA-N 2-[[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]bicyclo[2.2.2]octane-1-carbonyl]amino]methyl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(=O)NCC1=C(C(=O)O)C=CC=C1 TYOXRISAXXIVAF-UHFFFAOYSA-N 0.000 claims 2
• RQRIGFGPOOOHHM-UHFFFAOYSA-N 2-chloro-3-[[4-[2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]bicyclo[2.2.2]octane-1-carbonyl]amino]benzoic acid Chemical compound OC(=O)C1=CC=CC(NC(=O)C23CCC(CC2)(CC3)C=CC2=C(ON=C2C2=C(Cl)C=CC=C2Cl)C2CC2)=C1Cl RQRIGFGPOOOHHM-UHFFFAOYSA-N 0.000 claims 2
• QHILBULUBUBURK-UHFFFAOYSA-N 2-chloro-3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]bicyclo[2.2.2]octane-1-carbonyl]amino]benzoic acid Chemical compound OC(=O)C1=CC=CC(NC(=O)C23CCC(COCC4=C(ON=C4C4=C(Cl)C=CC=C4Cl)C4CC4)(CC2)CC3)=C1Cl QHILBULUBUBURK-UHFFFAOYSA-N 0.000 claims 2
• DMTLWRBTDNMMPU-UHFFFAOYSA-N 2-cyclopropyl-5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyrazole-3-carboxylic acid Chemical compound OC(=O)C1=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=NN1C1CC1 DMTLWRBTDNMMPU-UHFFFAOYSA-N 0.000 claims 2
• TUHGQIBMTUQNRU-UHFFFAOYSA-N 3-[2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-2-hydroxyethyl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(CC=1C=C(C(=O)O)C=CC=1)O TUHGQIBMTUQNRU-UHFFFAOYSA-N 0.000 claims 2
• NQMFSFLXPUEVTD-UHFFFAOYSA-N 3-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1-methylindole-6-carboxylic acid Chemical compound CN1C=C(C#CC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C2=CC=C(C=C12)C(O)=O NQMFSFLXPUEVTD-UHFFFAOYSA-N 0.000 claims 2
• WKCWRPFFAKBFQJ-UHFFFAOYSA-N 3-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-5-(methoxymethyl)benzoic acid Chemical compound COCC1=CC(=CC(=C1)C(O)=O)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 WKCWRPFFAKBFQJ-UHFFFAOYSA-N 0.000 claims 2
• ABDUJJAYDHOSBU-UHFFFAOYSA-N 3-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-5-(trifluoromethoxy)benzoic acid Chemical compound OC(=O)C1=CC(OC(F)(F)F)=CC(=C1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 ABDUJJAYDHOSBU-UHFFFAOYSA-N 0.000 claims 2
• PTHUMIAEZRHECP-UHFFFAOYSA-N 3-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-5-(trifluoromethyl)benzoic acid Chemical compound OC(=O)C1=CC(=CC(=C1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(F)(F)F PTHUMIAEZRHECP-UHFFFAOYSA-N 0.000 claims 2
• MIFSNPMXFRVBMY-UHFFFAOYSA-N 3-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-5-methoxybenzoic acid Chemical compound COC1=CC(=CC(=C1)C(O)=O)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 MIFSNPMXFRVBMY-UHFFFAOYSA-N 0.000 claims 2
• UHLIVNBWVKYELG-UHFFFAOYSA-N 3-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-5-propan-2-yloxybenzoic acid Chemical compound CC(C)OC1=CC(=CC(=C1)C(O)=O)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 UHLIVNBWVKYELG-UHFFFAOYSA-N 0.000 claims 2
• PZINQWGJMRPHLK-UHFFFAOYSA-N 3-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-8-carboxylic acid Chemical compound OC(=O)c1cc(cn2c(cnc12)C#CC12CCC(CC1)(CC2)OCc1c(onc1-c1c(Cl)cncc1Cl)C1CC1)C(F)(F)F PZINQWGJMRPHLK-UHFFFAOYSA-N 0.000 claims 2
• CTQGXEMFWKWLOG-UHFFFAOYSA-N 3-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-6-ethylimidazo[1,2-a]pyridine-8-carboxylic acid Chemical compound CCC1=CN2C(=CN=C2C(=C1)C(O)=O)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 CTQGXEMFWKWLOG-UHFFFAOYSA-N 0.000 claims 2
• HTHOEVYGLIKVHB-UHFFFAOYSA-N 3-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]imidazo[1,2-a]pyridine-7-carboxylic acid Chemical compound OC(=O)C1=CC2=NC=C(C#CC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)N2C=C1 HTHOEVYGLIKVHB-UHFFFAOYSA-N 0.000 claims 2
• MAAOAVJEYBCDTN-UHFFFAOYSA-N 3-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]imidazo[1,2-a]pyridine-8-carboxylic acid Chemical compound OC(=O)C1=CC=CN2C(=CN=C12)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 MAAOAVJEYBCDTN-UHFFFAOYSA-N 0.000 claims 2
• KOEWDFJNXGFEPL-CMDGGOBGSA-N 3-[3-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]phenyl]propanoic acid Chemical compound OC(=O)CCC1=CC=CC(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1 KOEWDFJNXGFEPL-CMDGGOBGSA-N 0.000 claims 2
• VMFAKWFEPOEJNC-UHFFFAOYSA-N 3-[3-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NC(=NO1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 VMFAKWFEPOEJNC-UHFFFAOYSA-N 0.000 claims 2
• OFRLZPLBXIKXMQ-UHFFFAOYSA-N 3-[3-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NC(=NO1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 OFRLZPLBXIKXMQ-UHFFFAOYSA-N 0.000 claims 2
• BFWJNSGEBQVPJR-UHFFFAOYSA-N 3-[3-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)C(F)(F)F)COC12CCC(CC1)(CC2)C1=NOC(=N1)C=1C=C(C(=O)O)C=CC=1 BFWJNSGEBQVPJR-UHFFFAOYSA-N 0.000 claims 2
• BXWKZOMMLRAZKI-BQYQJAHWSA-N 3-[4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-2-fluorophenyl]propanoic acid Chemical compound OC(=O)CCC1=CC=C(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1F BXWKZOMMLRAZKI-BQYQJAHWSA-N 0.000 claims 2
• LLTLKVNZUINLLD-UHFFFAOYSA-N 3-[4-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]phenyl]propanoic acid Chemical compound OC(=O)CCC1=CC=C(C=C1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 LLTLKVNZUINLLD-UHFFFAOYSA-N 0.000 claims 2
• KBTKDNSGMFQSJN-UHFFFAOYSA-N 3-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-N-methylsulfonylbenzamide Chemical compound CS(=O)(=O)NC(=O)C1=CC=CC(=C1)C12CCC(COCC3=C(ON=C3C3=C(Cl)C=CC=C3Cl)C3CC3)(CC1)CO2 KBTKDNSGMFQSJN-UHFFFAOYSA-N 0.000 claims 2
• LADYWUOKVAOOOU-UHFFFAOYSA-N 3-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12COC(CC1)(CC2)C=1C=C(C(=O)O)C=CC=1 LADYWUOKVAOOOU-UHFFFAOYSA-N 0.000 claims 2
• YVMWKSJWOQVWOA-UHFFFAOYSA-N 3-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-5-(trifluoromethyl)benzamide Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COCC12COC(CC1)(CC2)C=1C=C(C(=O)N)C=C(C=1)C(F)(F)F YVMWKSJWOQVWOA-UHFFFAOYSA-N 0.000 claims 2
• WHVBWQWYTWCBEJ-UHFFFAOYSA-N 3-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-5-(trifluoromethyl)benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COCC12COC(CC1)(CC2)C=1C=C(C(=O)O)C=C(C=1)C(F)(F)F WHVBWQWYTWCBEJ-UHFFFAOYSA-N 0.000 claims 2
• WIPJOIYNJSLXMU-UHFFFAOYSA-N 3-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-5-(trifluoromethyl)benzonitrile Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COCC12COC(CC1)(CC2)C=1C=C(C#N)C=C(C=1)C(F)(F)F WIPJOIYNJSLXMU-UHFFFAOYSA-N 0.000 claims 2
• BONYTGCCCNCUJZ-UHFFFAOYSA-N 3-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COCC12COC(CC1)(CC2)C=1C=C(C(=O)O)C=CC=1 BONYTGCCCNCUJZ-UHFFFAOYSA-N 0.000 claims 2
• ONZMWFFNQYDXJQ-UHFFFAOYSA-N 3-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]benzoic acid Chemical compound OC(=O)c1cccc(c1)C12CCC(COCc3c(onc3-c3ccccc3OC(F)(F)F)C3CC3)(CC1)CO2 ONZMWFFNQYDXJQ-UHFFFAOYSA-N 0.000 claims 2
• XXFYVQVCAJTJGU-BQYQJAHWSA-N 3-[5-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-2-(2,2-difluoroethoxy)phenyl]propanoic acid Chemical compound OC(=O)CCC1=C(OCC(F)F)C=CC(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1 XXFYVQVCAJTJGU-BQYQJAHWSA-N 0.000 claims 2
• FDIVVUVFFKKSSI-CMDGGOBGSA-N 3-[5-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-2-methoxyphenyl]propanoic acid Chemical compound COC1=C(CCC(O)=O)C=C(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1 FDIVVUVFFKKSSI-CMDGGOBGSA-N 0.000 claims 2
• HXULRUBKXIGJRK-UHFFFAOYSA-N 3-[5-[3-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[1.1.1]pentanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CC(C1)(C2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 HXULRUBKXIGJRK-UHFFFAOYSA-N 0.000 claims 2
• VFLGTLCZFLXKHK-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 VFLGTLCZFLXKHK-UHFFFAOYSA-N 0.000 claims 2
• BWOXSMAZSDLVLL-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3,4-oxadiazol-2-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NN=C(O1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 BWOXSMAZSDLVLL-UHFFFAOYSA-N 0.000 claims 2
• NADGBATYYSICMD-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3,4-thiadiazol-2-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NN=C(S1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 NADGBATYYSICMD-UHFFFAOYSA-N 0.000 claims 2
• STNYJQLDNCURKZ-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12COC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 STNYJQLDNCURKZ-UHFFFAOYSA-N 0.000 claims 2
• OJDZFOAVUNYLCO-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]cuban-1-yl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12C3C4C5(C(C14)C2C53)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 OJDZFOAVUNYLCO-UHFFFAOYSA-N 0.000 claims 2
• JCMOMIMABYTFMJ-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)triazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(N=NN1C1=C(Cl)C=CC=C1Cl)C1CC1 JCMOMIMABYTFMJ-UHFFFAOYSA-N 0.000 claims 2
• GFCMFCLCFCZIBJ-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2,5-dimethoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C(=C(C(=O)O)C=C(C=1)OC)OC GFCMFCLCFCZIBJ-UHFFFAOYSA-N 0.000 claims 2
• LIQADTAOIWSMRQ-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2,6-difluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C(=C(C(=O)O)C(=CC=1)F)F LIQADTAOIWSMRQ-UHFFFAOYSA-N 0.000 claims 2
• KMTRQYIVCJCUDB-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-fluoro-5-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C(=C(C(=O)O)C=C(C=1)OC)F KMTRQYIVCJCUDB-UHFFFAOYSA-N 0.000 claims 2
• XSBQAINLOLSXCK-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-fluoro-6-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C(=C(C(=O)O)C(=CC=1)OC)F XSBQAINLOLSXCK-UHFFFAOYSA-N 0.000 claims 2
• ZSVDAFBKKBTVNK-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C(=C(C(=O)O)C=CC=1)F ZSVDAFBKKBTVNK-UHFFFAOYSA-N 0.000 claims 2
• BZODDLTWRLDJFC-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-4-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1F BZODDLTWRLDJFC-UHFFFAOYSA-N 0.000 claims 2
• AZXOSCPIMLOMEF-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-4-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1OC AZXOSCPIMLOMEF-UHFFFAOYSA-N 0.000 claims 2
• SQJSAFXWLCRMII-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-5-(trifluoromethyl)benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=C(C=1)C(F)(F)F SQJSAFXWLCRMII-UHFFFAOYSA-N 0.000 claims 2
• URSGZIHPVYJOGW-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-5-fluoro-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C(=C(C(=O)O)C=C(C=1)F)OC URSGZIHPVYJOGW-UHFFFAOYSA-N 0.000 claims 2
• IWHOFALWOUHSFZ-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-5-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=C(C=1)F IWHOFALWOUHSFZ-UHFFFAOYSA-N 0.000 claims 2
• DROAEAYQUOSWBU-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-5-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=C(C=1)OC DROAEAYQUOSWBU-UHFFFAOYSA-N 0.000 claims 2
• ZNYPZGSPXJORTF-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-5-propan-2-yloxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=C(C=1)OC(C)C ZNYPZGSPXJORTF-UHFFFAOYSA-N 0.000 claims 2
• HFVDBDMXBCHOML-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 HFVDBDMXBCHOML-UHFFFAOYSA-N 0.000 claims 2
• SKGHKCOLDJYBOG-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CO2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 SKGHKCOLDJYBOG-UHFFFAOYSA-N 0.000 claims 2
• NLWIZKXHMCCCIF-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-4-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1F NLWIZKXHMCCCIF-UHFFFAOYSA-N 0.000 claims 2
• NPJLZPMCBSKGOG-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-4-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1OC NPJLZPMCBSKGOG-UHFFFAOYSA-N 0.000 claims 2
• ANMWGNOVKKRRFP-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-5-(trifluoromethyl)benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=C(C=1)C(F)(F)F ANMWGNOVKKRRFP-UHFFFAOYSA-N 0.000 claims 2
• KJTHTTUKYWWIQM-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3-fluoropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1)F)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 KJTHTTUKYWWIQM-UHFFFAOYSA-N 0.000 claims 2
• PXVJVPSOOURVKX-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3,4-oxadiazol-2-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)COC12CCC(CC1)(CC2)C1=NN=C(O1)C=1C=C(C(=O)O)C=CC=1 PXVJVPSOOURVKX-UHFFFAOYSA-N 0.000 claims 2
• HJHBACFCTKJTOW-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3,4-thiadiazol-2-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)COC12CCC(CC1)(CC2)C1=NN=C(S1)C=1C=C(C(=O)O)C=CC=1 HJHBACFCTKJTOW-UHFFFAOYSA-N 0.000 claims 2
• LBBDHXMSNKMXDO-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)c1cccc(c1)-c1noc(n1)C12CCC(CC1)(CO2)OCc1c(onc1-c1ccccc1OC(F)(F)F)C1CC1 LBBDHXMSNKMXDO-UHFFFAOYSA-N 0.000 claims 2
• XNZYEKZZXTWURN-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NOC(=N1)C12CCC(COCC3=C(ON=C3C3=CC=CC=C3OC(F)(F)F)C3CC3)(CC1)CC2 XNZYEKZZXTWURN-UHFFFAOYSA-N 0.000 claims 2
• OXRWPZWNYCYSBJ-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC(=CC=C1)C1=NOC(=N1)C12CCC(COCC3=C(ON=C3C3=C(OC(F)(F)F)C=CC=C3)C3CC3)(CC1)CO2 OXRWPZWNYCYSBJ-UHFFFAOYSA-N 0.000 claims 2
• YGCYIHIJUANYDQ-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1C(F)(F)F)C1CC1 YGCYIHIJUANYDQ-UHFFFAOYSA-N 0.000 claims 2
• GQQMUHQCHSPPLF-UHFFFAOYSA-N 3-[[4-[2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]bicyclo[2.2.1]heptane-1-carbonyl]amino]benzoic acid Chemical compound OC(=O)C1=CC=CC(NC(=O)C23CCC(CC2)(C3)C=CC2=C(ON=C2C2=C(Cl)C=CC=C2Cl)C2CC2)=C1 GQQMUHQCHSPPLF-UHFFFAOYSA-N 0.000 claims 2
• LYUQTVQFXODQEH-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-hydroxymethyl]-4-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(C=1C=C(C(=O)O)C=CC=1F)O LYUQTVQFXODQEH-UHFFFAOYSA-N 0.000 claims 2
• FXBUHUFGIZNKAY-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-2-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C(=C(C(=O)O)C=CC=1)F FXBUHUFGIZNKAY-UHFFFAOYSA-N 0.000 claims 2
• SVXNWHRRXDBJAY-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-2-methylbenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C(=C(C(=O)O)C=CC=1)C SVXNWHRRXDBJAY-UHFFFAOYSA-N 0.000 claims 2
• GDCAJVAYZJYLTR-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=O)O)C=CC=1F GDCAJVAYZJYLTR-UHFFFAOYSA-N 0.000 claims 2
• UOTYJVXOVGITDR-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-5-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=O)O)C=C(C=1)F UOTYJVXOVGITDR-UHFFFAOYSA-N 0.000 claims 2
• QWCKCBLCIJXSPP-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=O)O)C=CC=1 QWCKCBLCIJXSPP-UHFFFAOYSA-N 0.000 claims 2
• BWCRCWHVDZGJSG-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]benzonitrile Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C#N)C=CC=1 BWCRCWHVDZGJSG-UHFFFAOYSA-N 0.000 claims 2
• KRFRLPRRZHLQDL-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]methoxy]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)COC=1C=C(C(=O)O)C=CC=1 KRFRLPRRZHLQDL-UHFFFAOYSA-N 0.000 claims 2
• CGGZGXALPDLUCC-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=O)O)C=CC=1F CGGZGXALPDLUCC-UHFFFAOYSA-N 0.000 claims 2
• QLPYOMGYYAPNTB-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-5-(trifluoromethyl)benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=O)O)C=C(C=1)C(F)(F)F QLPYOMGYYAPNTB-UHFFFAOYSA-N 0.000 claims 2
• VNVBDQOPTQKPNV-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-5-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=O)O)C=C(C=1)F VNVBDQOPTQKPNV-UHFFFAOYSA-N 0.000 claims 2
• KQFKBSJNVWRFDY-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-5-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=O)O)C=C(C=1)OC KQFKBSJNVWRFDY-UHFFFAOYSA-N 0.000 claims 2
• WCGLTFMYGMEKEM-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-5-methylbenzoic acid Chemical compound CC1=CC(=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1)C(O)=O WCGLTFMYGMEKEM-UHFFFAOYSA-N 0.000 claims 2
• WLSQQQFVCWASFK-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-5-propan-2-yloxybenzoic acid Chemical compound CC(C)OC1=CC(=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1)C(O)=O WLSQQQFVCWASFK-UHFFFAOYSA-N 0.000 claims 2
• JCDWBUNJPCRIKN-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=O)O)C=CC=1 JCDWBUNJPCRIKN-UHFFFAOYSA-N 0.000 claims 2
• NGPYCTNCDHXSHB-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]quinoline-8-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=NC2=C(C=CC=C2C=1)C(=O)O NGPYCTNCDHXSHB-UHFFFAOYSA-N 0.000 claims 2
• ITHXHZGUFHHOMA-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxymethyl]benzoic acid Chemical compound OC(=O)C1=CC=CC(COCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1 ITHXHZGUFHHOMA-UHFFFAOYSA-N 0.000 claims 2
• XJPBANNKNSFKOE-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]bicyclo[2.2.2]octane-1-carbonyl]amino]-5-(trifluoromethyl)benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(=O)NC=1C=C(C(=O)O)C=C(C=1)C(F)(F)F XJPBANNKNSFKOE-UHFFFAOYSA-N 0.000 claims 2
• NYAOHXSBAWQFOZ-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]methoxy]-5-(trifluoromethyl)benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COCC12CCC(CC1)(CC2)COC=1C=C(C(=O)O)C=C(C=1)C(F)(F)F NYAOHXSBAWQFOZ-UHFFFAOYSA-N 0.000 claims 2
• XIZRNZVRNRWSFT-UHFFFAOYSA-N 3-[[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]bicyclo[2.2.2]octane-1-carbonyl]amino]methyl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(=O)NCC=1C=C(C(=O)O)C=CC=1 XIZRNZVRNRWSFT-UHFFFAOYSA-N 0.000 claims 2
• RVNRQGDQWVLPNS-UHFFFAOYSA-N 3-cyclobutyloxy-5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=C(OC2CCC2)C=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=N1 RVNRQGDQWVLPNS-UHFFFAOYSA-N 0.000 claims 2
• FGMDFCILNHZMHB-UHFFFAOYSA-N 4-(cyclobutylmethoxy)-6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]quinoline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2C(OCC2CCC2)=C1 FGMDFCILNHZMHB-UHFFFAOYSA-N 0.000 claims 2
• MWGLJKWWPIPPFU-BQYQJAHWSA-N 4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-1-methylindole-2-carboxylic acid Chemical compound CN1C(=CC2=C(\C=C\C34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=CC=C12)C(O)=O MWGLJKWWPIPPFU-BQYQJAHWSA-N 0.000 claims 2
• RSTHOGFJRGIBNW-BQYQJAHWSA-N 4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]benzoic acid Chemical compound OC(=O)C1=CC=C(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1 RSTHOGFJRGIBNW-BQYQJAHWSA-N 0.000 claims 2
• MCGUGGTZDFCMEC-HWKANZROSA-N 4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=NC=CC(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1 MCGUGGTZDFCMEC-HWKANZROSA-N 0.000 claims 2
• RSRQPPUCNAFDTM-UHFFFAOYSA-N 4-[2-(chloromethyl)-3-hydroxypropoxy]-6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]quinoline-2-carboxylic acid Chemical compound OCC(CCl)COC1=CC(=NC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C12)C(O)=O RSRQPPUCNAFDTM-UHFFFAOYSA-N 0.000 claims 2
• KZPIZJOOJNXZEA-UHFFFAOYSA-N 4-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1H-indole-6-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=CN2)C(=C1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 KZPIZJOOJNXZEA-UHFFFAOYSA-N 0.000 claims 2
• GIWJDTCXTLGCDY-UHFFFAOYSA-N 4-[3-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NC(=NO1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 GIWJDTCXTLGCDY-UHFFFAOYSA-N 0.000 claims 2
• ZRVBOYFDBQSGOI-UHFFFAOYSA-N 4-[3-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NOC(=N1)C1=CC(=NC=C1)C(=O)O ZRVBOYFDBQSGOI-UHFFFAOYSA-N 0.000 claims 2
• PZVQMSBIHKPIAA-UHFFFAOYSA-N 4-[3-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NC(=NO1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 PZVQMSBIHKPIAA-UHFFFAOYSA-N 0.000 claims 2
• WMURSFMOBYNJQS-UHFFFAOYSA-N 4-[3-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=NC=CC(=C1)C1=NC(=NO1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 WMURSFMOBYNJQS-UHFFFAOYSA-N 0.000 claims 2
• CMPUCDNLNFAGBQ-UHFFFAOYSA-N 4-[3-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)C(F)(F)F)COC12CCC(CC1)(CC2)C1=NOC(=N1)C1=CC=C(C(=O)O)C=C1 CMPUCDNLNFAGBQ-UHFFFAOYSA-N 0.000 claims 2
• HTWAKCUDAAATHL-UHFFFAOYSA-N 4-[3-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=NC=CC(=C1)C1=NC(=NO1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1C(F)(F)F)C1CC1 HTWAKCUDAAATHL-UHFFFAOYSA-N 0.000 claims 2
• YIYQGXGZPYLUAG-UHFFFAOYSA-N 4-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C1=CC=C(C(=O)O)C=C1 YIYQGXGZPYLUAG-UHFFFAOYSA-N 0.000 claims 2
• OARCYHJFTQEWHN-UHFFFAOYSA-N 4-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C12CCC(COCC3=C(ON=C3C3=C(Cl)C=CC=C3Cl)C3CC3)(CC1)CO2 OARCYHJFTQEWHN-UHFFFAOYSA-N 0.000 claims 2
• WEIJCVCCSSGFFL-UHFFFAOYSA-N 4-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(trifluoromethyl)quinoline-6-carboxylic acid Chemical compound OC(=O)C1=CC2=C(N=CC=C2C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(=C1)C(F)(F)F WEIJCVCCSSGFFL-UHFFFAOYSA-N 0.000 claims 2
• FCHMBRXQZPIBEH-UHFFFAOYSA-N 4-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]benzoic acid Chemical compound OC(=O)c1ccc(cc1)C12CCC(COCc3c(onc3-c3ccccc3OC(F)(F)F)C3CC3)(CC1)CO2 FCHMBRXQZPIBEH-UHFFFAOYSA-N 0.000 claims 2
• AEJICVPURLCZSH-UHFFFAOYSA-N 4-[4-[[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]amino]methyl]-2-oxabicyclo[2.2.2]octan-1-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)NCC12COC(CC1)(CC2)C1=CC=C(C(=O)O)C=C1 AEJICVPURLCZSH-UHFFFAOYSA-N 0.000 claims 2
• CMRFXFLXJJYIOY-UHFFFAOYSA-N 4-[5-[4-[[3-(4-chloro-2-methylpyrazol-3-yl)-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-6-methoxypyridine-2-carboxylic acid Chemical compound ClC=1C=NN(C=1C1=NOC(=C1COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=CC(=NC(=C1)OC)C(=O)O)C1CC1)C CMRFXFLXJJYIOY-UHFFFAOYSA-N 0.000 claims 2
• FOFXFNYIVXFEAT-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 FOFXFNYIVXFEAT-UHFFFAOYSA-N 0.000 claims 2
• AJQUFYGEEBGKRH-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=CC(=NC=C1)C(=O)O AJQUFYGEEBGKRH-UHFFFAOYSA-N 0.000 claims 2
• GWDLVBWIPFNXBN-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CO2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 GWDLVBWIPFNXBN-UHFFFAOYSA-N 0.000 claims 2
• MWORYOAEBQFXDR-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(COCC3=C(ON=C3C3=C(Cl)C=CC=C3Cl)C3CC3)(CC1)CC2 MWORYOAEBQFXDR-UHFFFAOYSA-N 0.000 claims 2
• MLGMMJBEJLQBQE-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(COCC3=C(ON=C3C3=C(Cl)C=CC=C3Cl)C3CC3)(CC1)CO2 MLGMMJBEJLQBQE-UHFFFAOYSA-N 0.000 claims 2
• BLWSFOHIXSETRP-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)triazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(N=NN1C1=C(Cl)C=CC=C1Cl)C1CC1 BLWSFOHIXSETRP-UHFFFAOYSA-N 0.000 claims 2
• GCLGNJFXKDPAQS-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-6-propan-2-yloxypyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=CC(=NC(=C1)OC(C)C)C(=O)O GCLGNJFXKDPAQS-UHFFFAOYSA-N 0.000 claims 2
• ROQSCVHIZWPAQX-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CO2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 ROQSCVHIZWPAQX-UHFFFAOYSA-N 0.000 claims 2
• OPWPEQHRUFBAMC-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=NC=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 OPWPEQHRUFBAMC-UHFFFAOYSA-N 0.000 claims 2
• WMFDVCAPMHVISM-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CO2)OCC1=C(ON=C1C1=C(OC(F)(F)F)C=CC=C1)C1CC1 WMFDVCAPMHVISM-UHFFFAOYSA-N 0.000 claims 2
• IDWDGORIBPSEQT-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(COCC3=C(ON=C3C3=CC=CC=C3OC(F)(F)F)C3CC3)(CC1)CC2 IDWDGORIBPSEQT-UHFFFAOYSA-N 0.000 claims 2
• JEXYEJHTRXRUMP-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1C(F)(F)F)C1CC1 JEXYEJHTRXRUMP-UHFFFAOYSA-N 0.000 claims 2
• OEHBBTWYSFNXKA-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=NC=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1C(F)(F)F)C1CC1 OEHBBTWYSFNXKA-UHFFFAOYSA-N 0.000 claims 2
• SIFRMFSRTSVHJF-UHFFFAOYSA-N 4-[5-[4-[[5-propan-2-yl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound CC(C)C1=C(COC23CCC(CC2)(CC3)C2=NC(=NO2)C2=CC=C(C=C2)C(O)=O)C(=NO1)C1=CC=CC=C1OC(F)(F)F SIFRMFSRTSVHJF-UHFFFAOYSA-N 0.000 claims 2
• GWVFONNDXDMUIX-UHFFFAOYSA-N 4-[5-[4-[[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]amino]methyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(CNC3=C(ON=C3C3=C(Cl)C=CC=C3Cl)C3CC3)(CC1)CC2 GWVFONNDXDMUIX-UHFFFAOYSA-N 0.000 claims 2
• QUKDBOMNJLPTSZ-UHFFFAOYSA-N 4-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-hydroxymethyl]-3-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(C1=C(C=C(C(=O)O)C=C1)F)O QUKDBOMNJLPTSZ-UHFFFAOYSA-N 0.000 claims 2
• BJPAPGXPJJWCSW-UHFFFAOYSA-N 4-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-hydroxymethyl]quinoline-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(C1=CC=NC2=CC(=CC=C12)C(=O)O)O BJPAPGXPJJWCSW-UHFFFAOYSA-N 0.000 claims 2
• PWFHKZKKGCMAME-UHFFFAOYSA-N 4-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=CC=C(C(=O)O)C=C1 PWFHKZKKGCMAME-UHFFFAOYSA-N 0.000 claims 2
• QQGPZJBHNOXQIW-UHFFFAOYSA-N 4-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-2-methoxybenzoic acid Chemical compound COC1=C(C=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1)C(O)=O QQGPZJBHNOXQIW-UHFFFAOYSA-N 0.000 claims 2
• ARFRUQUUKHDZFT-UHFFFAOYSA-N 4-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-(trifluoromethyl)benzoic acid Chemical compound OC(=O)C1=CC(=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1)C(F)(F)F ARFRUQUUKHDZFT-UHFFFAOYSA-N 0.000 claims 2
• AFCCCYPAVZDHFQ-UHFFFAOYSA-N 4-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=C(C=C(C(=O)O)C=C1)F AFCCCYPAVZDHFQ-UHFFFAOYSA-N 0.000 claims 2
• FQIZYXUKQARSKS-UHFFFAOYSA-N 4-[[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]isoquinoline-1-carboxylic acid Chemical compound OC(=O)C1=C2C=CC=CC2=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=CC=CC=C2C(F)(F)F)C2CC2)C=N1 FQIZYXUKQARSKS-UHFFFAOYSA-N 0.000 claims 2
• MDNDHAAVHUUPEM-UHFFFAOYSA-N 4-[[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]bicyclo[2.2.2]octane-1-carbonyl]amino]methyl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(=O)NCC1=CC=C(C(=O)O)C=C1 MDNDHAAVHUUPEM-UHFFFAOYSA-N 0.000 claims 2
• FPODYWBPWRTPBY-UHFFFAOYSA-N 4-cyclobutyloxy-6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]quinoline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=C(C=C(C=C2)C#CC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(OC2CCC2)=C1 FPODYWBPWRTPBY-UHFFFAOYSA-N 0.000 claims 2
• KSGCZEYUPFFYGI-UHFFFAOYSA-N 4-cyclobutyloxy-6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-8-fluoroquinoline-2-carboxylic acid Chemical compound C1(CCC1)OC1=CC(=NC2=C(C=C(C=C12)OCC12CCC(CC1)(CC2)OCC=1C(=NOC=1C1CC1)C1=C(C=NC=C1Cl)Cl)F)C(=O)O KSGCZEYUPFFYGI-UHFFFAOYSA-N 0.000 claims 2
• AIOLYNAVGXTJAS-UHFFFAOYSA-N 4-cyclobutyloxy-6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]quinoline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2C(OC2CCC2)=C1 AIOLYNAVGXTJAS-UHFFFAOYSA-N 0.000 claims 2
• KZNMJSLLSRSUOV-MDZDMXLPSA-N 4-cyclopentyloxy-6-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]quinoline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=C(C=C(\C=C\C34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2)C(OC2CCCC2)=C1 KZNMJSLLSRSUOV-MDZDMXLPSA-N 0.000 claims 2
• CDCFRCQSTWSJEV-UHFFFAOYSA-N 4-cyclopropyl-6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-8-fluoroquinoline-2-carboxylic acid Chemical compound C1(CC1)C1=CC(=NC2=C(C=C(C=C12)OCC12CCC(CC1)(CC2)OCC=1C(=NOC=1C1CC1)C1=C(C=NC=C1Cl)Cl)F)C(=O)O CDCFRCQSTWSJEV-UHFFFAOYSA-N 0.000 claims 2
• ZZVZUHIALJOOAG-ONEGZZNKSA-N 5-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CN=CC(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1 ZZVZUHIALJOOAG-ONEGZZNKSA-N 0.000 claims 2
• HMOFYJHMANKUQJ-UHFFFAOYSA-N 5-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1H-indazole-7-carboxylic acid Chemical compound OC(=O)C1=C2NN=CC2=CC(=C1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 HMOFYJHMANKUQJ-UHFFFAOYSA-N 0.000 claims 2
• KUSMNRGZYMYFLR-UHFFFAOYSA-N 5-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-2-methoxybenzoic acid Chemical compound COC1=C(C=C(C=C1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O KUSMNRGZYMYFLR-UHFFFAOYSA-N 0.000 claims 2
• WLIMYGZPVUOUPU-UHFFFAOYSA-N 5-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-3-methylpyridine-2-carboxylic acid Chemical compound CC1=CC(=CN=C1C(O)=O)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 WLIMYGZPVUOUPU-UHFFFAOYSA-N 0.000 claims 2
• TXZNQMHNBYFICC-UHFFFAOYSA-N 5-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-4-methylpyridine-2-carboxylic acid Chemical compound CC1=CC(=NC=C1C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O TXZNQMHNBYFICC-UHFFFAOYSA-N 0.000 claims 2
• AVBJOMCHKWSEJJ-UHFFFAOYSA-N 5-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-6-(4-methylpiperazin-1-yl)pyridine-3-carboxylic acid Chemical compound CN1CCN(CC1)C1=NC=C(C=C1C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O AVBJOMCHKWSEJJ-UHFFFAOYSA-N 0.000 claims 2
• QFWMXSJSFILRBU-UHFFFAOYSA-N 5-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-6-methoxypyridine-3-carboxylic acid Chemical compound COC1=NC=C(C=C1C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O QFWMXSJSFILRBU-UHFFFAOYSA-N 0.000 claims 2
• BVRVONYNOJFEIX-UHFFFAOYSA-N 5-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]pyrazine-2-carboxylic acid Chemical compound OC(=O)C1=NC=C(N=C1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 BVRVONYNOJFEIX-UHFFFAOYSA-N 0.000 claims 2
• BHBFVDMFPOJDNC-UHFFFAOYSA-N 5-[3-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]-2-methylpyrazole-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NOC(=N1)C1=NN(C(=C1)C(=O)O)C BHBFVDMFPOJDNC-UHFFFAOYSA-N 0.000 claims 2
• UTSCVCPBMKAODD-UHFFFAOYSA-N 5-[4-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3-oxazol-2-yl]-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1N=C(OC=1)C=1C=CC(=C(C(=O)O)C=1)OC UTSCVCPBMKAODD-UHFFFAOYSA-N 0.000 claims 2
• UJUBDXMUXAZMJA-UHFFFAOYSA-N 5-[4-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3-thiazol-2-yl]-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1N=C(SC=1)C=1C=CC(=C(C(=O)O)C=1)OC UJUBDXMUXAZMJA-UHFFFAOYSA-N 0.000 claims 2
• JDAOYDDDSNTGHH-UHFFFAOYSA-N 5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazole-3-carboxamide Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C(=O)N JDAOYDDDSNTGHH-UHFFFAOYSA-N 0.000 claims 2
• RSRGOYBWOBFVLU-UHFFFAOYSA-N 5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-2-fluorobenzoic acid Chemical compound OC(=O)C1=C(F)C=CC(=C1)C12CCC(COCC3=C(ON=C3C3=C(Cl)C=CC=C3Cl)C3CC3)(CC1)CO2 RSRGOYBWOBFVLU-UHFFFAOYSA-N 0.000 claims 2
• YMCZNWCHVOBTPB-UHFFFAOYSA-N 5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-2-fluorobenzoic acid Chemical compound OC(=O)c1cc(ccc1F)C12CCC(COCc3c(onc3-c3ccccc3OC(F)(F)F)C3CC3)(CC1)CO2 YMCZNWCHVOBTPB-UHFFFAOYSA-N 0.000 claims 2
• BLTHHBGIZDYSGE-UHFFFAOYSA-N 5-[5-[4-[[3-(4-chloro-2-methylpyrazol-3-yl)-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzoic acid Chemical compound ClC=1C=NN(C=1C1=NOC(=C1COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)O)C=1)OC)C1CC1)C BLTHHBGIZDYSGE-UHFFFAOYSA-N 0.000 claims 2
• JRVUMRYYCKYECS-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)O)C=1)F JRVUMRYYCKYECS-UHFFFAOYSA-N 0.000 claims 2
• DIEZEEGCLMMFQD-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzoic acid Chemical compound COC1=C(C=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1)C(O)=O DIEZEEGCLMMFQD-UHFFFAOYSA-N 0.000 claims 2
• ZXZIQBCDKQBELO-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=NC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 ZXZIQBCDKQBELO-UHFFFAOYSA-N 0.000 claims 2
• QRLMUZGBVACLIR-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CN=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 QRLMUZGBVACLIR-UHFFFAOYSA-N 0.000 claims 2
• NJHGZVVWFOCOIT-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]-2-fluorobenzoic acid Chemical compound OC(=O)C1=C(F)C=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CO2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 NJHGZVVWFOCOIT-UHFFFAOYSA-N 0.000 claims 2
• PXMMCIJJPZGEDM-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)O)C=1)F PXMMCIJJPZGEDM-UHFFFAOYSA-N 0.000 claims 2
• USHJTZXZAGPBFH-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxy-N-methylsulfonylbenzamide Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)NS(=O)(=O)C)C=1)OC USHJTZXZAGPBFH-UHFFFAOYSA-N 0.000 claims 2
• LCSVEGBYCMYDKD-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)O)C=1)OC LCSVEGBYCMYDKD-UHFFFAOYSA-N 0.000 claims 2
• OLQGSCLODSDUHN-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxypyridine-3-carboxylic acid Chemical compound COC1=NC=C(C=C1C(O)=O)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 OLQGSCLODSDUHN-UHFFFAOYSA-N 0.000 claims 2
• FKIOEQDWVYUFPH-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-propan-2-yloxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)O)C=1)OC(C)C FKIOEQDWVYUFPH-UHFFFAOYSA-N 0.000 claims 2
• ZVYCIBWSDREYGY-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-3-fluoro-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=C(C(=O)O)C=1)OC)F ZVYCIBWSDREYGY-UHFFFAOYSA-N 0.000 claims 2
• IAFBSDYCVALMRX-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1H-imidazol-2-yl]-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1N=C(NC=1)C=1C=CC(=C(C(=O)O)C=1)OC IAFBSDYCVALMRX-UHFFFAOYSA-N 0.000 claims 2
• DWZYVFYSQDDYMA-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12COC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)O)C=1)OC DWZYVFYSQDDYMA-UHFFFAOYSA-N 0.000 claims 2
• VVYCSMMIVOYHDI-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=NC=1)C(=O)O VVYCSMMIVOYHDI-UHFFFAOYSA-N 0.000 claims 2
• WTNPWTUTRJHPAM-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CN=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 WTNPWTUTRJHPAM-UHFFFAOYSA-N 0.000 claims 2
• YCGGCEABKZAAJT-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzoic acid Chemical compound COC1=C(C=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1C(F)(F)F)C1CC1)C(O)=O YCGGCEABKZAAJT-UHFFFAOYSA-N 0.000 claims 2
• ULQXKUPCZCEAAN-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=NC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1C(F)(F)F)C1CC1 ULQXKUPCZCEAAN-UHFFFAOYSA-N 0.000 claims 2
• MRAAWNFQBGUXFU-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)C(F)(F)F)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=NC=C(C(=O)O)C=1 MRAAWNFQBGUXFU-UHFFFAOYSA-N 0.000 claims 2
• LMRCIZRWNVSOGK-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-2-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=CC(=C(C(=O)O)C=1)F LMRCIZRWNVSOGK-UHFFFAOYSA-N 0.000 claims 2
• ABFMZSZMWTXJCO-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyridine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=NC=C(C(=O)O)C=1 ABFMZSZMWTXJCO-UHFFFAOYSA-N 0.000 claims 2
• CMMRGCPKNDCTPD-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methylamino]-2-methylpyrazole-3-carboxylic acid Chemical compound Cn1nc(NCC23CCC(CC2)(CC3)OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1C(O)=O CMMRGCPKNDCTPD-UHFFFAOYSA-N 0.000 claims 2
• XBNVIGFWWMLPML-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methylamino]pyridine-3-carboxylic acid Chemical compound OC(=O)c1cncc(NCC23CCC(CC2)(CC3)OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)c1 XBNVIGFWWMLPML-UHFFFAOYSA-N 0.000 claims 2
• XZNNOPZSBQJCQR-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-1-ethyl-4-fluoropyrazole-3-carboxylic acid Chemical compound CCN1N=C(C(O)=O)C(F)=C1OCC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 XZNNOPZSBQJCQR-UHFFFAOYSA-N 0.000 claims 2
• NWGNUPKHTNBRHW-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-1-ethylpyrazole-3-carboxylic acid Chemical compound CCN1N=C(C=C1OCC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O NWGNUPKHTNBRHW-UHFFFAOYSA-N 0.000 claims 2
• ONYOCMBSPOTMDK-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-1-methylpyrazole-3-carboxylic acid Chemical compound CN1N=C(C=C1OCC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O ONYOCMBSPOTMDK-UHFFFAOYSA-N 0.000 claims 2
• QXFCVSGVIHMYJM-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-2,4-dimethylpyrazole-3-carboxylic acid Chemical compound CN1N=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(C)=C1C(O)=O QXFCVSGVIHMYJM-UHFFFAOYSA-N 0.000 claims 2
• OTCIKYBWJGVFDZ-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-2-(cyclopropylmethyl)-4-fluoropyrazole-3-carboxylic acid Chemical compound OC(=O)C1=C(F)C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=NN1CC1CC1 OTCIKYBWJGVFDZ-UHFFFAOYSA-N 0.000 claims 2
• GFAHBVBVQXMMOO-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-2-(cyclopropylmethyl)-4-methylpyrazole-3-carboxylic acid Chemical compound CC1=C(N(CC2CC2)N=C1OCC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O GFAHBVBVQXMMOO-UHFFFAOYSA-N 0.000 claims 2
• SOQZOLPXBTWPRC-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-2-(cyclopropylmethyl)pyrazole-3-carboxylic acid Chemical compound OC(=O)C1=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=NN1CC1CC1 SOQZOLPXBTWPRC-UHFFFAOYSA-N 0.000 claims 2
• PUKKTSYWAPQYSF-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-2-ethyl-4-methylpyrazole-3-carboxylic acid Chemical compound CCN1N=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(C)=C1C(O)=O PUKKTSYWAPQYSF-UHFFFAOYSA-N 0.000 claims 2
• TWQDLGSODLDKLH-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-2-ethylpyrazole-3-carboxylic acid Chemical compound CCN1N=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1C(O)=O TWQDLGSODLDKLH-UHFFFAOYSA-N 0.000 claims 2
• BDMBFJYSCVHMGG-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-2-fluorobenzoic acid Chemical compound OC(=O)C1=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=CC=C1F BDMBFJYSCVHMGG-UHFFFAOYSA-N 0.000 claims 2
• ZIMSWRDTSMLLEI-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-2-methylpyrazole-3-carboxylic acid Chemical compound CN1N=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1C(O)=O ZIMSWRDTSMLLEI-UHFFFAOYSA-N 0.000 claims 2
• DXJIDCXCBNRCAX-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-(1,1-difluoroethyl)pyridine-2-carboxylic acid Chemical compound CC(F)(F)C1=C(N=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1)C(O)=O DXJIDCXCBNRCAX-UHFFFAOYSA-N 0.000 claims 2
• IYERYRYLSVIEBW-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=NC=1)C(=O)O)OCC(F)(F)F IYERYRYLSVIEBW-UHFFFAOYSA-N 0.000 claims 2
• DLMNWXCTCNZVLS-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-(2-methoxyethoxy)pyridine-2-carboxylic acid Chemical compound COCCOC1=C(N=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1)C(O)=O DLMNWXCTCNZVLS-UHFFFAOYSA-N 0.000 claims 2
• PYAADOMRMGVDPC-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-(cyclopropylmethoxy)pyridine-2-carboxylic acid Chemical compound OC(=O)C1=C(OCC2CC2)C=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=N1 PYAADOMRMGVDPC-UHFFFAOYSA-N 0.000 claims 2
• KNJSJIQZZCMTMQ-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-(methoxymethyl)pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=NC=1)C(=O)O)COC KNJSJIQZZCMTMQ-UHFFFAOYSA-N 0.000 claims 2
• DFJRNGSOAMODNW-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-(trifluoromethyl)pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=NC=1)C(=O)O)C(F)(F)F DFJRNGSOAMODNW-UHFFFAOYSA-N 0.000 claims 2
• BRCIBDPAOCHJJV-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-cyclopropyloxypyridine-2-carboxylic acid Chemical compound OC(=O)C1=C(OC2CC2)C=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=N1 BRCIBDPAOCHJJV-UHFFFAOYSA-N 0.000 claims 2
• JJLQSTCTEGETJB-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-ethoxypyridine-2-carboxamide Chemical compound CCOC1=C(N=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1)C(N)=O JJLQSTCTEGETJB-UHFFFAOYSA-N 0.000 claims 2
• CJSIRNJGHHRFIU-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-ethoxypyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=NC=1)C(=O)O)OCC CJSIRNJGHHRFIU-UHFFFAOYSA-N 0.000 claims 2
• ZHPQPBOLIUCJQY-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-methoxypyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=NC=1)C(=O)O)OC ZHPQPBOLIUCJQY-UHFFFAOYSA-N 0.000 claims 2
• YVJKQRJAVRTJTD-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-methylpyridine-2-carboxamide Chemical compound CC1=C(N=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1)C(N)=O YVJKQRJAVRTJTD-UHFFFAOYSA-N 0.000 claims 2
• RKLAKDFPMMYWJC-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-methylpyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=NC=1)C(=O)O)C RKLAKDFPMMYWJC-UHFFFAOYSA-N 0.000 claims 2
• GAOJINMGTKCGQC-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-propan-2-yloxypyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=NC=1)C(=O)O)OC(C)C GAOJINMGTKCGQC-UHFFFAOYSA-N 0.000 claims 2
• NDUJNEHQDYWIJJ-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-methyl-2-(oxetan-3-ylmethyl)pyrazole-3-carboxylic acid Chemical compound CC1=C(N(CC2COC2)N=C1OCC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O NDUJNEHQDYWIJJ-UHFFFAOYSA-N 0.000 claims 2
• YREQNBLIVBLKFB-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-methyl-2-propan-2-ylpyrazole-3-carboxylic acid Chemical compound CC(C)N1N=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(C)=C1C(O)=O YREQNBLIVBLKFB-UHFFFAOYSA-N 0.000 claims 2
• NIXOPQWMHLWRJT-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=N1 NIXOPQWMHLWRJT-UHFFFAOYSA-N 0.000 claims 2
• NGAMUSYLUKWVFP-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-2-fluorobenzoic acid Chemical compound OC(=O)C1=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=CC=CC=C2C(F)(F)F)C2CC2)=CC=C1F NGAMUSYLUKWVFP-UHFFFAOYSA-N 0.000 claims 2
• RCUKLBOMCGLIRX-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-ethoxypyridine-2-carboxamide Chemical compound CCOC1=C(N=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=CC=CC=C2C(F)(F)F)C2CC2)=C1)C(N)=O RCUKLBOMCGLIRX-UHFFFAOYSA-N 0.000 claims 2
• SFATYYDKFQXOFL-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-ethoxypyridine-2-carboxylic acid Chemical compound CCOC1=C(N=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=CC=CC=C2C(F)(F)F)C2CC2)=C1)C(O)=O SFATYYDKFQXOFL-UHFFFAOYSA-N 0.000 claims 2
• WPEGGCDSUBAHHX-UHFFFAOYSA-N 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-[[1-[3-(2H-tetrazol-5-yl)phenyl]-2-oxabicyclo[2.2.2]octan-4-yl]methoxymethyl]-1,2-oxazole Chemical compound N1N=NN=C1C=1C=C(C=CC=1)C12OCC(CC1)(CC2)COCC=1C(=NOC=1C1CC1)C1=C(C=CC=C1Cl)Cl WPEGGCDSUBAHHX-UHFFFAOYSA-N 0.000 claims 2
• UAISDRDPOMMDTE-BQYQJAHWSA-N 5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-4-[[4-[(E)-2-[4-(2H-tetrazol-5-ylmethyl)phenyl]ethenyl]-1-bicyclo[2.2.2]octanyl]oxymethyl]-1,2-oxazole Chemical compound ClC1=CN=CC(Cl)=C1C1=NOC(C2CC2)=C1COC12CCC(CC1)(CC2)\C=C\C1=CC=C(CC2=NNN=N2)C=C1 UAISDRDPOMMDTE-BQYQJAHWSA-N 0.000 claims 2
• OTPPXGVHWDQPCH-UHFFFAOYSA-N 6-(azetidin-1-yl)-5-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CN=C(N2CCC2)C(=C1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 OTPPXGVHWDQPCH-UHFFFAOYSA-N 0.000 claims 2
• STEFUOFHVMYJLH-VOTSOKGWSA-N 6-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-1-methylindole-2-carboxylic acid Chemical compound CN1C(=CC2=C1C=C(\C=C\C13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2)C(O)=O STEFUOFHVMYJLH-VOTSOKGWSA-N 0.000 claims 2
• IHHXTFZSKFIHQX-BQYQJAHWSA-N 6-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-4-ethoxyquinoline-2-carboxylic acid Chemical compound CCOC1=CC(=NC2=C1C=C(\C=C\C13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2)C(O)=O IHHXTFZSKFIHQX-BQYQJAHWSA-N 0.000 claims 2
• OCBYPFJVLBHLAY-VOTSOKGWSA-N 6-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-4-methoxyquinazoline-2-carboxylic acid Chemical compound COC1=NC(=NC2=C1C=C(\C=C\C13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2)C(O)=O OCBYPFJVLBHLAY-VOTSOKGWSA-N 0.000 claims 2
• XMHVVIZKDIEWNV-BQYQJAHWSA-N 6-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-4-propan-2-yloxyquinoline-2-carboxylic acid Chemical compound CC(C)OC1=CC(=NC2=C1C=C(\C=C\C13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2)C(O)=O XMHVVIZKDIEWNV-BQYQJAHWSA-N 0.000 claims 2
• CQRYVQKGTVZFLZ-AATRIKPKSA-N 6-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]imidazo[1,2-a]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CN=C2C=CC(\C=C\C34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)=CN12 CQRYVQKGTVZFLZ-AATRIKPKSA-N 0.000 claims 2
• JYRFKQFUBIKIRL-BQYQJAHWSA-N 6-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]quinoline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=C(C=C1)C=C(\C=C\C13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2 JYRFKQFUBIKIRL-BQYQJAHWSA-N 0.000 claims 2
• OHJIDDZOPJSSLT-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethyl]-4-(trifluoromethyl)quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)CCC=1C=C2C(=CC(=NC2=CC=1)C(=O)O)C(F)(F)F OHJIDDZOPJSSLT-UHFFFAOYSA-N 0.000 claims 2
• KUVGDRNPGBBSQX-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethyl]-4-propan-2-yloxyquinoline-2-carboxylic acid Chemical compound CC(C)OC1=CC(=NC2=C1C=C(CCC13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2)C(O)=O KUVGDRNPGBBSQX-UHFFFAOYSA-N 0.000 claims 2
• KGHFOIQKADFXOR-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethyl]quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)CCC=1C=C2C=CC(=NC2=CC=1)C(=O)O KGHFOIQKADFXOR-UHFFFAOYSA-N 0.000 claims 2
• FISSJEHGGPTWRB-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1-(3-methoxypropoxy)isoquinoline-3-carboxylic acid Chemical compound COCCCOC1=NC(=CC2=CC(=CC=C12)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O FISSJEHGGPTWRB-UHFFFAOYSA-N 0.000 claims 2
• QUCCUFPTCRJMDF-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1-(4-methylpiperazin-1-yl)isoquinoline-3-carboxylic acid Chemical compound CN1CCN(CC1)C1=NC(=CC2=CC(=CC=C12)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O QUCCUFPTCRJMDF-UHFFFAOYSA-N 0.000 claims 2
• VGLMCUAPQNXBMX-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1-methylpyrrolo[2,3-b]pyridine-3-carboxylic acid Chemical compound CN1C=C(C(O)=O)C2=CC=C(N=C12)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 VGLMCUAPQNXBMX-UHFFFAOYSA-N 0.000 claims 2
• FACWXGBOTJWNEG-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1-morpholin-4-ylisoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=CC(=CC=C2C(=N1)N1CCOCC1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 FACWXGBOTJWNEG-UHFFFAOYSA-N 0.000 claims 2
• UWVTWSJJCWMSBX-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1H-indazole-4-carboxylic acid Chemical compound OC(=O)c1cc(cc2[nH]ncc12)C#CC12CCC(CC1)(CC2)OCc1c(onc1-c1c(Cl)cncc1Cl)C1CC1 UWVTWSJJCWMSBX-UHFFFAOYSA-N 0.000 claims 2
• FVZHZZXEIXDCAU-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1H-indole-4-carboxylic acid Chemical compound OC(=O)c1cc(cc2[nH]ccc12)C#CC12CCC(CC1)(CC2)OCc1c(onc1-c1c(Cl)cncc1Cl)C1CC1 FVZHZZXEIXDCAU-UHFFFAOYSA-N 0.000 claims 2
• XJTSSGUDXBLJOX-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-2-methylpyridine-3-carboxylic acid Chemical compound CC1=NC(=CC=C1C(O)=O)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 XJTSSGUDXBLJOX-UHFFFAOYSA-N 0.000 claims 2
• IJOYJGSRLYNGHX-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-4-(difluoromethoxy)quinoline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=C(C=C(C=C2)C#CC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(OC(F)F)=C1 IJOYJGSRLYNGHX-UHFFFAOYSA-N 0.000 claims 2
• VEPGBJRNMANROF-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-4-(trifluoromethyl)pyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC(=CC(=N1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(F)(F)F VEPGBJRNMANROF-UHFFFAOYSA-N 0.000 claims 2
• FCWPHZAWBUUALF-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-4-(trifluoromethyl)pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CN=C(C=C1C(F)(F)F)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 FCWPHZAWBUUALF-UHFFFAOYSA-N 0.000 claims 2
• UNSXJCDEVKZFJC-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-4-(trifluoromethyl)quinoline-2-carboxylic acid Chemical compound C1=2C(=CC(=NC1=CC=C(C#CC13CCC(CC1)(OCC=1C(C4=C(Cl)C=NC=C4Cl)=NOC=1C1CC1)CC3)C=2)C(=O)O)C(F)(F)F UNSXJCDEVKZFJC-UHFFFAOYSA-N 0.000 claims 2
• BPUYJUCMMUUXKG-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-4-methoxypyridine-2-carboxylic acid Chemical compound COC1=CC(=NC(=C1)C(O)=O)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 BPUYJUCMMUUXKG-UHFFFAOYSA-N 0.000 claims 2
• BZPWHHFXRALUHJ-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-4-methoxyquinoline-2-carboxylic acid Chemical compound COC1=CC(=NC2=C1C=C(C=C2)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O BZPWHHFXRALUHJ-UHFFFAOYSA-N 0.000 claims 2
• BFOLGAJGUQFTOJ-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-4-propan-2-yloxyquinoline-2-carboxylic acid Chemical compound CC(C)OC1=CC(=NC2=C1C=C(C=C2)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O BFOLGAJGUQFTOJ-UHFFFAOYSA-N 0.000 claims 2
• BENHBDMPSKAHBL-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-5-fluoropyridine-3-carboxylic acid Chemical compound OC(=O)C1=CN=C(C#CC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(F)=C1 BENHBDMPSKAHBL-UHFFFAOYSA-N 0.000 claims 2
• OUAGUFBGXYYMER-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]imidazo[1,2-a]pyridine-8-carboxylic acid Chemical compound OC(=O)C1=CC(=CN2C=CN=C12)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 OUAGUFBGXYYMER-UHFFFAOYSA-N 0.000 claims 2
• DVDFNRLZPAAJID-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]pyridazine-3-carboxylic acid Chemical compound OC(=O)C1=CC=C(N=N1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 DVDFNRLZPAAJID-UHFFFAOYSA-N 0.000 claims 2
• KNOVNWAKJBUTEO-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]quinoline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=CC=C(C=C2C=C1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 KNOVNWAKJBUTEO-UHFFFAOYSA-N 0.000 claims 2
• VBGZNCZTIODECK-UHFFFAOYSA-N 6-[3-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC=CC(=N1)C1=NC(=NO1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 VBGZNCZTIODECK-UHFFFAOYSA-N 0.000 claims 2
• UZGHOHSXZJBXCY-UHFFFAOYSA-N 6-[3-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC=CC(=N1)C1=NC(=NO1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 UZGHOHSXZJBXCY-UHFFFAOYSA-N 0.000 claims 2
• QDCSPAMDZWYZGW-UHFFFAOYSA-N 6-[3-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)C(F)(F)F)COC12CCC(CC1)(CC2)C1=NOC(=N1)C1=CC=CC(=N1)C(=O)O QDCSPAMDZWYZGW-UHFFFAOYSA-N 0.000 claims 2
• KDPCKLDIXCMJIH-UHFFFAOYSA-N 6-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,5-naphthyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1N=C2C=CC(=NC2=CC=1)C(=O)O KDPCKLDIXCMJIH-UHFFFAOYSA-N 0.000 claims 2
• MJHFNWJSCIZWMS-UHFFFAOYSA-N 6-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1-methylpyrrolo[2,3-b]pyridine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=CC=C2C(=N1)N(C=C2C(=O)O)C MJHFNWJSCIZWMS-UHFFFAOYSA-N 0.000 claims 2
• XIQUUUJGRSAHID-UHFFFAOYSA-N 6-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]pyridine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC=C(C(=O)O)C=C1 XIQUUUJGRSAHID-UHFFFAOYSA-N 0.000 claims 2
• LWZWXVPIBBUZCS-UHFFFAOYSA-N 6-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,5-naphthyridine-2-carboxylic acid Chemical compound OC(=O)C1=NC2=C(C=C1)N=C(C=C2)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 LWZWXVPIBBUZCS-UHFFFAOYSA-N 0.000 claims 2
• JUOLNUVICVSFOF-UHFFFAOYSA-N 6-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1-ethylpyrazolo[3,4-b]pyridine-3-carboxylic acid Chemical compound CCN1N=C(C(O)=O)C2=CC=C(N=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 JUOLNUVICVSFOF-UHFFFAOYSA-N 0.000 claims 2
• URZCSQZZYMCUTH-UHFFFAOYSA-N 6-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1-methylpyrazolo[3,4-b]pyridine-3-carboxylic acid Chemical compound CN1N=C(C(O)=O)C2=CC=C(N=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 URZCSQZZYMCUTH-UHFFFAOYSA-N 0.000 claims 2
• LXOJWNYSHPQEMU-UHFFFAOYSA-N 6-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=CC=CC(=N1)C(=O)O LXOJWNYSHPQEMU-UHFFFAOYSA-N 0.000 claims 2
• XFNUKWLRGXKOHH-UHFFFAOYSA-N 6-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=CC=CC(=N1)C(=O)O XFNUKWLRGXKOHH-UHFFFAOYSA-N 0.000 claims 2
• CMJQZWWRGNZDMC-UHFFFAOYSA-N 6-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC=CC(=N1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 CMJQZWWRGNZDMC-UHFFFAOYSA-N 0.000 claims 2
• AOYIMGUJDVAAOL-UHFFFAOYSA-N 6-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CN=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 AOYIMGUJDVAAOL-UHFFFAOYSA-N 0.000 claims 2
• DZPUBFBGNVJPJQ-UHFFFAOYSA-N 6-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC=CC(=N1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1C(F)(F)F)C1CC1 DZPUBFBGNVJPJQ-UHFFFAOYSA-N 0.000 claims 2
• JKPLCBNWFFIWTP-UHFFFAOYSA-N 6-[[4-[[3-(3-chloro-5-methoxypyridin-4-yl)-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-methylpyridine-2-carboxylic acid Chemical compound ClC=1C=NC=C(C=1C1=NOC(=C1COC12CCC(CC1)(CC2)COC1=CC=C(C(=N1)C(=O)O)C)C1CC1)OC JKPLCBNWFFIWTP-UHFFFAOYSA-N 0.000 claims 2
• LKBUNXXRBNUZIG-UHFFFAOYSA-N 6-[[4-[[3-(3-chloro-5-methoxypyridin-4-yl)-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-methylpyridine-3-carboxylic acid Chemical compound ClC=1C=NC=C(C=1C1=NOC(=C1COC12CCC(CC1)(CC2)COC1=NC=C(C(=O)O)C(=C1)C)C1CC1)OC LKBUNXXRBNUZIG-UHFFFAOYSA-N 0.000 claims 2
• TZAKSOREWJSVGG-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-hydroxymethyl]naphthalene-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(C=1C=C2C=CC(=CC2=CC=1)C(=O)O)O TZAKSOREWJSVGG-UHFFFAOYSA-N 0.000 claims 2
• QNGXXBUVPJMLSB-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-1-methylindole-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=CC=C2C(=CN(C2=C1)C)C(=O)O QNGXXBUVPJMLSB-UHFFFAOYSA-N 0.000 claims 2
• LLFVOWYCDQTFOQ-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-(trifluoromethyl)quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=CC=1)C(=O)O)C(F)(F)F LLFVOWYCDQTFOQ-UHFFFAOYSA-N 0.000 claims 2
• JVJQBNMFLWJKGS-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyrazine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=CN=CC(=N1)C(=O)O JVJQBNMFLWJKGS-UHFFFAOYSA-N 0.000 claims 2
• OHCUYDYCGPDIPC-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyridine-2-carboxamide Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=CC=CC(=N1)C(=O)N OHCUYDYCGPDIPC-UHFFFAOYSA-N 0.000 claims 2
• XCNAMCFSOUZOFB-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=CC=CC(=N1)C(=O)O XCNAMCFSOUZOFB-UHFFFAOYSA-N 0.000 claims 2
• KPBJBOHVGKQDTP-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyridine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=NC=C(C(=O)O)C=C1 KPBJBOHVGKQDTP-UHFFFAOYSA-N 0.000 claims 2
• VMPROHZLTYVFOR-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-1,5-naphthyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1N=C2C=CC(=NC2=CC=1)C(=O)O VMPROHZLTYVFOR-UHFFFAOYSA-N 0.000 claims 2
• YWKIRXJMCGIMOM-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-1-methylindole-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=CC=C2C(=CN(C2=C1)C)C(=O)O YWKIRXJMCGIMOM-UHFFFAOYSA-N 0.000 claims 2
• JEJMNPWJFXSVTN-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-(2-methylpropoxy)quinoline-2-carboxylic acid Chemical compound CC(C)COC1=CC(=NC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C12)C(O)=O JEJMNPWJFXSVTN-UHFFFAOYSA-N 0.000 claims 2
• GODFICYVBREPEH-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-(3-methoxyazetidin-1-yl)quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=CC=1)C(=O)O)N1CC(C1)OC GODFICYVBREPEH-UHFFFAOYSA-N 0.000 claims 2
• LEQOJNMSKIRROL-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-(cyclopropylmethoxy)-7-fluoroquinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=CC=1F)C(=O)O)OCC1CC1 LEQOJNMSKIRROL-UHFFFAOYSA-N 0.000 claims 2
• AFPROGJJEKEZEQ-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-(cyclopropylmethoxy)quinoline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2C(OCC2CC2)=C1 AFPROGJJEKEZEQ-UHFFFAOYSA-N 0.000 claims 2
• HQGPWGYDCIJFKC-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-(difluoromethoxy)quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=CC=1)C(=O)O)OC(F)F HQGPWGYDCIJFKC-UHFFFAOYSA-N 0.000 claims 2
• KRUFBCCMOLEMGI-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-(oxetan-3-ylmethoxy)quinoline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2C(OCC2COC2)=C1 KRUFBCCMOLEMGI-UHFFFAOYSA-N 0.000 claims 2
• NJSGVLUIYNRMLB-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-(oxetan-3-yloxy)quinoline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2C(OC2COC2)=C1 NJSGVLUIYNRMLB-UHFFFAOYSA-N 0.000 claims 2
• SSSWRKXUHQHDEW-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-(trifluoromethyl)pyridine-3-carboxylic acid Chemical compound OC(=O)C1=C(C=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)N=C1)C(F)(F)F SSSWRKXUHQHDEW-UHFFFAOYSA-N 0.000 claims 2
• PPEDFXXWSUZXSG-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-(trifluoromethyl)quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=CC=1)C(=O)O)C(F)(F)F PPEDFXXWSUZXSG-UHFFFAOYSA-N 0.000 claims 2
• YBPASDREEFQDEN-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-cyclopropyloxyquinoline-2-carboxylic acid Chemical compound C1(CC1)OC1=CC(=NC2=CC=C(C=C12)OCC12CCC(CC1)(CC2)OCC=1C(=NOC=1C1CC1)C1=C(C=NC=C1Cl)Cl)C(=O)O YBPASDREEFQDEN-UHFFFAOYSA-N 0.000 claims 2
• IBPDZMRFYXTMIG-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-ethoxy-7-fluoroquinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=CC=1F)C(=O)O)OCC IBPDZMRFYXTMIG-UHFFFAOYSA-N 0.000 claims 2
• MHIBKXCBYXMDST-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-ethoxy-8-fluoroquinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=C(C=1)F)C(=O)O)OCC MHIBKXCBYXMDST-UHFFFAOYSA-N 0.000 claims 2
• SROOWOWZERCJKU-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-ethoxyquinoline-2-carboxylic acid Chemical compound CCOC1=CC(=NC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C12)C(O)=O SROOWOWZERCJKU-UHFFFAOYSA-N 0.000 claims 2
• GTKZANGPNBCQCM-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-ethylquinoline-2-carboxylic acid Chemical compound CCC1=CC(=NC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C12)C(O)=O GTKZANGPNBCQCM-UHFFFAOYSA-N 0.000 claims 2
• XHXAGNNTFOAPQP-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-methoxypyridine-2-carboxylic acid Chemical compound COC1=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=NC(=C1)C(O)=O XHXAGNNTFOAPQP-UHFFFAOYSA-N 0.000 claims 2
• SINTWJMSZIZWDB-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-methoxypyridine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=NC=C(C(=O)O)C(=C1)OC SINTWJMSZIZWDB-UHFFFAOYSA-N 0.000 claims 2
• IDHYHTJHJDQQJC-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-methoxyquinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=CC=1)C(=O)O)OC IDHYHTJHJDQQJC-UHFFFAOYSA-N 0.000 claims 2
• SYYLCGIHANJJDM-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-methylsulfonylquinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=CC=1)C(=O)O)S(=O)(=O)C SYYLCGIHANJJDM-UHFFFAOYSA-N 0.000 claims 2
• UQPVNESMQGSVPN-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-oxo-1H-quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=CC=1)C(=O)O)O UQPVNESMQGSVPN-UHFFFAOYSA-N 0.000 claims 2
• KGVLTKTXRFHOQF-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-propan-2-yloxyquinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=CC=1)C(=O)O)OC(C)C KGVLTKTXRFHOQF-UHFFFAOYSA-N 0.000 claims 2
• QJRZPTBGIRHTPX-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-propylquinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=CC=1)C(=O)O)CCC QJRZPTBGIRHTPX-UHFFFAOYSA-N 0.000 claims 2
• DTEBNIMQQGDJEM-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-5-fluoropyridine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=NC=C(C(=O)O)C=C1F DTEBNIMQQGDJEM-UHFFFAOYSA-N 0.000 claims 2
• JYAHYSPNAAVSLZ-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-8-fluoro-4-(oxetan-3-yloxy)quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=C(C=1)F)C(=O)O)OC1COC1 JYAHYSPNAAVSLZ-UHFFFAOYSA-N 0.000 claims 2
• WUEHDPQNJKMDJS-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-8-fluoro-4-methylquinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=C(C=1)F)C(=O)O)C WUEHDPQNJKMDJS-UHFFFAOYSA-N 0.000 claims 2
• MBYZYARPQUOHDN-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-8-fluoro-4-propan-2-yloxyquinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=C(C=1)F)C(=O)O)OC(C)C MBYZYARPQUOHDN-UHFFFAOYSA-N 0.000 claims 2
• OWWQJHFEDXHNQR-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-8-fluoro-4-propylquinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=C(C=1)F)C(=O)O)CCC OWWQJHFEDXHNQR-UHFFFAOYSA-N 0.000 claims 2
• JQAWTOGHWFIYHD-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-N-methylsulfonyl-4-(trifluoromethyl)quinoline-2-carboxamide Chemical compound CS(=O)(=O)NC(=O)c1cc(c2cc(OCC34CCC(CC3)(CC4)OCc3c(onc3-c3c(Cl)cncc3Cl)C3CC3)ccc2n1)C(F)(F)F JQAWTOGHWFIYHD-UHFFFAOYSA-N 0.000 claims 2
• FZEXMBSEHOHXAE-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]imidazo[1,2-b]pyridazine-3-carbonitrile Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=CC=2N(N=1)C(=CN=2)C#N FZEXMBSEHOHXAE-UHFFFAOYSA-N 0.000 claims 2
• TZUHLNVGYYTVSF-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]imidazo[1,2-b]pyridazine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=CC=2N(N=1)C(=CN=2)C(=O)O TZUHLNVGYYTVSF-UHFFFAOYSA-N 0.000 claims 2
• MBQCELYAKCNSLA-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=CC=CC(=N1)C(=O)O MBQCELYAKCNSLA-UHFFFAOYSA-N 0.000 claims 2
• PGLDMULBIRRRNY-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyridine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=NC=C(C(=O)O)C=C1 PGLDMULBIRRRNY-UHFFFAOYSA-N 0.000 claims 2
• HKLCQDDOPWQVSB-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C2C=CC(=NC2=CC=1)C(=O)O HKLCQDDOPWQVSB-UHFFFAOYSA-N 0.000 claims 2
• FFHAOOKVOPSHCO-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxymethyl]-4-(trifluoromethyl)pyridine-2-carboxylic acid Chemical compound OC(=O)C1=NC(COCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=CC(=C1)C(F)(F)F FFHAOOKVOPSHCO-UHFFFAOYSA-N 0.000 claims 2
• OYPJXVNKEXEFGZ-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-2-oxabicyclo[2.2.2]octan-1-yl]methoxy]-4-(difluoromethoxy)quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12COC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=CC=1)C(=O)O)OC(F)F OYPJXVNKEXEFGZ-UHFFFAOYSA-N 0.000 claims 2
• GMWOGVFLSCQHJC-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-(trifluoromethyl)quinoline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=CC=CC=C3C(F)(F)F)C3CC3)C=C2C(=C1)C(F)(F)F GMWOGVFLSCQHJC-UHFFFAOYSA-N 0.000 claims 2
• VIJZTGRVAYCBSJ-UHFFFAOYSA-N 6-[[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-methoxyquinoline-2-carboxylic acid Chemical compound COC1=CC(=NC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=CC=CC=C3C(F)(F)F)C3CC3)C=C12)C(O)=O VIJZTGRVAYCBSJ-UHFFFAOYSA-N 0.000 claims 2
• AMXXRXOALPXPBH-UHFFFAOYSA-N 6-cyclobutyloxy-4-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound C1(CCC1)OC1=CC(=CC(=N1)C(=O)O)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC=1C(=NOC=1C1CC1)C1=C(C=NC=C1Cl)Cl AMXXRXOALPXPBH-UHFFFAOYSA-N 0.000 claims 2
• MCRKSMWUNWGFAU-AATRIKPKSA-N 7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-1-(3-fluoroazetidin-1-yl)isoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C(\C=C\C34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2)C(=N1)N1CC(F)C1 MCRKSMWUNWGFAU-AATRIKPKSA-N 0.000 claims 2
• FABVVWZJGKTMKZ-AATRIKPKSA-N 7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-1-(3-hydroxyazetidin-1-yl)isoquinoline-3-carboxylic acid Chemical compound OC1CN(C1)C1=NC(=CC2=C1C=C(\C=C\C13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2)C(O)=O FABVVWZJGKTMKZ-AATRIKPKSA-N 0.000 claims 2
• TYJGIQVKKHAZHS-VOTSOKGWSA-N 7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-1-(3-methoxyazetidin-1-yl)isoquinoline-3-carboxylic acid Chemical compound COC1CN(C1)C1=NC(=CC2=C1C=C(\C=C\C13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2)C(O)=O TYJGIQVKKHAZHS-VOTSOKGWSA-N 0.000 claims 2
• ZAVPYEOKYCLCSH-BQYQJAHWSA-N 7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-1-(3-methoxypropoxy)isoquinoline-3-carboxylic acid Chemical compound COCCCOC1=NC(=CC2=C1C=C(\C=C\C13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2)C(O)=O ZAVPYEOKYCLCSH-BQYQJAHWSA-N 0.000 claims 2
• VFEBUNAVRGTMPU-AATRIKPKSA-N 7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-1-[3-(hydroxymethyl)azetidin-1-yl]isoquinoline-3-carboxylic acid Chemical compound OCC1CN(C1)C1=NC(=CC2=C1C=C(\C=C\C13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2)C(O)=O VFEBUNAVRGTMPU-AATRIKPKSA-N 0.000 claims 2
• MZBGAKNKNVCBPG-BQYQJAHWSA-N 7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-1-cyclopropyloxyisoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C(\C=C\C34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2)C(OC2CC2)=N1 MZBGAKNKNVCBPG-BQYQJAHWSA-N 0.000 claims 2
• PHXBORMTXKNQBY-BQYQJAHWSA-N 7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-1-ethoxyisoquinoline-3-carboxylic acid Chemical compound CCOC1=NC(=CC2=C1C=C(\C=C\C13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2)C(O)=O PHXBORMTXKNQBY-BQYQJAHWSA-N 0.000 claims 2
• LNKFLVYZFNTXSH-AATRIKPKSA-N 7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-1-morpholin-4-ylisoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C(\C=C\C34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2)C(=N1)N1CCOCC1 LNKFLVYZFNTXSH-AATRIKPKSA-N 0.000 claims 2
• ZYODQZJZOOPZDO-HWKANZROSA-N 7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]imidazo[1,2-a]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CN=C2C=C(\C=C\C34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=CN12 ZYODQZJZOOPZDO-HWKANZROSA-N 0.000 claims 2
• GZPUGVNZOVCVCT-UHFFFAOYSA-N 7-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1-(2-pyrrolidin-1-ylethoxy)isoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C(C=C2)C#CC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(OCCN2CCCC2)=N1 GZPUGVNZOVCVCT-UHFFFAOYSA-N 0.000 claims 2
• HCUVUOYNAMYMGZ-UHFFFAOYSA-N 7-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1-(3-fluoroazetidin-1-yl)isoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C(C=C2)C#CC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(=N1)N1CC(F)C1 HCUVUOYNAMYMGZ-UHFFFAOYSA-N 0.000 claims 2
• DAQIIRPVWHWLAI-UHFFFAOYSA-N 7-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1-(3-hydroxyazetidin-1-yl)isoquinoline-3-carboxylic acid Chemical compound OC1CN(C1)C1=NC(=CC2=C1C=C(C=C2)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O DAQIIRPVWHWLAI-UHFFFAOYSA-N 0.000 claims 2
• RMRNPIYWZQJVSA-UHFFFAOYSA-N 7-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1-(3-hydroxypyrrolidin-1-yl)isoquinoline-3-carboxylic acid Chemical compound OC1CCN(C1)C1=NC(=CC2=C1C=C(C=C2)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O RMRNPIYWZQJVSA-UHFFFAOYSA-N 0.000 claims 2
• FPYFQCXZXGLGLT-UHFFFAOYSA-N 7-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1-(4-hydroxypiperidin-1-yl)isoquinoline-3-carboxylic acid Chemical compound OC1CCN(CC1)C1=NC(=CC2=C1C=C(C=C2)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O FPYFQCXZXGLGLT-UHFFFAOYSA-N 0.000 claims 2
• OIPCKFACUTZLCI-UHFFFAOYSA-N 7-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1-[3-(dimethylamino)azetidin-1-yl]isoquinoline-3-carboxylic acid Chemical compound CN(C)C1CN(C1)C1=NC(=CC2=C1C=C(C=C2)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O OIPCKFACUTZLCI-UHFFFAOYSA-N 0.000 claims 2
• UUIOGVRAZSXXNM-UHFFFAOYSA-N 7-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1-methoxyisoquinoline-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C#CC1=CC=C2C=C(N=C(C2=C1)OC)C(=O)O UUIOGVRAZSXXNM-UHFFFAOYSA-N 0.000 claims 2
• YTFFITIOBXGTDI-UHFFFAOYSA-N 7-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1-morpholin-4-ylisoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C(C=C2)C#CC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(=N1)N1CCOCC1 YTFFITIOBXGTDI-UHFFFAOYSA-N 0.000 claims 2
• WEDCERDTHIVAIY-UHFFFAOYSA-N 7-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]-1-piperazin-1-ylisoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C(C=C2)C#CC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(=N1)N1CCNCC1 WEDCERDTHIVAIY-UHFFFAOYSA-N 0.000 claims 2
• UJBZFBGSKXDOMB-UHFFFAOYSA-N 7-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]imidazo[1,2-a]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=CN2C=CC(=CC2=N1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 UJBZFBGSKXDOMB-UHFFFAOYSA-N 0.000 claims 2
• TVMKOQXOKATKAL-UHFFFAOYSA-N 7-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-1-ethoxyisoquinoline-3-carboxylic acid Chemical compound CCOC1=NC(=CC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C12)C(O)=O TVMKOQXOKATKAL-UHFFFAOYSA-N 0.000 claims 2
• SUAVWWBKNLTFBI-UHFFFAOYSA-N 7-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-1-ethylisoquinoline-3-carboxylic acid Chemical compound CCC1=NC(=CC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C12)C(O)=O SUAVWWBKNLTFBI-UHFFFAOYSA-N 0.000 claims 2
• FDHGGOLHSWEJMP-UHFFFAOYSA-N 7-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]isoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2C=N1 FDHGGOLHSWEJMP-UHFFFAOYSA-N 0.000 claims 2
• ROWGGXHYZOKNRE-UHFFFAOYSA-N 7-chloro-1-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]isoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=NC(C#CC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C2C=C(Cl)C=CC2=C1 ROWGGXHYZOKNRE-UHFFFAOYSA-N 0.000 claims 2
• UIWMZEUVMWOTNT-UHFFFAOYSA-N 8-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]quinoline-5-carboxylic acid Chemical compound OC(=O)C1=C2C=CC=NC2=C(C=C1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 UIWMZEUVMWOTNT-UHFFFAOYSA-N 0.000 claims 2
• YGXWIWKYJUSMQH-UHFFFAOYSA-N 8-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]quinoline-5-carboxylic acid Chemical compound OC(=O)C1=C2C=CC=NC2=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1 YGXWIWKYJUSMQH-UHFFFAOYSA-N 0.000 claims 2
• SAOIVFMCMRLOPD-UHFFFAOYSA-N 8-[[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]quinoline-5-carboxylic acid Chemical compound OC(=O)C1=C2C=CC=NC2=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=CC=CC=C2C(F)(F)F)C2CC2)C=C1 SAOIVFMCMRLOPD-UHFFFAOYSA-N 0.000 claims 2
• QTKLZFBAUPDCBN-UHFFFAOYSA-N 8-chloro-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-6-methoxyquinoline-5-carboxylic acid Chemical compound COC1=C(C(O)=O)C2=C(N=C(C=C2)C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(Cl)=C1 QTKLZFBAUPDCBN-UHFFFAOYSA-N 0.000 claims 2
• SPIMLZZZZRKZIC-UHFFFAOYSA-N 8-chloro-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-6-propan-2-yloxyquinoline-5-carboxylic acid Chemical compound CC(C)OC1=C(C(O)=O)C2=C(N=C(C=C2)C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(Cl)=C1 SPIMLZZZZRKZIC-UHFFFAOYSA-N 0.000 claims 2
• YPWDJYRSYDWICV-UHFFFAOYSA-N 8-chloro-6-cyclobutyloxy-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]quinoline-5-carboxylic acid Chemical compound OC(=O)C1=C(OC2CCC2)C=C(Cl)C2=C1C=CC(=N2)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 YPWDJYRSYDWICV-UHFFFAOYSA-N 0.000 claims 2
• CDXOPRYHQWXKBA-UHFFFAOYSA-N 8-cyano-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]quinoline-5-carboxylic acid Chemical compound C(#N)C1=CC=C(C=2C=CC(=NC1=2)C12CCC(CC1)(CC2)OCC=1C(=NOC=1C1CC1)C1=C(C=NC=C1Cl)Cl)C(=O)O CDXOPRYHQWXKBA-UHFFFAOYSA-N 0.000 claims 2
• MZEPUGKXGDBXTQ-UHFFFAOYSA-N 8-cyclobutyloxy-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]quinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=C(OC2CCC2)C2=NC(=CC=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 MZEPUGKXGDBXTQ-UHFFFAOYSA-N 0.000 claims 2
• KSQYXXHEKGGTCB-UHFFFAOYSA-N 8-cyclobutyloxy-2-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]quinoline-5-carboxylic acid Chemical compound C1(CCC1)OC1=CC=C(C=2C=CC(=NC1=2)OCC12CCC(CC1)(CC2)OCC=1C(=NOC=1C1CC1)C1=C(C=NC=C1Cl)Cl)C(=O)O KSQYXXHEKGGTCB-UHFFFAOYSA-N 0.000 claims 2
• WAMNDRORUJZBBV-UHFFFAOYSA-N 8-cyclopentyloxy-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]quinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=C(OC2CCCC2)C2=NC(=CC=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 WAMNDRORUJZBBV-UHFFFAOYSA-N 0.000 claims 2
• JPOQQUGIOXZHPJ-UHFFFAOYSA-N 8-cyclopropyl-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]quinoline-5-carboxylic acid Chemical compound C1(CC1)C1=CC=C(C=2C=CC(=NC1=2)C12CCC(CC1)(CC2)OCC=1C(=NOC=1C1CC1)C1=C(C=NC=C1Cl)Cl)C(=O)O JPOQQUGIOXZHPJ-UHFFFAOYSA-N 0.000 claims 2
• RWKMIFJFMVXMQJ-UHFFFAOYSA-N 8-cyclopropyl-2-[4-[[5-cyclopropyl-3-(dicyclopropylmethyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]quinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=C(C2CC2)C2=C1C=CC(=N2)C12CCC(CC1)(CC2)OCC1=C(ON=C1C(C1CC1)C1CC1)C1CC1 RWKMIFJFMVXMQJ-UHFFFAOYSA-N 0.000 claims 2
• PEDNHFLGOMRXRQ-UHFFFAOYSA-N N-(benzenesulfonyl)-4-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzamide Chemical compound ClC1=CC=CC(Cl)=C1C1=NOC(C2CC2)=C1COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=CC=C(C=C1)C(=O)NS(=O)(=O)C1=CC=CC=C1 PEDNHFLGOMRXRQ-UHFFFAOYSA-N 0.000 claims 2
• PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 2
• GZBSUNIYGVGJSU-UHFFFAOYSA-N [5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]methanol Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)CO GZBSUNIYGVGJSU-UHFFFAOYSA-N 0.000 claims 2
• VZFUCHSFHOYXIS-UHFFFAOYSA-N cycloheptane carboxylic acid Natural products OC(=O)C1CCCCCC1 VZFUCHSFHOYXIS-UHFFFAOYSA-N 0.000 claims 2
• 230000002500 effect on skin Effects 0.000 claims 2
• VDFSIQSDJNIOOD-UHFFFAOYSA-N methyl 3-[5-[4-[2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoate Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)C=CC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)OC)C=CC=1 VDFSIQSDJNIOOD-UHFFFAOYSA-N 0.000 claims 2
• WLJZSKDVUWJILT-UHFFFAOYSA-N methyl 3-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoate Chemical compound COC(=O)C1=CC=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1C(F)(F)F)C1CC1 WLJZSKDVUWJILT-UHFFFAOYSA-N 0.000 claims 2
• OYHWOVSMSSOPTI-UHFFFAOYSA-N methyl 3-[[4-[2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]bicyclo[2.2.1]heptane-1-carbonyl]amino]benzoate Chemical compound COC(=O)C1=CC=CC(NC(=O)C23CCC(CC2)(C3)C=CC2=C(ON=C2C2=C(Cl)C=CC=C2Cl)C2CC2)=C1 OYHWOVSMSSOPTI-UHFFFAOYSA-N 0.000 claims 2
• OABNPDIAOXPPFP-UHFFFAOYSA-N methyl 3-[[4-[2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]bicyclo[2.2.2]octane-1-carbonyl]amino]benzoate Chemical compound COC(=O)C1=CC=CC(NC(=O)C23CCC(CC2)(CC3)C=CC2=C(ON=C2C2=C(Cl)C=CC=C2Cl)C2CC2)=C1 OABNPDIAOXPPFP-UHFFFAOYSA-N 0.000 claims 2
• VAALVAPJLHCRIN-UHFFFAOYSA-N methyl 3-chloro-4-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]bicyclo[2.2.2]octane-1-carbonyl]amino]benzoate Chemical compound ClC=1C=C(C(=O)OC)C=CC=1NC(=O)C12CCC(CC1)(CC2)COCC=1C(=NOC=1C1CC1)C1=C(C=CC=C1Cl)Cl VAALVAPJLHCRIN-UHFFFAOYSA-N 0.000 claims 2
• IZDNXPRTQBDGNZ-UHFFFAOYSA-N methyl 3-chloro-4-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]bicyclo[2.2.2]octane-1-carbothioyl]amino]benzoate Chemical compound ClC=1C=C(C(=O)OC)C=CC=1NC(=S)C12CCC(CC1)(CC2)COCC=1C(=NOC=1C1CC1)C1=C(C=CC=C1Cl)Cl IZDNXPRTQBDGNZ-UHFFFAOYSA-N 0.000 claims 2
• HKUGDXUNGFHYQO-UHFFFAOYSA-N methyl 4-[4-[[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]amino]methyl]-2-oxabicyclo[2.2.2]octan-1-yl]benzoate Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)NCC12COC(CC1)(CC2)C1=CC=C(C(=O)OC)C=C1 HKUGDXUNGFHYQO-UHFFFAOYSA-N 0.000 claims 2
• FTBVBXJOIYFYTH-UHFFFAOYSA-N methyl 4-[5-[4-[2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.1]heptanyl]-1,2,4-oxadiazol-3-yl]benzoate Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)C=CC12CCC(CC1)(C2)C1=NC(=NO1)C1=CC=C(C(=O)OC)C=C1 FTBVBXJOIYFYTH-UHFFFAOYSA-N 0.000 claims 2
• XFHPDROGGNEIBG-UHFFFAOYSA-N methyl 4-[5-[4-[2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoate Chemical compound COC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)C=CC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 XFHPDROGGNEIBG-UHFFFAOYSA-N 0.000 claims 2
• VASOJHSFFLJWJP-UHFFFAOYSA-N methyl 4-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoate Chemical compound COC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 VASOJHSFFLJWJP-UHFFFAOYSA-N 0.000 claims 2
• VYHXQXXUUBJWMT-UHFFFAOYSA-N methyl 4-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoate Chemical compound COC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(COCC3=C(ON=C3C3=CC=CC=C3OC(F)(F)F)C3CC3)(CC1)CC2 VYHXQXXUUBJWMT-UHFFFAOYSA-N 0.000 claims 2
• MIRSFJZHVONBQT-UHFFFAOYSA-N methyl 4-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoate Chemical compound COC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1C(F)(F)F)C1CC1 MIRSFJZHVONBQT-UHFFFAOYSA-N 0.000 claims 2
• UPYLQWAYRZZESB-UHFFFAOYSA-N methyl 4-[5-[4-[[5-propan-2-yl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoate Chemical compound COC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C(C)C UPYLQWAYRZZESB-UHFFFAOYSA-N 0.000 claims 2
• HMVYYTRDXNKRBQ-UHFFFAOYSA-N 1,3-thiazole-4-carboxylic acid Chemical compound OC(=O)C1=CSC=N1 HMVYYTRDXNKRBQ-UHFFFAOYSA-N 0.000 claims 1
• VDIYTACMJVFXCG-MDZDMXLPSA-N 3-[4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]phenyl]propanoic acid Chemical compound OC(=O)CCC1=CC=C(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1 VDIYTACMJVFXCG-MDZDMXLPSA-N 0.000 claims 1
• HFUUIPMSPWIDDU-VOTSOKGWSA-N 7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-1-(4-methylpiperazin-1-yl)isoquinoline-3-carboxylic acid Chemical compound CN1CCN(CC1)C1=NC(=CC2=C1C=C(\C=C\C13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2)C(O)=O HFUUIPMSPWIDDU-VOTSOKGWSA-N 0.000 claims 1
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