KR102711257B1 - 3-[5-아미노-4-(3-시아노벤조일)-피라졸 화합물의 제조를 위한 합성 방법 - Google Patents

3-[5-아미노-4-(3-시아노벤조일)-피라졸 화합물의 제조를 위한 합성 방법 Download PDF

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KR102711257B1
KR102711257B1 KR1020217008904A KR20217008904A KR102711257B1 KR 102711257 B1 KR102711257 B1 KR 102711257B1 KR 1020217008904 A KR1020217008904 A KR 1020217008904A KR 20217008904 A KR20217008904 A KR 20217008904A KR 102711257 B1 KR102711257 B1 KR 102711257B1
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aprotic solvent
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polar aprotic
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KR20210069044A (ko
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마르크 마이센바흐
벤야민 마르틴
니크 요하네스 론데
카르먼 라위스
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메레오 바이오파마 1 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/22—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020217008904A 2018-09-26 2019-09-26 3-[5-아미노-4-(3-시아노벤조일)-피라졸 화합물의 제조를 위한 합성 방법 Active KR102711257B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1815695.0A GB201815695D0 (en) 2018-09-26 2018-09-26 Synthetic method
GB1815695.0 2018-09-26
PCT/GB2019/052718 WO2020065323A1 (en) 2018-09-26 2019-09-26 Synthetic method for the preparation of a 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol compound

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KR20210069044A KR20210069044A (ko) 2021-06-10
KR102711257B1 true KR102711257B1 (ko) 2024-09-30

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US (1) US11649213B2 (enExample)
EP (1) EP3856721B1 (enExample)
JP (1) JP7291782B2 (enExample)
KR (1) KR102711257B1 (enExample)
CN (1) CN112839928B (enExample)
AU (1) AU2019350525B2 (enExample)
CA (1) CA3112993A1 (enExample)
DK (1) DK3856721T3 (enExample)
ES (1) ES2943289T3 (enExample)
GB (1) GB201815695D0 (enExample)
IL (1) IL281636B2 (enExample)
WO (1) WO2020065323A1 (enExample)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009973A1 (en) 2003-06-26 2005-02-03 Novartis Ag 5-membered heterocycle-based p38 kinase inhibitors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1809386A1 (de) 1968-11-16 1970-06-11 Bayer Ag Verfahren zur Herstellung von 1,5-disubstituierten 4-Cyanopyrazolen
US4686221A (en) * 1985-10-01 1987-08-11 Kanebo, Ltd. Quinolinecarboxylic acid compounds and antimicrobial agent containing the same
US6005109A (en) * 1997-10-30 1999-12-21 Pflizer Inc. Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity
US6103900A (en) * 1992-12-17 2000-08-15 Pfizer Inc Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity
FR2732967B1 (fr) 1995-04-11 1997-07-04 Sanofi Sa 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant
GB9608435D0 (en) * 1996-04-24 1996-06-26 Celltech Therapeutics Ltd Chemical compounds
PL344004A1 (en) * 1998-05-05 2001-09-10 Hoffmann La Roche Pyrazole derivatives as p-38 map kinase inhibitors
WO2005007632A1 (en) 2003-07-18 2005-01-27 Pharmacia Corporation Substituted pyridazinones as inhibitors of p38
US7485657B2 (en) * 2004-05-12 2009-02-03 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-cytokine heterocyclic compounds
WO2007083320A2 (en) 2006-01-19 2007-07-26 Matrix Laboratories Ltd Conversion of aromatic diazonium salt to aryl hydrazine
US20100292290A1 (en) 2007-08-02 2010-11-18 Vinayak Gore Novel process to prepare almotriptan
CN101910139B (zh) 2008-01-10 2012-09-26 北兴化学工业株式会社 苯基三唑啉酮类的制造方法
JP5602387B2 (ja) 2008-05-02 2014-10-08 キヤノン株式会社 インクジェット用インク、インクジェット記録方法、インクカートリッジ、記録ユニット、及びインクジェット記録装置
CN102964270B (zh) 2012-11-21 2015-01-07 合肥星宇化学有限责任公司 一种亚硫酸钠还原重氮盐合成肼的方法
WO2018059533A1 (zh) * 2016-09-29 2018-04-05 南京明德新药研发股份有限公司 p38αMAPK激酶抑制剂及其制备方法和应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009973A1 (en) 2003-06-26 2005-02-03 Novartis Ag 5-membered heterocycle-based p38 kinase inhibitors

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EP3856721B1 (en) 2023-03-29
CN112839928B (zh) 2024-04-30
US20210395207A1 (en) 2021-12-23
IL281636B1 (en) 2024-04-01
DK3856721T3 (da) 2023-04-24
CN112839928A (zh) 2021-05-25
EP3856721A1 (en) 2021-08-04
ES2943289T3 (es) 2023-06-12
CA3112993A1 (en) 2020-04-02
IL281636A (en) 2021-05-31
KR20210069044A (ko) 2021-06-10
AU2019350525A1 (en) 2021-04-15
JP7291782B2 (ja) 2023-06-15
WO2020065323A1 (en) 2020-04-02
JP2022502400A (ja) 2022-01-11
AU2019350525B2 (en) 2024-05-02
GB201815695D0 (en) 2018-11-07
IL281636B2 (en) 2024-08-01
US11649213B2 (en) 2023-05-16

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