KR102662499B1 - 개선된 혈청 알부민 결합제 - Google Patents

개선된 혈청 알부민 결합제 Download PDF

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Publication number
KR102662499B1
KR102662499B1 KR1020197024113A KR20197024113A KR102662499B1 KR 102662499 B1 KR102662499 B1 KR 102662499B1 KR 1020197024113 A KR1020197024113 A KR 1020197024113A KR 20197024113 A KR20197024113 A KR 20197024113A KR 102662499 B1 KR102662499 B1 KR 102662499B1
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gly
glu
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KR20190104608A (ko
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스테파니 스탤렌스
소렌 스테펜슨
에리카 모리조
안 세르도벨
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아블린쓰 엔.브이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020197024113A 2017-01-17 2018-01-17 개선된 혈청 알부민 결합제 Active KR102662499B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247002265A KR20240013861A (ko) 2017-01-17 2018-01-17 개선된 혈청 알부민 결합제

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762446988P 2017-01-17 2017-01-17
US62/446,988 2017-01-17
PCT/EP2018/051083 WO2018134235A1 (en) 2017-01-17 2018-01-17 Improved serum albumin binders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020247002265A Division KR20240013861A (ko) 2017-01-17 2018-01-17 개선된 혈청 알부민 결합제

Publications (2)

Publication Number Publication Date
KR20190104608A KR20190104608A (ko) 2019-09-10
KR102662499B1 true KR102662499B1 (ko) 2024-05-02

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Application Number Title Priority Date Filing Date
KR1020197024113A Active KR102662499B1 (ko) 2017-01-17 2018-01-17 개선된 혈청 알부민 결합제
KR1020247002265A Ceased KR20240013861A (ko) 2017-01-17 2018-01-17 개선된 혈청 알부민 결합제

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US (2) US11414481B2 (enExample)
EP (3) EP4442707A3 (enExample)
JP (3) JP7219220B2 (enExample)
KR (2) KR102662499B1 (enExample)
CN (2) CN110191896B (enExample)
AU (2) AU2018209151B2 (enExample)
BR (1) BR112019014599A2 (enExample)
CA (1) CA3050575A1 (enExample)
DK (1) DK3571225T3 (enExample)
ES (1) ES2991459T3 (enExample)
FI (1) FI3571225T3 (enExample)
HR (1) HRP20241469T1 (enExample)
HU (1) HUE068790T2 (enExample)
IL (2) IL267894B2 (enExample)
LT (1) LT3571225T (enExample)
MX (2) MX2019008496A (enExample)
PT (1) PT3571225T (enExample)
RS (1) RS66117B1 (enExample)
SG (2) SG11201906264YA (enExample)
SI (1) SI3571225T1 (enExample)
WO (1) WO2018134235A1 (enExample)

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WO2018134235A1 (en) 2018-07-26
RU2019125831A (ru) 2021-02-19
PT3571225T (pt) 2024-11-05
LT3571225T (lt) 2024-11-11
EP4442709A2 (en) 2024-10-09
JP2025026992A (ja) 2025-02-26
WO2018134235A8 (en) 2024-03-21
IL267894B2 (en) 2024-10-01
US11414481B2 (en) 2022-08-16
KR20240013861A (ko) 2024-01-30
EP4442707A2 (en) 2024-10-09
JP2023025232A (ja) 2023-02-21
AU2018209151B2 (en) 2025-02-27
EP4442707A3 (en) 2024-12-25
CA3050575A1 (en) 2018-07-26
AU2018209151A1 (en) 2019-07-25
BR112019014599A2 (pt) 2020-03-03
HUE068790T2 (hu) 2025-01-28
SI3571225T1 (sl) 2025-03-31
CN110191896A (zh) 2019-08-30
CN110191896B (zh) 2023-09-29
JP7219220B2 (ja) 2023-02-07
EP3571225B1 (en) 2024-08-07
KR20190104608A (ko) 2019-09-10
AU2025203430A1 (en) 2025-06-05
US20190367597A1 (en) 2019-12-05
US20230060574A1 (en) 2023-03-02
SG10202108972RA (en) 2021-09-29
IL312292A (en) 2024-06-01
JP2020515518A (ja) 2020-05-28
MX2019008496A (es) 2019-09-18
CN117285623A (zh) 2023-12-26
EP3571225A1 (en) 2019-11-27
IL267894B1 (en) 2024-06-01
RU2019125831A3 (enExample) 2021-03-09
SG11201906264YA (en) 2019-08-27
FI3571225T3 (fi) 2024-10-31
ES2991459T3 (es) 2024-12-03
IL267894A (en) 2019-09-26
MX2023005374A (es) 2023-05-22
DK3571225T3 (da) 2024-11-04
JP7628996B2 (ja) 2025-02-12
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