KR102651946B1 - 항암제로서의 시클릭 디뉴클레오티드 - Google Patents
항암제로서의 시클릭 디뉴클레오티드 Download PDFInfo
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- KR102651946B1 KR102651946B1 KR1020207008757A KR20207008757A KR102651946B1 KR 102651946 B1 KR102651946 B1 KR 102651946B1 KR 1020207008757 A KR1020207008757 A KR 1020207008757A KR 20207008757 A KR20207008757 A KR 20207008757A KR 102651946 B1 KR102651946 B1 KR 102651946B1
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- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Epidemiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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| PCT/US2018/048662 WO2019046498A1 (en) | 2017-08-31 | 2018-08-30 | CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS |
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| CN (1) | CN111051327B (enExample) |
| ES (1) | ES2945140T3 (enExample) |
| WO (1) | WO2019046498A1 (enExample) |
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| US11660311B2 (en) | 2017-10-10 | 2023-05-30 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
| WO2019123339A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| WO2019123340A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| ES2980374T3 (es) * | 2018-03-08 | 2024-10-01 | Bristol Myers Squibb Co | Dinucleótidos cíclicos como agentes anticancerosos |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| CN112236438B (zh) * | 2018-04-13 | 2024-10-15 | 百时美施贵宝公司 | 基于磷(v)的试剂，其制备方法，以及其在制备立体限定的有机磷(v)化合物中的用途 |
| KR20210015937A (ko) | 2018-06-01 | 2021-02-10 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 방광암을 치료하기 위한 방법 |
| US11110106B2 (en) | 2018-10-29 | 2021-09-07 | Venenum Biodesign, LLC | Sting agonists for treating bladder cancer and solid tumors |
| AU2019371206A1 (en) | 2018-10-29 | 2021-05-27 | Venenum Biodesign, LLC | Novel sting agonists |
| WO2020212600A1 (en) | 2019-04-18 | 2020-10-22 | Nuseed Global Innovation Ltd. | Meal fraction of brassica carinata oilseed |
| WO2020227421A1 (en) | 2019-05-09 | 2020-11-12 | Aligos Therapeutics, Inc. | Modified cyclic dinucleoside compounds as sting modulators |
| TW202114710A (zh) * | 2019-07-25 | 2021-04-16 | 英屬開曼群島商百濟神州有限公司 | 作為sting促效劑之環狀二核苷酸 |
| CN115244061A (zh) * | 2020-01-16 | 2022-10-25 | 百时美施贵宝公司 | 试剂及其用于模块化对映发散性合成c-p键的用途 |
| EP4134098A4 (en) | 2020-04-10 | 2024-05-15 | ONO Pharmaceutical Co., Ltd. | Method of cancer therapy |
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| WO2016120305A1 (en) | 2015-01-29 | 2016-08-04 | Glaxosmithkline Intellectual Property Development Limited | Cyclic dinucleotides useful for the treatment of inter alia cancer |
| WO2017123657A1 (en) | 2016-01-11 | 2017-07-20 | Gary Glick | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
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2018
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- 2018-08-30 WO PCT/US2018/048662 patent/WO2019046498A1/en not_active Ceased
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- 2018-08-30 KR KR1020207008757A patent/KR102651946B1/ko active Active
- 2018-08-30 CN CN201880055306.3A patent/CN111051327B/zh active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016120305A1 (en) | 2015-01-29 | 2016-08-04 | Glaxosmithkline Intellectual Property Development Limited | Cyclic dinucleotides useful for the treatment of inter alia cancer |
| WO2017123657A1 (en) | 2016-01-11 | 2017-07-20 | Gary Glick | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111051327B (zh) | 2023-11-03 |
| JP7209697B2 (ja) | 2023-01-20 |
| US20200223883A1 (en) | 2020-07-16 |
| WO2019046498A1 (en) | 2019-03-07 |
| EP3676278A1 (en) | 2020-07-08 |
| ES2945140T3 (es) | 2023-06-28 |
| EP3676278B1 (en) | 2023-04-12 |
| US10947263B2 (en) | 2021-03-16 |
| JP2020532542A (ja) | 2020-11-12 |
| KR20200042939A (ko) | 2020-04-24 |
| CN111051327A (zh) | 2020-04-21 |
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