KR102638149B1 - 근적외선 글루코스 센서 - Google Patents

근적외선 글루코스 센서 Download PDF

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KR102638149B1
KR102638149B1 KR1020197021712A KR20197021712A KR102638149B1 KR 102638149 B1 KR102638149 B1 KR 102638149B1 KR 1020197021712 A KR1020197021712 A KR 1020197021712A KR 20197021712 A KR20197021712 A KR 20197021712A KR 102638149 B1 KR102638149 B1 KR 102638149B1
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tautomer
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KR20190102023A (ko
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소야 감지
비아차슬라우 버나트
알렉스 쿠티아빈
제이콥 윌리엄 클레어리
술로리트 프라한
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프로퓨사 인코퍼레이티드
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    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
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    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
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  • Saccharide Compounds (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
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KR1020197021712A 2016-12-27 2017-12-27 근적외선 글루코스 센서 Active KR102638149B1 (ko)

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Application Number Priority Date Filing Date Title
US201662439363P 2016-12-27 2016-12-27
US201662439364P 2016-12-27 2016-12-27
US62/439,363 2016-12-27
US62/439,364 2016-12-27
PCT/US2017/068531 WO2018125913A1 (en) 2016-12-27 2017-12-27 Near-ir glucose sensors

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KR20190102023A KR20190102023A (ko) 2019-09-02
KR102638149B1 true KR102638149B1 (ko) 2024-02-19

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US (4) US10717751B2 (https=)
EP (1) EP3562952A4 (https=)
JP (1) JP7209624B2 (https=)
KR (1) KR102638149B1 (https=)
CN (1) CN110121561A (https=)
AU (1) AU2017388213B2 (https=)
BR (1) BR112019011712A2 (https=)
CA (1) CA3045485A1 (https=)
IL (1) IL267554B2 (https=)
JO (1) JOP20190161A1 (https=)
RU (1) RU2019120813A (https=)
WO (1) WO2018125913A1 (https=)

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US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
BR112015022763A8 (pt) 2013-03-14 2019-11-26 Profusa Inc sensor para detectar um analito
WO2017155879A1 (en) 2016-03-07 2017-09-14 Agrofresh Inc. Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
WO2018119204A1 (en) 2016-12-21 2018-06-28 Profusa, Inc. Polymerizable near-ir dyes
CA3045485A1 (en) 2016-12-27 2018-07-05 Profusa, Inc. Near-ir glucose sensors
AU2018291393A1 (en) 2017-06-29 2020-01-02 Profusa, Inc. Multi-analyte sensing tissue-integrating sensors
AU2019293250A1 (en) * 2018-06-27 2021-01-07 Profusa, Inc. Near-IR glucose sensors
WO2020247662A1 (en) * 2019-06-04 2020-12-10 The Regents Of The University Of California Diboronic acid compounds and methods of making and using thereof
EP4017363A4 (en) 2019-08-20 2023-08-02 Profusa, Inc. OPTICAL FILTER DEVICE, SYSTEM AND METHOD FOR IMPROVED OPTICAL REJECTION OF OUT-OF-BAND WAVELENGTHS
US20220403442A1 (en) * 2019-10-21 2022-12-22 President And Fellows Of Harvard College Compositions and methods for detection of oxidizable analytes
CN111393461B (zh) * 2020-03-17 2022-03-29 广东省测试分析研究所(中国广州分析测试中心) 一种基于bodipy的钯离子荧光探针化合物及其合成方法
CN113683631B (zh) * 2020-05-19 2023-01-17 王凯 一种有机硼酸类葡萄糖探针及其制备方法和应用
CN111603176A (zh) * 2020-05-25 2020-09-01 上海梅斯医药科技有限公司 一种半植入式光学血糖监测方法、终端设备和服务器
CN116917419B (zh) * 2020-08-14 2025-10-21 康奈尔大学 用于肿瘤检测和外科手术指导的化合物和组合物
CN112679533B (zh) * 2020-12-25 2021-09-14 中国科学院兰州化学物理研究所 一种含氟探针及其制备方法与应用
CN112869707A (zh) * 2021-01-14 2021-06-01 复旦大学 近红外第二窗口检测pH的双通道比率荧光传感器及其制备方法和应用
CN113637472B (zh) * 2021-08-04 2022-07-15 南开大学 具有良好生物相容性的脂质体葡萄糖荧光探针及其制备方法
CN114045045B (zh) * 2021-10-26 2022-11-04 大连理工大学 一类单光子上转换五甲川菁类光敏染料、其制备方法和应用
CN113820378B (zh) * 2021-10-29 2023-06-16 重庆医科大学 GNFs/CC及其葡萄糖传感器和应用
CN114874123B (zh) * 2022-04-24 2022-11-29 伊明泰(山东)生物科技有限公司 一种近红外&双光子动力学双模高稳定荧光染料、NTR&HClO探针及合成方法与应用
WO2024081635A2 (en) * 2022-10-10 2024-04-18 The Trustees Of The University Of Pennsylvania Targeted quinocyanine dyes for the intraoperative delineation of cancer margins
CN115960110B (zh) * 2023-01-31 2024-04-12 山西大学 一种高效的光动力光敏剂及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006036664A (ja) 2004-07-23 2006-02-09 Terumo Corp 糖類測定用蛍光モノマー化合物、糖類測定用蛍光センサー物質および体内埋め込み用の糖類測定用センサー
CN104277061A (zh) 2014-09-28 2015-01-14 苏州富顿光谱仪器有限公司 一种硼酸荧光分子探针及其制备方法和应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2883824B2 (ja) * 1993-11-07 1999-04-19 科学技術振興事業団 ボロン酸基を有する発蛍光性化合物
US6013122A (en) 1998-08-18 2000-01-11 Option Technologies, Inc. Tattoo inks
US6858403B2 (en) 1999-05-11 2005-02-22 M-Biotech, Inc. Polymer matrix containing catalase co-immobilized with analytic enzyme that generates hydrogen peroxide
US6682938B1 (en) * 1999-09-15 2004-01-27 The Regents Of The University Of California Glucose sensing molecules having selected fluorescent properties
WO2002012251A1 (en) * 2000-08-04 2002-02-14 Sensors For Medicine And Science, Inc. Detection of analytes in aqueous environments
US20020119581A1 (en) * 2001-01-05 2002-08-29 Daniloff George Y. Detection of analytes
US6800451B2 (en) * 2001-01-05 2004-10-05 Sensors For Medicine And Science, Inc. Detection of glucose in solutions also containing an alpha-hydroxy acid or a beta-diketone
US20020127626A1 (en) * 2001-01-05 2002-09-12 Sensors For Medicine And Science, Inc. Detection of glucose in solutions also containing an alpha-hydroxy acid or a beta-diketone
AU2003220547A1 (en) * 2003-03-28 2004-11-23 Terumo Corporation Of Japan Solid-phase saccharide sensing compounds
US7358094B2 (en) * 2003-05-01 2008-04-15 Bell Michael L Sensor system for saccharides
WO2005032418A2 (en) 2003-10-01 2005-04-14 University Of Washington Novel porous biomaterials
EP1619229B1 (en) 2004-07-23 2007-04-11 Terumo Kabushiki Kaisha Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor
US20070036682A1 (en) * 2005-08-15 2007-02-15 Honeywell International Inc. Microoptic glucose detector
GB0522796D0 (en) * 2005-11-08 2005-12-14 Smart Holograms Ltd Novel boronate complex and its use in a glucose sensor
CN100361999C (zh) * 2006-03-03 2008-01-16 大连理工大学 含硅元素的阳离子发色团及其衍生物
JP5159778B2 (ja) 2006-07-25 2013-03-13 グルメトリックス,インコーポレイテッド グルコース検知における使用のための蛍光色素
WO2008066921A2 (en) 2006-11-30 2008-06-05 Sensors For Medicine And Science, Inc. Oxidation resistant indicator molecules
GB0906318D0 (en) 2009-04-09 2009-05-20 Glysure Ltd Fluorophore and fluorescent sensor compound containing same
EP4449978B1 (en) 2010-10-06 2026-03-18 Profusa, Inc. Tissue-integrating sensors
WO2012083064A1 (en) * 2010-12-16 2012-06-21 Southern Illinois University Carbondale Silaanthracene as a red and near infrared sensor and a method to manufacture such a sensor
US9250246B2 (en) * 2011-06-29 2016-02-02 Portland State University Near-infrared fluorescent dyes with large stokes shifts
CN102735667B (zh) * 2012-06-28 2014-05-21 南京大学 基于氟硼二吡咯-苯硼酸的荧光传感膜及其制备方法和应用
WO2014106957A1 (ja) 2013-01-07 2014-07-10 国立大学法人 東京大学 非対称Siローダミン及びロドールの合成
JP6349091B2 (ja) * 2013-01-18 2018-06-27 国立大学法人 東京大学 超解像蛍光イメージング用プローブ
WO2015129705A1 (ja) * 2014-02-28 2015-09-03 国立大学法人 東京大学 グルタチオン検出用蛍光プローブ
US9410958B2 (en) 2014-03-25 2016-08-09 The Regents Of The University Of California Alkyne-activated fluorogenic azide compounds and methods of use thereof
JP6275253B2 (ja) * 2014-06-17 2018-02-07 国立大学法人大阪大学 蛍光プローブ、一重項酸素検出剤、又は一重項酸素検出方法
WO2016136328A1 (ja) * 2015-02-27 2016-09-01 国立大学法人 東京大学 超解像蛍光イメージング用プローブ
WO2017218903A1 (en) * 2016-06-17 2017-12-21 Colvin Arthur E Jr Nir long lifetime indicator molecule
CA3045485A1 (en) 2016-12-27 2018-07-05 Profusa, Inc. Near-ir glucose sensors
AU2019293250A1 (en) 2018-06-27 2021-01-07 Profusa, Inc. Near-IR glucose sensors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006036664A (ja) 2004-07-23 2006-02-09 Terumo Corp 糖類測定用蛍光モノマー化合物、糖類測定用蛍光センサー物質および体内埋め込み用の糖類測定用センサー
CN104277061A (zh) 2014-09-28 2015-01-14 苏州富顿光谱仪器有限公司 一种硼酸荧光分子探针及其制备方法和应用

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