KR102629654B1 - 아미노피리미딘 유도체 화합물의 염, 이의 결정형 및 이의 제조 방법 - Google Patents

아미노피리미딘 유도체 화합물의 염, 이의 결정형 및 이의 제조 방법 Download PDF

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KR102629654B1
KR102629654B1 KR1020180044850A KR20180044850A KR102629654B1 KR 102629654 B1 KR102629654 B1 KR 102629654B1 KR 1020180044850 A KR1020180044850 A KR 1020180044850A KR 20180044850 A KR20180044850 A KR 20180044850A KR 102629654 B1 KR102629654 B1 KR 102629654B1
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crystalline form
acid salt
mesylic acid
formula
organic solvent
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KR20180118535A (ko
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오상호
김종균
오세웅
한태동
정수용
이성란
김경배
이영성
신우섭
주현
강정기
박수민
김동균
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주식회사유한양행
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020180044850A 2017-04-21 2018-04-18 아미노피리미딘 유도체 화합물의 염, 이의 결정형 및 이의 제조 방법 Active KR102629654B1 (ko)

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KR1020230184208A KR102835717B1 (ko) 2017-04-21 2023-12-18 아미노피리미딘 유도체 화합물의 염, 이의 결정형 및 이의 제조 방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170051687 2017-04-21
KR20170051687 2017-04-21

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KR1020230184208A Division KR102835717B1 (ko) 2017-04-21 2023-12-18 아미노피리미딘 유도체 화합물의 염, 이의 결정형 및 이의 제조 방법

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KR20180118535A KR20180118535A (ko) 2018-10-31
KR102629654B1 true KR102629654B1 (ko) 2024-01-29

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KR1020180044850A Active KR102629654B1 (ko) 2017-04-21 2018-04-18 아미노피리미딘 유도체 화합물의 염, 이의 결정형 및 이의 제조 방법
KR1020230184208A Active KR102835717B1 (ko) 2017-04-21 2023-12-18 아미노피리미딘 유도체 화합물의 염, 이의 결정형 및 이의 제조 방법
KR1020250093917A Pending KR20250111074A (ko) 2017-04-21 2025-07-11 아미노피리미딘 유도체 화합물의 염, 이의 결정형 및 이의 제조 방법

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KR1020250093917A Pending KR20250111074A (ko) 2017-04-21 2025-07-11 아미노피리미딘 유도체 화합물의 염, 이의 결정형 및 이의 제조 방법

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US (3) US11453656B2 (enExample)
EP (1) EP3612529A4 (enExample)
JP (2) JP7126514B2 (enExample)
KR (3) KR102629654B1 (enExample)
CN (1) CN110869367B (enExample)
AR (1) AR111469A1 (enExample)
AU (2) AU2018256227B2 (enExample)
BR (1) BR112019021868A2 (enExample)
CA (1) CA3059543A1 (enExample)
CO (1) CO2019011578A2 (enExample)
EA (1) EA201992501A1 (enExample)
IL (2) IL270018B (enExample)
MA (1) MA49696A (enExample)
MX (2) MX392634B (enExample)
MY (1) MY201919A (enExample)
NZ (1) NZ758443A (enExample)
PH (1) PH12019502370A1 (enExample)
SA (1) SA519410342B1 (enExample)
SG (1) SG11201909615YA (enExample)
TW (1) TWI776882B (enExample)
UA (1) UA124364C2 (enExample)
WO (1) WO2018194356A1 (enExample)
ZA (1) ZA201907687B (enExample)

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AR111469A1 (es) 2017-04-21 2019-07-17 Yuhan Corp Sal de un compuesto del derivado de aminopiridina, una forma cristalina de la misma, y un proceso para preparar la misma
DK3658552T3 (da) 2017-07-28 2023-11-20 Yuhan Corp Fremgangsmåde til fremstilling af n-(5-((4-(4-((dimethylamino)methyl)-3-phenyl-1h-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamid ved reaktion af den tilsvarende amin med et 3-halogen-propionylchlorid
KR20200043618A (ko) * 2018-10-18 2020-04-28 주식회사유한양행 아미노피리미딘 유도체 또는 이의 염을 포함하는 경구투여용 약학 조성물
KR101973074B1 (ko) * 2018-11-30 2019-04-26 주식회사 티움바이오 퓨로피리미딘 화합물의 염 및 결정형, 및 이를 포함하는 약학적 조성물
CN111349084B (zh) * 2018-12-21 2022-11-25 深圳市塔吉瑞生物医药有限公司 用于抑制蛋白激酶活性的氨基嘧啶类化合物
AU2020229467A1 (en) 2019-02-26 2021-08-12 Janssen Biotech, Inc. Combination therapies and patient stratification with bispecific anti-EGFR/c-met antibodies
CA3140360A1 (en) * 2019-05-14 2020-11-19 Janssen Biotech, Inc. Combination therapies with bispecific anti-egfr/c-met antibodies and 3rd generation egfr tyrosine kinase inhibitors
US11850248B2 (en) * 2019-05-14 2023-12-26 Yuhan Corporation Therapies with 3rd generation EGFR tyrosine kinase inhibitors
PH12021552798A1 (en) 2019-05-14 2022-09-19 Janssen Biotech Inc Combination therapies with bispecific anti-egfr/c-met antibodies and 3rd generation egfr tyrosine kinase inhibitors
JOP20220184A1 (ar) 2020-02-12 2023-01-30 Janssen Biotech Inc علاج مصابي السرطان ممن لديهم طفرات تخطي c-Met إكسون14
TW202207940A (zh) * 2020-04-14 2022-03-01 美商健生生物科技公司 包含胺基嘧啶衍生物或其醫藥上可接受之鹽、水合物、或溶劑化物之用於經口投予之醫藥組成物
CN117425651A (zh) * 2021-06-01 2024-01-19 杭州领业医药科技有限公司 Lazertinib甲磺酸盐的水合物晶型及其制备方法和用途
CA3228195A1 (en) 2023-05-23 2025-06-30 Janssen Biotech, Inc. Methods for treatment of non-small cell lung cancer (nsclc)
WO2025052273A1 (en) 2023-09-05 2025-03-13 Janssen Biotech, Inc. Methods of treating non-small cell lung cancer

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JP4648835B2 (ja) 2003-12-25 2011-03-09 エーザイ・アール・アンド・ディー・マネジメント株式会社 ４−（３−クロロ−４−（シクロプロピルアミノカルボニル）アミノフェノキシ）−７−メトキシ−６−キノリンカルボキサミドの塩またはその溶媒和物の結晶およびそれらの製造方法
CA2555804C (en) 2004-02-11 2012-06-26 Natco Pharma Limited Polymorphic form of imatinib mesylate and a process for its preparation
TWI458721B (zh) 2008-06-27 2014-11-01 Celgene Avilomics Res Inc 雜芳基化合物及其用途
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AR111469A1 (es) 2017-04-21 2019-07-17 Yuhan Corp Sal de un compuesto del derivado de aminopiridina, una forma cristalina de la misma, y un proceso para preparar la misma
KR20200043618A (ko) 2018-10-18 2020-04-28 주식회사유한양행 아미노피리미딘 유도체 또는 이의 염을 포함하는 경구투여용 약학 조성물

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Also Published As

Publication number Publication date
KR102835717B1 (ko) 2025-07-18
CN110869367B (zh) 2023-09-15
KR20180118535A (ko) 2018-10-31
EP3612529A1 (en) 2020-02-26
TW201841910A (zh) 2018-12-01
JP7390444B2 (ja) 2023-12-01
CN110869367A (zh) 2020-03-06
IL270018A (enExample) 2019-12-31
KR20250111074A (ko) 2025-07-22
IL294666A (en) 2022-09-01
IL294666B1 (en) 2024-01-01
JP2022166179A (ja) 2022-11-01
AU2018256227B2 (en) 2022-03-03
US20230021395A1 (en) 2023-01-26
TWI776882B (zh) 2022-09-11
MX2022006357A (es) 2022-06-23
CA3059543A1 (en) 2018-10-25
IL270018B (en) 2022-08-01
US20210139461A1 (en) 2021-05-13
MY201919A (en) 2024-03-23
AU2022203486A1 (en) 2022-06-09
NZ758443A (en) 2023-03-31
US11453656B2 (en) 2022-09-27
MA49696A (fr) 2020-06-03
JP7126514B2 (ja) 2022-08-26
CO2019011578A2 (es) 2020-02-28
SA519410342B1 (ar) 2023-02-09
PH12019502370A1 (en) 2020-07-13
IL294666B2 (en) 2024-05-01
WO2018194356A1 (en) 2018-10-25
US12428401B2 (en) 2025-09-30
AU2022203486B2 (en) 2024-06-06
KR20230175161A (ko) 2023-12-29
EP3612529A4 (en) 2020-11-18
US20240279203A1 (en) 2024-08-22
JP2020517611A (ja) 2020-06-18
SG11201909615YA (en) 2019-11-28
ZA201907687B (en) 2023-04-26
UA124364C2 (uk) 2021-09-01
EA201992501A1 (ru) 2020-02-18
US11981659B2 (en) 2024-05-14
AR111469A1 (es) 2019-07-17
BR112019021868A2 (pt) 2020-05-26
AU2018256227A1 (en) 2019-10-31
MX392634B (es) 2025-03-24

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