KR102605045B1 - Il33 및 il1rl1을 코딩하는 유전자에서의 위험 대립유전자를 갖는 환자에서의 폐 질환의 치료 및 저해 - Google Patents

Il33 및 il1rl1을 코딩하는 유전자에서의 위험 대립유전자를 갖는 환자에서의 폐 질환의 치료 및 저해 Download PDF

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KR102605045B1
KR102605045B1 KR1020197030870A KR20197030870A KR102605045B1 KR 102605045 B1 KR102605045 B1 KR 102605045B1 KR 1020197030870 A KR1020197030870 A KR 1020197030870A KR 20197030870 A KR20197030870 A KR 20197030870A KR 102605045 B1 KR102605045 B1 KR 102605045B1
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섀넌 브루즈
셰인 매카시
아리스 바라스
프레드릭 드웨이
옴리 고테스만
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리제너론 파마슈티칼스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020197030870A 2017-04-13 2018-03-20 Il33 및 il1rl1을 코딩하는 유전자에서의 위험 대립유전자를 갖는 환자에서의 폐 질환의 치료 및 저해 Active KR102605045B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237039438A KR102751957B1 (ko) 2017-04-13 2018-03-20 Il33 및 il1rl1을 코딩하는 유전자에서의 위험 대립유전자를 갖는 환자에서의 폐 질환의 치료 및 저해

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762485077P 2017-04-13 2017-04-13
US62/485,077 2017-04-13
PCT/US2018/023266 WO2018190990A1 (en) 2017-04-13 2018-03-20 Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding il33 and il1rl1

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020237039438A Division KR102751957B1 (ko) 2017-04-13 2018-03-20 Il33 및 il1rl1을 코딩하는 유전자에서의 위험 대립유전자를 갖는 환자에서의 폐 질환의 치료 및 저해

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KR20190140928A KR20190140928A (ko) 2019-12-20
KR102605045B1 true KR102605045B1 (ko) 2023-11-27

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KR1020197030870A Active KR102605045B1 (ko) 2017-04-13 2018-03-20 Il33 및 il1rl1을 코딩하는 유전자에서의 위험 대립유전자를 갖는 환자에서의 폐 질환의 치료 및 저해
KR1020237039438A Active KR102751957B1 (ko) 2017-04-13 2018-03-20 Il33 및 il1rl1을 코딩하는 유전자에서의 위험 대립유전자를 갖는 환자에서의 폐 질환의 치료 및 저해

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US (2) US11708415B2 (https=)
EP (3) EP4549586A3 (https=)
JP (3) JP7321939B2 (https=)
KR (2) KR102605045B1 (https=)
CN (2) CN110431240B (https=)
AU (3) AU2018252974B2 (https=)
CA (1) CA3059350A1 (https=)
ES (1) ES3052989T3 (https=)
IL (2) IL314591A (https=)
MX (2) MX2019012171A (https=)
SG (1) SG11201909457XA (https=)
WO (1) WO2018190990A1 (https=)

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CA3236201A1 (en) * 2021-11-11 2023-05-19 Regeneron Pharmaceuticals, Inc. Treatment of lung disease based upon stratification of polygenic risk score for interleukin 33 (il-33)

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US20160168640A1 (en) 2014-11-10 2016-06-16 Genentech, Inc. Therapeutic and diagnostic methods for il-33-mediated disorders

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Also Published As

Publication number Publication date
IL314591A (en) 2024-09-01
AU2024220214A1 (en) 2024-11-07
EP4549586A2 (en) 2025-05-07
IL269873A (en) 2019-11-28
EP3957752A2 (en) 2022-02-23
JP7557581B2 (ja) 2024-09-27
US12612462B2 (en) 2026-04-28
JP2024163308A (ja) 2024-11-21
JP2020516289A (ja) 2020-06-11
CN110431240B (zh) 2026-02-24
RU2019136253A3 (https=) 2021-12-17
KR20230164197A (ko) 2023-12-01
EP3957752A3 (en) 2022-06-15
CN121951033A (zh) 2026-05-01
AU2018252974A1 (en) 2019-11-28
KR102751957B1 (ko) 2025-01-09
WO2018190990A1 (en) 2018-10-18
MX2024002689A (es) 2024-03-20
IL269873B1 (en) 2024-09-01
AU2024220212A1 (en) 2024-11-07
JP2023129607A (ja) 2023-09-14
KR20190140928A (ko) 2019-12-20
SG11201909457XA (en) 2019-11-28
EP4549586A3 (en) 2025-07-23
AU2018252974B2 (en) 2024-10-17
IL269873B2 (en) 2025-01-01
US20200031922A1 (en) 2020-01-30
CA3059350A1 (en) 2018-10-18
MX2019012171A (es) 2019-11-25
EP3610041A1 (en) 2020-02-19
US20230374145A1 (en) 2023-11-23
ES3052989T3 (en) 2026-01-16
JP7321939B2 (ja) 2023-08-07
CN110431240A (zh) 2019-11-08
RU2019136253A (ru) 2021-05-13
US11708415B2 (en) 2023-07-25
EP3957752B1 (en) 2025-08-20

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