KR102604503B1 - 페니실린-g 아실라아제 - Google Patents

페니실린-g 아실라아제 Download PDF

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KR102604503B1
KR102604503B1 KR1020177033631A KR20177033631A KR102604503B1 KR 102604503 B1 KR102604503 B1 KR 102604503B1 KR 1020177033631 A KR1020177033631 A KR 1020177033631A KR 20177033631 A KR20177033631 A KR 20177033631A KR 102604503 B1 KR102604503 B1 KR 102604503B1
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KR20180004169A (ko
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고타미 바너지
지에 양
시윤 장
에리카 엠 밀크젝
멜리사 앤 마요
스테판 젠느
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코덱시스, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020177033631A 2015-05-07 2016-05-06 페니실린-g 아실라아제 Active KR102604503B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562158118P 2015-05-07 2015-05-07
US62/158,118 2015-05-07
PCT/US2016/031132 WO2016179464A1 (en) 2015-05-07 2016-05-06 Penicillin-g acylases

Publications (2)

Publication Number Publication Date
KR20180004169A KR20180004169A (ko) 2018-01-10
KR102604503B1 true KR102604503B1 (ko) 2023-11-20

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KR1020177033631A Active KR102604503B1 (ko) 2015-05-07 2016-05-06 페니실린-g 아실라아제

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US (6) US9944916B2 (https=)
EP (1) EP3292136B1 (https=)
JP (1) JP6755886B2 (https=)
KR (1) KR102604503B1 (https=)
CN (1) CN107531762A (https=)
AU (1) AU2016258091B2 (https=)
CA (1) CA2983620A1 (https=)
DK (1) DK3292136T3 (https=)
HU (1) HUE053863T2 (https=)
IL (1) IL255245B (https=)
MX (1) MX381306B (https=)
SG (1) SG11201708356PA (https=)
WO (1) WO2016179464A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107531762A (zh) 2015-05-07 2018-01-02 科德克希思公司 青霉素g酰化酶
US10724025B2 (en) 2016-05-05 2020-07-28 Codexis, Inc. Penicillin-G acylases
EP3565893A4 (en) * 2017-01-05 2020-12-09 Codexis, Inc. PENICILLIN G ACYLASES
CN117737045A (zh) * 2017-06-27 2024-03-22 科德克希思公司 青霉素g酰化酶
KR101985911B1 (ko) * 2017-12-28 2019-06-04 아미코젠주식회사 Achromobacter sp. CCM 4824 유래 페니실린 G 아실라제 변이체 및 이의 이용
CN109207466B (zh) * 2018-11-08 2021-01-08 山东鲁抗医药股份有限公司 一种青霉素酰化酶的固定化方法及固定化酶
KR102363768B1 (ko) * 2019-11-15 2022-02-16 아미코젠주식회사 세파졸린 생산성이 증가된 페니실린 g 아실라제 변이체 및 이의 이용

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WO2010054319A2 (en) * 2008-11-10 2010-05-14 Codexis, Inc. Penicillin-g acylases

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US5891703A (en) 1994-08-12 1999-04-06 Gist-Hrocades Mutated penicillin G acylase genes
WO2010054319A2 (en) * 2008-11-10 2010-05-14 Codexis, Inc. Penicillin-g acylases

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Publication number Publication date
US20180201919A1 (en) 2018-07-19
US20250346882A1 (en) 2025-11-13
MX2017014213A (es) 2018-03-28
KR20180004169A (ko) 2018-01-10
US11180747B2 (en) 2021-11-23
US20190345474A1 (en) 2019-11-14
IL255245A0 (en) 2017-12-31
US12378541B2 (en) 2025-08-05
JP6755886B2 (ja) 2020-09-16
EP3292136A4 (en) 2019-04-10
US20220042004A1 (en) 2022-02-10
CN107531762A (zh) 2018-01-02
JP2018515089A (ja) 2018-06-14
HUE053863T2 (hu) 2021-07-28
NZ736220A (en) 2024-03-22
AU2016258091B2 (en) 2020-10-01
MX381306B (es) 2025-03-12
US10781436B2 (en) 2020-09-22
US20160326508A1 (en) 2016-11-10
US9944916B2 (en) 2018-04-17
WO2016179464A1 (en) 2016-11-10
SG11201708356PA (en) 2017-11-29
DK3292136T3 (da) 2021-03-22
EP3292136B1 (en) 2021-02-17
IL255245B (en) 2020-03-31
EP3292136A1 (en) 2018-03-14
US10400231B2 (en) 2019-09-03
AU2016258091A1 (en) 2017-11-02
US20200385699A1 (en) 2020-12-10
CA2983620A1 (en) 2016-11-10

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