KR102593667B1 - 5-콜레스텐-3, 25-디올, 3-술페이트 (25hc3s) 또는 이의 약학적으로 허용 가능한 염, 및 적어도 하나의 시클릭 올리고당을 포함하는 조성물 - Google Patents

5-콜레스텐-3, 25-디올, 3-술페이트 (25hc3s) 또는 이의 약학적으로 허용 가능한 염, 및 적어도 하나의 시클릭 올리고당을 포함하는 조성물 Download PDF

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KR102593667B1
KR102593667B1 KR1020227038844A KR20227038844A KR102593667B1 KR 102593667 B1 KR102593667 B1 KR 102593667B1 KR 1020227038844 A KR1020227038844 A KR 1020227038844A KR 20227038844 A KR20227038844 A KR 20227038844A KR 102593667 B1 KR102593667 B1 KR 102593667B1
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25hc3s
liver
disease
pharmaceutically acceptable
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KR20220154250A (ko
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슌린 렌
šœ린 렌
레위안 수
얀시아 닝
진경 김
웨이치 린
미진 김
앤드류 알 믹슈탈
홍웨이 우
민 엘 이
윌마 탐라즈
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버지니아 커먼웰스 유니버시티
듀렉트 코퍼레이션
더 유나이티드 스테이츠 거번먼트 애즈 리프리젠티드 바이 더 디파트먼트 오브 베테랑스 어페어즈
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KR1020227038844A 2016-08-02 2017-08-01 5-콜레스텐-3, 25-디올, 3-술페이트 (25hc3s) 또는 이의 약학적으로 허용 가능한 염, 및 적어도 하나의 시클릭 올리고당을 포함하는 조성물 Active KR102593667B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237036153A KR20230152787A (ko) 2016-08-02 2017-08-01 5-콜레스텐-3, 25-디올, 3-술페이트 (25hc3s) 또는 이의 약학적으로 허용 가능한 염, 및 적어도 하나의 시클릭 올리고당을 포함하는 조성물

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662370024P 2016-08-02 2016-08-02
US62/370,024 2016-08-02
US201762470578P 2017-03-13 2017-03-13
US62/470,578 2017-03-13
KR1020197005371A KR102465046B1 (ko) 2016-08-02 2017-08-01 5-콜레스텐-3, 25-디올, 3-술페이트 (25hc3s) 또는 이의 약학적으로 허용 가능한 염, 및 적어도 하나의 시클릭 올리고당을 포함하는 조성물
PCT/US2017/044840 WO2018026781A1 (en) 2016-08-02 2017-08-01 Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide

Related Parent Applications (1)

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KR1020197005371A Division KR102465046B1 (ko) 2016-08-02 2017-08-01 5-콜레스텐-3, 25-디올, 3-술페이트 (25hc3s) 또는 이의 약학적으로 허용 가능한 염, 및 적어도 하나의 시클릭 올리고당을 포함하는 조성물

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KR1020237036153A Division KR20230152787A (ko) 2016-08-02 2017-08-01 5-콜레스텐-3, 25-디올, 3-술페이트 (25hc3s) 또는 이의 약학적으로 허용 가능한 염, 및 적어도 하나의 시클릭 올리고당을 포함하는 조성물

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KR20220154250A KR20220154250A (ko) 2022-11-21
KR102593667B1 true KR102593667B1 (ko) 2023-10-24

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KR1020227038844A Active KR102593667B1 (ko) 2016-08-02 2017-08-01 5-콜레스텐-3, 25-디올, 3-술페이트 (25hc3s) 또는 이의 약학적으로 허용 가능한 염, 및 적어도 하나의 시클릭 올리고당을 포함하는 조성물
KR1020197005371A Active KR102465046B1 (ko) 2016-08-02 2017-08-01 5-콜레스텐-3, 25-디올, 3-술페이트 (25hc3s) 또는 이의 약학적으로 허용 가능한 염, 및 적어도 하나의 시클릭 올리고당을 포함하는 조성물
KR1020237036153A Ceased KR20230152787A (ko) 2016-08-02 2017-08-01 5-콜레스텐-3, 25-디올, 3-술페이트 (25hc3s) 또는 이의 약학적으로 허용 가능한 염, 및 적어도 하나의 시클릭 올리고당을 포함하는 조성물

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KR1020197005371A Active KR102465046B1 (ko) 2016-08-02 2017-08-01 5-콜레스텐-3, 25-디올, 3-술페이트 (25hc3s) 또는 이의 약학적으로 허용 가능한 염, 및 적어도 하나의 시클릭 올리고당을 포함하는 조성물
KR1020237036153A Ceased KR20230152787A (ko) 2016-08-02 2017-08-01 5-콜레스텐-3, 25-디올, 3-술페이트 (25hc3s) 또는 이의 약학적으로 허용 가능한 염, 및 적어도 하나의 시클릭 올리고당을 포함하는 조성물

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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
EA032777B1 (ru) 2013-12-24 2019-07-31 Вирджиния Коммонвелт Юниверсити Способ предотвращения или лечения почечной недостаточности
CA3031224A1 (en) * 2016-08-02 2018-02-08 Shunlin Ren Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide
WO2021067297A1 (en) * 2019-09-30 2021-04-08 Durect Corporation Treatment of alcoholic hepatitis
EP4103195A4 (en) * 2020-02-11 2024-04-17 Durect Corporation TREATMENT OF INFECTIOUS DISEASES
WO2021202608A1 (en) * 2020-03-31 2021-10-07 The Regents Of The University Of Michigan Serum metabolites as biomarkers for carnitine treatment of sepsis
CA3195103A1 (en) * 2020-05-22 2021-11-25 Durect Corporation Treatment of non-alcoholic steatohepatitis (nash)
CA3187310A1 (en) * 2020-06-26 2021-12-30 Durect Corporation Use of oxygenated cholesterol sulfates for treating autoimmune conditions
CN112967234B (zh) * 2021-02-09 2022-12-09 复旦大学附属中山医院 冠状动脉功能生理学病变模式定量评价方法
EP4359420A4 (en) * 2021-06-25 2025-07-16 Durect Corp 25-HYDROXY-CHOLEST-5-EN-3-SULFATE CHOLINE, PROCESSES FOR THEIR PREPARATION, AND THEIR USES
CN113750039B (zh) * 2021-10-26 2023-08-18 浙江中医药大学 一种黄芩苷-海藻酸钙温敏纳米凝胶、制备方法及其应用
WO2023196412A1 (en) * 2022-04-06 2023-10-12 Nobias Therapeutics, Inc. Liquid formulations comprising mitogen-activated protein kinase kinase (mek) inhibitors and methods using same
CN119896674A (zh) * 2023-10-27 2025-04-29 上海交通大学医学院附属新华医院 胆固醇硫酸酯在制备治疗特应性皮炎的药物中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995015165A1 (en) * 1993-11-30 1995-06-08 New York University Medical Center Administration of a 27-hydroxycholesterol or related compound or sterol-27-hydroxylase stimulant to prevent restenosis following vascular endothelial injuri
WO2015100312A1 (en) * 2013-12-24 2015-07-02 Virginia Commonwealth University Uses of oxygenated cholesterol sulfates (ocs)

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459731A (en) 1966-12-16 1969-08-05 Corn Products Co Cyclodextrin polyethers and their production
BE794362A (fr) 1972-01-22 1973-07-23 Merck Patent Gmbh Sulfates hydrosolubles de sterine
US3928397A (en) 1973-03-02 1975-12-23 Eisai Co Ltd New 5-cholestene derivatives and preparation thereof
US3822254A (en) 1973-05-21 1974-07-02 Hoffmann La Roche Synthesis of 25-hydroxycholesterol
US4264512A (en) 1975-09-29 1981-04-28 The Regents Of The University Of California 3-Deoxy-1α-hydroxy- and 3-deoxy-1α,25-dihydroxycholecalciferol and processes for the preparation thereof
US4202891A (en) 1977-05-16 1980-05-13 Kandutsch Andrew A 15-Oxygenated sterol compounds and the use of such compounds to inhibit the biosynthesis of sterols
GB1595020A (en) 1977-06-24 1981-08-05 Chugai Pharmaceutical Co Ltd 3a-hydroxy steroid derivatives of the cholestane series
US4427668A (en) 1982-04-01 1984-01-24 New York University 26-Hydroxycholesterol and derivatives and analogs thereof in regulation of cholesterol accumulation in body tissue
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US4743597A (en) * 1986-01-27 1988-05-10 Javitt Norman B Composition comprising an oxygenated cholesterol and use thereof for topical treatment of diseases
US4863970A (en) 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
US5510340A (en) 1992-06-12 1996-04-23 Sri International Antihypercholesterolemic compounds and related pharmaceutical compositions and methods of use
US5371077A (en) 1992-08-03 1994-12-06 William Marsh Rice University Side chain derivatized 15-oxygenated sterols, methods of using them and a process for preparing them
US5599659A (en) 1993-03-11 1997-02-04 Breonics, Inc. Preservation solution for ex vivo, warm preservation of tissues, explants,organs and vascular endothelial cells comprising retinal-derived fibroblast growth factor, cyclodextrin and chondroitin sulfate
CZ408097A3 (cs) 1995-06-23 1998-06-17 Novo Nordisk A/S Sloučeniny regulující meiosu
US6645953B2 (en) 1995-06-23 2003-11-11 Novo Nordisk A/S Meiosis regulating compounds
US20030153541A1 (en) 1997-10-31 2003-08-14 Robert Dudley Novel anticholesterol compositions and method for using same
ATE256144T1 (de) 1998-05-13 2003-12-15 Novo Nordisk As Verwendung von verbindungen mit der fähigkeit die meiose zu regulieren
KR20010043558A (ko) 1998-05-13 2001-05-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물
US7374779B2 (en) 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
WO2000066611A1 (en) 1999-04-30 2000-11-09 Arch Development Corporation Steroid derivatives
US20060025393A1 (en) 1999-04-30 2006-02-02 Shutsung Liao Steroid derivatives
EP1239848A2 (en) 1999-09-01 2002-09-18 University of British Columbia Compositions and methods for modulating hdl cholesterol and triglyceride levels
JP4018312B2 (ja) 2000-02-21 2007-12-05 株式会社ルネサステクノロジ 無線通信装置
IN191090B (enExample) 2000-08-29 2003-09-20 Ranbanx Lab Ltd
CA2438221A1 (en) * 2001-02-08 2002-08-15 The University Of Chicago Steroidal derivatives
US20020164310A1 (en) 2001-03-02 2002-11-07 Mgvs Ltd. Nucleic acid constructs, cells transformed therewith and methods utilizing same for inducing liver regeneration and alleviation of portal hypertension
CA2446314C (en) 2001-05-03 2011-02-22 The University Of Chicago Liver x receptor agonists
US20070197484A1 (en) 2001-05-03 2007-08-23 Ching Song Method of treating disorder related to high cholesterol concentration
CA2466033A1 (en) 2001-11-08 2003-05-15 The University Of Chicago Method of treating disorder related to high cholesterol concentration
GEP20063996B (en) * 2002-08-20 2006-12-11 Bristol Myers Squibb Co Aripiprazole complex formulation and use thereof
ATE498613T1 (de) 2004-06-30 2011-03-15 Janssen Pharmaceutica Nv Chinazolinonderivate als parp-hemmer
US8399441B2 (en) 2004-10-25 2013-03-19 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
WO2007095462A2 (en) 2006-02-13 2007-08-23 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
DE102006021181B3 (de) 2006-05-06 2007-05-03 Laux, Thomas, Dr. Zahnprothesen-Trägerimplantat
GB0625965D0 (en) 2006-12-23 2007-02-07 Renovo Ltd Medicaments for wound healing
WO2009002873A1 (en) 2007-06-22 2008-12-31 Cvi Pharmaceuticals Limited Compounds, compositions and methods for reducing lipid levels
US8831674B2 (en) 2007-09-27 2014-09-09 Multi-Tech Systems, Inc. Message server
CN101952281B (zh) 2008-01-04 2014-04-02 株式会社Lg生命科学 具有细胞、组织及器官保存效果的吲哚及吲唑衍生物
WO2011077245A2 (en) 2009-12-23 2011-06-30 Fondazione Centro San Raffaele Del Monte Tabor Compositions
EP2902019B1 (en) * 2010-08-04 2017-10-04 Pierrel Pharma S.R.L. Compositions comprising inclusion complexes of cyclodextrins with spermidine for use in oral care
KR101739816B1 (ko) * 2010-12-01 2017-05-25 주식회사유한양행 레바프라잔 또는 그의 염을 함유하는 주사용 액제 조성물 또는 주사용 건조 분말
US9034859B2 (en) * 2011-04-06 2015-05-19 Virginia Commonwealth University Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
RS64332B1 (sr) 2011-09-08 2023-08-31 Sage Therapeutics Inc Neuroaktivni steroidi, kompozicije i njihova upotreba
CN104220450B (zh) 2012-04-12 2016-07-06 弗吉尼亚联邦大学 用于治疗代谢障碍、高脂血症、糖尿病、脂肪肝疾病和动脉粥样硬化的新的胆固醇代谢物5-胆甾烯-3β,25-二醇二硫酸酯(25HCDS)
BR112015001150A2 (pt) 2012-07-17 2017-06-27 Univ Michigan método não cirúrgico para o tratamento da catarata
AU2013296170A1 (en) 2012-08-03 2015-03-12 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Cyclodextrin for the treatment of lysosomal storage diseases
US20140220112A1 (en) * 2013-02-01 2014-08-07 Zoneone Pharma, Inc. Transformation of drug cyclodextrin complex compositions into compositions of mixtures of lipid vesicle encapsulated drug and cyclodextrin drug complexes
EP2842547A1 (en) * 2013-08-27 2015-03-04 Freund Pharmatec Ltd. Improved fenofibrate compositions
PE20170907A1 (es) * 2014-10-07 2017-07-12 Sage Therapeutics Inc Compuestos neuroactivos y metodos de uso de los mismos
CN107106576A (zh) 2014-10-10 2017-08-29 弗吉尼亚联邦大学 用于因减弱的瘦蛋白活性和脂质贮积障碍中的至少一种导致的障碍的疗法的氧化胆固醇硫酸酯类
US10398709B2 (en) 2015-07-27 2019-09-03 Catacore, Inc. Compositions for the treatment of cataracts
CN109922811B (zh) 2016-08-02 2023-09-19 度勒科特公司 包含至少一种氧化胆固醇硫酸酯以及聚亚烷基二醇、羧甲基纤维素和聚氧乙烯甘油酯中的至少一种的组合物及其使用方法
EP3493671A4 (en) 2016-08-02 2020-04-08 Virginia Commonwealth University USE OF OXYGENATED CHOLESTEROL SULFATES (OCS) TO TREAT INFLAMMATORY SKIN DISEASES AND SKIN INJURIES
CA3031224A1 (en) 2016-08-02 2018-02-08 Shunlin Ren Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide
WO2021067297A1 (en) 2019-09-30 2021-04-08 Durect Corporation Treatment of alcoholic hepatitis
WO2021133976A1 (en) 2019-12-27 2021-07-01 Durect Corporation Crystalline and liquid crystalline 25-hydroxy-cholest-5-en-3-sulfate sodium and methods for preparing same
EP4103195A4 (en) 2020-02-11 2024-04-17 Durect Corporation TREATMENT OF INFECTIOUS DISEASES
CA3183119A1 (en) 2020-05-22 2021-11-25 Durect Corporation Treatment of non-alcoholic steatohepatitis (nash)
CA3195103A1 (en) 2020-05-22 2021-11-25 Durect Corporation Treatment of non-alcoholic steatohepatitis (nash)
CA3187310A1 (en) 2020-06-26 2021-12-30 Durect Corporation Use of oxygenated cholesterol sulfates for treating autoimmune conditions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995015165A1 (en) * 1993-11-30 1995-06-08 New York University Medical Center Administration of a 27-hydroxycholesterol or related compound or sterol-27-hydroxylase stimulant to prevent restenosis following vascular endothelial injuri
WO2015100312A1 (en) * 2013-12-24 2015-07-02 Virginia Commonwealth University Uses of oxygenated cholesterol sulfates (ocs)

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