KR102565132B1 - Tnf 활성의 조절인자로서의 융합된 펜타사이클릭 이미다졸 유도체 - Google Patents
Tnf 활성의 조절인자로서의 융합된 펜타사이클릭 이미다졸 유도체 Download PDFInfo
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- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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Landscapes
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| EP17168027 | 2017-04-25 | ||
| EP17168027.5 | 2017-04-25 | ||
| PCT/EP2018/060489 WO2018197503A1 (en) | 2017-04-25 | 2018-04-24 | Fused pentacyclic imidazole derivatives as modulators of tnf activity |
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| KR20190141200A KR20190141200A (ko) | 2019-12-23 |
| KR102565132B1 true KR102565132B1 (ko) | 2023-08-08 |
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| EA201892144A1 (ru) * | 2016-04-01 | 2019-04-30 | Юсб Байофарма Спрл | Конденсированные гексациклические производные имидазола в качестве модуляторов активности tnf |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| ES2951837T3 (es) * | 2018-10-24 | 2023-10-25 | UCB Biopharma SRL | Derivados de imidazol pentacíclicos condensados como moduladores de la actividad de TNF |
| US12384808B2 (en) | 2022-11-23 | 2025-08-12 | Forward Therapeutics, Inc. | Modulators of TNF-α activity |
| TW202508596A (zh) | 2023-04-26 | 2025-03-01 | 法商賽諾菲公司 | 使用腫瘤壞死因子α之小分子抑制劑治療乾癬 |
| WO2024251282A1 (zh) * | 2023-06-09 | 2024-12-12 | 上海翰森生物医药科技有限公司 | 五环类衍生物抑制剂、其制备方法和应用 |
| TW202519231A (zh) | 2023-07-04 | 2025-05-16 | 法商賽諾菲公司 | 結晶形式 |
| WO2025068505A1 (en) | 2023-09-29 | 2025-04-03 | Sanofi | Preparation of bridged pentacyclic imidazole derivatives as modulators of tnf activity, intermeditates and their preparation |
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| BR112014030940B1 (pt) * | 2012-06-11 | 2022-09-06 | UCB Biopharma SRL | Benzimidazóis que modulam tnf-alfa e composição farmacêutica compreendendo os mesmos |
| GB201212513D0 (en) * | 2012-07-13 | 2012-08-29 | Ucb Pharma Sa | Therapeutic agents |
| JP6259823B2 (ja) * | 2012-07-13 | 2018-01-10 | ユーシービー バイオファルマ エスピーアールエル | Ｔｎｆ活性の調節物質としてのイミダゾピリジン誘導体 |
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| US9856253B2 (en) | 2015-04-17 | 2018-01-02 | Abbvie, Inc. | Tricyclic modulators of TNF signaling |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2016050975A1 (en) * | 2014-10-03 | 2016-04-07 | Ucb Biopharma Sprl | Fused pentacyclic imidazole derivatives |
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