KR102553386B1 - 세포에서 lpa의 발현을 저해하기 위한 핵산 - Google Patents

세포에서 lpa의 발현을 저해하기 위한 핵산 Download PDF

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KR102553386B1
KR102553386B1 KR1020217017471A KR20217017471A KR102553386B1 KR 102553386 B1 KR102553386 B1 KR 102553386B1 KR 1020217017471 A KR1020217017471 A KR 1020217017471A KR 20217017471 A KR20217017471 A KR 20217017471A KR 102553386 B1 KR102553386 B1 KR 102553386B1
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nucleic acid
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nucleotides
rna
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KR20210095878A (ko
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다비드 안토니 라이더
루카스 베트게
크리스티안 프라우엔도르프
아드리언 바인가르트너
유디트 하우프트만
시빌 다머스
스테판 슈베르트
스테판 텐바움
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사일런스 테라퓨틱스 게엠베하
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KR1020217017471A 2018-11-13 2019-11-13 세포에서 lpa의 발현을 저해하기 위한 핵산 Active KR102553386B1 (ko)

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Application Number Priority Date Filing Date Title
EPPCT/EP2018/081106 2018-11-13
PCT/EP2018/081106 WO2019092283A1 (en) 2017-11-13 2018-11-13 Nucleic acids for inhibiting expression of lpa in a cell
EP19174466.3 2019-05-14
EP19174466 2019-05-14
PCT/EP2019/081158 WO2020099476A1 (en) 2018-11-13 2019-11-13 Nucleic acids for inhibiting expression of lpa in a cell

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KR102553386B1 true KR102553386B1 (ko) 2023-07-07

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AU2019380628B2 (en) 2018-11-13 2024-10-31 Silence Therapeutics Gmbh Nucleic acids for inhibiting expression of LPA in a cell
EP4229201A1 (en) 2020-10-16 2023-08-23 Sanofi Rna compositions and methods for inhibiting lipoprotein(a)
US20250283076A1 (en) * 2021-09-14 2025-09-11 Argonaute RNA Limited Treatment of cardiovascular disease
KR20240103025A9 (ko) 2021-11-16 2025-12-10 상하이 아르고 바이오파마슈티칼 씨오., 엘티디. 안지오텐시노겐(agt) 단백질의 발현을 저해하는 조성물 및 방법
TW202345865A (zh) * 2022-01-24 2023-12-01 大陸商上海舶望製藥有限公司 抑制LPA(Apo(a))蛋白表達的組合物和方法
WO2023152194A1 (en) 2022-02-09 2023-08-17 Silence Therapeutics Gmbh Therapeutic inhibition of lpa expression
CN114703184B (zh) * 2022-03-11 2024-06-18 厦门甘宝利生物医药有限公司 Lpa抑制剂及其用途
CN115044584A (zh) * 2022-06-10 2022-09-13 上海鼎新基因科技有限公司 一种siRNA体外稳定性检测方法
WO2024013334A1 (en) * 2022-07-15 2024-01-18 Silence Therapeutics Gmbh Nucleic acids for inhibiting expression of agt in a cell
CN115851723B (zh) * 2022-10-24 2023-10-03 厦门甘宝利生物医药有限公司 一种抑制lpa基因表达的rna抑制剂及其应用
KR20250131826A (ko) * 2023-01-13 2025-09-03 일라이 릴리 앤드 캄파니 치료 올리고뉴클레오티드-함유 제약 조성물 및 그를 사용한 투여 요법
WO2024227458A2 (zh) * 2023-08-22 2024-11-07 成都先衍生物技术有限公司 一种靶向AGT基因表达的siRNA及其缀合物和用途
UY40897A (es) 2023-09-21 2025-03-31 Ionis Pharmaceuticals Inc Compuestos y métodos para inhibir lpa
TW202540420A (zh) 2023-11-15 2025-10-16 大陸商北京加科瑞康醫藥科技有限公司 用於抑制LPA的基因表現的siRNA，含其的組合物及其用途
WO2026046152A1 (zh) * 2024-08-26 2026-03-05 倍臻生物技术（苏州）有限公司 修饰的双链核糖核酸及其应用

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IL283159A (en) 2021-06-30
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EP4219712A2 (en) 2023-08-02
SI3880818T1 (sl) 2023-01-31
CR20210301A (es) 2021-09-16
JP7245328B2 (ja) 2023-03-23
KR20210095878A (ko) 2021-08-03
ES2932295T3 (es) 2023-01-17
CN119842706A (zh) 2025-04-18
US20260078372A1 (en) 2026-03-19
AU2019380628A1 (en) 2021-05-20
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HRP20221358T1 (hr) 2022-12-23
EP3880818B1 (en) 2022-09-28
CN113227372A (zh) 2021-08-06
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FI3880818T3 (fi) 2022-12-15

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