JP7245328B2 - 細胞におけるｌｐａの発現を抑制するための核酸 - Google Patents

細胞におけるｌｐａの発現を抑制するための核酸 Download PDF

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JP7245328B2
JP7245328B2 JP2021525771A JP2021525771A JP7245328B2 JP 7245328 B2 JP7245328 B2 JP 7245328B2 JP 2021525771 A JP2021525771 A JP 2021525771A JP 2021525771 A JP2021525771 A JP 2021525771A JP 7245328 B2 JP7245328 B2 JP 7245328B2
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nucleic acid
nucleotides
modified
seq
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JP2022507282A5 (enExample
JP2022507282A (ja
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アントニー ライダー，デイビッド
ベートゲ，ルーカス
フラウエンドーフ，クリスチャン
ウェインガートナー，アドリーン
ハウプトマン，ジュディス
デイムス，シバイル
シューベルト，ステッフェン
テンバウム，ステファン
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Silence Therapeutics GmbH
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Atugen AG
Silence Therapeutics GmbH
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JP2021525771A 2018-11-13 2019-11-13 細胞におけるｌｐａの発現を抑制するための核酸 Active JP7245328B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EPPCT/EP2018/081106 2018-11-13
PCT/EP2018/081106 WO2019092283A1 (en) 2017-11-13 2018-11-13 Nucleic acids for inhibiting expression of lpa in a cell
EP19174466.3 2019-05-14
EP19174466 2019-05-14
PCT/EP2019/081158 WO2020099476A1 (en) 2018-11-13 2019-11-13 Nucleic acids for inhibiting expression of lpa in a cell

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JP2022507282A JP2022507282A (ja) 2022-01-18
JP2022507282A5 JP2022507282A5 (enExample) 2022-08-25
JP7245328B2 true JP7245328B2 (ja) 2023-03-23

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CN119120476A (zh) 2017-11-13 2024-12-13 赛伦斯治疗有限责任公司 用于抑制细胞中lpa的表达的核酸
AU2019380628B2 (en) 2018-11-13 2024-10-31 Silence Therapeutics Gmbh Nucleic acids for inhibiting expression of LPA in a cell
EP4229201A1 (en) 2020-10-16 2023-08-23 Sanofi Rna compositions and methods for inhibiting lipoprotein(a)
US20250283076A1 (en) * 2021-09-14 2025-09-11 Argonaute RNA Limited Treatment of cardiovascular disease
KR20240103025A9 (ko) 2021-11-16 2025-12-10 상하이 아르고 바이오파마슈티칼 씨오., 엘티디. 안지오텐시노겐(agt) 단백질의 발현을 저해하는 조성물 및 방법
TW202345865A (zh) * 2022-01-24 2023-12-01 大陸商上海舶望製藥有限公司 抑制LPA(Apo(a))蛋白表達的組合物和方法
WO2023152194A1 (en) 2022-02-09 2023-08-17 Silence Therapeutics Gmbh Therapeutic inhibition of lpa expression
CN114703184B (zh) * 2022-03-11 2024-06-18 厦门甘宝利生物医药有限公司 Lpa抑制剂及其用途
CN115044584A (zh) * 2022-06-10 2022-09-13 上海鼎新基因科技有限公司 一种siRNA体外稳定性检测方法
WO2024013334A1 (en) * 2022-07-15 2024-01-18 Silence Therapeutics Gmbh Nucleic acids for inhibiting expression of agt in a cell
CN115851723B (zh) * 2022-10-24 2023-10-03 厦门甘宝利生物医药有限公司 一种抑制lpa基因表达的rna抑制剂及其应用
KR20250131826A (ko) * 2023-01-13 2025-09-03 일라이 릴리 앤드 캄파니 치료 올리고뉴클레오티드-함유 제약 조성물 및 그를 사용한 투여 요법
WO2024227458A2 (zh) * 2023-08-22 2024-11-07 成都先衍生物技术有限公司 一种靶向AGT基因表达的siRNA及其缀合物和用途
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WO2026046152A1 (zh) * 2024-08-26 2026-03-05 倍臻生物技术（苏州）有限公司 修饰的双链核糖核酸及其应用

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WO2020099476A1 (en) 2020-05-22
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CO2021007372A2 (es) 2021-07-09
IL283159A (en) 2021-06-30
PH12021550801A1 (en) 2021-10-04
EP4219712A3 (en) 2023-11-22
BR112021009213A2 (pt) 2021-08-10
JP2022507282A (ja) 2022-01-18
EP4219712A2 (en) 2023-08-02
SI3880818T1 (sl) 2023-01-31
CR20210301A (es) 2021-09-16
KR20210095878A (ko) 2021-08-03
ES2932295T3 (es) 2023-01-17
CN119842706A (zh) 2025-04-18
US20260078372A1 (en) 2026-03-19
AU2019380628A1 (en) 2021-05-20
CA3119239C (en) 2024-06-04
HRP20221358T1 (hr) 2022-12-23
EP3880818B1 (en) 2022-09-28
CN113227372A (zh) 2021-08-06
CA3119239A1 (en) 2020-05-22
PT3880818T (pt) 2022-12-06
US20220170016A1 (en) 2022-06-02
CL2021001225A1 (es) 2021-12-24
HUE060703T2 (hu) 2023-04-28
MX2021005590A (es) 2023-01-24
IL283159B2 (en) 2026-05-01
US20220002722A1 (en) 2022-01-06
SMT202300050T1 (it) 2023-03-17
SG11202103882QA (en) 2021-05-28
RS63778B1 (sr) 2022-12-30
DK3880818T3 (da) 2022-12-05
US11499153B2 (en) 2022-11-15
SA521421963B1 (ar) 2024-03-25
PE20211282A1 (es) 2021-07-19
EP3880818A1 (en) 2021-09-22
EA202190895A1 (ru) 2021-08-10
IL283159B1 (en) 2026-01-01
PH12021550801B1 (en) 2024-04-26
KR102553386B1 (ko) 2023-07-07
LT3880818T (lt) 2022-12-27
FI3880818T3 (fi) 2022-12-15

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