KR102547996B1 - Photoreactive cosmetic composition comprising Curcuma longa extract or curcumin as an active ingredient - Google Patents

Abstract

The present invention includes turmeric extract or curcumin, which is used together with a light irradiation skin care device that improves the skin by irradiating light of a specific wavelength to the skin using an LED or OLED light source and exhibits better skin elasticity enhancement and wrinkle improvement effects It is expected to be widely used as a cosmetic to maximize the effect of expensive light irradiation skin care devices in the expanded home care market.

Description

Photoreactive cosmetic composition comprising Curcuma longa extract or curcumin as an active ingredient}

The present invention includes turmeric extract or curcumin, which is used together with a light irradiation skin care device that improves the skin by irradiating light of a specific wavelength to the skin using an LED or OLED light source and exhibits better skin elasticity enhancement and wrinkle improvement effects It relates to a photoreactive cosmetic composition and the like.

Cosmetics have been used for the purpose of protecting the skin and imparting beauty. However, in recent years, by emphasizing functionality, functional cosmetics with various functions such as skin wrinkles or elasticity improvement, antioxidant, and whitening beyond simple skin protection or moisturizing are in the limelight. Accordingly, components having various activities are contained, which may cause skin trouble or inflammation. Accordingly, interest in cosmetics using safe natural ingredients is increasing, and efforts are being made to find natural materials that are safe and have skin useful activity.

On the other hand, recently, beauty devices such as anti-aging and wrinkle improvement have been developed to prevent aging, etc., and the expansion of various consumer groups due to the increase in the aging population, the development of beauty and medical technology, and the interest of consumers who want healthy and beautiful skin It has been used more actively due to an increase in

Accordingly, by further emphasizing functionality, aesthetic shops and dermatologists, which use cosmetics and beauty devices with various functions such as skin wrinkle improvement, elasticity improvement, and whitening, are in the limelight. Along with this, interest in cosmetics and beauty devices that can be safely used by individuals at home is increasing, and efforts are being made to find materials that can promote their efficacy and effects and maximize them cosmetically.

As an example of such research and development, Korean Patent Publication No. 2015-0125149 discloses a light emitting diode (Light Emitting-Diode, LED) or organic light emitting diode (OLED) in “a display device and a light treatment method using the same” Disclosed is a method for a user to easily perform phototherapy using a device regardless of time and place.

The present inventors searched for natural materials used together with LED / OLED devices to maximize the effect of skin improvement, and through the combination of natural materials with active ingredients, substances that affect the activity such as skin wrinkle improvement and skin elasticity enhancement effects tried to find

KR 10-1801223

The technical problem to be achieved by the present invention is to irradiate the skin with light of a specific wavelength using an LED / OLED light source to improve the skin, and use it together with a light irradiation skin care device to show more excellent skin improvement activity and / or curcumin It is an object to provide a cosmetic composition containing as an active ingredient.

In addition, another object of the present invention is to provide a cosmetic composition for improving skin wrinkles and/or enhancing skin elasticity, which contains turmeric extract and/or curcumin as an active ingredient and exhibits a more excellent effect by reacting under light conditions of a specific wavelength. to be

In addition, an object of the present invention is to provide a cosmetic method having the effect of improving skin wrinkles and enhancing skin elasticity, including the step of applying the photoreactive cosmetic composition to the skin and irradiating a specific wavelength.

However, the technical problem to be achieved by the present invention is not limited to the above-mentioned problems, and other problems not mentioned will be clearly understood by those skilled in the art from the description below.

In order to solve the above problems, the present invention is used under light conditions of 545 ± 5nm wavelength, and provides a photoreactive cosmetic composition containing a turmeric extract as an active ingredient.

In addition, the present invention provides a photoreactive cosmetic composition that is used under light conditions of a wavelength of 545±5 nm and includes curcumin as an active ingredient.

As an embodiment of the present invention, the cosmetic composition may be used under a light condition of a wavelength of 545 ± 5 nm to exhibit effects of improving skin wrinkles and enhancing skin elasticity.

As another embodiment of the present invention, the turmeric extract may contain curcumin.

As another embodiment of the present invention, the curcumin may be derived from turmeric.

As another embodiment of the present invention, the turmeric extract in the cosmetic composition may be included at a concentration of 10 to 30 ug / ml, preferably at a concentration of 15 to 25 ug / ml, more preferably 20 ug / ml concentration may be included.

As another embodiment of the present invention, in the cosmetic composition, curcumin may be included at a concentration of 0.2 to 0.9 uM, preferably at a concentration of 0.4 to 0.6 uM, and more preferably at a concentration of 0.5 uM.

In addition, the present invention provides a cosmetic method for improving skin wrinkles and enhancing skin elasticity comprising the following steps:

Applying a photoreactive cosmetic composition exhibiting skin wrinkle improvement and elasticity enhancement effects under the above-described 545±5 nm wavelength light conditions to human skin; and

Irradiating light of 545 ± 5 nm to the human skin with an LED or OLED light source.

In addition, the present invention provides a photoreactive cosmetic composition that is used under light conditions of a wavelength of 655±5 nm and includes curcumin as an active ingredient.

As an embodiment of the present invention, the cosmetic composition may be used under a light condition of a wavelength of 655 ± 5 nm to exhibit effects of improving skin wrinkles and enhancing skin elasticity.

As another embodiment of the present invention, the curcumin may be derived from turmeric.

As another embodiment of the present invention, in the cosmetic composition, curcumin may be included at a concentration of 0.8 to 1.2 uM, preferably at a concentration of 0.9 to 1.1 uM, and more preferably at a concentration of 1 uM.

In addition, the present invention provides a cosmetic method for improving skin wrinkles and enhancing skin elasticity comprising the following steps:

Applying a photoreactive cosmetic composition exhibiting skin wrinkle improvement and elasticity enhancement effects under the light conditions of the above-mentioned 655±5 nm wavelength to human skin; and

Irradiating light of 655 ± 5 nm to the human skin with an LED or OLED light source.

Since the turmeric extract and curcumin of the present invention further promote collagen synthesis and inhibit its decomposition under light conditions of a specific wavelength, the cosmetic composition containing them is used together with a skin care device using an LED or OLED light source to improve skin wrinkles and , It can be used as a functional cosmetic for skin aging prevention and treatment by enhancing skin elasticity.

1 is a graph quantifying changes in the expression levels of COL1A and MMP1 when fibroblasts were treated with curcumin at various concentrations alone.
Figure 2 is a graph quantifying changes in the expression levels of COL1A and MMP1 when fibroblasts are treated with curcumin at various concentrations and LED with a wavelength of 545 nm or 655 nm.
Figure 3 is a graph confirming the cytotoxicity in the case of combined treatment with curcumin alone at various concentrations and a 545 nm or 655 nm wavelength LED.
Figure 4 confirms the change in the expression levels of COL1A and MMP1 when fibroblasts are treated with Curcuma extract at various concentrations alone and when treated with a 545 nm or 655 nm wavelength LED in combination.
Figure 5 is a graph confirming the cytotoxicity in the case of treatment with turmeric extract of various concentrations alone and in the case of combined treatment with LED of 545nm or 655nm wavelength.

The present invention is a photoreactive cosmetic that exhibits excellent skin improvement activity when used together with a skin care device that improves skin by irradiating light under specific conditions to the skin using a light emitting diode (LED) or organic light emitting diode (OLED) light source. It relates to a composition, and relates to a cosmetic composition for improving skin wrinkles and enhancing skin elasticity containing turmeric extract and/or curcumin as an active ingredient.

Turmeric ( Curcuma longa ) is a perennial plant belonging to the ginger order and is mainly cultivated in tropical and subtropical regions around India, and its stems and roots are used for food and medicine. The rhizome of turmeric is mainly used as a herbal medicine. It is a yellow medicine with a spicy and bitter taste. It is effective for pain relief and menstrual irregularities.

Curcumin is a type of polyphenol mainly contained in turmeric and is recognized as a food additive and is known to have stable, anti-inflammatory, antioxidant, and antibacterial effects.

The present inventors found that inducing a light response to human-derived fibroblasts by treating turmeric extract or curcumin with LED irradiation for 10 minutes using an LED irradiation device of various wavelengths resulted in collagen synthesis and collagen degradation in the dermal layer. To confirm the effect, the expression levels of COL1A and MMP1 were measured. As a result, it was confirmed that the turmeric extract and curcumin significantly increased the level of collagen through the enhancement of collagen synthesis and inhibition of cell degradation by photoreaction with a 545 nm wavelength LED at a specific concentration. On the other hand, when curcumin was irradiated with a 655nm wavelength LED at a specific concentration, there was an excellent collagen enhancement effect similar to the 545nm result, but in the case of Curcumin extract, it did not react to a 655nm wavelength light source at all concentrations.

In addition, in order to confirm the safety of using turmeric extract and curcumin, which have the effect of enhancing skin collagen level under light conditions, as a cosmetic composition, the cytotoxicity of each material was confirmed, and it was confirmed that there was no cytotoxicity in turmeric extract and curcumin at all concentrations. could

Accordingly, the present invention provides a photoreactive cosmetic composition in which turmeric extract or curcumin is activated under light conditions of a wavelength of 545 ± 5 nm to exhibit excellent skin wrinkle improvement and skin elasticity enhancement effects.

In addition, the present invention provides a photoreactive cosmetic composition that activates curcumin at a high concentration under a light condition of a wavelength of 655 ± 5 nm and exhibits excellent skin wrinkle improvement and skin elasticity enhancement effects.

In this specification, "photoreactive cosmetic composition" is used with a skin care device that improves skin by irradiating light under specific conditions using an LED/OLED light source, etc., and reacts to light under specific conditions to improve the skin's activity It is used to mean a cosmetic composition that increases.

The Curcuma extract of the present invention can be obtained using a conventional extraction method, and for example, an ultrasonic extraction method, a subcritical extraction method, a high temperature extraction method, a high pressure extraction method, a filtration method, or a reflux extraction method may be used.

In addition, the turmeric extract may be extracted with one solvent selected from the group consisting of water, alcohol having 1 to 4 carbon atoms, and a mixed solvent thereof, and its ethyl acetate, butanol, hexane, water, or a mixed solvent thereof It may be a fractionated fraction.

The formulation of the cosmetic composition according to the present invention is skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrient lotion, massage cream, nutrient cream, moisture cream, hand cream, foundation, essence, nutrient essence, It may be in the form of a pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion or body cleanser.

The cosmetic composition of the present invention may further include a composition selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, high-molecular peptides, high-molecular polysaccharides, and sphingolipids.

Any water-soluble vitamin can be used as long as it can be formulated into cosmetics, but preferably vitamin B1, vitamin B2, vitamin B6, pyridoxine, pyridoxine hydrochloride, vitamin B12, pantothenic acid, nicotinic acid, nicotinic acid amide, folic acid, vitamin C, vitamin H, etc. salts (thiamin hydrochloride, sodium ascorbate, etc.) or derivatives (sodium ascorbic acid-2-phosphate, magnesium salt of ascorbic acid-2-phosphate, etc.) included Water-soluble vitamins can be obtained by conventional methods such as a microbial transformation method, a purification method from a microbial culture, an enzymatic method, or a chemical synthesis method.

Any useful vitamin may be used as long as it can be formulated into cosmetics, but preferably vitamin A, carotene, vitamin D2, vitamin D3, vitamin E (d1-alpha tocopherol, d-alpha tocopherol, d-alpha tocopherol), etc. are mentioned. , their derivatives (ascorbine palmitate, ascorbine stearate, ascorbine dipalmitate, dl-alpha tocopherol acetate, dl-alpha tocopherol nicotinate, vitamin E, DL-pantothenyl alcohol, D-pantothenyl alcohol, pantothenylethyl ether, etc.) and the like are also included in the useful vitamins used in the present invention. The useful vitamins can be obtained by conventional methods such as microbial transformation, purification from microbial culture, enzymatic or chemical synthesis.

Any polymeric peptide may be used as long as it can be formulated into cosmetics, but preferably collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, keratin and the like are mentioned. Polymer peptides can be purified and obtained by conventional methods such as a purification method from a culture medium of microorganisms, an enzyme method, or a chemical synthesis method, or can be used after being purified from natural products such as pig or cow dermis or silkworm silk fibers.

Any polymeric polysaccharide may be used as long as it can be incorporated into cosmetics, but hydroxyethyl cellulose, xanthan gum, sodium hyaluronate, chondroitin sulfate or a salt thereof (sodium salt or the like) is preferable. For example, chondroitin sulfate or a salt thereof can be used after being purified from mammals or fish.

Any sphingolipid can be used as long as it can be incorporated into cosmetics, but ceramide, phytosphingosine, sphingoglycolipid and the like are preferred. Sphingolipids can be purified by conventional methods or obtained by chemical synthesis from mammals, fish, shellfish, yeast, or plants.

In the cosmetic composition of the present invention, in addition to the above essential ingredients, other ingredients normally formulated in cosmetics may be blended as necessary.

Other ingredients that may be added include fats and oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, preservatives, bactericides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, fragrances, blood circulation promoters, A cooling agent, an antiperspirant, purified water, etc. are mentioned.

Examples of the oil and fat component include ester oils, hydrocarbon oils, silicone oils, fluorine oils, animal fats and vegetable oils.

Examples of ester oils include glyceryl tri-2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, and stearic acid. Butyl, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, adipine Diisopropyl acid, isoalkyl neopentanoate, tri(capryl, capric acid) glyceryl, trimethylolpropane tri2-ethylhexanoate, trimethylolpropane triisostearate, pentaelislitol tetra2-ethylhexanoate , Cetyl caprylate, decyl laurate, hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, stearyl stearate, decyl oleate, cetyl ricinooleate, isostea laurate Lil, isotridecyl myristate, isocetyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl linoleate, isopropyl isostearate, 2-ethylhexanoate Aryl, 2-ethyl stearyl hexanoate, hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicaprate, di(caprylic, capric acid) propylene glycol, propylene glycol dicaprylate, dicap Neopentyl glycol prinate, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl triundecylate, glyceryl triisopalmitate, glyceryl triisostearate, octyldodecyl neopentanoate, isostearyl octanoate , Octyl isononanoate, hexyldecyl neodecanoate, octyldodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, octyldecyl isostearate, polyglycerin oleate, polyglycerin isostearate, Triisocetyl citrate, triisoalkyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyldecyl lactate, triethyl citrate, acetyltriethyl citrate, acetyltributyl citrate, trioctyl citrate, dimalate Isostearyl, 2-ethylhexyl hydroxystearate, di2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, Cholesteryl Hydroxystearate, Cholesteryl Oleate, Dihydrocholesteryl Oleate, Physteryl Isostearate, Physteryl Oleate, Isocetyl 12-stealoylhydroxystearate, 12-stealoyylhydro and esters such as stearyl oxystearate and isostearyl 12-stealoylhydroxystearate.

Examples of hydrocarbon-based fats and oils include hydrocarbon-based fats and oils such as squalene, liquid paraffin, alpha-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybuden, microcrystalline wax, and vaseline.

Examples of silicone oils include polymethylsilicone, methylphenylsilicone, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, dimethylsiloxane/methylcetyloxysiloxane copolymer, dimethylsiloxane/methylstealoxysiloxane copolymer, alkyl Modified silicone oil, amino modified silicone oil, etc. are mentioned.

Examples of fluorine-based fats and oils include perfluoropolyether and the like.

Animal or vegetable oils include avocado oil, almond oil, olive oil, sesame oil, rice bran oil, birdflower oil, soybean oil, corn oil, rapeseed oil, algae oil, palm kernel oil, palm oil, castor oil, sunflower oil, grape seed oil , cottonseed oil, palm oil, kukui nut oil, wheat germ oil, rice germ oil, shea butter, moonshine colostrum, marker damian nut oil, meadowsweet oil, egg yolk oil, beef tallow, horse oil, mink oil, orange raffia oil, jojoba oil , animal or plant fats and oils such as candelilla wax, carnaba wax, liquid lanolin, and hydrogenated castor oil.

Examples of the moisturizer include water-soluble low-molecular moisturizers, fat-soluble molecular moisturizers, water-soluble polymers, and oil-soluble polymers.

Examples of water-soluble low-molecular moisturizers include serine, glutamine, sorbitol, mannitol, pyrrolidone-sodium carboxylate, glycerin, propylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol B (polymerization degree n = 2 or more), polypropylene Glycol (polymerization degree n = 2 or more), polyglycerol B (polymerization degree n = 2 or more), lactic acid, lactate, etc. are mentioned.

Cholesterol, cholesterol ester, etc. are mentioned as a fat-soluble low-molecular moisturizer.

Examples of water-soluble polymers include carboxyvinyl polymer, polyaspartate, tragacanth, xanthan gum, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, water-soluble chitin, chitosan, dextrin, and the like. can

Examples of the fat-soluble polymer include polyvinylpyrrolidone/eicosene copolymer, polyvinylpyrrolidone/hexadecene copolymer, nitrocellulose, dextrin fatty acid ester, and high molecular silicone.

Examples of the emollient agent include long-chain acyl glutamic acid cholesteryl ester, hydroxystearic acid cholesteryl, 12-hydroxystearic acid, stearic acid, rosin acid, lanolin fatty acid cholesteryl ester, and the like.

Examples of the surfactant include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants.

Nonionic surfactants include self-emulsifying glycerin monostearate, propylene glycol fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, sorbitan fatty acid esters, POE (polyoxyethylene) sorbitan fatty acid esters, POE sorbitan fatty acid esters, POE Glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE hydrogenated castor oil, POE castor oil, POE·POP (polyoxyethylene·polyoxypropylene) copolymer, POE·POP alkyl ether, polyether modified silicone, lauric acid alkanolamides, alkylamine oxides, hydrogenated soybean phospholipids, and the like.

Anionic surfactants include fatty acid soaps, alpha-acyl sulfonates, alkyl sulfonates, alkyl allyl sulfonates, alkyl naphthalene sulfonates, alkyl sulfates, POE alkyl ether sulfates, alkyl amide sulfates, alkyl phosphates, POE alkyl phosphates, and alkyl amide phosphates. , alkyloylalkyl taurine salts, N-acylamino acid salts, POE alkyl ether carboxylate salts, alkyl sulfosuccinic acid salts, sodium alkyl sulfoacetate, acylated hydrolyzed collagen peptide salts, perfluoroalkyl phosphate esters, and the like. .

As the cationic surfactant, alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behenyltrimethylammonium bromide, chloride Benzalkonium, stearic acid diethylaminoethylamide, stearic acid dimethylaminopropylamide, lanolin derivative quaternary ammonium salt, etc. are mentioned.

Amphoteric surfactants include carboxybetaine type, amidebetaine type, sulfobetaine type, hydroxysulfobetaine type, amide sulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amideamine type, etc. An amphoteric surfactant etc. are mentioned.

As organic and inorganic pigments, silicic acid, silicic anhydride, magnesium silicate, talc, sericite, mica, kaolin, bengala, clay, bentonite, titanium-coated mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, aluminum oxide inorganic pigments such as calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, ultramarine blue, chromium oxide, chromium hydroxide, calamine and complexes thereof; Polyamide, polyester, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenolic resin, fluororesin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, divinylbenzene/styrene copolymer, organic pigments such as silk powder, cellulose, CI pigment yellow and CI pigment orange, and composite pigments of these inorganic pigments and organic pigments.

Examples of the organic powder include metal soaps such as calcium stearate; Alkyl phosphate metal salts, such as zinc sodium cetylrate, zinc laurylate, and calcium laurylate; polyvalent metal salts of acyl amino acids such as N-lauroyl-beta-alanine calcium, N-lauroyl-beta-alanine zinc, and N-lauroyl glycine calcium; polyvalent metal salts of amide sulfonic acids such as N-lauroyl-taurine calcium and N-palmitoyl-taurine calcium; N-epsilon-lauroyl-L-lysine, N-epsilon-palmitoylizine, N-alpha-paritoylolnithine, N-alpha-lauroylarginine, N-alpha-hardened beef fatty acid acylarginine, etc. -acyl basic amino acids; N-acyl polypeptides such as N-lauroyl glycyl glycine; alpha-amino fatty acids such as alpha-aminocaprylic acid and alpha-aminolauric acid; polyethylene, polypropylene, nylon, polymethyl methacrylate, polystyrene, divinylbenzene/styrene copolymer, tetrafluoroethylene, and the like.

Bactericides include hinokitiol, triclosan, trichlorohydroxydiphenyl ether, chlorhexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, zincophylthione, benzalkonium chloride, photosensitizer So No. 301, mononitroguacol sodium, undecyrenic acid, etc. are mentioned.

Examples of antioxidants include butylhydroxyanisole, propyl gallic acid, and elisorbic acid.

Examples of the pH adjuster include citric acid, sodium citrate, malic acid, sodium malate, fumaric acid, sodium fumalate, succinic acid, sodium succinate, sodium hydroxide, and sodium monohydrogenphosphate.

Examples of alcohol include higher alcohols such as cetyl alcohol.

In addition, the blending components that may be added are not limited to these, and any of the above components can be blended within a range not impairing the objects and effects of the present invention, but preferably 0.01 to 5% by weight relative to the total weight, More preferably, it is formulated at 0.01-3% by weight percentage.

When the formulation of the present invention is a lotion, paste, cream or gel, animal fiber, vegetable fiber, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide as a carrier component can be used

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluorohydrocarbon, propane / May contain a propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butyl glycol oil, fatty acid esters of glycerol, polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, an ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline Cellulose, aluminum metahydroxide, bentonite, agar or tracanth and the like may be used.

When the formulation of the present invention is surfactant-containing cleansing, as carrier components, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives, or ethoxylated glycerol fatty acid esters may be used.

Hereinafter, embodiments will be described in detail with reference to the accompanying drawings. However, since various changes can be made to the embodiments, the scope of the patent application is not limited or limited by these embodiments. It should be understood that all changes, equivalents or substitutes to the embodiments are included within the scope of rights.

Terms used in the examples are used only for descriptive purposes and should not be construed as limiting. Singular expressions include plural expressions unless the context clearly dictates otherwise. In this specification, terms such as "include" or "have" are intended to designate that there is a feature, number, step, operation, component, part, or combination thereof described in the specification, but one or more other features It should be understood that the presence or addition of numbers, steps, operations, components, parts, or combinations thereof is not precluded.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by a person of ordinary skill in the art to which the embodiment belongs. Terms such as those defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related art, and unless explicitly defined in the present application, they should not be interpreted in an ideal or excessively formal meaning. don't

In addition, in the description with reference to the accompanying drawings, the same reference numerals are given to the same components regardless of reference numerals, and overlapping descriptions thereof will be omitted. In describing the embodiment, if it is determined that a detailed description of a related known technology may unnecessarily obscure the gist of the embodiment, the detailed description will be omitted.

[Example]

In the following examples, the present inventors treated human-derived fibroblasts with various concentrations of turmeric extract or curcumin, irradiated a certain amount of LED light using an LED irradiation device of various wavelengths, obtained cells, and measured the levels of COL1A and MMP1 by qRT. -Confirmed through PCR and Western blot.

Example 1. Collagen level change confirmation when curcumin alone treatment and light irradiation are combined

Human-derived fibroblasts (HS68 cell line) were treated with curcumin at a concentration of 0.1, 0.5, or 1 uM, and after 10 minutes, the expression levels of type 1 collagen (COL1A) and MMP1 in the cells were examined.

As a result, as shown in FIG. 1, in the case of the curcumin 0.1 uM and 0.5 uM treated groups, the COL1A expression level was not affected, and the MMP1 expression decreased in a concentration-dependent manner, but the decrease was insignificant.

Subsequently, the effect on the level of collagen was examined when light treatment was applied to fibroblasts treated with curcumin at each of the above concentrations. Furthermore, in order to identify light in a wavelength band that can more effectively promote collagen synthesis when curcumin and light irradiation are combined, light irradiation was performed for 10 minutes by dividing the 545 nm LED combination group and the 655 nm LED combination group into cells. Expression levels of COL1A and MMP1 were examined. For comparison, the same experiment was performed on a control group in which both curcumin and light irradiation were not performed and an LED treatment group in which only 545 nm or 655 nm LED was treated without curcumin treatment. The results are shown in FIG. 2 .

As can be seen in FIG. 2 , in the fibroblasts treated with curcumin at a concentration of 0.5 uM, when irradiated with a 545 nm wavelength LED, the COL1A expression level was significantly increased, and the expression of MMP1 was decreased. Curcumin exhibited the best collagen enhancement effect at a concentration of 0.5 μM under LED irradiation conditions with a wavelength of 545 nm, and it was confirmed that the effect was reduced at lower and higher concentrations. Furthermore, when 655 nm wavelength LED was irradiated, 0.5 uM curcumin at a concentration of 1 uM induced an increase in COL1A expression and a decrease in MMP-1 expression similar to that of 545 nm wavelength.

On the other hand, the 545 nm LED alone treatment group did not significantly affect the COL1A expression level, but rather increased the MMP1 expression level. In addition, the 655nm LED alone treatment group did not significantly affect the expression level of MMP1 and slightly increased the expression level of COL1A.

From the above results, the collagen enhancement effect of the 0.5uM curcumin + 545 nm LED combination group and 1uM curcumin + 655nm LED combination group is not due to the effect of curcumin alone or 545nm or 655nm LED alone, but a new effect or synergy by the combination thereof. effect could be seen.

Example 2. Confirmation of the safety of curcumin

In order to confirm the safety of using curcumin in cosmetics, the cytotoxicity of various concentrations of curcumin was confirmed in human-derived fibroblasts. As a result, fibroblasts treated with curcumin at a concentration of 0.1 to 1 uM showed no significant difference in cell viability compared to the control group treated with PBS, confirming the safety of curcumin at this concentration for cosmetic use (FIG. 3).

Subsequently, in order to confirm cytotoxicity when light irradiation is performed concurrently at the above concentration of curcumin whose safety has been confirmed, human-derived fibroblasts were irradiated with various concentrations of curcumin and 545 nm or 655 nm wavelength LED for 10 minutes, and cell viability was confirmed. . As a result, both the 545 nm LED combination group and the 655 nm LED combination group showed no cytotoxicity regardless of the curcumin treatment concentration.

Example 3. Collagen level change confirmation when turmeric extract alone treatment and light irradiation are combined

Human-derived fibroblasts (HS68 cell line) were treated with turmeric extract at a concentration of 10, 20, or 40 ug/ml, and after 10 minutes, the expression levels of COL1A and MMP1 in the cells were examined. In addition, when the turmeric extract of the above concentration and LED irradiation were used in combination, changes in collagen levels were confirmed in fibroblasts. 545 nm and 655 nm wavelength LEDs were used as the irradiated LEDs. The result is shown in FIG. 4 .

In the case of the group treated with turmeric extract alone, there was no significant difference in the expression levels of COL1A and MMP1 up to the concentration of 20ug/ml, and a decrease in the expression of MMP1 was confirmed when treated with 40ug/ml turmeric extract alone. The expression level also decreased together.

In the case of both turmeric extract and 545nm LED irradiation, a significant increase in COL1A expression and a significant decrease in MMP1 expression were confirmed in the 20ug/ml turmeric extract treatment group. The decrease in MMP1 expression level was greatest when treated with 40 μg/ml of turmeric extract, but in this case, the decrease in COL1A expression level was also confirmed.

In the case of concurrent irradiation with turmeric extract and 655nm LED, an overall increase in COL1A expression level and a decrease in MMP1 expression were confirmed compared to the control group that was not treated with anything, but the level was insignificant.

Example 4. Confirmation of safety of turmeric extract

In order to confirm the safety of using the turmeric extract in cosmetics, human-derived fibroblasts were treated with the turmeric extract in the same manner as in Example 2 in which the safety of curcumin was confirmed, and cell viability was confirmed.

As a result, as shown in FIG. 5, the turmeric extract at all concentrations did not show cytotoxicity, and even when LED irradiation was performed in parallel, it did not show cytotoxicity at all concentrations.

As described above, although the embodiments have been described with limited drawings, those skilled in the art can apply various technical modifications and variations based on the above. For example, the described techniques may be performed in an order different from the method described, and/or the components of the described system, structure, device, circuit, etc. may be combined or combined in a different form than the method described, or other components may be used. Or even if it is replaced or substituted by equivalents, appropriate results can be achieved.

Therefore, other implementations, other embodiments, and equivalents of the claims are within the scope of the following claims.

Claims (10)

A cosmetic composition containing turmeric extract as an active ingredient,
In the cosmetic composition, the turmeric extract is included at a concentration of 15 to 25 ug / ml,
The composition is a photoreactive cosmetic composition that is used under light conditions of a wavelength of 545 ± 5 nm to show the effect of improving skin wrinkles and enhancing elasticity. According to claim 1,
The turmeric extract is a photoreactive cosmetic composition comprising curcumin. delete According to claim 2,
In the cosmetic composition, curcumin is contained in a concentration of 0.5 uM, a photoreactive cosmetic composition. A cosmetic composition containing curcumin as an active ingredient,
In the cosmetic composition, curcumin is included at a concentration of 0.4 to 0.6 uM,
The composition is a photoreactive cosmetic composition that is used under light conditions of a wavelength of 545 ± 5 nm to show the effect of improving skin wrinkles and enhancing elasticity. delete Applying the cosmetic composition of claim 1 or 5 to human skin; and
A cosmetic method for improving skin wrinkles and enhancing skin elasticity, comprising: irradiating light of 545±5 nm to the human skin with an LED or OLED light source. A cosmetic composition containing curcumin as an active ingredient,
In the cosmetic composition, curcumin is included at a concentration of 0.9 to 1.1 uM,
The composition is a photoreactive cosmetic composition that is used under light conditions of a wavelength of 655 ± 5 nm to show the effect of improving skin wrinkles and enhancing elasticity. delete Applying the cosmetic composition of claim 8 to human skin; and
A cosmetic method for improving skin wrinkles and enhancing skin elasticity, comprising: irradiating light of 655±5 nm to the human skin with an LED or OLED light source.

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